Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
Randomized trial18,645 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
Meta-analysis134,144 participants18 studies pooledflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Meta-analysis Comparing Combined Use of Eicosapentaenoic Acid and Statin to Statin Alone.
Doshi R; Kumar A; Thakkar S; Shariff M; Adalja D; Doshi A; Taha M; Gupta R; Desai R; Shah J; Gullapalli N · The American journal of cardiology · 2020
Meta-analysis27,415 participants5 studies pooledflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
Randomized trial14,981 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Eicosapentaenoic Acid combined with optimal statin therapy improves endothelial dysfunction in patients with coronary artery disease.
Toyama K; Nishioka T; Isshiki A; Ando T; Inoue Y; Kirimura M; Kamiyama T; Sasaki O; Ito H; Maruyama Y; Yoshimoto N · Cardiovascular drugs and therapy · 2014
Randomized trial80 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome.
Satoh N; Shimatsu A; Kotani K; Himeno A; Majima T; Yamada K; Suganami T; Ogawa Y · Hypertension research : official journal of the Japanese Society of Hypertension · 2010
Randomized trial92 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review.
Innes JK; Calder PC · International journal of molecular sciences · 2018
Systematic review527 participants6 studies pooledflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids.
Grimsgaard S; Bonaa KH; Hansen JB; Nordøy A · The American journal of clinical nutrition · 1997
Randomized trial234 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials.
Hidayat K; Yang J; Zhang Z; Chen GC; Qin LQ; Eggersdorfer M; Zhang W · European journal of clinical nutrition · 2019
Meta-analysis3,000 participants51 studies pooledflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Long-Chain Polyunsaturated Fatty Acids Are Associated with Blood Pressure and Hypertension over 10-Years in Black South African Adults Undergoing Nutritional Transition.
Zec MM; Schutte AE; Ricci C; Baumgartner J; Kruger IM; Smuts CM · Foods (Basel, Switzerland) · 2020
Cohort study300 participantsflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
Randomized trialflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
OtherflagHeart Health forscienceEPA (Eicosapentaenoic Acid)
- Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
Randomized trial1,537 participantsflagHeart Health forscienceVitamin D
- Paricalcitol and endothelial function in chronic kidney disease trial.
Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
Randomized trial88 participantsflagHeart Health forscienceVitamin D
- Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
Meta-analysis81 studies pooledflagHeart Health forscienceVitamin D
- Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
Meta-analysis45 studies pooledflagHeart Health forscienceVitamin D
- Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
Meta-analysisflagHeart Health forscienceVitamin D
- Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
Berbert AA; Kondo CR; Almendra CL; Matsuo T; Dichi I · Nutrition (Burbank, Los Angeles County, Calif.) · 2005
Randomized trial43 participantsflagJoint Health forscienceOmega-3
- Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
Stonehouse W; Benassi-Evans B; Bednarz J; Vincent AD; Hall S; Hill CL · The American journal of clinical nutrition · 2022
Randomized trial235 participantsflagJoint Health forscienceOmega-3
- Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Wang W; Xu Y; Zhou J; Zang Y · Clinical rheumatology · 2024
Meta-analysis1,018 participants18 studies pooledflagJoint Health forscienceOmega-3
- Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.
Sigaux J; Mathieu S; Nguyen Y; Sanchez P; Letarouilly JG; Soubrier M; Czernichow S; Flipo RM; Sellam J; Daïen C · Arthritis research & therapy · 2022
Meta-analysis1,420 participants30 studies pooledflagJoint Health forscienceOmega-3
- A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
Goldberg RJ; Katz J · Pain · 2007
Meta-analysis17 studies pooledflagJoint Health forscienceOmega-3
- Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
Wang X; Cicuttini F; Jin X; Wluka AE; Han W; Zhu Z; Blizzard L; Antony B; Winzenberg T; Jones G; Ding C · Osteoarthritis and cartilage · 2018
Randomized trial413 participantsflagJoint Health forscienceVitamin D
- Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes: A Systematic Review and Meta-Analysis.
Vivek K; Kamal R; Perera E; Gupte CM · JBJS reviews · 2024
Meta-analysis146,054 participants10 studies pooledflagJoint Health forscienceVitamin D
- Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis.
Zhao ZX; He Y; Peng LH; Luo X; Liu M; He CS; Chen J · Aging clinical and experimental research · 2021
Meta-analysis1,599 participants6 studies pooledflagJoint Health forscienceVitamin D
- Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.
Wang T; Zheng S; Jin X; Cen H; Zhu Z; Han W; Wluka A; Cicuttini F; Cao P; Ding C · Rheumatology advances in practice · 2025
Randomized trial413 participantsflagJoint Health forscienceVitamin D
- The Efficacy and Safety of Disease-Modifying Osteoarthritis Drugs for Knee and Hip Osteoarthritis-a Systematic Review and Network Meta-Analysis.
Yang W; Sun C; He SQ; Chen JY; Wang Y; Zhuo Q · Journal of general internal medicine · 2021
Meta-analysis11,890 participants28 studies pooledflagJoint Health forscienceVitamin D
- The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
Meta-analysis9,660 participants24 studies pooledflagMental Focus forscienceEPA (Eicosapentaenoic Acid)
- EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
Randomized trial92 participantsflagMental Focus forscienceEPA (Eicosapentaenoic Acid)
- Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
Narrative reviewflagMental Focus forscienceEPA (Eicosapentaenoic Acid)
- Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
Randomized trial310 participantsflagMental Focus forscienceEPA (Eicosapentaenoic Acid)
- Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials.
Liu W; Gao M; Yang S; Sun C; Bi Y; Li Y; Wang J; Yuan X · Journal of diabetes and its complications · 2023
Meta-analysis331 participants6 studies pooledflagMetabolism Boost forscienceOmega-3
- Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.
Green CJ; Pramfalk C; Charlton CA; Gunn PJ; Cornfield T; Pavlides M; Karpe F; Hodson L · BMJ open diabetes research & care · 2021
Randomized trial38 participantsflagMetabolism Boost forscienceOmega-3
- Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
Randomized trial60 participantsflagMetabolism Boost flagSkin Health forscienceOmega-3
- The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Mirmasoumi G; Fazilati M; Foroozanfard F; Vahedpoor Z; Mahmoodi S; Taghizadeh M; Esfeh NK; Mohseni M; Karbassizadeh H; Asemi Z · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2018
Randomized trial60 participantsflagMetabolism Boost forscienceOmega-3
- A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: a randomized and controlled clinical trial.
Wang JF; Zhang HM; Li YY; Xia S; Wei Y; Yang L; Wang D; Ye JJ; Li HX; Yuan J; Pan RR · Lipids in health and disease · 2019
Randomized trial200 participantsflagMetabolism Boost forscienceOmega-3
- Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial.
Duan Y; Zhang S; Ma X; Li L; Jia K · African journal of reproductive health · 2026
Randomized trial120 participantsflagMetabolism Boost forscienceVitamin D
- Vitamin D3 improves glucose metabolism and attenuates inflammation in prediabetic human and mice.
Zhang Y; Ni P; Miao Y; Chen H; Tang L; Song H; Li W; Li X · The Journal of nutritional biochemistry · 2024
Randomized trialflagMetabolism Boost forscienceVitamin D
- Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial.
Mitri J; Dawson-Hughes B; Hu FB; Pittas AG · The American journal of clinical nutrition · 2011
Randomized trial92 participantsflagMetabolism Boost forscienceVitamin D
- The Effects of Vitamin D Supplementation on Glycemic Control, Lipid Profiles and C-Reactive Protein Among Patients with Cardiovascular Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ostadmohammadi V; Milajerdi A; Ghayour-Mobarhan M; Ferns G; Taghizadeh M; Badehnoosh B; Mirzaei H; Asemi Z · Current pharmaceutical design · 2020
Meta-analysis630 participants8 studies pooledflagMetabolism Boost forscienceVitamin D
- The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis.
Mirhosseini N; Vatanparast H; Mazidi M; Kimball SM · The Journal of clinical endocrinology and metabolism · 2017
Meta-analysis1,528 participants24 studies pooledflagMetabolism Boost forscienceVitamin D
- Dietetic intervention in psoriatic arthritis: the DIETA trial.
Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
Randomized trial97 participantsflagSkin Health forscienceOmega-3
- Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
Randomized trial49 participantsflagSkin Health forscienceOmega-3
- Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
Randomized trial50 participantsflagSkin Health forscienceOmega-3
- Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
Randomized trial42 participantsflagSkin Health forscienceOmega-3
- Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
Meta-analysis471 participants6 studies pooledflagSkin Health forscienceVitamin A
- Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
Randomized trial120 participantsflagSkin Health forscienceVitamin A
- Antiaging action of retinol: from molecular to clinical.
Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
Randomized trial48 participantsflagSkin Health forscienceVitamin A
- An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
Narrative reviewflagSkin Health forscienceVitamin A
- Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
Randomized trialflagSkin Health forscienceVitamin A
- Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
Randomized trial45 participantsflagSkin Health forscienceVitamin E
- Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
Meta-analysis20 studies pooledflagSkin Health forscienceVitamin E
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceVitamin E
- Effects of tocotrienol on aging skin: A systematic review.
Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
Systematic reviewflagSkin Health forscienceVitamin E
- Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
Randomized trialflagSkin Health forscienceVitamin E