Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
Meta-analysis55,614 participants4 studies pooledflagVision Support forscienceVitamin C flagVision Support forscienceVitamin E
- What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
Systematic review27 studies pooledflagVision Support forscienceVitamin C flagVision Support forscienceCopper
- Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
Case-control study530 participantsflagVision Support forscienceVitamin C flagVision Support forscienceVitamin E
- Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
Randomized trial64 participantsflagVision Support forscienceAstaxanthin
- Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
Randomized trial60 participantsflagVision Support forscienceAstaxanthin
- Sports and Kinetic Visual Acuity.
Sawaki K; Kohmura Y; Aoki K; Nakamura M; Murakami S; Suzuki Y · Juntendo Iji zasshi = Juntendo medical journal · 2024
Narrative reviewflagVision Support forscienceAstaxanthin
- Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
Single-arm trial60 participantsflagVision Support forscienceAstaxanthin
- The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial.
Youssef FM; Ateyya H; Hanna Samy AE; Elmokadem EM · Frontiers in pharmacology · 2025
Randomized trial80 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.
Malcangi G; Inchingolo AM; Casamassima L; Trilli I; Ferrante L; Longo M; Inchingolo F; Marinelli G; Palermo A; Dipalma G; Inchingolo AD · International journal of molecular sciences · 2026
Systematic review15 studies pooledflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
Rostami S; Alyasin A; Saedi M; Nekoonam S; Khodarahmian M; Moeini A; Amidi F · Frontiers in endocrinology · 2023
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate.
Sharifi-Rigi A; Zal F; Aarabi MH; Dehghani M; Roustaei Rad N; Taghiyar S · International journal of endocrinology · 2025
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
Basereh A; Khoramipour K; Hosseini N; HajHosseini M; Khodabakhshi A; Amirkhosravi L; Khoramipour K · Scientific reports · 2025
Randomized trial90 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Selenium and the course of mild Graves' orbitopathy.
Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
Randomized trial159 participantsflagAnti-Inflammatory Support forscienceSelenium
- Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
Randomized trial70 participantsflagAnti-Inflammatory Support forscienceSelenium
- Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
Randomized trial60 participantsflagAnti-Inflammatory Support forscienceSelenium
- The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
Meta-analysis656 participants11 studies pooledflagAnti-Inflammatory Support forscienceSelenium
- Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
Randomized trial33 participantsflagAnti-Inflammatory Support forscienceSelenium
- Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
Randomized trial107 participantsflagAnti-Inflammatory Support forscienceVitamin C
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
Meta-analysis1,162 participants10 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
Meta-analysis852 participants8 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
Systematic review811 participants17 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
Randomized trial44 participantsflagAnti-Inflammatory Support forscienceVitamin C
- Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
Randomized trial110 participantsflagAnti-Inflammatory Support forscienceVitamin E
- Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
Meta-analysis495 participants12 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
Meta-analysis46 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
Meta-analysis8 studies pooledflagAnti-Inflammatory Support forscienceVitamin E
- Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
Randomized trial71 participantsflagAnti-Inflammatory Support forscienceVitamin E
- Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
Randomized trial40 participantsflagAnti-Inflammatory Support forscienceZinc
- Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
Meta-analysis23 studies pooledflagAnti-Inflammatory Support forscienceZinc
- The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
Meta-analysis73 studies pooledflagAnti-Inflammatory Support forscienceZinc
- The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
Randomized trial46 participantsflagAnti-Inflammatory Support forscienceZinc
- Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
Meta-analysis75 studies pooledflagAnti-Inflammatory Support forscienceZinc
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
Meta-analysis95 participants20 studies pooledflagGeneral Health forscienceSelenium
- Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
Meta-analysis507,251 participants41 studies pooledflagGeneral Health forscienceSelenium
- The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
Meta-analysis4 studies pooledflagGeneral Health forscienceSelenium
- Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
Cohort study6,155 participantsflagGeneral Health forscienceSelenium
- Updates on clinical studies of selenium supplementation in radiotherapy.
Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
Systematic review16 studies pooledflagGeneral Health forscienceSelenium
- Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
Meta-analysis69 studies pooledflagGeneral Health forscienceVitamin C
- Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagGeneral Health forscienceVitamin C
- Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
Cohort study598 participantsflagGeneral Health forscienceVitamin C
- Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
Cohort study12,530 participantsflagGeneral Health forscienceVitamin C
- Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
Cohort study19,496 participantsflagGeneral Health forscienceVitamin C
- Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
Randomized trial144 participantsflagGeneral Health forscienceZinc
- Zinc supplementation in young children with acute diarrhea in India.
Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
Randomized trial937 participantsflagGeneral Health forscienceZinc
- Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
Randomized trial4,753 participantsflagGeneral Health forscienceZinc
- Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
Randomized trial84 participantsflagGeneral Health forscienceZinc
- Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
Randomized trial142 participantsflagGeneral Health forscienceZinc
- Effects of omega-3 fatty acids on hyper-inflammatory response and clinical outcomes in critically ill patients: a meta-analysis.
Liu T; Wang X; Wang XH; Wang C; Cai JZ; Wang HF · Intensive & critical care nursing · 2025
Meta-analysis3,152 participants41 studies pooledflagImmunity forscienceOmega-3
- Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China.
Zhao Y; Wang C · Medicine · 2018
Meta-analysis1,008 participants16 studies pooledflagImmunity forscienceOmega-3
- Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis.
Yu J; Liu L; Zhang Y; Wei J; Yang F · BMC cancer · 2017
Meta-analysis623 participants9 studies pooledflagImmunity forscienceOmega-3
- Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers.
Ferguson JF; Mulvey CK; Patel PN; Shah RY; Doveikis J; Zhang W; Tabita-Martinez J; Terembula K; Eiden M; Koulman A; Griffin JL; Mehta NN; Shah R; Propert KJ; Song WL; Reilly MP · Molecular nutrition & food research · 2015
Randomized trial60 participantsflagImmunity forscienceOmega-3
- Omega-3 fatty acid supplementation during pregnancy and respiratory symptoms in children.
Escamilla-Nuñez MC; Barraza-Villarreal A; Hernández-Cadena L; Navarro-Olivos E; Sly PD; Romieu I · Chest · 2014
Randomized trial1,094 participantsflagImmunity forscienceOmega-3
- Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
Randomized trial119 participantsflagImmunity forscienceSelenium
- Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
Randomized trial62 participantsflagImmunity forscienceSelenium
- Chemoprevention trial of human hepatitis with selenium supplementation in China.
Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
Non-randomized trial20,847 participantsflagImmunity forscienceSelenium
- Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
Randomized trial70 participantsflagImmunity forscienceSelenium
- Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
Randomized trial70 participantsflagImmunity forscienceSelenium
- Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagImmunity forscienceVitamin C
- Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
Meta-analysis2,334 participants14 studies pooledflagImmunity forscienceVitamin C
- Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
Meta-analysisflagImmunity forscienceVitamin C
- New evidence for antioxidant properties of vitamin C.
Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
Randomized trial20 participantsflagImmunity forscienceVitamin C
- Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
Calder PC; Kreider RB; McKay DL · Nutrients · 2025
Systematic review13 studies pooledflagImmunity forscienceVitamin C
- Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
Randomized trial32 participantsflagImmunity forscienceVitamin E
- Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
Randomized trial150 participantsflagImmunity forscienceVitamin E
- Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
Randomized trialflagImmunity forscienceVitamin E
- Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
Randomized trial29,133 participantsflagImmunity forscienceVitamin E
- Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD · JAMA · 1997
Randomized trial88 participantsflagImmunity forscienceVitamin E
- Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
Meta-analysis199,055 participants115 studies pooledflagImmunity forscienceZinc
- Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
Randomized trial609 participantsflagImmunity forscienceZinc
- A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
Randomized trial64 participantsflagImmunity forscienceZinc
- The effect of zinc and vitamin A supplementation on immune response in an older population.
Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
Randomized trial136 participantsflagImmunity forscienceZinc
- The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
Systematic review13 studies pooledflagImmunity forscienceZinc
- The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
Ito N; Seki S; Ueda F · Nutrients · 2018
Randomized trial23 participantsflagSkin Health forscienceAstaxanthin
- Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
Randomized trial44 participantsflagSkin Health forscienceAstaxanthin
- Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
Single-arm trial31 participantsflagSkin Health forscienceAstaxanthin
- The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
Randomized trial34 participantsflagSkin Health forscienceAstaxanthin
- Cosmetic benefits of astaxanthin on humans subjects.
Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
Other66 participantsflagSkin Health forscienceAstaxanthin
- Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
Randomized trialflagSkin Health forscienceLycopene
- Topical lycopene emulgel significantly improves biophysical parameters of human skin.
Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
Clinical trialflagSkin Health forscienceLycopene
- Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
Randomized trialflagSkin Health forscienceLycopene
- Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
Cohort study123,570 participantsflagSkin Health forscienceLycopene
- β-Carotene and other carotenoids in protection from sunlight.
Stahl W; Sies H · The American journal of clinical nutrition · 2013
Narrative reviewflagSkin Health forscienceLycopene
- Dietetic intervention in psoriatic arthritis: the DIETA trial.
Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
Randomized trial97 participantsflagSkin Health forscienceOmega-3
- Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
Randomized trial49 participantsflagSkin Health forscienceOmega-3
- Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
Randomized trial60 participantsflagSkin Health forscienceOmega-3
- Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
Randomized trial50 participantsflagSkin Health forscienceOmega-3
- Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
Randomized trial42 participantsflagSkin Health forscienceOmega-3
- Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
Chu AC · Dermatologica · 1985
Randomized trial38 participantsflagSkin Health forscienceSelenium
- Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
Randomized trial1,312 participantsflagSkin Health forscienceSelenium
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceSelenium flagSkin Health forscienceVitamin E flagSkin Health forscienceZinc
- A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
Randomized trial121 participantsflagSkin Health forscienceSelenium
- The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
Clinical trial31 participantsflagSkin Health forscienceSelenium
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
Randomized trial45 participantsflagSkin Health forscienceVitamin E
- Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
Meta-analysis20 studies pooledflagSkin Health forscienceVitamin E
- Effects of tocotrienol on aging skin: A systematic review.
Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
Systematic reviewflagSkin Health forscienceVitamin E
- Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
Randomized trialflagSkin Health forscienceVitamin E
- Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
Meta-analysis2,088 participants20 studies pooledflagSkin Health forscienceZinc
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
Cohort study23 participantsflagSkin Health forscienceZinc
- Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
Randomized trial30 participantsflagSkin Health forscienceZinc
- A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
Randomized trial90 participantsflagSkin Health forscienceZinc
- Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
Narrative reviewflagVision Support forscienceAstaxanthin
- Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Martinez-Perez C; Oliveira AP · Nutrients · 2026
Systematic review9 studies pooledflagVision Support forscienceAstaxanthin
- Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
Cohort study8,242 participantsflagVision Support forscienceCopper
- Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
Observational study4,996 participantsflagVision Support forscienceCopper
- Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
Yang Y; Zou H · The journal of nutrition, health & aging · 2026
Cohort study103,192 participantsflagVision Support forscienceCopper
- Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
Case-control study151 participantsflagVision Support forscienceCopper
- Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
Randomized trial400 participantsflagVision Support forscienceVitamin C
- Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
Observational studyflagVision Support forscienceVitamin C
- Nutritional modulation of cataract.
Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
Narrative reviewflagVision Support forscienceVitamin C
- Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
Case-control study883 participantsflagVision Support forscienceVitamin C
- Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
Cohort study35,551 participantsflagVision Support forscienceVitamin E
- Long-term nutrient intake and 5-year change in nuclear lens opacities.
Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
Cohort study408 participantsflagVision Support forscienceVitamin E
- Dietary intake of antioxidants and risk of age-related macular degeneration.
van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
Cohort study4,765 participantsflagVision Support forscienceVitamin E
- Antioxidant vitamin and mineral supplements for age-related macular degeneration.
Evans JR · The Cochrane database of systematic reviews · 2002
Systematic review170 participants7 studies pooledflagVision Support forscienceZinc
- Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
Meta-analysis3,790 participants5 studies pooledflagVision Support forscienceZinc
- Oral zinc in macular degeneration.
Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
Randomized trial151 participantsflagVision Support forscienceZinc
- A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
Randomized trial3,640 participantsflagVision Support forscienceZinc
- Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
Randomized trial133 participantsflagVision Support forscienceZinc