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Calcium Mag & Zinc Mineral Complex

Nature's Way
4.7
★ ★ ★ ★ ★
(1745 ratings)
Calcium 500 mg
Magnesium 250 mg
Product Image
Score79
A better-than-basic mixed mineral complex with several useful chelated or organic forms, held back by oxide content and unclear source splits.
How scoring works
Quantity:100 Capsule(s) • (33 servings)
Goals:
General Health
Bone Health
Heart Health
Testosterone Support
Energy
Stress Relief

Score 79

A better-than-basic mixed mineral complex with several useful chelated or organic forms, held back by oxide content and unclear source splits.
How scoring works

Also available as

1 option
250 servings Magnesium 250 mg, Calcium 500 mg • 250 Capsule(s) • 83 servings $23.13 ($0.27 per serving)
$12.49($0.37 per serving)
Vitacost
$ 12.49
iHerb
$ 12.49
Vitacost
$ 12.49
Report prices

Analysis

The combination covers calcium, magnesium, and zinc with several well-chosen forms. Calcium malate and citrate, magnesium citrate or aspartate, and zinc bisglycinate give the formula meaningful nutritional quality.

Calcium carbonate and magnesium oxide dilute those strengths. The repeated amounts assigned to multiple forms also make it difficult to know how much each source contributes to the total serving.

The product offers good mineral breadth and reasonable value in capsules. It works best for users who want a mixed-form foundation and can tolerate the serving, while those seeking precise source splits or an oxide-free formula should look elsewhere.

Who is it for
  • Adults seeking a mixed-form calcium and magnesium complex
  • Users who also want a maintenance zinc amount
Best for
  • General mineral support
  • Bone nutrition
  • Users prioritizing form variety

Pros

  • Includes calcium citrate and malate
  • Uses magnesium citrate and aspartate
  • Provides zinc bisglycinate
  • Offers broad mineral support

Cons

  • Still contains carbonate and oxide forms
  • Elemental source splits are unclear
  • Lacks vitamin D
  • Three-capsule serving may be inconvenient

Warnings

  • Magnesium may cause loose stools or cramping in sensitive users
  • Large calcium servings may cause constipation
  • Calcium and magnesium may need separation from medicines affected by mineral binding

Nutrient quality

88 Highest impact

Diverse mineral forms and balanced doses provide solid formulation quality. Included carbonate and oxide forms are the main compromise.

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Ingredient transparency

75 High impact

Named actives have amounts, but totals repeated across several forms leave each form’s contribution unclear. Non-active ingredients are not supplied, so excipient disclosure cannot be verified.

.

Customer satisfaction

68 High impact

The average customer rating is very strong. No specific review comments were supplied, so repeated negative experiences cannot be ruled out.

.

Value for money

81 Highest impact

The varied mineral forms provide fair support for the asking price. It is reasonably competitive but not a category value leader.

.
Report analysis

Goals

General Health
Stress Resilience
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA Formula Quality
Magnesium · 250 mgZinc · 15 mg

Three foundational minerals support bone structure, muscle function, and numerous metabolic processes. Useful amounts of magnesium and zinc strengthen its relevance, although calcium occupies much of the formula.

The magnesium amount is practical and the zinc uses a well-absorbed bisglycinate form. Magnesium combines citrate and aspartate with less absorbable oxide, and the contribution of each form is not separated.

Study evidence
Magnesium Supportive 114 studies
Zinc Supportive 60 studies
Bone Health
Bone Health
Impact
Highest effect
A- Goal FitA- Strength of SupportB CoverageB+ Formula Quality
Magnesium · 250 mgCalcium · 500 mgZinc · 15 mg

Calcium, magnesium, and zinc provide a strong foundational mineral combination for bone structure and remodeling. Meaningful amounts and several citrate, malate, and bisglycinate forms support practical use.

Carbonate and oxide lower average form quality, and the formula lacks vitamin D, MK-7, and protein-matrix support. Dividing the three-capsule serving across meals may improve tolerance and avoid taking the full mineral load at once.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Zinc Supportive 33 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
B+ Goal FitB Strength of SupportC- CoverageA- Formula Quality
Magnesium · 250 mg

A meaningful magnesium amount supports heart rhythm and vascular tone, with calcium and zinc adding broader mineral coverage. Citrate and aspartate improve parts of the magnesium blend.

Magnesium oxide is also present, and the amounts from each form are not separated. The formula is mineral focused and does not address lipids, cardiac energy, or homocysteine.

Study evidence
Magnesium Supportive 158 studies
Testosterone Support
Natural Hormone ProductionFree Testosterone Support
Testosterone Support
Impact
High effect
C+ Goal FitB+ Strength of SupportC- CoverageB Formula Quality
Magnesium · 250 mgZinc · 15 mg

Magnesium and zinc provide two foundational minerals relevant to normal testosterone production and free-hormone status. Their amounts are useful, but the product remains a general calcium-mineral complex.

Zinc bisglycinate is a strong form, while magnesium mixes citrate and aspartate with lower-absorption oxide. The formula lacks vitamin D, boron, or a stress-modulating ingredient for broader endocrine coverage.

Study evidence
Magnesium Disputed 5 studies
Zinc Disputed 7 studies
Energy
Energy
Impact
High effect
B- Goal FitB Strength of SupportD+ CoverageB+ Formula Quality
Magnesium · 250 mg

Magnesium supports ATP reactions and muscle function, but the mineral complex does not address alertness or stress resilience. The role of magnesium in energy metabolism is established, while direct fatigue benefit is greatest when intake is low.

The 250 mg elemental magnesium amount meets the configured effective range. Aspartate and citrate are useful forms, but their proportions relative to poorly absorbed oxide are not disclosed.

Study evidence
Magnesium Supportive 4 studies
Stress Relief
Calm and Tension Relief
Stress Relief
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageC+ Formula Quality
Magnesium · 250 mg

A useful magnesium amount provides foundational nervous-system support, but the formula is a general mineral complex rather than a targeted calming product. Evidence for magnesium is relevant, although the mixed forms include lower-absorption oxide and are not proportioned separately.

The elemental amount is well aligned while form quality remains uncertain. Calcium and zinc add mineral context but little direct breadth for stress relief.

Study evidence
Magnesium Supportive 13 studies
Zinc Supportive 9 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Calcium (Calcium Carbonate, Calcium Citrate, Calcium Malate)
 500 mg
Magnesium (Magnesium Aspartate, Magnesium Citrate, Magnesium Oxide)
 250 mg
Zinc (Zinc Bisglycinate)
 15 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Calcium (Calcium Carbonate, Calcium Citrate, Calcium Malate) · 500 mg OverallScore90
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

A mixed calcium blend balances premium malate and citrate with less absorbable carbonate. The elemental amount is efficient for one dose, and magnesium plus zinc broaden mineral support. Good serving value fits the quality of the blended forms.

View ingredientView products
Magnesium (Magnesium Aspartate, Magnesium Citrate, Magnesium Oxide) · 250 mg OverallScore61
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB- Value

Aspartate and citrate are paired with oxide without separate form weights, limiting absorption confidence. The 250 mg elemental amount is well aligned with the therapeutic range. The calcium ratio does not exceed the competition threshold, and the low serving cost supports good value.

View ingredientView products
Loading alternative details
88 Performance

Calcium Citrate Pure Powder

NOW
<p>Pure calcium citrate provides a substantial, well-absorbed amount with simple active disclosure. The focused powder improves calcium form quality but does not include magnesium, vitamin D, or vitamin K.</p>
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides stronger absorption quality than oxide-containing blends and a useful elemental amount. The clean powder is limited to magnesium, so it does not replace the original calcium component.</p>
83 Performance

Albion Chelated Calcium 180 mg

Swanson Ultra
<p>Calcium glycinate chelate offers favorable form quality with a small vitamin D3 addition. The product name and supplied serving amount conflict, and the focused formula contains no magnesium.</p>
85 Budget

600+D3

21st Century
<p>Calcium carbonate and vitamin D3 provide focused bone support at a much lower serving cost. The formula omits magnesium, and carbonate is better suited to use with food than citrate-based calcium.</p>
88 Budget

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate provides a well-absorbed form at a lower serving cost than the original. The adjustable powder is clearly labeled but supplies no calcium or vitamin D.</p>
91 Budget

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a lower serving cost, with potassium adding another useful electrolyte. The focused formula does not replace the original product's calcium contribution.</p>
84 Value

Calcium Citrate +D3 Petites

21st Century
<p>Calcium citrate and vitamin D3 deliver practical bone support with strong serving efficiency. The active amounts are clear, although missing excipient details and the absence of magnesium narrow the formula.</p>
82 Value

Calcium Citrate

Nature's Way
<p>Citrate and malate provide useful calcium forms at an economical serving cost. The formula supplies no magnesium, while missing excipient and full-use details limit transparency.</p>
84 Value

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate offers favorable absorption and a useful amount with solid serving value. The tablet remains a single-mineral option and therefore does not replace calcium coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  3. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  4. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  5. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  6. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  7. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  8. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  9. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  10. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  11. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  12. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  13. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  14. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  15. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  16. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  17. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  18. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  19. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  20. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  21. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  22. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  23. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  24. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  25. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  26. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  27. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  28. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  29. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.
    Lamberti LM; Walker CL; Chan KY; Jian WY; Black RE · Nutrients · 2014
    Meta-analysis18,822 participants104 studies pooledDigestive Health forZinc
  30. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial.
    Bhatnagar S; Bahl R; Sharma PK; Kumar GT; Saxena SK; Bhan MK · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial287 participantsDigestive Health forZinc
  31. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial.
    Dhingra U; Kisenge R; Sudfeld CR; Dhingra P; Somji S; Dutta A; Bakari M; Deb S; Devi P; Liu E; Chauhan A; Kumar J; Semwal OP; Aboud S; Bahl R; Ashorn P; Simon J; Duggan CP; Sazawal S; Manji K · The New England journal of medicine · 2020
    Randomized trial4,500 participantsDigestive Health forZinc
  32. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsDigestive Health General Health forZinc
  33. Short-course prophylactic zinc supplementation for diarrhea morbidity in infants of 6 to 11 months.
    Malik A; Taneja DK; Devasenapathy N; Rajeshwari K · Pediatrics · 2013
    Randomized trial272 participantsDigestive Health forZinc
  34. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  35. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  36. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  37. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  38. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  39. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  40. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  41. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  42. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  43. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  44. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  45. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  46. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  47. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  48. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  49. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  50. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  51. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  52. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  53. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  54. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  55. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment.
    Amini Z; HeidariFarsani E · Substance abuse treatment, prevention, and policy · 2023
    Randomized trial68 participantsStress Relief forZinc
  56. A systematic review of the association between zinc and anxiety.
    Azargoonjahromi A · Nutrition reviews · 2024
    Systematic review9 studies pooledStress Relief forZinc
  57. Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report.
    Brandão-Neto J; de Mendonça BB; Shuhama T; Marchini JS; Pimenta WP; Tornero MT · Biological trace element research · 1991
    Clinical trial27 participantsStress Relief forZinc
  58. Low Zinc, Copper, and Manganese Intake is Associated with Depression and Anxiety Symptoms in the Japanese Working Population: Findings from the Eating Habit and Well-Being Study.
    Nakamura M; Miura A; Nagahata T; Shibata Y; Okada E; Ojima T · Nutrients · 2019
    Cross-sectional study2,089 participantsStress Relief forZinc
  59. Mediation effects of thyroid hormones in the associations between essential metal elements and anxiety or depression symptoms in the elderly.
    Li J; Wang W; Peng Y; Qin N; Li J; Wei Y; Wang B; Zeng H; Li H; Cheng L · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Observational study416 participantsStress Relief forZinc
  60. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  61. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  62. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  63. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  64. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium
  65. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  66. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  67. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  68. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  69. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc