Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
Barel A; Calomme M; Timchenko A; De Paepe K; Demeester N; Rogiers V; Clarys P; Vanden Berghe D · Archives of dermatological research · 2006
Randomized trial50 participantsflagSkin Health flagHair Health flagNail Health forscienceSilicon
- The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Patel MN; Maheshvari J; Patel N · Cureus · 2025
Randomized trial105 participantsflagHair Health flagNail Health flagSkin Health forscienceBiotin flagSkin Health forscienceSilicon
- The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
Narrative reviewflagHair Health forscienceBiotin
- Vitamins A, B, C, and D: A Short Review for the Dermatologist.
Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
Narrative reviewflagHair Health forscienceBiotin
- Low serum biotinidase activity in children with valproic acid monotherapy.
Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
Clinical trial125 participantsflagHair Health flagSkin Health forscienceBiotin
- Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
Randomized trial114 participantsflagHair Health forscienceCollagen
- Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
Randomized trialflagHair Health forscienceCollagen
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
Narrative reviewflagHair Health forscienceCollagen
- Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair
R R Wickett, E Kossmann, A Barel, N Demeester, P Clarys, D Vanden Berghe, M Calomme · Archives of Dermatological Research · 2007
Randomized trial48 participantsflagHair Health forscienceSilicon
- The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
Randomized trial200 participantsflagHair Health forscienceZinc
- Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
Randomized trialflagHair Health forscienceZinc
- A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
Randomized trial40 participantsflagHair Health forscienceZinc
- BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
Case-control study216 participantsflagHair Health forscienceZinc
- Analysis of serum zinc and copper concentrations in hair loss.
Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
Case-control study342 participantsflagHair Health forscienceZinc
- Biotin for the treatment of nail disease: what is the evidence?
Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
Narrative reviewflagNail Health forscienceBiotin
- Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
Other32 participantsflagNail Health forscienceBiotin
- Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
Randomized trial50 participantsflagNail Health forscienceBiotin
- Vitamins and minerals: their role in nail health and disease.
Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
Narrative reviewflagNail Health forscienceBiotin flagNail Health forscienceZinc
- Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
Single-arm trial25 participantsflagNail Health forscienceCollagen
- Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
Randomized trial85 participantsflagNail Health forscienceCollagen
- Nail Supplements: When, How, and Why?
Zaraa I; Richert B · Skin appendage disorders · 2026
Narrative reviewflagNail Health forscienceCollagen flagNail Health forscienceSilicon
- Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
Observational study41 participantsflagNail Health forscienceCollagen
- Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
Non-randomized trial60 participantsflagSkin Health forscienceBiotin
- Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
Non-randomized trial25 participantsflagSkin Health forscienceBiotin
- Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
Case series4 participantsflagSkin Health forscienceBiotin
- Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
Meta-analysis967 participants14 studies pooledflagSkin Health forscienceCollagen
- Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
Meta-analysis646 participants10 studies pooledflagSkin Health forscienceCollagen
- Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
Randomized trial100 participantsflagSkin Health forscienceCollagen
- Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
Randomized trial64 participantsflagSkin Health forscienceCollagen
- Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
Meta-analysis1,125 participants19 studies pooledflagSkin Health forscienceCollagen
- The Efficacy of a Silicone Sheet in Postoperative Scar Management.
Kim JS; Hong JP; Choi JW; Seo DK; Lee ES; Lee HS · Advances in skin & wound care · 2018
Randomized trialflagSkin Health forscienceSilicon
- A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers.
Zhang L; Yang J; Wang H; Cai Y; Zhao W; Dong R; Liu D; Lu X · Wound management & prevention · 2023
Randomized trial130 participantsflagSkin Health forscienceSilicon
- Retrospective Study on the Clinical Superiority of the Vacuum-Assisted Closure System with a Silicon-based Dressing over the Conventional Tie-over Bolster Technique in Skin Graft Fixation.
Chou PR; Wu SH; Hsieh MC; Huang SH · Medicina (Kaunas, Lithuania) · 2020
Cohort study26 participantsflagSkin Health forscienceSilicon
- Silicon gel sheeting for preventing and treating hypertrophic and keloid scars.
O'Brien L; Pandit A · The Cochrane database of systematic reviews · 2006
Meta-analysis559 participants13 studies pooledflagSkin Health forscienceSilicon
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
Randomized trial45 participantsflagSkin Health forscienceVitamin E
- Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
Meta-analysis20 studies pooledflagSkin Health forscienceVitamin E
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceVitamin E flagSkin Health forscienceZinc
- Effects of tocotrienol on aging skin: A systematic review.
Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
Systematic reviewflagSkin Health forscienceVitamin E
- Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
Randomized trialflagSkin Health forscienceVitamin E
- Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
Meta-analysis2,088 participants20 studies pooledflagSkin Health forscienceZinc
- Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
Cohort study23 participantsflagSkin Health forscienceZinc
- Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
Randomized trial30 participantsflagSkin Health forscienceZinc
- A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
Randomized trial90 participantsflagSkin Health forscienceZinc