SAMe 200 mg + Cofactors
Metabolic Maintenance
SAMe 200 mg + Cofactors
4.6
★ ★ ★ ★ ★
(30 ratings)
SAMe 200 mg
Score 85.0
Comprehensive and high-quality SAMe with essential cofactors, offering good value for a premium blend.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 85.0
Comprehensive and high-quality SAMe with essential cofactors, offering good value for a premium blend.
insights Analysis
Metabolic Maintenance is a reputable brand often favored by healthcare professionals, known for high-quality, targeted formulations. This SAMe product stands out for its intelligent design, including not just SAMe but also a suite of key cofactors like Methylcobalamin (B12), Pyridoxal 5-Phosphate (B6), Folate, Magnesium Bisglycinate, and Calcium Citrate. These additions are vital for maximizing SAMe's benefits, especially for mood and liver support, by ensuring optimal methylation cycle function. Although the price per serving is higher than basic SAMe products, it offers better value than other cofactor-inclusive alternatives, making it a robust option for those seeking enhanced efficacy.
- Excellent comprehensive formulation with crucial B vitamin cofactors (B6, B12, Folate) in active forms.
- Includes additional supportive minerals like Magnesium and Calcium in bioavailable forms.
- Metabolic Maintenance is a reputable professional-grade brand.
- Provides enhanced support for methylation pathways, crucial for SAMe's efficacy.
- Higher price per serving compared to basic SAMe supplements, potentially limiting accessibility.
- Lower review count compared to mass-market SAMe brands.
- Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$73.00($1.21 per serving)
 iHerb | $ 73.00 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 2 mg |
Folate | 333 mcg DFE |
Vitamin B12 | 500 mcg |
Calcium | 20 mg |
Magnesium | 20 mg |
SAMe | 200 mg |
Categories
SAMe 85.0
This SAMe product stands out in the collection for its thoughtful and comprehensive formulation, which includes essential cofactors. While positioned at a premium price, it delivers exceptional value for those seeking a highly effective and synergistic SAMe supplement.
Goals
Mood Support 95.0
The complete profile of B vitamins and minerals makes this product highly effective for mood support, as it optimizes the methylation cycle essential for neurotransmitter synthesis. It's a top-tier choice for this specific goal.
Digestive Health 90.0
The cofactors in this formulation significantly enhance SAMe's role in liver detoxification and overall digestive health. This makes it a highly effective and well-rounded product for these benefits, justifying its position as a premium choice.
Joint Health 85.0
While the B vitamins don't directly target joint health, the 200mg SAMe dose combined with overall metabolic support makes it effective. Its comprehensive nature, though premium-priced, contributes to overall wellness that can indirectly benefit joints.
Recommended Alternatives
95 Value 
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Offers a very similar comprehensive formulation with high-quality, bioavailable B vitamin cofactors, providing comparable benefits and excellent value for a complete formula.
68 Value 
SAMe (S-Adenosylmethionine)
Pure Encapsulations
4.5
★★★★★
(18 ratings)
A trusted brand for purity and quality in a standalone SAMe product, offering good value for those who prioritize clean ingredients and prefer to manage cofactors separately.
70 Value 
SAMe 400 mg
Protocol For Life Balance
4.9
★★★★★
(46 ratings)
Provides a higher 400mg SAMe dose from a reputable brand, offering good value for increased potency, especially for those who need a higher daily amount.
85 Performance 
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
While lacking cofactors, it offers a higher 400mg dose of SAMe which may be preferred for certain therapeutic needs where a higher SAMe concentration is desired.
90 Performance 
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Provides a higher 400mg dose of SAMe from a stable form at an excellent value, suitable for individuals seeking higher SAMe potency, and can be combined with separate B vitamins.
84 Performance 
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Offers a robust 400mg dose of SAMe from a stable form at a strong value, providing higher potency for those who need it and are willing to supplement cofactors separately.
92 Budget 
SAMe 200 mg
NOW
4.5
★★★★★
(1741 ratings)
Offers SAMe at a significantly lower price per serving, providing excellent affordability, though without the comprehensive cofactor blend.
88 Budget 
SAMe 200
Jarrow Formulas
4.7
★★★★★
(263 ratings)
Extremely cost-effective SAMe option from a reputable brand, providing basic SAMe support at a much lower cost for budget-conscious users.
82 Budget 
SAMe 200 mg
Natural Factors
4.6
★★★★★
(578 ratings)
Provides a good quantity of SAMe for a considerably lower cost, suitable for those who prefer to add cofactors separately or do not need them.
95 Value
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Offers a very similar comprehensive formulation with high-quality, bioavailable B vitamin cofactors, providing comparable benefits and excellent value for a complete formula.
68 Value
SAMe (S-Adenosylmethionine)
Pure Encapsulations
4.5
★★★★★
(18 ratings)
A trusted brand for purity and quality in a standalone SAMe product, offering good value for those who prioritize clean ingredients and prefer to manage cofactors separately.
70 Value
SAMe 400 mg
Protocol For Life Balance
4.9
★★★★★
(46 ratings)
Provides a higher 400mg SAMe dose from a reputable brand, offering good value for increased potency, especially for those who need a higher daily amount.
85 Performance
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
While lacking cofactors, it offers a higher 400mg dose of SAMe which may be preferred for certain therapeutic needs where a higher SAMe concentration is desired.
90 Performance
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Provides a higher 400mg dose of SAMe from a stable form at an excellent value, suitable for individuals seeking higher SAMe potency, and can be combined with separate B vitamins.
84 Performance
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Offers a robust 400mg dose of SAMe from a stable form at a strong value, providing higher potency for those who need it and are willing to supplement cofactors separately.