SAMe 200 mg + Cofactors

SAMe 200 mg + Cofactors

Metabolic Maintenance4.7 (80 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$73.00 $1.21 per serving
iHerbLowest$73.00iHerb$73.00

About this product

SAMe is combined logically with active vitamin B6, folate, and methylcobalamin, which support the same methylation cycle. The compact formula avoids unrelated ingredients and clearly identifies most useful forms.

The 200 mg SAMe serving is a moderate starting amount rather than a high-potency dose. Calcium and magnesium are too small to provide meaningful mineral support, and the label does not identify a stabilized SAMe salt or acid-protected delivery.

The formula may suit targeted methylation or mood-related use under appropriate guidance. It is not a broad energy, detoxification, general-health, or hair supplement despite its relevant cofactors.

Who is it for
  • Adults seeking a moderate SAMe starting amount
  • Users wanting methylation cofactors in the same capsule
  • People using SAMe with clinical guidance
Best for
  • Targeted SAMe supplementation
  • Methylation cofactor support
  • Mood-related nutritional support

Pros

  • Pairs SAMe with logical methylation cofactors
  • Uses P-5-P and methylcobalamin
  • Compact and fully quantified formula
  • Avoids an unrelated proprietary blend

Cons

  • SAMe amount is only moderate
  • No stabilized salt is identified
  • Acid-protected delivery is not stated
  • Calcium and magnesium are token doses

Warnings

  • SAMe can aggravate mania or hypomania in susceptible people, so anyone with bipolar-spectrum illness should use it only with clinical guidance.
  • SAMe may interact with serotonergic medicines such as SSRIs, SNRIs, MAO inhibitors, or certain migraine drugs; concurrent use requires professional review.

Product analysis

69 out of 100
A coherent SAMe-and-cofactor blend with good B-vitamin forms, limited by moderate potency and unclear SAMe delivery protection.

AI assessment of the formula, label and price. How scoring works

Nutrient quality85

P5P, methylcobalamin, citrate, and bisglycinate are favorable forms. SAMe is only moderately dosed, while the mineral amounts are too small to add much.

Ingredient transparency77

Every active has a specific amount, but the folate form and SAMe stabilization are not described. Daily directions and inactive ingredients are not supplied.

Customer satisfaction62

The aggregate rating is strong, but the evidence base is small. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money44

Active cofactors and coherent formulation provide some quality value. The very high serving cost and modest SAMe amount make it uncompetitive.

Format
Capsule
Container
60 Capsule(s)
Per serving
$1.21
Customer rating
4.7 · 80 ratings
Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
Moderate effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Magnesium · 20 mgVitamin B12 · 500 mcg
Study evidence
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
Highest effect
B+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Folate · 333 mcg DFEVitamin B12 · 500 mcgMagnesium · 20 mg

Folate, vitamin B12 and vitamin B6 contribute nutrients involved in normal blood formation. They may help meet needs your diet isn't covering, rather than reliably improve how you feel when you already get enough. The declared B12 forms and amount don't imply a special benefit from the delivery method or superiority over other nutrient preparations.

How this product is rated for General Health

Ingredient fit85

Calcium, Vitamin B6, Vitamin B12, Vitamin B9 (Folate), Magnesium supply the declared nutrients.
Goal fit
Calcium, Vitamin B6, Vitamin B12, Vitamin B9 (Folate), Magnesium supply the declared nutrients.
Dose adequacy
Calcium: 20 mg; Vitamin B6: 2 mg; Vitamin B12: 500 mcg; Vitamin B9 (Folate): 333 mcg DFE; Magnesium: 20 mg per serving.

Pathways60

The ingredients relate to one-carbon metabolism and blood formation, with the scope determined by the nutrients present.
Depth
The strongest connection concerns one-carbon metabolism and blood formation.
Breadth
The ingredients relate to one-carbon metabolism and blood formation, with the scope determined by the nutrients present.

Evidence82

Vitamin B9 (Folate) can contribute to nutrient needs, without implying extra benefit when intake is already adequate.
Evidence strength
Vitamin B9 (Folate) can contribute to nutrient needs, without implying extra benefit when intake is already adequate.
Studied preparation
The identified nutrient preparations supply nutrients; the preparation alone does not imply superior health benefits.

Formulation logic100

The relevant ingredients can contribute on their own or have their necessary partners present. No particular ingredient conflict is identified.
Partner coverage
The relevant ingredients can contribute on their own or have their necessary partners present.
Conflicts
No particular ingredient conflict is identified.
Effective doses
Calcium: 20 mg; Vitamin B6: 2 mg; Vitamin B12: 500 mcg; Vitamin B9 (Folate): 333 mcg DFE; Magnesium: 20 mg per serving.
Study evidence
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Vitamin B12 Adverse 66 studies
Detoxification
Detoxification
Impact
High effect
B- Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Folate · 333 mcg DFEVitamin B12 · 500 mcgVitamin B6 · 2 mgMagnesium · 20 mgSAMe · 200 mg

SAMe and the B vitamins relate to methyl-group supply, a normal chemical process in your body. That role does not show that taking this combination clears unspecified toxins faster. Folate has a more specific connection to arsenic handling in people with relevant exposure and nutrient status, but those effects cannot automatically be applied to everyday use or to every folate form.

How this product is rated for Detoxification

Ingredient fit73

SAMe and B vitamins relate to normal methyl-group processes, without demonstrating routine toxin removal.
Goal fit
SAMe and B vitamins relate to normal methyl-group processes, without demonstrating routine toxin removal.
Dose adequacy
Folate is 333 mcg DFE per serving; these amounts alone do not establish routine toxin clearance.

Pathways60

The ingredients relate to normal methyl-group and enzyme processes, rather than demonstrated broad toxin clearance.
Depth
The ingredients relate to normal methyl-group and enzyme processes, rather than demonstrated broad toxin clearance.
Breadth
Normal biochemical roles span several processes, without showing that the serving removes a broad range of toxins.

Evidence100

Folate’s arsenic-related effects concern specific exposure and nutrient status; they do not transfer automatically to routine use or methylfolate.
Evidence strength
Folate’s arsenic-related effects concern specific exposure and nutrient status; they do not transfer automatically to routine use or methylfolate.
Studied preparation
The declared ingredient forms do not remove the exposure and nutrient-status limits on potential benefit.

Formulation logic100

No particular ingredient conflict or missing required companion is identified. Combining the ingredients does not by itself demonstrate additional toxin-removal benefit.
Partner coverage
No required companion ingredient is missing for the relevant ingredients.
Conflicts
No particular ingredient conflict is identified for the declared serving.
Effective doses
Folate is 333 mcg DFE per serving; these amounts alone do not establish routine toxin clearance.
Study evidence
Folate Supportive 16 studies
SAMe Supportive 30 studies
Vitamin B12 Supportive 8 studies
Productivity Boost
Cognitive Energy and Stamina
Productivity Boost
Impact
Moderate effect
C Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Vitamin B12 · 500 mcgVitamin B12 · 500 mcgVitamin B6 · 2 mgMagnesium · 20 mg
Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Vitamin B6 Disputed 6 studies

Ingredients

IngredientAmount per servingScore
Vitamin B6 (Pyridoxal 5-Phosphate)
 2 mg
Folate
333 mcg DFE
Vitamin B12 (Methylcobalamin)
 500 mcg 76
Calcium (Calcium Citrate)
 20 mg
Magnesium (Magnesium Bisglycinate)
 20 mg
SAMe
200 mg 70
Gluten Free Adults 18–50 Dairy Free
Report overview
Vitamin B12 (Methylcobalamin) · 500 mcg OverallScore76
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
SAMe 200 mg + Cofactors lists 500 mcg of B12 as methylcobalamin, with the form and amount clearly named. The serving provides a substantial amount, while its cost per 1,000 mcg is high and limits its value.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

Its only listed B12 form is methylcobalamin.
Bioactive B12 Form Selection
The label identifies methylcobalamin as its B12 form.

Dose, Safety & Label Transparency79

It lists 500 mcg per serving and identifies the B12 form.
Therapeutic Dosage Level
The 500 mcg serving provides a substantial amount of B12.
Label and Form Transparency
The label states both the 500 mcg amount and methylcobalamin form.

Value20

The cost per 1,000 mcg is high.
Price per 1,000 mcg B12
The cost for each 1,000 mcg is high, which limits the value of its B12.
View ingredientView products
SAMe · 200 mg OverallScore70
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
SAMe 200 mg + Cofactors lists a named disulfate tosylate salt among its ingredients and states a 200 mg serving. The saved facts indicate the net SAMe amount is distinguished, though source proportions remain unclear. Individually sealed foil blisters are not recorded, and the cost for a 400 mg comparison amount is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

A named stabilized salt appears in the nested ingredients, but individually sealed foil blisters are not recorded.
Stabilized Salt Form
The ingredients include S-adenosyl-L-methionine disulfate p-toluenesulfonate, a stabilized salt form; its proportion is unknown.
Packaging Integrity
The saved facts do not identify individually sealed foil blister packs.

Dose, Safety & Label Transparency88

The serving lists 200 mg of SAMe, and the saved facts indicate the net amount is distinguished from the salt complex.
Active Dosage Strength
It lists 200 mg of SAMe per serving.
Net SAMe Yield Transparency
The facts indicate the label separates net SAMe from the salt complex.

Value20

The cost for a 400 mg comparison amount is high; this is a price-normalization unit.
Price Per 400mg Active Dose
The cost is high when normalized to a 400 mg SAMe amount.
View ingredientView products
Loading alternative details
94 Performance

SAMe 400 mg

Lake Avenue Nutrition

A stabilized disulfate tosylate salt and enteric coating address two major quality gaps in the original while supplying a full commonly used amount. Net active yield and moisture-resistant packaging remain uncertain, but the SAMe design is much more complete.

87 Performance

SAMe 400 mg

Source Naturals

Enteric coating protects a full SAMe amount from stomach acid and offers more credible delivery than an ordinary capsule. The unidentified salt, unclear active yield, and unconfirmed moisture protection keep it behind the most fully specified option.

86 Performance

SAMe 400 mg

Swanson

A stable disulfate tosylate form supplies a full SAMe amount in one tablet. Enteric protection and moisture-resistant packaging are not stated, but the active form and depth improve on the original’s unspecified SAMe.

91 Budget

SAMe 400 mg

Nutricost

A stabilized SAMe salt supplies twice the labeled amount at roughly half the serving cost. Acid-resistant delivery and moisture protection are not stated, but the active depth and value clearly exceed the original.

92 Budget

SAMe 400 mg

Life Extension

An enteric-coated tablet supplies a full commonly used SAMe amount at much stronger serving value. Salt identity, net active yield, and moisture protection remain unclear, but delivery and dose are more purposeful than the original capsules.

90 Budget

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt provides twice the SAMe amount at a substantially lower serving cost. Missing enteric protection and moisture-resistant packaging reduce delivery confidence, but active depth is still stronger.

84 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension

The same SAMe amount comes in an enteric-coated tablet at a much lower serving cost. It lacks the original’s methylation cofactors and does not identify the stabilized salt, but delivery and economy are stronger.

89 Value

SAMe 400 mg

NOW

A stabilized SAMe salt doubles the labeled amount while keeping favorable serving value. Missing enteric and moisture protection are trade-offs, yet the formula offers more active ingredient for the cost.

83 Value

SAMe 400 mg

California Gold Nutrition

A substantial enteric-coated SAMe amount provides stronger dose-adjusted value than the original. Stabilization and protective packaging remain unclear, and the same cautions apply with serotonergic medicines or bipolar disorder.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
    Randomized trial55 participantsDetoxification forFolate
  2. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
    Yuan S; Chen J; Dan L; Xie Y; Sun Y; Li X; Larsson SC · The American journal of clinical nutrition · 2022
    Meta-analysis30,368 participants22 studies pooledDetoxification forFolate
  3. Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
    Zhang X; Xu X; Zhong Y; Power MC; Taylor BD; Carrillo G · Journal of exposure science & environmental epidemiology · 2020
    Cross-sectional study11,016 participantsDetoxification forFolate
  4. Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
    Wu Z; Hu H; Wang C; Wu J; Xiong Y; Fu Y; Cheng X; Su H; Li P · Environmental science and pollution research international · 2022
    Cross-sectional study15,501 participantsDetoxification forFolate
  5. Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Molaqanbari MR; Zarringol S; Talari HR; Taghizadeh M; Bahmani F; Mohtashamian A; Ebrahimzadeh A; Sharifi N · Advanced biomedical research · 2023
    Randomized trial66 participantsDetoxification forFolate
  6. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
    Noureddin M; Sander-Struckmeier S; Mato JM · World journal of hepatology · 2020
    Systematic review9 studies pooledDetoxification forSAMe
  7. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
    Zhang L; Liu XH; Qi HB; Li Z; Fu XD; Chen L; Shao Y · European review for medical and pharmacological sciences · 2016
    Randomized trial120 participantsDetoxification forSAMe
  8. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
    Guo T; Chang L; Xiao Y; Liu Q · PloS one · 2015
    Meta-analysis705 participants11 studies pooledDetoxification forSAMe
  9. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    Liu GY; Wang W; Jia WD; Xu GL; Ma JL; Ge YS; Yu JH; Sun QK; Meng FL · World journal of surgical oncology · 2014
    Non-randomized trial81 participantsDetoxification forSAMe
  10. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
    Mato JM; Cámara J; Fernández de Paz J; Caballería L; Coll S; Caballero A; García-Buey L; Beltrán J; Benita V; Caballería J; Solà R; Moreno-Otero R; Barrao F; Martín-Duce A; Correa JA; Parés A; Barrao E; García-Magaz I; Puerta JL; Moreno J; Boissard G; Ortiz P; Rodés J · Journal of hepatology · 1999
    Randomized trial123 participantsDetoxification forSAMe
  11. Antidotes for acute cyanide poisoning.
    Borron SW; Baud FJ · Current pharmaceutical biotechnology · 2013
    Narrative reviewDetoxification forVitamin B12
  12. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation.
    Borron SW; Baud FJ; Barriot P; Imbert M; Bismuth C · Annals of emergency medicine · 2007
    Case series69 participantsDetoxification forVitamin B12
  13. Comment on "Rapid visual detection of blood cyanide" by C. Männel-Croisé and F. Zelder, Analytical Methods, 2012, 4, 2632.
    Kadjo AF; Dasgupta PK; Boss GR · Analytical methods : advancing methods and applications · 2023
    Editorial / commentaryDetoxification forVitamin B12
  14. [Acute intoxication in adults - what you should know].
    Zilker T · Deutsche medizinische Wochenschrift (1946) · 2014
    Narrative reviewDetoxification forVitamin B12
  15. Investigating vitamin B12 levels in children with obesity: the role of metformin.
    Iwańska A; Goncerz D; Ahmed M; Aoun R; Kozioł-Kozakowska A; Szczudlik E; Stępniewska A; Wójcik M; Starzyk JB · European journal of pediatrics · 2026
    Observational study500 participantsDetoxification forVitamin B12
  16. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  17. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  18. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  19. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  20. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  21. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  22. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  23. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  24. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  25. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  26. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  27. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  28. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  29. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  30. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  31. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  32. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  33. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  34. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  35. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  36. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  37. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  38. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  39. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  40. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  41. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  42. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  43. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  44. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12
  45. Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
    Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
    Cross-sectional study2,421 participantsProductivity Boost forVitamin B6
  46. Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
    Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
    Non-randomized trialProductivity Boost forVitamin B6
  47. Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
    Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
    Cohort studyProductivity Boost forVitamin B6
  48. Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
    Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
    Case-control study49 participantsProductivity Boost forVitamin B6
  49. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsProductivity Boost forVitamin B6