Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
Randomized trial202 participantsflagSleep Support forscienceValerian
- Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.
Fernández-San-Martín MI; Masa-Font R; Palacios-Soler L; Sancho-Gómez P; Calbó-Caldentey C; Flores-Mateo G · Sleep medicine · 2010
Meta-analysis18 studies pooledflagSleep Support forscienceValerian
- Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
Systematic review15 studies pooledflagSleep Support forscienceValerian
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Meta-analysis516 participants8 studies pooledflagSleep Support forscienceMelatonin
- Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
Peltz JS; Rogge R · Sleep and biological rhythms · 2025
Cohort study331 participantsflagSleep Support forscienceMelatonin
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
Randomized trial63 participantsflagMood Support flagStress Relief forscienceGABA
- Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
Cohort study56 participantsflagMood Support forscienceGABA
- The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
Case-control study69 participantsflagMood Support forscienceGABA
- Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
Observational studyflagMood Support forscienceGABA
- Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
Systematic review11 studies pooledflagMood Support forscienceGABA
- A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Kikuchi AM, Tanabe A, Iwahori Y · Journal of Dietary Supplements · 2021
Systematic review11 studies pooledflagMood Support forscienceTryptophan
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
Randomized trial80 participantsflagMood Support forscienceValerian
- Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
Meta-analysis12 studies pooledflagMood Support forscienceValerian
- Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
Meta-analysis6,894 participants60 studies pooledflagMood Support forscienceValerian
- Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
Randomized trial20 participantsflagMood Support forscienceValerian
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
Systematic review327 participants12 studies pooledflagMood Support forscienceValerian
- Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
Randomized trial40 participantsflagSleep Support forscienceGABA
- Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
Randomized trial160 participantsflagSleep Support forscienceGABA
- Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
Case-control study40 participantsflagSleep Support forscienceGABA
- GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
Randomized trial30 participantsflagSleep Support flagStress Relief forscienceGABA
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin
- The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
Meta-analysis4 studies pooledflagSleep Support forscienceTryptophan
- Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
Clinical trial30 participantsflagStress Relief forscienceGABA
- Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
Case-control study45 participantsflagStress Relief forscienceGABA
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagStress Relief forscienceGABA
- The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
Randomized trial202 participantsflagStress Relief forscienceMelatonin
- Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
Randomized trial90 participantsflagStress Relief forscienceMelatonin
- Melatonin for pre- and postoperative anxiety in adults.
Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
Meta-analysis774 participants12 studies pooledflagStress Relief forscienceMelatonin
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
Meta-analysis441 participants5 studies pooledflagStress Relief forscienceMelatonin
- Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
Randomized trial88 participantsflagStress Relief forscienceMelatonin