Product Image

MediClear-SGS Vanilla Flavored

Thorne
4.7
★ ★ ★ ★ ★
(398 ratings)
Betaine Anhydrous 50 mg
Molybdenum 50 mcg
Selenium 70 mcg
Vitamin B5 50 mg
Lysine 500 mg
Chromium 100 mcg
Thiamin 12 mg
Product Image
Score55
Protein, quality nutrient forms, curcumin, milk thistle, and broccoli glucosinolate create broad nutritional and detoxification-oriented coverage. Opaque blending and very high cost are substantial compromises.
How scoring works
Quantity:34 Ounce(s) • (21 servings)
Goals:
Detoxification
Energy
General Health
Immunity
Weight Gain
Hair Health

Score 55

Protein, quality nutrient forms, curcumin, milk thistle, and broccoli glucosinolate create broad nutritional and detoxification-oriented coverage. Opaque blending and very high cost are substantial compromises.
How scoring works
$90.00($4.28 per serving)
Vitacost
$ 90.00
iHerb
$ 90.00
Pure Formulas
$ 90.00
iHerb
$ 90.00
Report prices

Analysis

Twenty grams of protein and a broad vitamin-and-mineral base make the powder useful for meal-style nutritional support. Methylcobalamin, P-5-P, riboflavin phosphate, zinc bisglycinate, selenomethionine, magnesium citrate, and calcium citrate are sound form choices.

Curcumin phytosome, milk thistle, glycine, and 30 mg sulforaphane glucosinolate give this version a clearer detoxification-oriented profile. Glutamine, lysine, taurine, betaine, glutathione, green tea, and grape seed are present, but several are too modest to carry the formula.

The serving supplies 190 calories, so it can add protein and energy but is not a complete high-calorie mass gainer. A proprietary blend over 26 grams and premium positioning make it best suited to users who specifically want the combined nutrition and broccoli-extract design.

Who is it for
  • Adults seeking a broad nutrition shake with broccoli extract
  • Users wanting protein plus active-form micronutrients
  • People specifically prioritizing detoxification-oriented ingredients
Best for
  • Broad meal-style nutrition
  • Protein with vitamins and minerals
  • Combining glycine, curcumin, milk thistle, and broccoli glucosinolate

Pros

  • Provides 20 grams of protein
  • Includes 30 mg sulforaphane glucosinolate
  • Uses active B-vitamin forms
  • Provides chelated and citrate minerals
  • Curcumin phytosome and milk thistle are meaningful additions

Cons

  • Very large proprietary blend limits assessment
  • Very high serving cost
  • Several specialty ingredients are token doses
  • Only 21 servings per container
  • Not calorie-dense enough for standalone mass gain

Warnings

  • Vitamin E and curcumin deserve care with anticoagulant or antiplatelet medicines
  • The proprietary blend prevents a complete allergen and interaction assessment from the supplied data
  • Chromium and vanadium may affect blood glucose alongside glucose-lowering medication

Nutrient quality

76 High impact

Protein, active B vitamins, chelated minerals, and two targeted liver-support pathways create a strong nutritional core. Numerous modest specialty ingredients and a very large hidden blend reduce depth and focus.

Ingredient transparency

42 Lower impact

Many named nutrients and botanicals have specific amounts and forms. A very large proprietary blend, incomplete botanical markers, missing directions, and absent non-active ingredients create major disclosure gaps.

Customer satisfaction

70 High impact

The supplied satisfaction metric is strong and response volume is substantial. Specific firsthand feedback was not supplied, so recurring complaints and purpose alignment remain uncertain.

Value for money

31 Situational impact

High-quality forms and broad nutrition partly support the cost. The exceptionally expensive serving, hidden base, and many modest extras make the formula poorly competitive.

Report analysis

Goals

Detoxification
Detoxification
Impact
Highest effect
A Goal FitB+ Strength of SupportA CoverageA- Formula Quality
Folate · 500 mcg DFEVitamin B12 · 50 mcgVitamin B6 · 10 mgMolybdenum · 50 mcgSelenium · 70 mcgMagnesium · 150 mgMilk Thistle · 250 mgBetaine Anhydrous · 50 mgGlutamine · 500 mgVitamin E · 80.6 mgCurcumin · 400 mgZinc · 10 mgVitamin C · 300 mgCholine · 11 mgTaurine · 110 mgRiboflavin · 5 mgGlycine · 1.65 Gram(s)

Glycine, curcumin phytosome, milk thistle, glucoraphanin from broccoli, glutamine, selenium, and molybdenum address several liver and antioxidant pathways. The added glucoraphanin gives this version another direct route into cellular detox-enzyme support.

Strong mineral and vitamin forms improve confidence, and glycine provides meaningful conjugation substrate. Milk thistle lacks silymarin standardization, while taurine, betaine, glutathione, and green tea remain modest.

Study evidence
Betaine Anhydrous Mixed 4 studies
Curcumin Supportive 30 studies
Glutamine Supportive 8 studies
Glycine Supportive 5 studies
Green Tea Disputed 16 studies
Milk Thistle Supportive 46 studies
Molybdenum Adverse 1 study
Selenium Supportive 10 studies
Taurine Supportive 2 studies
Energy
Physical StaminaEssential Energy Nutrients
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportB+ CoverageB- Formula Quality
Vitamin D · 10 mcgVitamin B5 · 50 mgMagnesium · 150 mgRiboflavin · 5 mgThiamin · 12 mgVitamin B12 · 50 mcgPotassium · 100 mg

Protein, medium-chain triglycerides, active B vitamins, magnesium, and micronutrients support fuel availability and cellular energy metabolism. Evidence is strong for protein and essential nutrient repletion, while several detoxification-oriented extras have less direct fatigue evidence.

Twenty grams of protein and useful B-vitamin amounts provide meaningful support, although magnesium falls below the configured target. Methylcobalamin, P5P, riboflavin phosphate, citrate minerals, and chelates are favorable, but a 26.12 gram proprietary blend limits full assessment.

Study evidence
Magnesium Supportive 4 studies
Riboflavin Mixed 6 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportA- CoverageC+ Formula Quality
Folate · 500 mcg DFEVitamin B12 · 50 mcgVitamin D · 10 mcgMagnesium · 150 mgBoron · 100 mcgGlycine · 1.65 Gram(s)Selenium · 70 mcgTaurine · 110 mgCurcumin · 400 mgZinc · 10 mgVitamin C · 300 mg

Protein, a broad micronutrient profile, amino acids, curcumin phytosome, milk thistle, and broccoli-derived glucosinolate give this powder unusually wide nutritional coverage. Many vitamin and mineral forms are favorable, including methylcobalamin, active B6, zinc bisglycinate, and L-selenomethionine.

A 26.12 g proprietary blend prevents complete assessment even though many components are listed separately, and several specialty ingredients are modest. The product works best as a broad nutrition formula rather than proof of a specific cleansing effect.

Study evidence
Curcumin Supportive 64 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
High effect
B+ Goal FitB Strength of SupportA- CoverageC Formula Quality
Magnesium · 150 mgVitamin C · 300 mgZinc · 10 mgVitamin A · 1.5 mgVitamin D · 10 mcgSelenium · 70 mcg

A broad nutrient base supports immune barriers, antioxidant systems, protein adequacy, and cellular function. Chelated zinc, selenium, vitamin D3, curcumin, and substantial protein provide several relevant forms of support.

Vitamin C and zinc fall below the preferred immune-focused amounts, while several botanicals lack active-marker disclosure. A very large proprietary blend and numerous specialty additions make it difficult to separate meaningful immune support from formula complexity.

Study evidence
Curcumin Supportive 10 studies
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
Weight Gain
Weight Gain
Impact
High effect
B+ Goal FitB Strength of SupportB- CoverageC+ Formula Quality

Twenty grams of protein provides meaningful material for muscle repair, while 190 calories can contribute to daily energy intake. MCT oil, glycine, glutamine, vitamins, minerals, and enhanced curcumin add recovery and nutritional support.

The serving is not calorie-dense enough to function as a complete mass gainer without additional food. Betaine at 50 mg and taurine at 110 mg are far below performance amounts, so protein carries most of the weight-gain value.

Study evidence
Betaine Anhydrous Disputed 13 studies
Taurine No effect 7 studies
Hair Health
Hair Health
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageC+ Formula Quality
Biotin · 150 mcgVitamin D · 10 mcgZinc · 10 mgLysine · 500 mgVitamin C · 300 mg

Twenty grams of protein provides a meaningful structural foundation, supported by lysine, vitamin C, zinc, selenium, biotin, and B vitamins. Chelated zinc and selenomethionine improve the quality of key mineral support.

The formula lacks keratin or a targeted hormonal active and includes many ingredients intended for broader nutrition. Hair support is credible but remains one part of a much wider meal-replacement design.

Study evidence
Biotin Supportive 4 studies
Lysine Supportive 1 study
Selenium Disputed 7 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
Moderate effect
D Goal FitC- Strength of SupportC+ CoverageD Formula Quality
Magnesium · 150 mgVitamin B12 · 50 mcgVitamin B6 · 10 mgTaurine · 110 mgGreen Tea · 50 mgCurcumin · 400 mgFolate · 500 mcg DFEVitamin D · 10 mcg

A comprehensive nutrition powder provides several indirect cardiovascular supports, including magnesium, active B vitamins, curcumin, and grape-seed compounds. No single heart-focused active dominates the formula.

Many forms are well chosen, but potassium, taurine, and several botanicals are too lightly dosed for strong cardiovascular depth. A large proprietary base and an extensive ingredient list make the formula difficult to evaluate as a focused heart product.

Study evidence
Curcumin Supportive 70 studies
Magnesium Supportive 158 studies
Potassium Supportive 182 studies
Taurine Supportive 25 studies

Ingredients

IngredientAmount per serving
Calories
190 Calorie(s)
Total Fat
5 Gram(s)
Total Carbohydrates
10 Gram(s)
Protein
20 Gram(s)
Vitamin A
1.5 mg
Vitamin C (Ascorbic Acid)
 300 mg
Vitamin D (Vitamin D3)
 10 mcg
Vitamin E
80.6 mg
Thiamine (Thiamine Hydrochloride)
 12 mg
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 5 mg
Niacin
38 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 10 mg
Folate
500 mcg DFE
Vitamin B12 (Methylcobalamin)
 50 mcg
Biotin
150 mcg
Pantothenic Acid (Calcium Pantothenate)
 50 mg
Choline (Choline Citrate)
 11 mg
Calcium (Calcium Citrate)
 300 mg
Magnesium (Magnesium Citrate)
 150 mg
Zinc (TRAACS Zinc Bisglycinate Chelate)
 10 mg
Selenium (L-Selenomethionine)
 70 mcg
Manganese (TRAACS Manganese Bisglycinate Chelate)
 1.5 mg
Chromium (TRAACS Chromium Nicotinate Glycinate Chelate)
 100 mcg
Molybdenum (TRAACS Molybdenum Glycinate Chelate)
 50 mcg
Potassium (Potassium Citrate)
 100 mg
Proprietary Blend
26.12 Gram(s)
Glycine
1.65 Gram(s)
Medium Chain Triglyceride
1.5 Gram(s)
L-Glutamine
500 mg
L-Lysine (L-Lysine Monohydrochloride)
 500 mg
Curcumin Phytosome (Curcuma longa extract, Phospholipid complex)
 400 mg
Milk Thistle extract
250 mg
Taurine
110 mg
Methyl Sulfonyl Methane
100 mg
Grape seed Phytosome (Phospholipid Complex)
 50 mg
Green Tea Phytosome extract (Phospholipid complex)
 50 mg
Betaine Anhydrous (Trimethylglycine)
 50 mg
Sulforaphane Glucosinolate (Broccoli extract)
 30 mg
Glutathione
30 mg
Boron (Bororganic Boron Glycinate Complex)
 100 mcg
Lutein (Aztec Marigold extract)
 60 mcg
Vanadium (Vanadium Citrate)
 50 mcg
Gluten Free Adults 18–50 Children 4+
Report overview
Betaine Anhydrous (Trimethylglycine) · 50 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

The formula uses trimethylglycine and clearly states a 50 mg serving. That amount fits modest wellness use but is far below a performance-oriented dose. Its high cost reflects a broad protein, micronutrient, phytosome, and broccoli-extract formula rather than betaine alone.

View ingredientView products
Selenium (L-Selenomethionine) · 70 mcg OverallScore76
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

L-selenomethionine provides a well-absorbed organic selenium source with clear isomer labeling. The 70 mcg amount offers modest daily support and leaves a wide safety margin. Its high selenium-specific cost is partly offset by an extensive broader formula.

View ingredientView products
Molybdenum (TRAACS Molybdenum Glycinate Chelate) · 50 mcg OverallScore76
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD+ Value

A verified glycinate chelate provides excellent expected absorption and stronger quality assurance. The disclosed amount is below the effective collection range, though it remains comfortably within the stated safety limit. The serving cost is moderate or partly justified by useful cofactors in the broader formula.

View ingredientView products

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial.
    Sharifi S; Bagherniya M; Khoram Z; Ebrahimi Varzaneh A; Atkin SL; Jamialahmadi T; Sahebkar A; Askari G · Phytotherapy research : PTR · 2023
    Randomized trial60 participantsDetoxification forCurcumin
  3. Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn's Disease After Surgery in a Randomized Controlled Trial.
    Bommelaer G; Laharie D; Nancey S; Hebuterne X; Roblin X; Nachury M; Peyrin-Biroulet L; Fumery M; Richard D; Pereira B; Goutte M; Buisson A; POPCUR study group · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
    Randomized trial62 participantsGeneral Health forCurcumin
  4. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  5. Effects of non-linear resistance training and curcumin supplementation on the liver biochemical markers levels and structure in older women with non-alcoholic fatty liver disease.
    Moradi Kelardeh B; Rahmati-Ahmadabad S; Farzanegi P; Helalizadeh M; Azarbayjani MA · Journal of bodywork and movement therapies · 2021
    Randomized trial45 participantsDetoxification forCurcumin
  6. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults.
    Schönenberger KA; Laval J; Woods T; Truillet R; Naranjo-Modad S; Mettler S; Fança-Berthon P · Journal of the International Society of Sports Nutrition · 2025
    Randomized trial44 participantsGeneral Health forCurcumin
  7. Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study.
    Goyal S; Beniwal SK; Agarwal P; Brar RK; Jain P; Kumar HS; Das BC · Phytotherapy research : PTR · 2025
    Randomized trial120 participantsGeneral Health forCurcumin
  8. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  9. Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
    Vajdi M; Hassanizadeh S; Hassanizadeh R; Bagherniya M · Nutrition reviews · 2024
    Meta-analysis905 participants15 studies pooledDetoxification forCurcumin
  10. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial.
    Jazayeri-Tehrani SA; Rezayat SM; Mansouri S; Qorbani M; Alavian SM; Daneshi-Maskooni M; Hosseinzadeh-Attar MJ · Nutrition & metabolism · 2024
    Randomized trial84 participantsDetoxification forCurcumin
  11. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  12. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.
    Sadeghi N; Mansoori A; Shayesteh A; Hashemi SJ · Phytotherapy research : PTR · 2020
    Randomized trial70 participantsGeneral Health forCurcumin
  13. Therapeutic effects of curcumin supplementation on liver enzymes of nonalcoholic fatty liver disease patients: A systematic review and meta-analysis of randomized clinical trials.
    Ebrahimzadeh A; Ebrahimzadeh A; Fooladshekan S; Mohseni S; Mohtashamian A; Babajafari S; Sohrabi Z · Food science & nutrition · 2025
    Meta-analysis14 studies pooledDetoxification forCurcumin
  14. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial.
    Parohan M; Sarraf P; Javanbakht MH; Foroushani AR; Ranji-Burachaloo S; Djalali M · Nutritional neuroscience · 2021
    Randomized trial100 participantsGeneral Health forCurcumin
  15. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  16. Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Prasad N; Agarwal Y · Journal of pain research · 2025
    Randomized trial139 participantsGeneral Health forCurcumin
  17. Effect of nano-curcumin supplementation on liver fibrosis in patients with NAFLD-associated fibrosis: a double-blind randomized controlled trial.
    Gerami H; Mozaffari-Khosravi H; Mansour A; Sohrabpour AA; Poustchi H; Hashemi Taheri AP; Jaafari MR; Jambarsang S; Khayyatzadeh SS · Scientific reports · 2025
    Randomized trial55 participantsDetoxification forCurcumin
  18. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  19. A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study.
    T Krishnareddy N; Thomas JV; Nair SS; N Mulakal J; Maliakel BP; Krishnakumar IM · BioMed research international · 2019
    Randomized trial48 participantsDetoxification forCurcumin
  20. Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials.
    Onakpoya IJ; Spencer EA; Perera R; Heneghan CJ · International journal of rheumatic diseases · 2018
    Meta-analysis797 participants7 studies pooledGeneral Health forCurcumin
  21. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  22. Effects of Curcumin on Postmenopausal Women's Health: A Systematic Review and Meta-Analysis.
    Jin D; Jin S; Sheng G; Cui Z; Gao P; Li G · Phytotherapy research : PTR · 2025
    Meta-analysis982 participants14 studies pooledGeneral Health forCurcumin
  23. Effects of curcumin/turmeric supplementation on liver function in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
    Dehzad MJ; Ghalandari H; Amini MR; Askarpour M · Complementary therapies in medicine · 2023
    Meta-analysisDetoxification forCurcumin
  24. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  25. Effectiveness and safety of turmeric for the treatment of COVID-19: An updated systematic review and meta-analysis of randomized controlled trials.
    Sawangjit R; Sadoyu S; Manosanthipaibul S; Teerawattanapong N; Puttarak P; Wanaratna K; Charoensup R; Hiransai P; Meetam T; Chaiyakunapruk N · Complementary therapies in medicine · 2025
    Meta-analysis1,407 participants23 studies pooledGeneral Health forCurcumin
  26. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials.
    Mansour-Ghanaei F; Pourmasoumi M; Hadi A; Joukar F · Integrative medicine research · 2022
    Meta-analysis228 participants4 studies pooledDetoxification forCurcumin
  27. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  28. Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial.
    Nouri-Vaskeh M; Afshan H; Malek Mahdavi A; Alizadeh L; Fan X; Zarei M · Complementary therapies in medicine · 2020
    Randomized trial70 participantsGeneral Health forCurcumin
  29. Effects of curcumin/turmeric supplementation on the liver enzymes, lipid profiles, glycemic index, and anthropometric indices in non-alcoholic fatty liver patients: An umbrella meta-analysis.
    Molani-Gol R; Dehghani A; Rafraf M · Phytotherapy research : PTR · 2024
    Meta-analysis5,546 participants11 studies pooledDetoxification forCurcumin
  30. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  31. Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies.
    Yeroshkina K; Rossokha Z; Fishchuk L; Gorovenko N · Nutrition reviews · 2023
    Narrative reviewDetoxification forBetaine Anhydrous
  32. Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
    Ashtary-Larky D; Bagheri R; Ghanavati M; Asbaghi O; Tinsley GM; Mombaini D; Kooti W; Kashkooli S; Wong A · Critical reviews in food science and nutrition · 2022
    Meta-analysisDetoxification forBetaine Anhydrous
  33. Decoding Betaine: A Critical Analysis of Therapeutic Potential Compared with Marketing Hype-A Narrative Review.
    Nikrandt G; Chmurzynska A · The Journal of nutrition · 2024
    Narrative reviewDetoxification forBetaine Anhydrous
  34. Therapy of NAFLD: antioxidants and cytoprotective agents.
    Chang CY; Argo CK; Al-Osaimi AM; Caldwell SH · Journal of clinical gastroenterology · 2006
    Narrative reviewDetoxification forBetaine Anhydrous
  35. Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
    Yaikwawong M; Kamdee K; Chuengsamarn S · International journal of molecular sciences · 2025
    Randomized trial227 participantsDetoxification forCurcumin
  36. Efficacy of glutamine supplementation in postoperative patients undergoing hepatic surgery: a systematic review and meta-analysis of randomized controlled trials.
    Meng X; Zhang M; Wang X · Clinics (Sao Paulo, Brazil) · 2026
    Meta-analysis1,198 participants18 studies pooledDetoxification forGlutamine
  37. Glutamine supplementation in preterm infants receiving parenteral nutrition leads to an early improvement in liver function.
    Wang Y; Cai W; Tao YX; Tang QY; Feng Y; Wu J · Asia Pacific journal of clinical nutrition · 2014
    Randomized trial30 participantsDetoxification forGlutamine
  38. Parenteral glutamine protects hepatic function during bone marrow transplantation.
    Brown SA; Goringe A; Fegan C; Davies SV; Giddings J; Whittaker JA; Burnett AK; Poynton CH · Bone marrow transplantation · 1998
    Randomized trial34 participantsDetoxification forGlutamine
  39. Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants.
    Wang Y; Tao YX; Cai W; Tang QY; Feng Y; Wu J · Clinical nutrition (Edinburgh, Scotland) · 2010
    Randomized trial30 participantsDetoxification forGlutamine
  40. A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.
    Laghi L; Román E; Lan Q; Nieto JC; Canalda-Baltrons A; Poca M; Sánchez-Rodríguez MB; Clària J; Alvarado E; Cuyàs B; Sánchez E; Vidal S; Guarner C; Escorsell À; Manichanh C; Soriano G · Hepatology communications · 2023
    Randomized trial32 participantsDetoxification forGlutamine
  41. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  42. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  43. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  44. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  45. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine
  46. Therapeutic benefits of green tea extract on various parameters in non-alcoholic fatty liver disease patients.
    Hussain M; Habib-Ur-Rehman; Akhtar L · Pakistan journal of medical sciences · 2024
    Randomized trial80 participantsDetoxification forGreen Tea
  47. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease.
    Pezeshki A; Safi S; Feizi A; Askari G; Karami F · International journal of preventive medicine · 2016
    Randomized trial80 participantsDetoxification forGreen Tea
  48. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study.
    Sakata R; Nakamura T; Torimura T; Ueno T; Sata M · International journal of molecular medicine · 2014
    Randomized trial17 participantsDetoxification forGreen Tea
  49. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype.
    Hakim IA; Chow HH; Harris RB · The Journal of nutrition · 2008
    Randomized trialDetoxification forGreen Tea
  50. Modulation of human glutathione s-transferases by polyphenon e intervention.
    Chow HH; Hakim IA; Vining DR; Crowell JA; Tome ME; Ranger-Moore J; Cordova CA; Mikhael DM; Briehl MM; Alberts DS · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007
    Single-arm trial42 participantsDetoxification forGreen Tea
  51. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  52. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  53. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  54. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  55. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  56. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  57. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  58. Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
    Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
    Non-randomized trial24 participantsDetoxification forTaurine
  59. Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
    Single-arm trial32 participantsDetoxification forTaurine
  60. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  61. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  62. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  63. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  64. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  65. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  66. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  67. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  68. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  69. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  70. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  71. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  72. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  73. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  74. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  75. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  76. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  77. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  78. Causes of hair loss and the developments in hair rejuvenation.
    Rushton DH; Norris MJ; Dover R; Busuttil N · International journal of cosmetic science · 2010
    Narrative reviewHair Health forLysine
  79. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  80. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  81. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  82. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  83. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  84. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  85. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  86. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  87. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  88. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  89. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  90. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  91. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  92. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  93. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  94. The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Alidadi M; Sahebkar A; Eslami S; Vakilian F; Jarahi L; Alinezhad-Namaghi M; Arabi SM; Vakili S; Tohidinezhad F; Nikooiyan Y; Norouzy A · Advances in experimental medicine and biology · 2021
    Randomized trial66 participantsHeart Health forCurcumin
  95. The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial.
    Shafabakhsh R; Asemi Z; Reiner Z; Soleimani A; Aghadavod E; Bahmani F · Iranian journal of kidney diseases · 2021
    Randomized trial60 participantsHeart Health forCurcumin
  96. Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk.
    El-Rakabawy OM; Elkholy AA; Mahfouz AA; Abdelsalam MM; El Wakeel LM · Scientific reports · 2025
    Randomized trial72 participantsHeart Health forCurcumin
  97. Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial.
    Helli B; Gerami H; Kavianpour M; Heybar H; Hosseini SK; Haghighian HK · Endocrine, metabolic & immune disorders drug targets · 2022
    Randomized trial90 participantsHeart Health forCurcumin
  98. The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
    Yaikwawong M; Jansarikit L; Jirawatnotai S; Chuengsamarn S · Nutrients · 2024
    Randomized trial227 participantsHeart Health forCurcumin
  99. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health forMagnesium
  100. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  101. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  102. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  103. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forMagnesium
  104. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledHeart Health forPotassium
  105. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.
    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A · PloS one · 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  106. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators · BMJ (Clinical research ed.) · 2019
    Cohort study103,570 participantsHeart Health forPotassium
  107. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F · Nutrients · 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  108. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T · American journal of hypertension · 1999
    Randomized trial55 participantsHeart Health forPotassium
  109. Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial.
    Li Y; Wang Q; Liu Y; Li Q; Xia W; Lin S; Yang Q; Scholze A; Zhao Z; He H; Zhang H; Yan Z; Tepel M; Mu H; Zhu Z; Liu D · iScience · 2025
    Randomized trial165 participantsHeart Health forTaurine
  110. Seafood diets: hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids.
    Elvevoll EO; Eilertsen KE; Brox J; Dragnes BT; Falkenberg P; Olsen JO; Kirkhus B; Lamglait A; Østerud B · Atherosclerosis · 2009
    Randomized trial80 participantsHeart Health forTaurine
  111. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.
    Sun Q; Wang B; Li Y; Sun F; Li P; Xia W; Zhou X; Li Q; Wang X; Chen J; Zeng X; Zhao Z; He H; Liu D; Zhu Z · Hypertension (Dallas, Tex. : 1979) · 2016
    Randomized trial120 participantsHeart Health forTaurine
  112. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
    Guan L; Miao P · European journal of pharmacology · 2021
    Meta-analysis12 studies pooledHeart Health forTaurine
  113. The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.
    Waldron M; Patterson SD; Tallent J; Jeffries O · Current hypertension reports · 2019
    Meta-analysis103 participants7 studies pooledHeart Health forTaurine
  114. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis.
    Wu S; Xiao D · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017
    Randomized trial241 participantsImmunity forCurcumin
  115. Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study.
    Kuwabara Y; Hirose A; Lee H; Kakinuma T; Baba A; Takara T · Journal of dietary supplements · 2023
    Randomized trial99 participantsImmunity forCurcumin
  116. Effects of curcumin-piperine supplementation on systemic immunity in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial.
    Bahrami A; Mohammadifard M; Rajabi Z; Motahari-Nasab M; Ferns GA · European journal of obstetrics, gynecology, and reproductive biology · 2022
    Randomized trial80 participantsImmunity forCurcumin
  117. The roles of curcumin in regulating the tumor immunosuppressive microenvironment.
    Wang Y; Lu J; Jiang B; Guo J · Oncology letters · 2020
    Narrative reviewImmunity forCurcumin
  118. Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature.
    Nebrisi EE · International journal of molecular sciences · 2021
    Narrative reviewImmunity forCurcumin
  119. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  120. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  121. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  122. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  123. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  124. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  125. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  126. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  127. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  128. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  129. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  130. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  131. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  132. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  133. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  134. Effects of betaine on body composition, performance, and homocysteine thiolactone.
    Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V · Journal of the International Society of Sports Nutrition · 2013
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  135. Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II.
    Trujillo-González I; Barisione G; Bottiglieri T; Reyes M; Garmendia ML; Mujica-Coopman MF · The Journal of nutrition · 2026
    Cohort study150 participantsWeight Gain forBetaine Anhydrous
  136. Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.
    Huang BX; Zhu YY; Tan XY; Lan QY; Li CL; Chen YM; Zhu HL · The British journal of nutrition · 2017
    Cohort study1,996 participantsWeight Gain forBetaine Anhydrous
  137. Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
    Long JA; Zhong RH; Chen S; Wang F; Luo Y; Lu XT; Yishake D; Chen YM; Fang AP; Zhu HL · The British journal of nutrition · 2021
    Cohort study1,242 participantsWeight Gain forBetaine Anhydrous
  138. Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females.
    Waldman HS; Bryant AR; McAllister MJ · Journal of dietary supplements · 2023
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  139. Effect of taurine supplementation on growth and development in preterm or low birth weight infants.
    Verner A; Craig S; McGuire W · The Cochrane database of systematic reviews · 2008
    Meta-analysis189 participants9 studies pooledWeight Gain forTaurine
  140. Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis.
    Cao SL; Jiang H; Niu SP; Wang XH; Du S · Indian journal of pediatrics · 2018
    Meta-analysis216 participants9 studies pooledWeight Gain forTaurine
  141. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
    Rosa FT; Freitas EC; Deminice R; Jordão AA; Marchini JS · European journal of nutrition · 2015
    Randomized trial24 participantsWeight Gain forTaurine
  142. Taurine and cholesterol supplementation in the term infant: responses of growth and metabolism.
    Rassin DK; Räihä NC; Minoli I; Moro G · JPEN. Journal of parenteral and enteral nutrition · 1990
    Non-randomized trialWeight Gain forTaurine
  143. Taurine supplementation prevents hyperaminoacidemia in growing term infants fed high-protein cow's milk formula.
    Räihä NC; Fazzolari-Nesci A; Boehm G · Acta paediatrica (Oslo, Norway : 1992) · 1997
    Randomized trialWeight Gain forTaurine