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5-HTP 5-Hydroxytryptophan 50 mg

Natural Factors Stress-Relax
4.6
★ ★ ★ ★ ★
(359 ratings)
5-HTP 50 mg
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Score74
50 mg of 5-HTP provides cautious serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Mood Support
Sleep Support
Stress Relief

Score 74

50 mg of 5-HTP provides cautious serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.
How scoring works
$13.97($0.23 per serving)
Vitacost
$ 19.95
iHerb
$ 13.97
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Analysis

A cautious 50 mg 5-HTP serving gives the formula a clear and focused role in serotonin-related mood and sleep support. The amount works as a conservative starting level but may be modest for someone seeking a pronounced standalone effect.

Griffonia simplicifolia is identified as the source, although no active standardization percentage is supplied. Time-release delivery may suit people who prefer a steadier format, while the tablet still keeps dosing simple.

The small calcium addition does not materially broaden the product’s main purpose. Value is reasonable for a focused 5-HTP serving. It best fits people seeking a cautious starting amount or gradual dose adjustment.

Who is it for
  • Adults new to 5-HTP
  • People who prefer a cautious starting amount
  • Users seeking focused mood or sleep support
Best for
  • Focused serotonin-pathway mood support
  • Indirect sleep support through serotonin and melatonin pathways
  • Stress accompanied by low mood or disrupted sleep

Pros

  • Clearly discloses 50 mg of 5-HTP
  • Tablet(s) format is easy to use
  • Names Griffonia simplicifolia as the botanical source
  • Time-release delivery may support gradual exposure
  • Focused formula is easy to assess
  • Good value for the disclosed active amount

Cons

  • No 5-HTP standardization percentage is provided
  • Lower amount may be too modest for some users
  • Single-pathway formula offers limited support beyond serotonin production

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines because serotonin toxicity can occur.
  • The 50 mg 5-HTP serving may cause nausea or digestive upset.
  • Avoid stacking it with other serotonin-focused supplements such as tryptophan or SAMe unless a qualified clinician has reviewed the combination.

Nutrient quality

77 High impact

The Griffonia source and time-release design are useful, though extract standardization is absent. The 5-HTP amount suits cautious starting use but is modest for a standard serving, while missing extract standardization limits source-potency confidence.

Ingredient transparency

80 Highest impact

Every listed active amount is disclosed, and no proprietary blend hides dosing. Complete directions, inactive ingredients, and some source or standardization details remain unavailable.

Customer satisfaction

66 High impact

The aggregate rating is favorable, and the large review count supports confidence. No detailed feedback is supplied, so repeated complaints and purpose fit cannot be judged.

Value for money

71 High impact

A lower time-release amount offers flexible starting use. Reaching a standard amount weakens serving value and category competitiveness.

Report analysis

Goals

Mood Support
Impact
High effect
B Goal FitB Strength of SupportC- CoverageA- Formula Quality
5-HTP · 50 mg

5-HTP is a direct serotonin precursor with plausible mood relevance, and the 50 mg amount provides a conservative introductory serving. Human evidence for mood improvement is limited by small and inconsistent trials, so it should not be treated as a substitute for established care.

The Griffonia source and exact active amount are clearly disclosed, while added calcium has no meaningful mood role. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonergic drugs can raise the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 9 studies
Sleep Support
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageA Formula Quality

The time-release caplet offers a cautious starting amount. It provides 50 mg of 5-HTP from Griffonia simplicifolia for a defined sleep-related pathway.

The lower amount may be insufficient for some users and the extract lacks standardization. 5-HTP can dangerously raise serotonin activity with SSRIs, MAO inhibitors, or other serotonin-modulating medicines.

Study evidence
5-HTP Supportive 1 study
Stress Relief
Impact
Moderate effect
C- Goal FitC Strength of SupportD- CoverageA- Formula Quality

5-HTP may support emotional well-being through serotonin production, but it is not a direct or reliably proven stress-relief treatment. The 50 mg amount may be more useful for mood or sleep-related stress than for immediate calm.

Griffonia is named as the source, and the time-release format may provide steadier delivery. The extract lacks a standardization percentage, and combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising drugs may increase the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 18 studies

Ingredients

IngredientAmount per serving
Calcium (Dicalcium Phosphate)
35 mg
5-Hydroxytryptophan (Griffonia simplicifolia)
50 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
B+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyC Value

The lower-dose time-release format may suit users who want to start cautiously or adjust intake gradually. Griffonia is identified as the source, but extract standardization is not disclosed. Reaching a standard dose reduces cost efficiency, and the supplied label data do not show a warning about serotonin-modulating medicines.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  12. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  13. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  14. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  15. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP