Product Image

St. John's Wort 300 mg

Nature's Way
4.3
★ ★ ★ ★ ★
(471 ratings)
St. John's Wort 300 mg
Rosemary
Product Image
Score75
A practical St. John's wort extract with modest rosemary and spirulina additions. Clear dosing is offset by broad interaction risk and limited rosemary detail.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Mood Support

Score 75

A practical St. John's wort extract with modest rosemary and spirulina additions. Clear dosing is offset by broad interaction risk and limited rosemary detail.
How scoring works
$18.14($0.20 per serving)
Vitacost
$ 18.99
Pure Formulas
$ 18.14
Vitacost
$ 18.99
Amazon
$ 18.49
iHerb
$ 18.99
Report prices

Analysis

St. John's wort defines the product and is supplied as a clearly measured extract. Dianthrones are named, giving more potency information than a plain herb powder.

Rosemary and spirulina broaden the formula but remain small supporting amounts. Rosemary is not described by plant part, extract type, or active markers.

A one-capsule serving and high count are practical for regular use. Medication screening is essential because St. John's wort can change the effectiveness of many common drugs.

Who is it for
  • Adults specifically considering St. John's wort
  • Users who have screened medication interactions
Best for
  • Focused St. John's wort routines
  • People who value a one-capsule serving

Pros

  • St. John's wort amount is clearly stated
  • Dianthrone markers are identified
  • High serving count

Cons

  • Rosemary is poorly characterized
  • Marker concentration is modest
  • Spirulina is only a small addition

Warnings

  • St. John's wort interacts with antidepressants, hormonal contraceptives, anticoagulants, transplant medicines, and many other drugs
  • May increase sun sensitivity
  • Avoid combining with other serotonin-raising products unless clinician-directed

Nutrient quality

72 High impact

The Saint John’s wort extract is standardized to dianthrones, while rosemary and spirulina are less specifically characterized. Saint John’s wort is present at a meaningful amount, with modest rosemary and spirulina additions.

.

Ingredient transparency

79 High impact

Active amounts are stated and no proprietary blend hides a core dose. Missing excipient details and complete use directions leave the supplied label information incomplete.

.

Customer satisfaction

61 Moderate impact

The supplied aggregate satisfaction average provides a broad signal, while the response volume determines how stable it appears. No comment-level evidence is available to assess repeated complaints or confirm intended-use experiences.

.

Value for money

85 Highest impact

Useful active delivery supports favorable serving value. The secondary rosemary and spirulina additions offer limited value beside the main standardized extract.

.
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitC+ Strength of SupportD- CoverageA- Formula Quality

St. John's Wort 300 mg provides 300 mg per serving and uses a St. John's wort extract with incomplete active-marker detail, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.41 from 468 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort extract (Dianthrones)
 300 mg
Rosemary
80 mg
Spirulina
40 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
St. John's Wort (Dianthrones) · 300 mg OverallScore68
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB- Value

Nature's Way Saint John's Wort 300 mg Extract provides 300 mg per serving and uses an extract standardized to 0.15% dianthrones measured as hypericin and pseudohypericin, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.41 from 468 reviews, while the published label includes a specific interaction warning.

View ingredientView products
Rosemary · 80 mg OverallScore61
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB+ Value

Nature's Way St. John's Wort 300 mg includes 80 mg of separately listed rosemary leaf in a convenient capsule, but the rosemary is neither standardized nor identified as an extract. The $0.15 per-serving price is low and customer feedback is positive, yet the product is primarily positioned around St. John's wort rather than concentrated rosemary. St. John's wort can interact with many medications, so the formula's broader safety context deserves attention even though the rosemary dose is clearly disclosed.

View ingredientView products
Loading alternative details
81 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
<p>A larger total St. John’s wort extract amount is fully disclosed, although no active-marker yield is stated. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
85 Performance

Perika St. John's Wort

Nature's Way
<p>A named WS 5570 St. John’s wort extract identifies hyperforin, giving the main active better definition. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
85 Performance

St. John's Wort 300 mg

Nature's Bounty
<p>A standard St. John’s wort amount identifies hypericin in a simple formula. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
86 Budget

St. John's Wort Extract

Swanson Superior Herbs
<p>The serving cost is lower than the original. A standard St. John’s wort amount identifies hypericins and removes the original secondary rosemary and spirulina. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
85 Budget

St. John's Wort 300 mg

NOW
<p>The serving cost is lower than the original. A standard St. John’s wort amount identifies hypericin in a focused single-ingredient formula. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
84 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
<p>The serving cost is lower than the original. A standard St. John’s wort amount identifies hypericin and keeps the formula concise. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
79 Value

St. John's Wort 700 mg

Herbal Secrets
<p>A larger St. John’s wort extract amount is stated clearly, though no hypericin or hyperforin yield is supplied. The lower serving cost improves value relative to the original. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
79 Value

St. John's Wort Extract

21st Century
<p>A standard St. John’s wort extract amount is clearly disclosed, but the active-marker yield is not stated. The lower serving cost improves value relative to the original. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
81 Value

St. John's Wort 450

Source Naturals
<p>A larger St. John’s wort amount is provided in a simple formula, although extract standardization is not supplied. The lower serving cost improves value relative to the original. It omits rosemary; St. John’s wort can also interact with many medicines and may increase sun sensitivity, so the original safety cautions still apply.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort