Product Image

Hair/Skin/Nails Ultra

Pure Encapsulations
4.8
★ ★ ★ ★ ★
(111 ratings)
PABA 150 mg
Zinc 30 mg
Copper 1 mg
Manganese 2 mg
Silicon 30 mg
Coenzyme Q-10 60 mg
Collagen 500 mg
Product Image
Score67
A well-targeted hair, skin, and nail formula with useful silica and strong supporting nutrients. Small collagen, zinc-copper imbalance, and an implausible biotin label entry require caution.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Hair Health
Skin Health
Nail Health
Immunity

Score 67

A well-targeted hair, skin, and nail formula with useful silica and strong supporting nutrients. Small collagen, zinc-copper imbalance, and an implausible biotin label entry require caution.
How scoring works
$51.50($1.71 per serving)
Walmart
$ 51.50
Pure Formulas
$ 51.50
Report prices

Analysis

Silica, vitamin C, zinc, copper, folate, grape polyphenols, and collagen cover several structural and antioxidant pathways relevant to hair, skin, and nails. The mineral forms are generally good, and the silicon amount is useful.

The hydrolyzed chicken collagen amount is far below that of dedicated collagen powders. Coenzyme Q10 uses a sustained-release complex, but the label does not identify ubiquinone or ubiquinol and the amount is modest for a specialized CoQ10 product.

The supplied label lists biotin in an implausibly large milligram amount, so the current bottle should be checked before any dose is taken. Zinc is also high relative to copper, making long-term mineral balance a concern despite the inclusion of both.

Who is it for
  • Adults seeking a multi-nutrient beauty formula
  • People wanting silica with zinc and vitamin C
  • Users willing to verify the current biotin label
Best for
  • Hair and nail nutrient support
  • Skin-focused antioxidant coverage
  • Silica supplementation

Pros

  • Useful bamboo-derived silica amount
  • Uses zinc citrate and copper glycinate
  • Includes active folate and sustained-release CoQ10

Cons

  • Collagen amount is small
  • Zinc-to-copper ratio is poorly balanced
  • Serving cost is high for the delivered amounts

Warnings

  • Verify the biotin amount before use because the supplied label lists an implausible milligram quantity.
  • High-dose biotin can distort thyroid, hormone, and cardiac laboratory tests; disclose use before testing.
  • Long-term use of high zinc with relatively little copper may contribute to copper imbalance.
  • Chicken-derived collagen is unsuitable for people with a chicken allergy or related dietary restriction.

Nutrient quality

67 High impact

Active folate, citrate minerals, copper glycinate, and sustained-release CoQ10 provide several quality forms. The small collagen amount, zinc-heavy mineral balance, and implausible biotin listing create major dosing concerns.

Ingredient transparency

72 High impact

The label discloses individual active amounts and identifies many specialized forms. The questionable biotin unit, duplicated CoQ10 listing, absent directions, and missing excipient details reduce clarity.

Customer satisfaction

68 High impact

The aggregate rating is strong and supported by a moderate number of responses. No review text is supplied, so common complaints and purpose-specific experiences remain unknown.

Value for money

59 Moderate impact

Premium nutrient forms and broad ingredient coverage provide some justification for the price. Modest collagen, uncertain biotin labeling, and a relatively high serving cost limit practical value.

Report analysis

Goals

Hair Health
Scalp Health and Protection
Hair Health
Impact
High effect
B+ Goal FitB- Strength of SupportB+ CoverageB Formula Quality
Biotin · 6000 mgZinc · 30 mgVitamin C · 250 mgCollagen · 500 mg

Collagen, silica, zinc, copper, vitamin C, active folate, biotin, grape polyphenols, and CoQ10 cover structure, collagen formation, and oxidative protection. The formula is strongly aligned with hair health, although several label and dose issues reduce confidence.

Silica and zinc reach useful amounts, while the collagen amount is small and the zinc-to-copper ratio is unbalanced. The listed 6,000 mg biotin amount appears implausible and should be verified because high biotin intake can distort thyroid, hormone, and cardiac laboratory tests.

Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Copper Adverse 4 studies
Folate Mixed 15 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Skin Health
Skin Health
Impact
High effect
B+ Goal FitB- Strength of SupportB+ CoverageB+ Formula Quality
Zinc · 30 mgVitamin C · 250 mgCollagen · 500 mgCopper · 1 mgSilicon · 30 mg

Hydrolyzed collagen, silicon, vitamin C, zinc, copper, grape polyphenols, and CoQ10 form a well-targeted skin formula. Silicon and the collagen cofactors are meaningful strengths, and the ingredient forms are generally well identified.

The collagen amount is much smaller than common peptide servings, and the zinc-to-copper balance is heavily weighted toward zinc. The listed biotin amount appears implausibly high and should be verified because high biotin intake can distort thyroid, cardiac, and other laboratory tests.

Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Copper Supportive 16 studies
Silicon Supportive 16 studies
Vitamin C Supportive 53 studies
Zinc Supportive 66 studies
Nail Health
Nail Health
Impact
High effect
B+ Goal FitC+ Strength of SupportB+ CoverageB Formula Quality
Silicon · 30 mgCollagen · 500 mgBiotin · 6000 mg

Silica, zinc, vitamin C, biotin, copper, collagen, and folate cover structural, cross-linking, cofactor, and growth pathways. Silicon reaches a useful amount, but the collagen contribution is small relative to typical peptide servings.

The label lists an implausibly large biotin unit that should be verified with the manufacturer before use. High-dose biotin can distort thyroid, cardiac, and hormone laboratory tests, so clinicians and laboratories need to know about use.

Study evidence
Biotin Supportive 8 studies
Collagen Supportive 4 studies
Silicon Supportive 2 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
Immunity
Immunity
Impact
High effect
C Goal FitB- Strength of SupportC- CoverageC+ Formula Quality
Vitamin C · 250 mgZinc · 30 mg

Vitamin C and zinc provide some direct immune relevance, but the formula is mainly designed for hair, skin, and nails. Zinc citrate and disclosed nutrient amounts support a transparent label.

Vitamin C falls below the targeted immune threshold and much of the formula serves structural or cosmetic goals instead. The very high listed biotin amount deserves label verification before use.

Study evidence
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
General Health
General Health
Impact
Moderate effect
C Goal FitC+ Strength of SupportC- CoverageC+ Formula Quality
Folate · 667 mcg DFECollagen · 500 mgZinc · 30 mgVitamin C · 250 mg

Zinc, vitamin C, folate, copper, manganese, collagen, and CoQ10 offer some nutritional support beyond the formula’s cosmetic focus. Several forms are clearly identified, including Metafolin, zinc citrate, copper glycinate, and a sustained-release CoQ10 complex.

The collagen amount is small, and the listed biotin amount appears implausibly high and should be verified before use. Because the design centers on hair, skin, and nails, it is only moderately aligned with broad general health.

Study evidence
Collagen Supportive 31 studies
Folate Supportive 80 studies
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Testosterone Support
Testosterone Support
Impact
Moderate effect
C- Goal FitA- Strength of SupportD CoverageF Formula Quality
Zinc · 30 mg

Zinc provides a direct nutritional connection to testosterone synthesis, with copper helping maintain mineral balance. The remaining formula is designed for hair, skin, and nails rather than hormone support.

Zinc reaches a strong amount in a suitable citrate form. Missing vitamin D, magnesium, stress support, and other endocrine pathways make the goal fit narrow.

Study evidence
Zinc Disputed 7 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 250 mg
Niacin (Niacinamide)
 20 mg
Folate (Metafolin)
 667 mcg DFE
Biotin
6000 mg
Zinc (Zinc Citrate)
 30 mg
Copper (Copper Glycinate)
 1 mg
Manganese (Manganese Citrate)
 2 mg
Silica (Bamboo)
 30 mg
PABA
150 mg
BioCell Collagen hydrolyzed Collagen Complex (Chicken Sternal Cartilage)
 500 mg
Grape (Vitis vinifera) extract (Polyphenols)
 140 mg
CoQ10 (sustained-release MicroActive Q10-Cyclodextrin Complex)
 60 mg
Gluten Free Adults 18–50
Report overview
PABA · 150 mg OverallScore84
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The 150 mg amount provides a well-aligned standalone-level dose within the combination. PABA is named directly, and immediate release suits this nutritional amount. Cost efficiency is weak for the PABA amount delivered.

View ingredientView products
Zinc (Zinc Citrate) · 30 mg OverallScore77
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The zinc citrate source offers sound form quality, while the standard capsule format is serviceable. Its 30 mg elemental serving is clearly stated and fits the preferred effective range. Included copper supports mineral balance, while value is weak because it costs well above the collection benchmark.

View ingredientView products
Copper (Copper Glycinate) · 1 mg OverallScore71
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

Copper glycinate is a premium chelate with strong absorption potential. The 1 mg amount supports maintenance and the 30:1 zinc-to-copper ratio is substantially more zinc-heavy than preferred despite including copper. Clear amount-and-form disclosure supports assessment, while serving cost is very high for copper-focused use.

View ingredientView products
Loading alternative details
82 Performance

Calcium Citrate

NOW
Compared with 60 mg of CoQ10 as sustained-release MicroActive Q10-Cyclodextrin Complex, 60 mg of CoQ10 and 140 mg of Grape (Vitis vinifera) extract as Polyphenols, the alternative provides 10 mcg of Vitamin D2 as Ergocalciferol, 600 mg of Calcium as Calcium Citrate and 300 mg of Magnesium as Magnesium Aspartate, and the supplied analysis indicates stronger alignment with Zinc, Manganese, Copper. Magnesium oxide and vitamin D2 lower form quality, while the simple formula offers practical value.
82 Performance

Skin Nails & Hair

Solgar
Compared with 60 mg of CoQ10 as sustained-release MicroActive Q10-Cyclodextrin Complex, 60 mg of CoQ10 and 140 mg of Grape (Vitis vinifera) extract as Polyphenols, the alternative provides 120 mg of Vitamin C as L-Ascorbic Acid, 15 mg of Zinc as Zinc Citrate and 2 mg of Copper as Copper Glycinate Amino Acid Chelate, and the supplied analysis indicates stronger alignment with Silicon, Zinc, Copper. Well-regarded zinc and copper forms are strengths, though the silicon source and inactive tablet ingredients are not fully clear.
81 Performance

Hair Skin & Nails Collagen Plus Formula

Life Extension
Compared with 60 mg of CoQ10 as sustained-release MicroActive Q10-Cyclodextrin Complex, 60 mg of CoQ10 and 140 mg of Grape (Vitis vinifera) extract as Polyphenols, the alternative provides 18 mg NE of Niacin as Niacinamide, 2 mg of Vitamin B6 as Pyridoxine Hydrochloride and 2500 mcg of Biotin, and the supplied analysis indicates stronger overall quality. Substantial collagen peptides and keratin directly fit hair, skin, and nail support, while biotin and supporting nutrients add breadth.
80 Budget

Calcium Citrate

NOW
The supplied serving cost is lower, while the formula provides 10 mcg of Vitamin D2 as Ergocalciferol, 600 mg of Calcium as Calcium Citrate and 300 mg of Magnesium as Magnesium Aspartate. Magnesium oxide and vitamin D2 lower form quality, while the simple formula offers practical value.
82 Budget

Skin Nails & Hair

Solgar
The supplied serving cost is lower, while the formula provides 120 mg of Vitamin C as L-Ascorbic Acid, 15 mg of Zinc as Zinc Citrate and 2 mg of Copper as Copper Glycinate Amino Acid Chelate. Well-regarded zinc and copper forms are strengths, though the silicon source and inactive tablet ingredients are not fully clear.
72 Budget

Healthy Eyes Extra

21st Century
The supplied serving cost is lower, while the formula provides 300 mcg of Vitamin A as Beta-Carotene, 300 mg of Vitamin C as Ascorbic Acid and 45 mg of Vitamin E as DL-Alpha-Tocopheryl Acetate. Vitamin C and a small lutein amount offer some eye-support value at a very low cost, but the mineral forms are weak and zinc is unusually high.
80 Value

Calcium Citrate

NOW
10 mcg of Vitamin D2 as Ergocalciferol, 600 mg of Calcium as Calcium Citrate and 300 mg of Magnesium as Magnesium Aspartate offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Magnesium oxide and vitamin D2 lower form quality, while the simple formula offers practical value.
82 Value

Skin Nails & Hair

Solgar
120 mg of Vitamin C as L-Ascorbic Acid, 15 mg of Zinc as Zinc Citrate and 2 mg of Copper as Copper Glycinate Amino Acid Chelate offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Well-regarded zinc and copper forms are strengths, though the silicon source and inactive tablet ingredients are not fully clear.
81 Value

Hair Skin & Nails Collagen Plus Formula

Life Extension
18 mg NE of Niacin as Niacinamide, 2 mg of Vitamin B6 as Pyridoxine Hydrochloride and 2500 mcg of Biotin offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Substantial collagen peptides and keratin directly fit hair, skin, and nail support, while biotin and supporting nutrients add breadth.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence.
    Dhaliwal S; Nguyen M; Vaughn AR; Notay M; Chambers CJ; Sivamani RK · American journal of clinical dermatology · 2020
    Systematic review22 studies pooledSkin Health forZinc
  2. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  3. Hair Loss and Zinc Deficiency: A Cross-Sectional Study.
    Liran O; Vered S; Cohen B; Shapiro Ben David S; Nakhleh A; Rahamim-Cohen D; Azuri J; Adler L · Healthcare (Basel, Switzerland) · 2025
    Cross-sectional study23,975 participantsHair Health forZinc
  4. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forZinc Nail Health forBiotin
  5. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  6. Zinc, Copper, and Iron in Selected Skin Diseases.
    Podgórska A; Kicman A; Naliwajko S; Wacewicz-Muczyńska M; Niczyporuk M · International journal of molecular sciences · 2024
    Narrative reviewSkin Health forCopper
  7. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  8. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  9. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  10. Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study.
    Guadanhim LRS; Miot HA; Soares JLM; Silva SAM; Leonardi GR; Lopes RD; Bagatin E · Dermatology and therapy · 2023
    Randomized trial56 participantsSkin Health forCollagen
  11. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  12. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  13. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
    Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
    Single-arm trial25 participantsNail Health forCollagen
  14. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forCollagen Nail Health forSilicon
  15. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
    Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
    Randomized trialGeneral Health forCollagen
  16. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsGeneral Health forCollagen
  17. Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
    Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
    Randomized trial100 participantsGeneral Health forCollagen
  18. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
    Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
    Randomized trial64 participantsGeneral Health forCollagen
  19. The use of a collagen matrix in hard-to-heal venous leg ulcers.
    Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
    Randomized trial40 participantsGeneral Health forCollagen
  20. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  21. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  22. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  23. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  24. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  25. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  26. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  27. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  28. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  29. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  30. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  31. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  32. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  33. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  34. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  35. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin Skin Health forSilicon
  36. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  37. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  38. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  39. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  40. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  41. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  42. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  43. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  44. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  45. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  46. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  47. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  48. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  49. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  50. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  51. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  52. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  53. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  54. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  55. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  56. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  57. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  58. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  59. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  60. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  61. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  62. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  63. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  64. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  65. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  66. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  67. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  68. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  69. Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
    Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
    Randomized trial85 participantsNail Health forCollagen
  70. Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
    Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
    Observational study41 participantsNail Health forCollagen
  71. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
    Barel A; Calomme M; Timchenko A; De Paepe K; Demeester N; Rogiers V; Clarys P; Vanden Berghe D · Archives of dermatological research · 2006
    Randomized trial50 participantsNail Health forSilicon
  72. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  73. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  74. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  75. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  76. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  77. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsSkin Health forCollagen
  78. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  79. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledSkin Health forCollagen
  80. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  81. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  82. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  83. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  84. The Efficacy of a Silicone Sheet in Postoperative Scar Management.
    Kim JS; Hong JP; Choi JW; Seo DK; Lee ES; Lee HS · Advances in skin & wound care · 2018
    Randomized trialSkin Health forSilicon
  85. A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers.
    Zhang L; Yang J; Wang H; Cai Y; Zhao W; Dong R; Liu D; Lu X · Wound management & prevention · 2023
    Randomized trial130 participantsSkin Health forSilicon
  86. Retrospective Study on the Clinical Superiority of the Vacuum-Assisted Closure System with a Silicon-based Dressing over the Conventional Tie-over Bolster Technique in Skin Graft Fixation.
    Chou PR; Wu SH; Hsieh MC; Huang SH · Medicina (Kaunas, Lithuania) · 2020
    Cohort study26 participantsSkin Health forSilicon
  87. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars.
    O'Brien L; Pandit A · The Cochrane database of systematic reviews · 2006
    Meta-analysis559 participants13 studies pooledSkin Health forSilicon
  88. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  89. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  90. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  91. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  92. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  93. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  94. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  95. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  96. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  97. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  98. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  99. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  100. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  101. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  102. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc