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St. John's Wort Extended Release

NaturesPlus Herbal Actives
4.6
★ ★ ★ ★ ★
(421 ratings)
St. John's Wort 450 mg
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Score83
A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Mood Support
Stress Relief

Score 83

A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
$23.76($0.39 per serving)
Pure Formulas
$ 23.76
Vitacost
$ 24.15
Amazon
$ 23.76
Walmart
$ 23.76
iHerb
$ 23.76
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Analysis

The 450 mg serving uses a defined St. John’s wort extract linked to hypericin. That is easier to assess than a raw-herb weight alone.

The supplied data does not state a precise hypericin percentage or yield, so exact potency comparison remains limited. Extended release may spread exposure through the day, but it does not reduce the interaction burden.

Adults with mild mood concerns who take no interacting medicines are the clearest audience. The one tablet format is convenient, but suitability depends more on medication compatibility than ease of use.

Who is it for
  • Adults seeking focused St. John’s wort support
  • People who take no interacting medicines
  • Users who prefer a extended-release tablet
Best for
  • Focused mood-support supplementation
  • Defined St. John’s wort extract intake
  • one tablet daily use

Pros

  • Uses a hypericin extract
  • Clearly states a 450 mg serving
  • one tablet format

Cons

  • Marker percentage is not fully disclosed
  • Extensive medication interactions restrict use
  • No supporting nutrients are included

Warnings

  • St. John’s wort can sharply reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, HIV medicines, and many other drugs by speeding their clearance.
  • Combining St. John’s wort with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or dextromethorphan can cause dangerous serotonin excess.
  • St. John’s wort can increase sensitivity to sunlight, so strong sun or UV exposure may require extra skin and eye protection.

Nutrient quality

87 Highest impact

A marker-standardized extended-release extract provides purposeful form quality. The daily amount is moderate but sustained delivery may improve practical coverage.

.

Ingredient transparency

85 Highest impact

The active amount, marker, and release design are clearly disclosed without a hidden blend. Complete intake directions and inactive ingredients are not supplied.

.

Customer satisfaction

69 High impact

The supplied average rating is strong. A substantial rating base makes the average reasonably dependable, but no detailed experience evidence was supplied.

.

Value for money

89 Highest impact

Serving economics are favorable. Formula quality supports the asking price well.

.
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
A Goal FitB Strength of SupportD CoverageA Formula Quality

St. John's Wort Extended Release provides 450 mg per serving and uses a clearly standardized St. John's wort extract, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.64 from 420 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies
Stress Relief
Stress Relief
Impact
High effect
D+ Goal FitB- Strength of SupportD CoverageA Formula Quality

NaturesPlus Herbal Actives St. John's Wort Extended Release supplies 450 mg of St. John's wort in an extended-release extract standardized to 0.3% hypericin, offering a focused but situational route to stress-related emotional balance.

Supplied feedback averages 4.64 across 420 reviews, while published safety information makes medication-interaction and photosensitivity review important before use.

Study evidence
St. John's Wort Mixed 6 studies

Ingredients

IngredientAmount per serving
St. John's Wort (Hypericin)
 450 mg
Gluten Free Adults 18–50
Report overview
St. John's Wort (Hypericin) · 450 mg OverallScore64
A+ Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

NaturesPlus Herbal Actives Saint John's Wort Extended Release provides 450 mg per serving and uses an extended-release extract standardized to 0.3% hypericin, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.64 from 420 reviews, while the available label warning remains general rather than drug-class specific.

View ingredientView products
Loading alternative details
88 Performance

Full Spectrum St. John's Wort Extract 600 mg

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A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort Extract 300 mg

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A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort Extract

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  6. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  7. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  8. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  9. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  10. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort