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Magnesium 250 mg

Nature Made
4.7
★ ★ ★ ★ ★
(4766 ratings)
Magnesium 250 mg
Product Image
Score78
A cheap one-tablet magnesium oxide product is easy to use but poorly suited to dependable systemic magnesium support.
How scoring works
Quantity:100 Tablet(s) • (100 servings)
Goals:
Digestive Health
General Health
Energy
Heart Health

Score 78

A cheap one-tablet magnesium oxide product is easy to use but poorly suited to dependable systemic magnesium support.
How scoring works

Also available as

1 option
200 servings Magnesium 250 mg • 200 Tablet(s) • 200 servings $10.72 ($0.05 per serving)
$5.30($0.05 per serving)
Vitacost
$ 5.49
Vitacost
$ 5.49
Pure Formulas
$ 5.30
iHerb
$ 5.49
Walmart
$ 6.31
Report prices

Analysis

The tablet provides 250 mg of elemental magnesium as oxide. Although the amount is clearly stated, oxide typically delivers less absorbed magnesium than citrate, glycinate, or malate.

A single tablet and inexpensive serving make daily use simple. Digestive effects may appear before the user obtains the systemic benefit expected from the label amount.

It suits someone who knowingly prefers oxide or wants occasional bowel support. People targeting muscle, nerve, or sleep-related magnesium needs should consider a better-absorbed form.

Who is it for
  • Adults intentionally choosing magnesium oxide
  • People focused on low cost
  • Users seeking one-tablet convenience
Best for
  • Basic magnesium intake
  • Occasional bowel support
  • Simple budget use

Pros

  • Clearly states 250 mg elemental magnesium
  • One-tablet serving
  • Very low serving cost
  • Simple single-active formula

Cons

  • Oxide has poor absorption
  • Digestive effects may limit use
  • No chelation or absorption aid
  • Weak fit for targeted repletion

Warnings

  • The 250 mg oxide serving of supplemental magnesium may cause loose stools, cramping, or nausea; a smaller divided amount may be easier to tolerate.
  • Magnesium can reduce absorption of tetracycline or quinolone antibiotics; follow the prescriber or pharmacist’s spacing instructions.
  • Magnesium can interfere with levothyroxine absorption and should be separated according to medication guidance.
  • People with significantly reduced kidney function can accumulate magnesium and need clinician-guided use.

Nutrient quality

72 High impact

Magnesium oxide is clearly named but provides weak systemic absorption. The elemental amount is meaningful for basic supplementation, while the amount is not extreme, though oxide may still cause loose stools in sensitive users.

Ingredient transparency

81 Highest impact

The active form and elemental amount are easy to identify. Serving totals are apparent, but full directions and inactive ingredients are not supplied.

Customer satisfaction

69 High impact

The supplied average rating is favorable. The very large rating base makes the average unusually stable, while complaint and firsthand experience details are unavailable.

Value for money

87 Highest impact

Formula quality provides partial support for the asking position. The serving value is reasonably competitive within the category.

Report analysis

Goals

Digestive Health
Digestive Health
Impact
High effect
A- Goal FitB- Strength of SupportD- CoverageA+ Formula Quality
Magnesium · 250 mg

Magnesium oxide can draw water into the bowel and may support occasional regularity. Its low absorption makes it less suitable for broader magnesium functions and may cause loose stools in sensitive users.

The disclosed elemental amount is substantial for the narrow motility pathway. The clean formula avoids padding but does not support digestion, the microbiome, or the gut barrier.

Study evidence
Magnesium Supportive 50 studies
General Health
Stress Resilience
General Health
Impact
High effect
A- Goal FitC Strength of SupportD+ CoverageB Formula Quality
Magnesium · 250 mg

Magnesium provides relevant foundational support for muscle, nerve, and metabolic function. The elemental amount is clearly disclosed and can contribute meaningfully to daily intake.

Magnesium oxide is poorly absorbed compared with better supplemental forms, which limits expected systemic benefit. The simple tablet remains focused but offers only one pathway of general health support.

Study evidence
Magnesium Supportive 114 studies
Energy
Energy
Impact
High effect
B Goal FitC Strength of SupportD- CoverageA Formula Quality
Magnesium · 250 mg

Magnesium is required for ATP-dependent enzymes, and the 250 mg amount meets the stated energy threshold. Magnesium oxide provides focused metabolic and neuromuscular support rather than acute stimulation.

Magnesium oxide has poor systemic absorption, which limits its effective contribution. The single-mineral design is transparent and free from unrelated ingredients.

Study evidence
Magnesium Supportive 4 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
B- Goal FitC Strength of SupportD- CoverageB+ Formula Quality
Magnesium · 250 mg

Magnesium provides a direct nutritional link to vascular tone and normal heart rhythm. The elemental amount is substantial enough to contribute to daily intake.

Magnesium oxide is the main weakness because it is absorbed less efficiently than citrate or chelated forms. The lean formula is transparent, but it offers only one cardiovascular pathway.

Study evidence
Magnesium Supportive 158 studies
Stress Relief
Stress Relief
Impact
Moderate effect
B- Goal FitC Strength of SupportD- CoverageB+ Formula Quality
Magnesium · 250 mg

The label supplies a useful elemental magnesium amount in a simple tablet. Magnesium has a foundational role in nervous-system regulation.

Magnesium oxide has poor systemic absorption and is more likely to affect the bowel than provide dependable calming support. A more absorbable chelate or citrate would better match the stress goal.

Study evidence
Magnesium Supportive 13 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
B- Goal FitD- Strength of SupportF CoverageA- Formula Quality
Magnesium · 250 mg

The clearly stated magnesium amount is relevant to vascular tone and normal rhythm. Magnesium oxide, however, is absorbed less reliably than better organic forms.

The single-ingredient design is simple and transparent. Its narrow scope and weak form quality limit how strongly it can contribute to cardiovascular support.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Oxide)
 250 mg
Gluten Free Adults 18–50
Report overview
Magnesium (Magnesium Oxide) · 250 mg OverallScore54
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

Magnesium oxide supplies a clear therapeutic elemental amount but offers poor systemic absorption. The clean single-ingredient tablet has no patented processing or uptake cofactor. Very low cost provides some value, though the form is a major limitation.

View ingredientView products
Loading alternative details
88 Performance

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate supplies a well-absorbed form at a practical, moderate amount. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
85 Performance

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>Chelated calcium and magnesium provide a focused, balanced mineral formula with strong form quality. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
85 Performance

Magnesium Bisglycinate 200 mg

Natural Factors
<p>A focused magnesium bisglycinate powder uses a highly absorbable form at a moderate, practical amount. Compared with the original, its magnesium form, dose clarity, and focused design offer a stronger quality-oriented option.</p>
83 Budget

Magnesium Citrate Pure Powder

Best Naturals
<p>A well-aligned amount of magnesium citrate delivers useful absorption in a focused powder. Its lower supplied serving cost makes it a more economical magnesium option than the original.</p>
85 Budget

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides high-quality absorption quality, a useful elemental amount, and strong serving value in a clean powder. The supplied serving cost is not lower; it is included only because fewer than three eligible lower-cost choices from different brands are available.</p>
91 Budget

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful amount, with a modest potassium contribution. The supplied serving cost is not lower; it is included only because fewer than three eligible lower-cost choices from different brands are available.</p>
84 Value

Magnesium Glycinate

NOW
<p>Magnesium glycinate is a well-absorbed form that is often gentle on digestion. Its stated magnesium form and dose may improve formulation value, although the supplied serving cost is not lower than the original.</p>
83 Value

Magnesium Citrate 420 mg

Nutricost
<p>A substantial amount of magnesium citrate offers useful absorption and a focused formula. Its stated magnesium form and dose may improve formulation value, although the supplied serving cost is not lower than the original.</p>
83 Value

Magnesium Citrate 200 mg

Best Naturals
<p>A substantial amount of magnesium citrate combines useful absorption with a focused single-active design. Its stated magnesium form and dose may improve formulation value, although the supplied serving cost is not lower than the original.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  3. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  4. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
    Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC · Pediatrics international : official journal of the Japan Pediatric Society · 2007
    Randomized trial45 participantsDigestive Health forMagnesium
  5. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  6. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  7. Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
    Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
    Randomized trial40 participantsDigestive Health forMagnesium
  8. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  9. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  10. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  17. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  18. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  19. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  20. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  21. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  22. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  23. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  24. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  25. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  26. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  27. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  28. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  29. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  30. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  31. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  32. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  33. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  34. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  35. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  36. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  37. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  38. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  39. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  40. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  41. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  42. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  43. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium