5-HTP 100 mg

5-HTP 100 mg

Source Naturals Serene Science4.5 (451 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$19.53 $0.16 per serving
AmazonLowest$19.53iHerb$32.55Vitacost$32.55Pure Formulas$32.55Walmart$32.55Vitacost$32.55

About this product

A standard 100 mg 5-HTP serving gives the formula a clear and focused role in serotonin-related mood and sleep support. The amount matches the practical middle ground represented in the supplied goal analyses without pushing into a high-strength serving.

Griffonia simplicifolia is identified as the source, although no active standardization percentage is supplied. The capsule(s) format is convenient, but it does not add a disclosed release or absorption feature.

The simple design makes the active easy to judge, although it covers only one main pathway. Cost efficiency is a clear strength for the disclosed amount. It best fits adults seeking a straightforward middle-dose option for mood or sleep support.

Who is it for
  • Adults seeking a standard 5-HTP amount
  • People focused on mood or sleep support
  • Users who prefer a simple capsule or tablet routine
Best for
  • Focused serotonin-pathway mood support
  • Indirect sleep support through serotonin and melatonin pathways
  • Stress accompanied by low mood or disrupted sleep

Pros

  • Clearly discloses 100 mg of 5-HTP
  • Capsule(s) format is easy to use
  • Names Griffonia simplicifolia as the botanical source
  • Focused formula is easy to assess
  • Good value for the disclosed active amount

Cons

  • No 5-HTP standardization percentage is provided
  • No controlled-release or enteric delivery feature is disclosed
  • Single-pathway formula offers limited support beyond serotonin production

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines because serotonin toxicity can occur.
  • The 100 mg 5-HTP serving may cause nausea or digestive upset.
  • Avoid stacking it with other serotonin-focused supplements such as tryptophan or SAMe unless a qualified clinician has reviewed the combination.

Product analysis

82 out of 100
100 mg of 5-HTP provides standard serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.

AI assessment of the formula, label and price. How scoring works

Nutrient quality85

Griffonia simplicifolia identifies the botanical source, but no active standardization percentage is supplied. The 5-HTP amount matches a common standard serving, while missing extract standardization limits source-potency confidence.

Ingredient transparency81

Every listed active amount is disclosed, and no proprietary blend hides dosing. Complete directions, inactive ingredients, and some source or standardization details remain unavailable.

Customer satisfaction65

The aggregate rating is favorable, and the large review count supports confidence. No detailed feedback is supplied, so repeated complaints and purpose fit cannot be judged.

Value for money93

A standard amount and favorable serving economics provide strong value. Missing extract standardization is the main limitation.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.16
Also available
5-HTP 50 mg5-HTP 100 mg • 120 Capsule(s) • 60 servings$16.09
Customer rating
4.5 · 451 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 100 mg

5-HTP is a precursor your body can use to make serotonin, a chemical involved in mood signalling. That role alone doesn't show that taking it will improve everyday mood. The declared amount is clear, but a reliable mood benefit for general use remains uncertain, and a larger amount wouldn't resolve that uncertainty.

How this product is rated for Mood Support

Ingredient fit95

5-HTP provide the relevant connections to mood. The declared amounts differ in how closely they match comparison amounts.
Goal fit
5-HTP relate to mood through their individual roles.
Dose adequacy
5-HTP: 100 mg per serving.

Pathways59

5-HTP is a serotonin precursor; its everyday mood benefit remains uncertain.
Depth
5-HTP is a serotonin precursor; its everyday mood benefit remains uncertain.
Breadth
5-HTP is a serotonin precursor; its everyday mood benefit remains uncertain.

Evidence94

5-HTP is a serotonin precursor; its everyday mood benefit remains uncertain.
Evidence strength
5-HTP is a serotonin precursor; its everyday mood benefit remains uncertain.
Studied preparation
The ingredient identities allow comparison, but this does not guarantee an everyday mood benefit.

Formulation logic100

The ingredients have no identified requirement for an additional partner. No particular ingredient conflict is identified.
Partner coverage
No additional partner ingredient is required for these individual roles.
Conflicts
No particular ingredient conflict is identified.
Effective doses
5-HTP: 100 mg per serving.
Study evidence
5-HTP Supportive 9 studies
Sleep Support
Sleep Support
Impact
Moderate effect
A Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic

5-HTP may relate to the serotonin–melatonin precursor pathway, but its sleep benefit remains uncertain outside particular circumstances. At 100 mg, it is the only clear sleep-related ingredient in this product.

The formula contains no melatonin for sleep timing and no separate calming ingredient. Its potential is therefore narrow and centered on the precursor pathway.

How this product is rated for Sleep Support

Ingredient fit95

5-HTP is the only sleep-related active, giving this simple product a focused but narrow role.
Goal fit
5-HTP is the only sleep-related active, so the formula has a narrow role for this goal.
Dose adequacy
The 100 mg 5-HTP amount is the only declared sleep-related contribution.

Pathways60

5-HTP provides a link to the precursor route, without direct timing or calming ingredients.
Depth
5-HTP provides a clear link to the precursor route.
Breadth
The product centers on one pathway and does not cover several distinct sleep routes.

Evidence58

5-HTP offers a limited, context-specific sleep link rather than a broad sleep-quality role.
Evidence strength
5-HTP offers a limited, context-specific sleep link rather than a broad sleep-quality role.
Studied preparation
The active 5-HTP form is identified, with no separate extract uncertainty.

Formulation logic100

The sole ingredient can contribute without a partner; no second route broadens its possible role.
Partner coverage
5-HTP can have a possible role alone; no sleep-specific partner is needed.
Conflicts
No bedtime stimulant or activating combination is identified among the listed ingredients.
Effective doses
The 5-HTP amount is the only ingredient at a usable level for this sleep context.
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic

5-HTP may help with some anxiety-related symptoms, although whether that translates into everyday stress relief is unclear. Its connection here concerns mood and nerve-signaling chemicals. The declared amount gives a clear quantity to compare, but does not resolve who will benefit or show that stress will become easier to manage.

How this product is rated for Stress Relief

Ingredient fit95

5-HTP has possible anxiety-related effects, with uncertain applicability to everyday stress.
Goal fit
5-HTP is relevant to selected anxiety-related situations; everyday stress relief remains uncertain.
Dose adequacy
5-HTP: 100 mg. These are amounts per selected serving.

Pathways46

The main connection concerns mood-related nerve signaling, with a smaller connection to sleep-associated stress.
Depth
The strongest connection concerns mood and neurotransmitter synthesis, without guaranteeing relief from everyday stress.
Breadth
The connection centers on mood-related nerve signaling rather than many different stress processes.

Evidence56

5-HTP has possible anxiety-related effects, with uncertain applicability to everyday stress.
Evidence strength
5-HTP has conditional anxiety-related benefits; broad everyday applicability remains uncertain.
Studied preparation
The 5-HTP declaration gives a clear amount, but that does not resolve its everyday applicability.

Formulation logic100

No particular ingredient conflict or missing required partner is identified for the relevant ingredients.
Partner coverage
The relevant ingredients can contribute individually or have their specified partners.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The serving supplies 100 mg 5-HTP, matching the central comparison amount; that is not a guarantee of relief.
Study evidence
5-HTP Supportive 18 studies
Weight Loss
Weight Loss
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia)
 100 mg 85
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
5-HTP (Griffonia simplicifolia) · 100 mg OverallScore85
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value
5-HTP 100 mg states 100 mg per serving and identifies Griffonia simplicifolia, though no standardization percentage is provided. A specific warning about combining it with serotonin-modulating medicines is recorded. Its cost per 100 mg of 5-HTP is relatively low in the saved comparison.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The botanical source is named, but the extract's 5-HTP standardization is not stated.
Botanical Source & Standardization
The saved facts name Griffonia simplicifolia but do not give a standardization percentage.

Dose, Safety & Label Transparency100

The amount per serving is clear, and a specific medication interaction warning is recorded.
Dosage Potency & Range
The label states 100 mg of 5-HTP per serving.
Safety Warnings & Label Clarity
The saved facts record a specific warning about combining 5-HTP with antidepressants or other serotonin-modulating medicines.

Value85

Its cost for the declared 5-HTP amount is comparatively low.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is relatively low compared with the saved reference.
View ingredientView products
Loading alternative details
85 Performance

5-HTP 100 mg

NOW
Clearer botanical sourcing makes this a stronger quality alternative. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and strong formula value make this a practical value alternative. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  5. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  6. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  7. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  8. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  9. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  10. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  11. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  12. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  13. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  14. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  15. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  16. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  17. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP