Product Image

SHINE

Advanced Nutrition by Zahler
4.7
★ ★ ★ ★ ★
(67 ratings)
Keratin 500 mg
Iodine 150 mcg
Tyrosine 500 mg
Selenium 55 mcg
Lycopene 2 mg
Silicon 2 mg
Chromium 70 mcg
Product Image
Score79
A broad beauty formula built around MSM, keratin, tyrosine, hyaluronic acid, zinc, and active vitamins. Strong structural coverage is offset by four capsules and several disclosure gaps.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:
Nail Health
Hair Health
Energy
General Health

Score 79

A broad beauty formula built around MSM, keratin, tyrosine, hyaluronic acid, zinc, and active vitamins. Strong structural coverage is offset by four capsules and several disclosure gaps.
How scoring works
$25.97($0.86 per serving)
Vitacost
$ 25.97
iHerb
$ 0.00
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Analysis

MSM and hydrolyzed keratin form the structural core for hair and nails, while hyaluronic acid adds skin-hydration relevance. Tyrosine, zinc bisglycinate, selenium, copper, iodine, D3, active folate, and methylcobalamin provide a broad nutritional background.

The major structural actives are individually listed at meaningful amounts, and several vitamin and mineral forms are well chosen. Horsetail is not standardized for silica, the separate silica amount is modest, carotenoids are light, and the B6 entry lacks a conventional unit.

The formula fits adults who want a comprehensive beauty supplement and accept four capsules daily. It is less suitable for people with thyroid conditions, medication-sensitive routines, or anyone seeking a simple biotin-only product.

Who is it for
  • Adults seeking broad hair, skin, and nail support
  • People who prefer structural proteins and MSM over a biotin-heavy formula
Best for
  • Hair and nail structure support
  • Combining keratin, MSM, hyaluronic acid, and micronutrients

Pros

  • Substantial MSM and hydrolyzed keratin
  • Meaningful tyrosine and hyaluronic acid
  • Zinc bisglycinate plus selenium and copper
  • Uses active folate, methylcobalamin, P5P, and D3
  • Avoids an excessive biotin dose

Cons

  • Four-capsule serving
  • Horsetail is not standardized for silica
  • Separate silica amount is modest
  • B6 quantity lacks a clear unit
  • Carotenoids are supporting rather than targeted

Warnings

  • Iodine and L-tyrosine may affect thyroid management, especially when combined with thyroid medicine.
  • L-tyrosine can interact with monoamine oxidase inhibitors and may not suit people with uncontrolled high blood pressure.
  • Selenium and iodine intake should be checked before stacking this product with a multivitamin.
  • Horsetail source details are limited, which matters for users who need strict botanical screening.

Nutrient quality

87 Highest impact

Bioactive B vitamins, chelated zinc, MSM, keratin, and hyaluronic acid make a coherent beauty-focused core. Horsetail, silica, lutein, and lycopene are much lighter additions, but no amount appears excessive.

Ingredient transparency

76 High impact

Most active forms and amounts are specific, and no proprietary blend obscures the core formula. Duplicate folate entries, an unclear vitamin B6 unit, missing directions, and absent capsule excipients reduce confidence.

Customer satisfaction

67 High impact

The supplied aggregate rating is strong, while the amount of feedback provides moderate confidence. No comments were supplied, so repeated complaints and beauty-specific experiences remain unknown.

Value for money

85 Highest impact

A broad set of favorable forms and meaningful core doses supports strong daily value. Smaller beauty extras reduce efficiency slightly but do not outweigh the useful MSM, keratin, and hyaluronic acid core.

Report analysis

Goals

Nail Health
Healthy Nail Growth
Nail Health
Impact
Highest effect
A+ Goal FitA Strength of SupportA+ CoverageA Formula Quality
Silicon · 2 mgBiotin · 30 mcgHorsetail · 100 mgKeratin · 500 mg

A direct keratin and sulfur core makes the formula closely aligned with nail strength and growth. Silica is modest, but the other structural ingredients provide substantial depth.

High-quality forms and full dose disclosure strengthen confidence. The formula is focused, coherent, and contains limited padding.

Study evidence
Biotin Supportive 8 studies
Keratin Adverse 7 studies
Silicon Supportive 2 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
Hair Health
Hair Health
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageA- Formula Quality
Biotin · 30 mcgVitamin D · 20 mcgZinc · 11 mgVitamin C · 90 mgKeratin · 500 mg

Branded Cynatine keratin provides a direct structural hair active at a substantial amount. MSM, vitamin C, zinc, selenium, iodine, tyrosine, and hyaluronic acid add complementary structural, thyroid, and antioxidant support.

Silicon and horsetail contributions are small or poorly standardized, while biotin is only nutritional. The four-capsule serving is broad but remains anchored by a well-disclosed keratin dose.

Study evidence
Biotin Supportive 4 studies
Horsetail Not classified

No linked studies yet.

Iodine No effect 1 study
Keratin Disputed 14 studies
Selenium Disputed 7 studies
Silicon Supportive 2 studies
Vitamin C Mixed 5 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Energy
Essential Energy Nutrients
Energy
Impact
High effect
B Goal FitB Strength of SupportB- CoverageB+ Formula Quality
Iodine · 150 mcgVitamin D · 20 mcgVitamin B5 · 5 mgRiboflavin · 1.3 mgThiamin · 1.2 mgVitamin B12 · 2.4 mcg

Tyrosine, iodine, selenium, B vitamins, and chromium can support neurotransmitter and thyroid-related energy pathways. The formula is designed mainly for hair and skin, while most B-vitamin amounts remain at basic maintenance levels.

Methylcobalamin, active folate, P5P, zinc bisglycinate, and clear dose disclosure are quality strengths. Tyrosine is meaningfully dosed, but the rest of the energy pathway is comparatively light.

Study evidence
Iodine Adverse 3 studies
General Health
General Health
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Folate · 400 mcg DFEVitamin B12 · 2.4 mcgVitamin D · 20 mcgSelenium · 55 mcgZinc · 11 mgVitamin C · 90 mg

The micronutrient base supports several general nutritional needs, but much of the formula targets hair, skin, and beauty outcomes. Active folate, methylcobalamin, vitamin D3, zinc bisglycinate, and selenium yeast improve the foundational core.

MSM, keratin, tyrosine, and hyaluronic acid receive meaningful amounts for the intended specialty use. Smaller horsetail, silica, lutein, and lycopene additions broaden the label without adding much systemic depth.

Study evidence
Folate Supportive 80 studies
Selenium Supportive 70 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportC CoverageD- Formula Quality
Vitamin C · 90 mgZinc · 11 mgVitamin A · 900 mcgVitamin D · 20 mcgSelenium · 55 mcg

Vitamin D3, zinc, vitamin A, vitamin C, and selenium provide modest daily immune nutrition. Chelated zinc and active B-vitamin forms improve the nutrient quality.

The amounts are geared toward maintenance rather than focused immune support, especially for vitamin C and selenium. Most of the formula is devoted to hair, skin, and connective-tissue ingredients that add little to immune readiness.

Study evidence
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
Brain Health
Essential Brain Nutrition
Brain Health
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD CoverageF Formula Quality
Folate · 400 mcg DFEVitamin B12 · 2.4 mcgVitamin B6 · 1.7 NPVitamin D · 20 mcgThiamin · 1.2 mg

L-tyrosine and active B vitamins provide limited support for neurotransmitter production and normal neurological function. The formula is chiefly designed for hair, skin, and nails rather than cognition.

Tyrosine reaches a useful amount, and methylfolate plus methylcobalamin are good form choices. Large beauty-focused ingredients dominate the serving and leave little room for a coherent brain-health strategy.

Study evidence
Tyrosine Supportive 7 studies
Vitamin B6 Supportive 29 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 900 mcg
Vitamin C (Pureway-C)
 90 mg
Vitamin D3 (Cholecalciferol)
 20 mcg
Vitamin E (D-Alpha-Tocopherol Succinate)
 15 mg
Thiamin (Thiamine Hydrochloride)
 1.2 mg
Riboflavin
1.3 mg
Niacin (Inositol Hexaniacinate)
 16 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 1.7 NP
Folate ((6S)-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
 400 mcg DFE
Vitamin B12 (Methylcobalamin)
 2.4 mcg
Biotin
30 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 5 mg
Iodine (Potassium Iodine)
 150 mcg
Zinc (Zinc Bisglycinate Chelate)
 11 mg
Selenium (Selenium Yeast)
 55 mcg
Copper (Copper Citrate)
 0.45 mg
Chromium (Chromium Picolinate)
 70 mcg
Methylsulfonylmethane
1 Gram(s)
Cynatine (Keratin)
 500 mg
L-Tyrosine
500 mg
Hyaluronic Acid (Sodium Hyaluronate)
 100 mg
Horsetail herb powder
100 mg
Silica (Bamboo stem/shoot extract)
 2 mg
Lutein (Aztec Marigold flower extract)
 2 mg
Lycopene (Lycobeads)
 2 mg
Gluten Free Adults 18–50 Kosher Dairy Free Vegetarian
Report overview
Keratin · 500 mg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The full serving provides a substantial dose of branded Cynatine keratin. Its named source supports confidence in processing and absorption, while the exact amount is clearly disclosed. The near-median serving cost makes the high active dose a strong value.

View ingredientView products
Iodine (Potassium Iodine) · 150 mcg OverallScore91
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC+ Value

Potassium iodide provides a stable, readily absorbed source without marine-contamination concerns. The 150 mcg serving supports daily maintenance and stays below the upper limit, with elemental intake clearly stated. Moderate serving cost is easier to justify because selenium and L-tyrosine adds useful thyroid-support value. The 4-unit serving also makes dosing less convenient and slightly increases accidental-overuse risk.

View ingredientView products
Tyrosine · 500 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Standard L-Tyrosine is supplied at a well-aligned 500 mg amount with full dose disclosure. No tyrosine-specific source, purity grade, or testing information is provided. The broad beauty-focused formula makes the cost per gram of tyrosine unfavorable.

View ingredientView products
Loading alternative details
92 Performance

Heavenly Hair Tropical Citrus

OLLY
<p>A more focused ingredient profile improves alignment with the main goals: biotin, zinc citrate, silica, horsetail, keratin, and amla align closely with hair and nail support. Keratin and botanical extracts are light, while high-dose biotin can interfere with laboratory tests.</p>
86 Performance

Thyrocsin

Thorne
<p>A more focused ingredient profile improves alignment with the main goals: well-chosen iodine, selenium, tyrosine, active vitamins, and modest ashwagandha provide targeted thyroid-related nutrient support. The formula is not a complete hair-and-nail product, and iodine or ashwagandha may complicate thyroid treatment.</p>
70 Performance

Men's Multi

Garden of Life MyKind Organics
<p>A more focused ingredient profile improves alignment with the main goals: vitamin D3, methylcobalamin, selenium, iodine, and broad vitamins provide general nutritional support that can include hair health. The food blend and many mineral forms are vague, and the formula lacks the original’s MSM, keratin, and hyaluronic acid focus.</p>
92 Budget

Heavenly Hair Tropical Citrus

OLLY
<p>A lower-cost serving improves affordability while keeping relevant ingredients: biotin, zinc citrate, silica, horsetail, keratin, and amla align closely with hair and nail support. Keratin and botanical extracts are light, while high-dose biotin can interfere with laboratory tests.</p>
86 Budget

Thyrocsin

Thorne
<p>A lower-cost serving improves affordability while keeping relevant ingredients: well-chosen iodine, selenium, tyrosine, active vitamins, and modest ashwagandha provide targeted thyroid-related nutrient support. The formula is not a complete hair-and-nail product, and iodine or ashwagandha may complicate thyroid treatment.</p>
40 Budget

Thyroid Care Plus

Terry Naturally
<p>A lower-cost serving improves affordability while keeping relevant ingredients: iodine, selenium, and tyrosine form a concise thyroid-focused combination at lower serving cost. The listed iodine amount is dangerously excessive, so direct medical supervision and label verification are necessary.</p>
92 Value

Heavenly Hair Tropical Citrus

OLLY
<p>The mix of relevant ingredients and practical serving value is more favorable: biotin, zinc citrate, silica, horsetail, keratin, and amla align closely with hair and nail support. Keratin and botanical extracts are light, while high-dose biotin can interfere with laboratory tests.</p>
86 Value

Thyrocsin

Thorne
<p>The mix of relevant ingredients and practical serving value is more favorable: well-chosen iodine, selenium, tyrosine, active vitamins, and modest ashwagandha provide targeted thyroid-related nutrient support. The formula is not a complete hair-and-nail product, and iodine or ashwagandha may complicate thyroid treatment.</p>
68 Value

Women's Multi 40+

Garden of Life MyKind Organics
<p>The mix of relevant ingredients and practical serving value is more favorable: vitamin D3, methylcobalamin, selenium, iodine, and broad vitamins provide women-focused maintenance coverage. Two opaque blends and modest trace nutrients limit precision, while MSM, keratin, and hyaluronic acid are absent.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women.
    Tursi F; Nobile V; Cestone E; De Ponti I; Lepoudere A; Sergheraert R; Soulard JP · Journal of cosmetic dermatology · 2025
    Randomized trialHair Health Nail Health forKeratin
  2. Comparative Analysis of Type I Keratin Expression By Nail Consistency: An Immunohistochemistry Study.
    Mingorance Álvarez E; Rodríguez-León J; Pérez Pico AM; Mayordomo R · Applied immunohistochemistry & molecular morphology : AIMM · 2022
    Cross-sectional study32 participantsNail Health forKeratin
  3. Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
    Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
    Randomized trial24 participantsBrain Health forTyrosine
  4. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
    Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
    Narrative reviewBrain Health forTyrosine
  5. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
    Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
    Cross-sectional study286 participantsBrain Health forTyrosine
  6. Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
    Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
    Cross-sectional study398 participantsBrain Health forTyrosine
  7. Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
    Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
    Randomized trial45 participantsBrain Health forTyrosine
  8. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  9. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  10. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  11. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  12. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  13. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  14. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  15. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  16. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  17. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  18. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  19. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  20. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  21. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  22. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  23. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  24. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  25. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  26. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  27. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  28. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  29. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  30. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  31. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health forBiotin
  32. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  33. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  34. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  35. [Evaluation of the role of dietary intake in the occurrence of alopecia].
    El Fékih N; Kamoun H; Fazaa B; El Ati J; Zouari B; Kamoun MR; Gaigi S · Revue medicale de Liege · 2010
    Case-control study272 participantsHair Health forIodine
  36. Halloysite/Keratin Nanocomposite for Human Hair Photoprotection Coating.
    Cavallaro G; Milioto S; Konnova S; Fakhrullina G; Akhatova F; Lazzara G; Fakhrullin R; Lvov Y · ACS applied materials & interfaces · 2021
    In vitro / ex vivo studyHair Health forKeratin
  37. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial.
    Tenore GC; Caruso D; Buonomo G; D'Avino M; Santamaria R; Irace C; Piccolo M; Maisto M; Novellino E · Journal of medicinal food · 2018
    Randomized trialHair Health forKeratin
  38. Keratin/alginate hybrid hydrogels filled with halloysite clay nanotubes for protective treatment of human hair.
    Cavallaro G; Caruso MR; Milioto S; Fakhrullin R; Lazzara G · International journal of biological macromolecules · 2022
    In vitro / ex vivo studyHair Health forKeratin
  39. Patient Satisfaction and Adverse Effects Following the use of Topical Hair Fiber Fillers.
    Babadjouni A; Juhasz M; Pham C; Csuka E; Hedayati B; Evron E; Mesinkovska NA · International journal of trichology · 2024
    Cross-sectional study40 participantsHair Health forKeratin
  40. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  41. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  42. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  43. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  44. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  45. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
    Barel A; Calomme M; Timchenko A; De Paepe K; Demeester N; Rogiers V; Clarys P; Vanden Berghe D · Archives of dermatological research · 2006
    Randomized trial50 participantsHair Health Nail Health forSilicon
  46. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair
    R R Wickett, E Kossmann, A Barel, N Demeester, P Clarys, D Vanden Berghe, M Calomme · Archives of Dermatological Research · 2007
    Randomized trial48 participantsHair Health forSilicon
  47. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  48. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  49. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  50. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  51. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  52. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  53. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  54. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  55. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  56. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  57. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  58. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  59. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  60. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  61. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  62. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  63. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  64. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  65. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  66. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  67. Depressed immune response to tetanus in children with vitamin A deficiency.
    Semba RD; Muhilal; Scott AL; Natadisastra G; Wirasasmita S; Mele L; Ridwan E; West KP; Sommer A · The Journal of nutrition · 1992
    Randomized trial236 participantsImmunity forVitamin A
  68. Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants.
    Roy SK; Islam A; Molla A; Akramuzzaman SM; Jahan F; Fuchs G · European journal of clinical nutrition · 1997
    Randomized trial50 participantsImmunity forVitamin A
  69. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial.
    Coutsoudis A; Broughton M; Coovadia HM · The American journal of clinical nutrition · 1991
    Randomized trial60 participantsImmunity forVitamin A
  70. Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
    Coutsoudis A; Kiepiela P; Coovadia HM; Broughton M · The Pediatric infectious disease journal · 1992
    Randomized trial60 participantsImmunity forVitamin A
  71. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
    Long KZ; Santos JI; Estrada Garcia T; Haas M; Firestone M; Bhagwat J; Dupont HL; Hertzmark E; Rosado JL; Nanthakumar NN · The Journal of nutrition · 2006
    Randomized trial127 participantsImmunity forVitamin A
  72. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  73. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  74. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  75. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  76. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  77. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  78. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  79. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  80. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  81. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  82. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  83. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  84. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  85. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin Nail Health forZinc
  86. Exposure to toxic agents alters organic elemental composition in human fingernails.
    Schumacher E; Dindorf W; Dittmar M · The Science of the total environment · 2009
    Cross-sectional study120 participantsNail Health forKeratin
  87. Human keratin diseases: hereditary fragility of specific epithelial tissues.
    Corden LD; McLean WH · Experimental dermatology · 1997
    Narrative reviewNail Health forKeratin
  88. Phenotype and genotype features of Vietnamese children with pachyonychia congenita.
    Chu HT; Dinh Duong TA; Le DH; Le TV; Nguyen BB; Dang CV; Vu QV · Pediatrics and neonatology · 2023
    Case series7 participantsNail Health forKeratin
  89. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forSilicon
  90. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C