Tranquil Sleep

Tranquil Sleep

Natural Factors Stress-Relax4.4 (2,102 ratings)
Format:Softgel Quantity: 45 Softgel(s) · 22 servings
Goals
$13.97 $0.63 per serving

Product analysis

53 out of 100

Tranquil Sleep supports sleep timing and may help with relaxation around sleep. Melatonin makes the combination better suited to bedtime than daytime focus.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality25

The 5-HTP plant source is named, but the theanine and melatonin forms are unspecified. Their absorption quality cannot be compared with confidence.

Ingredient Transparency75

Ingredient amounts and the 5-HTP source are stated. Theanine and melatonin forms remain unspecified.

Value For Money45

Value is mixed, with a reasonably competitive cost for theanine but high costs relative to 5-HTP and melatonin. Paying for the combination may be less appealing if only one ingredient is wanted.

Customer Satisfaction77

Customer feedback is positive. A large number of ratings gives that view a broader base, though reviews do not establish effectiveness.

Product Focus66

The combination is most clearly aligned with sleep timing and relaxation around sleep. Its broader brain and mood uses are less certain, and melatonin may work against daytime alertness.

Format
Softgel
Container
45 Softgel(s)
Per serving
$0.63
Customer rating
4.4 · 2,102 ratings
Report analysis

Goals

Sleep Support
Impact
Highest effect
A- Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Melatonin · 3 mgTheanine · 200 mg
Study evidence
5-HTP Supportive 1 study
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Stress Relief
Impact
High effect
B+ Ingredient FitB+ PathwaysB EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
5-HTP Supportive 18 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Brain Health
Impact
High effect
B+ Ingredient FitC- PathwaysB EvidenceA+ Formulation Logic
Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Mood Support
Impact
High effect
C+ Ingredient FitD- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 30 mg
Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Productivity Boost
Impact
Lower effect
B- Ingredient FitC PathwaysB- EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 5 studies
Cognitive Support
Impact
High effect
B- Ingredient FitD+ PathwaysB+ EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 25 studies
Mental Focus
Impact
Lower effect
B- Ingredient FitC PathwaysB EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per servingScore
Suntheanine L-Theanine
200 mg 96
5-HTP (Griffonia simplicifolia)
30 mg 55
Melatonin
3 mg 70
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Theanine · 200 mg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
Each serving provides 200 mg of L-Theanine, at a moderate cost per 100 mg when the full product price is used. The amount is associated with relaxation and focus. A branded form is indicated, though its name is not specified in the available information.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The ingredient is specified as L-Theanine. A branded form is indicated, though its name is not specified in the available information.
Isomer Specificity (L-Theanine)
The ingredient is specified as L-Theanine.
Branded Forms & Purity Standards
A branded form is indicated, though its name is not specified in the available information.

Dose, Safety & Label Transparency100

The serving clearly states 200 mg of L-Theanine, an amount associated with relaxation and focus.
Theanine Dosage Efficacy
At 200 mg per serving, it provides an amount associated with relaxation and focus.
Label Transparency & Blends
The L-Theanine amount is individually stated as 200 mg per serving.

Value80

The full product cost per 100 mg of theanine is moderate.
Price per 100mg L-Theanine
Using the full product price, the cost per 100 mg of theanine is moderate.
Melatonin · 3 mg OverallScore70
C Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 3 mg of melatonin at a high cost per serving. It is an amount aligned with natural circadian rhythms. A third-party laboratory certification claim is present, though it has not been independently verified. The melatonin form is unspecified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

A third-party laboratory certification claim is present, though it has not been independently verified.
Third-Party Purity Verification
A third-party lab certification is claimed; the claim has not been independently verified.

Dose, Safety & Label Transparency100

Each serving contains 3 mg of melatonin. That amount aligns with natural circadian rhythms.
Physiological Dosing Alignment
The serving provides 3 mg of melatonin. The amount aligns with natural circadian rhythms.

Value30

The cost per serving is high.
Price Per Serving Efficiency
Each serving costs high.
B- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
A serving provides 30 mg of 5-HTP, at a high cost per 100 mg. Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated. General warnings are present, but a specific warning about serotonin-related medications is not stated. The serving also contains 200 mg L-theanine and 3 mg melatonin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated.
Botanical Source & Standardization
Griffonia simplicifolia is named, but its 5-HTP standardization percentage is not stated.

Dose, Safety & Label Transparency67

The serving provides 30 mg of 5-HTP. The serving also contains 200 mg L-theanine and 3 mg melatonin. General warnings are present, but a specific warning about serotonin-related medications is not stated.
Dosage Potency & Range
The serving provides 30 mg of 5-HTP. The serving also contains 200 mg L-theanine and 3 mg melatonin.
Safety Warnings & Label Clarity
General warnings are present, but a specific warning about serotonin-related medications is not stated.

Value0

The cost per 100 mg of 5-HTP is high.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  2. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  3. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  4. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  5. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  7. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  8. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  9. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  10. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  11. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  12. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  13. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  14. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  15. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  16. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  17. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  18. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  19. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  20. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine