5-Hydroxytryptophan
Thorne
5-Hydroxytryptophan
4.7
★ ★ ★ ★ ★
(2289 ratings)
5-HTP 100 mg
Score 95.0
A premium 5-HTP supplement from Thorne, featuring an effective 100mg dose and active Vitamin B6 (P-5-P) for optimized serotonin conversion, making it highly effective though at a higher price point.
Quantity: 90 Capsule(s)Servings size: 1 Capsule(s) (90 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
leaderboard Score 95.0
A premium 5-HTP supplement from Thorne, featuring an effective 100mg dose and active Vitamin B6 (P-5-P) for optimized serotonin conversion, making it highly effective though at a higher price point.
insights Analysis
Thorne is renowned as a top-tier brand in the supplement industry, consistently delivering high-quality, research-backed formulations. This 5-Hydroxytryptophan product exemplifies that reputation by providing an effective 100mg dose of 5-HTP alongside 6mg of Pyridoxal 5-Phosphate (P-5-P), the active and most bioavailable form of Vitamin B6. This intelligent pairing is critical, as B6 is an essential cofactor for the body to convert 5-HTP into serotonin efficiently. While the price per serving is on the higher end, reflecting its premium quality and advanced formulation, it is widely considered an excellent investment by nutritionists and users for those seeking optimal results in mood, stress, and sleep support without compromise on purity or effectiveness.
- Premium brand (Thorne) known for high quality, purity, and rigorous testing.
- Includes Pyridoxal 5-Phosphate (P-5-P), the active and most bioavailable form of Vitamin B6, crucial for optimal 5-HTP conversion.
- Provides a standard and effective 100mg dose of 5-HTP.
- High review count and strong industry reputation for efficacy.
- High price per serving (41 cents), making it a more significant financial investment.
- May be cost-prohibitive for some budget-conscious consumers.
- Consult a healthcare professional before use if pregnant, nursing, taking medications (especially antidepressants), or have a medical condition due to potential interactions.
- May cause drowsiness; do not drive or operate heavy machinery after taking until you know how it affects you.
$33.30($0.37 per serving)
 iHerb | $ 33.30 | |
 Pure Formulas | $ 37.00 | |
 Vitacost | $ 37.00 | |
 Amazon | $ 37.00 |
bolt Effectiveness for goals
5-HTP is a precursor to serotonin, a neurotransmitter that plays a key role in mood regulation. Some studies suggest that 5-HTP supplementation may help support a balanced mood, particularly in individuals with lower serotonin levels. However, it is not a treatment for mood disorders and should not replace professional medical advice.
As 5-HTP converts to serotonin, which can then be converted into melatonin, it is thought to play a role in sleep regulation. Some research indicates that 5-HTP may help improve sleep quality and reduce the time it takes to fall asleep for certain individuals. Consistent evidence across all populations is still being gathered.
5-Hydroxytryptophan (5-HTP) is a precursor to serotonin, a neurotransmitter involved in mood, sleep, and appetite. Some research suggests it may help support these functions by increasing serotonin levels, but more definitive studies are needed to establish broad effectiveness across all individuals. Individual results can vary depending on various factors.
Some research suggests that 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in feelings of well-being and happiness. However, more extensive research is needed to fully understand its effects.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Some studies indicate that 5-HTP may contribute to improved sleep quality and duration. Individual responses can vary.
schedule Dosage, timing & forms
Many sources suggest beginning with a low dose, such as 50 mg, taken once or twice daily. This approach allows individuals to assess their tolerance and response. Doses can be gradually increased if needed, often under professional guidance.
5-HTP is often taken in the evening, sometimes 30-60 minutes before bedtime, particularly if supporting sleep is a goal. For other uses, it may be taken throughout the day, often divided into multiple doses. Timing can vary based on individual response and desired effects.
5-HTP is often taken in the evening, particularly if used for sleep support. For other purposes, it can be taken throughout the day, sometimes with meals to help minimize potential stomach upset.
While specific recommendations vary, dosages beyond 300-500 mg per day are generally not advised without professional guidance. Higher doses may increase the risk of side effects. It is important to adhere to recommended serving sizes or consult a healthcare provider.
Taking 5-HTP with food may help reduce gastrointestinal side effects like nausea, which some individuals experience. However, some sources suggest taking it on an empty stomach might enhance absorption for specific uses. Following product label instructions is generally recommended.
health_and_safety Safety & interactions
Yes, 5-HTP can have significant interactions with antidepressant medications, including SSRIs (Selective Serotonin Reuptake Inhibitors) and MAOIs (Monoamine Oxidase Inhibitors). Combining 5-HTP with these drugs can elevate serotonin levels excessively, increasing the risk of serotonin syndrome. Consultation with a healthcare provider is essential before combining them.
No, combining 5-HTP with antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs) is not recommended. This combination can significantly increase serotonin levels, potentially leading to serotonin syndrome. It is crucial to consult a healthcare professional before combining supplements with prescription drugs.
Yes, 5-HTP can potentially contribute to serotonin syndrome, especially when taken with other medications that increase serotonin levels. Serotonin syndrome is a serious condition caused by excessive serotonin activity in the brain. It is crucial to avoid combining 5-HTP with such medications without professional guidance.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin activity in the brain. Taking 5-HTP, which increases serotonin levels, especially with other serotonergic medications, may elevate this risk. Symptoms can include agitation, rapid heart rate, confusion, and muscle rigidity.
Yes, 5-HTP may interact with other substances that affect serotonin levels, including triptans for migraines, dextromethorphan (found in cough medicines), and certain herbal supplements like St. John's Wort. Combining these can increase the risk of serotonin syndrome. Always discuss all current medications and supplements with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Vitamin B6 (Pyridoxal 5-Phosphate) | 6.8 mg |
| 5-HTP | 100 mg |
Categories
5-HTP 95.0
Within the 5-HTP category, Thorne stands out for its premium quality and the crucial inclusion of active Vitamin B6, which optimizes 5-HTP's effectiveness. This formulation places it among the very best, justifying its higher price for those seeking maximum benefit.
Goals
Mood Support 98.0
The synergy between 100mg of 5-HTP and active Vitamin B6 (P-5-P) significantly enhances its potential for mood support, as P-5-P directly facilitates the conversion of 5-HTP into serotonin, a key neurotransmitter for mood regulation. This formulation is designed for optimal impact on mood balance.
Stress Relief 95.0
The 100mg of 5-HTP, combined with the highly bioavailable active form of Vitamin B6 (P-5-P), makes this product exceptionally effective for stress relief. B6 ensures the most efficient conversion of 5-HTP to serotonin, promoting a calming effect and comprehensively mitigating stress responses.
Sleep Support 95.0
For sleep support, this product excels due to the highly efficient serotonin synthesis enabled by the active B6, leading to superior melatonin production. The 100mg dose of 5-HTP, combined with its optimized conversion pathway, means it's likely to be highly effective in promoting restful sleep and improving sleep quality.
Recommended Alternatives
92 Value 
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
This product provides a 100mg 5-HTP dose with B6 and C at a significantly lower price per serving (12 cents vs 41 cents), offering exceptional value for a comprehensive, enhanced formula.
88 Value 
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offering 100mg of 5-HTP with B6 and C at a very competitive 18 cents per serving, this product delivers excellent value for enhanced benefits, providing a more cost-effective solution.
88 Value 
5-HTP 100 mg
NOW
4.7
★★★★★
(48226 ratings)
For a pure 5-HTP supplement, NOW offers a 100mg dose at a very low price per serving (13 cents), providing superior value for those who prefer to add B6 separately or don't require it.
92 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While Thorne uses active B6, Doctor's Best provides a solid 100mg dose with Pyridoxine HCl and Vitamin C, offering a good synergistic blend for overall health and antioxidant support.
75 Performance 
Healthy Mood 5-HTP Elite 100 mg Natural Raspberry Flavor
Carlson
4.6
★★★★★
(282 ratings)
Carlson also includes Vitamin B6 (both P-5-P and Pyridoxine HCl forms), providing a comprehensive B6 approach for enhanced serotonin synthesis, making it a strong competitor in terms of formulation quality.
88 Performance
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
This alternative offers a robust blend of 5-HTP with both B6 and C, providing broad-spectrum support for mood and sleep, making it a highly effective and well-rounded choice.
92 Budget
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
This alternative offers an enhanced formula including B6 (though not active P-5-P) and C, at a significantly lower price per serving (12 cents vs 41 cents), providing excellent value for comprehensive support.
88 Budget
5-HTP 100 mg
NOW
4.7
★★★★★
(48226 ratings)
NOW's 5-HTP provides a standard 100mg dose at a substantially lower price per serving (13 cents), making it a much more economical choice if active B6 is not a primary concern.
85 Budget 
5-HTP 100 mg Extra Strength
Swanson
4.8
★★★★★
(3247 ratings)
Swanson offers a pure 100mg 5-HTP product at an exceptionally low price per serving (11 cents), presenting a significantly cheaper option for basic 5-HTP supplementation.
92 Value
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
This product provides a 100mg 5-HTP dose with B6 and C at a significantly lower price per serving (12 cents vs 41 cents), offering exceptional value for a comprehensive, enhanced formula.
88 Value
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offering 100mg of 5-HTP with B6 and C at a very competitive 18 cents per serving, this product delivers excellent value for enhanced benefits, providing a more cost-effective solution.
88 Value
5-HTP 100 mg
NOW
4.7
★★★★★
(48226 ratings)
For a pure 5-HTP supplement, NOW offers a 100mg dose at a very low price per serving (13 cents), providing superior value for those who prefer to add B6 separately or don't require it.
92 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While Thorne uses active B6, Doctor's Best provides a solid 100mg dose with Pyridoxine HCl and Vitamin C, offering a good synergistic blend for overall health and antioxidant support.
75 Performance
Healthy Mood 5-HTP Elite 100 mg Natural Raspberry Flavor
Carlson
4.6
★★★★★
(282 ratings)
Carlson also includes Vitamin B6 (both P-5-P and Pyridoxine HCl forms), providing a comprehensive B6 approach for enhanced serotonin synthesis, making it a strong competitor in terms of formulation quality.
88 Performance
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
This alternative offers a robust blend of 5-HTP with both B6 and C, providing broad-spectrum support for mood and sleep, making it a highly effective and well-rounded choice.