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Ultra Strength One-per-Day RxOmega-3

Natural Factors
4.9
★ ★ ★ ★ ★
(10747 ratings)
DHA 300 mg
Fish Oil 1425 mg
Omega-3 900 mg
Product Image
Score80
A concentrated one-per-day dose is the main strength, while ambiguous EPA disclosure and ethyl ester delivery are the main trade-offs.
How scoring works
Quantity:60 Softgel(s) • (60 servings)
Goals:
Anti-Inflammatory Support
Cardiovascular Support
Skin Health

Score 80

A concentrated one-per-day dose is the main strength, while ambiguous EPA disclosure and ethyl ester delivery are the main trade-offs.
How scoring works

Also available as

2 options
150 servings Omega-3 900 mg, DHA 600 mg +1 more • 150 Softgel(s) • 150 servings $47.57 ($0.31 per serving) 900.00mg Omega-3 Fatty Acids, 25.00mcg Vitamin D3 • 150 Softgel(s) servings Omega-3 900 mg, Fish Oil 1407 mg +1 more • 150 Softgel(s) • 150 servings $49.67 ($0.33 per serving)
$25.17($0.41 per serving)
Pure Formulas
$ 25.17
iHerb
$ 25.17
iHerb
$ 25.17
Walmart
$ 25.17
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Analysis

The 1,425 mg fish-oil concentrate supplies 900 mg total omega-3 in a convenient one-per-day softgel. That amount is more useful for focused daily support than the brand's lower-strength versions.

Both fatty-acid entries are labeled DHA ethyl ester, at 600 mg and 300 mg, without a distinct EPA line. The duplicated naming makes the ratio unclear, and ethyl esters are less readily absorbed than triglyceride oils.

Named anchovy, mackerel, and sardine sources improve source transparency. Antioxidant protection and independent purity or oxidation testing are not stated, leaving important quality-control details unresolved.

Who is it for
  • Adults seeking a concentrated one-softgel omega-3
  • People supporting cardiovascular or inflammatory balance
  • Users who accept an ethyl ester formulation
Best for
  • Higher-potency daily omega-3 intake
  • One-per-day convenience
  • Skin-barrier and cardiovascular support

Pros

  • Delivers 900 mg total omega-3
  • Requires one softgel per serving
  • Names small-fish sources

Cons

  • Lists two DHA entries and no clear EPA amount
  • Uses the ethyl ester form
  • Does not state antioxidant or independent testing

Warnings

  • Not suitable for people allergic to the named fish sources
  • Fish oil may increase bleeding tendency alongside anticoagulant or antiplatelet medicines

Nutrient quality

89 Highest impact

The concentrated serving provides substantial omega-fatty-acid support in one softgel. Ethyl-ester delivery and an unclear EPA-to-DHA split limit quality.

Ingredient transparency

72 High impact

Important active-label details are incomplete or ambiguous. Complete use directions and inactive-ingredient details are not available.

Customer satisfaction

74 High impact

The aggregate satisfaction measure is favorable, with response volume determining how much confidence it deserves. Comment-level evidence is absent, so recurring complaints and purpose fit cannot be verified.

Value for money

84 Highest impact

High active concentration creates good one-softgel value. A smaller supply and basic ethyl-ester form keep value below the bulk options.

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Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
A Goal FitC+ Strength of SupportC CoverageA+ Formula Quality
Fish Oil · 1425 mg

A concentrated fish-oil serving supplies a meaningful total omega-3 amount for pro-resolving inflammatory pathways. Human evidence for EPA and DHA is strong, but the individual fatty-acid listing is ambiguous and does not clearly identify EPA.

Small-fish sourcing and pharmaceutical-grade concentrate support quality. The ethyl ester form is less readily absorbed than triglyceride oil, and antioxidant protection is not disclosed.

Study evidence
Fish Oil Supportive 68 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
A Goal FitC Strength of SupportC CoverageA+ Formula Quality
Fish Oil · 1425 mg

Concentrated marine omega fats directly support triglycerides, vascular function, and inflammatory balance. The total omega-fat amount is practical for daily cardiovascular support.

The ethyl ester form is less efficiently absorbed than triglyceride forms. EPA is not separately identified and two DHA entries create label ambiguity, so the active profile cannot be fully assessed.

Skin Health
Skin Health
Impact
High effect
B+ Goal FitB- Strength of SupportC+ CoverageB+ Formula Quality
Omega-3 · 900 mg

A concentrated omega-3 amount may support skin-barrier lipids and balanced inflammatory signaling. The active amount is substantial relative to the fish-oil concentrate.

Ethyl ester delivery offers moderate absorption. Repeated DHA labeling without a clearly stated EPA amount and absent oxidation or purity details reduce confidence in the active profile.

Study evidence
Omega-3 Supportive 35 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
1.5 Gram(s)
Cholesterol
5 mg
pharmaceutical grade Fish Oil concentrate
1425 mg
Omega-3 Fatty Acids
900 mg
Docosahexaenoic Acid Ethyl Ester
300 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
DHA · 300 mg OverallScore73
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The label identifies DHA as an ethyl ester, a less bioavailable form than triglyceride DHA. The 900 mg DHA serving reaches a high-potency amount. No protective antioxidant is listed, while pharmaceutical-grade anchovy, mackerel, and sardine oil strengthens contaminant transparency and value is strong.

View ingredientView products
Fish Oil · 1425 mg OverallScore56
D+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyB+ Value

Small-fish sourcing and pharmaceutical-grade oil are positives, while ethyl ester form is less bioavailable. The active amount is concentrated, but EPA is absent from the individual disclosure and the DHA listing is ambiguous. Active-dose value is good, though antioxidant protection is not shown.

View ingredientView products
Omega-3 · 900 mg OverallScore51
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value

The ethyl ester form provides moderate absorption and a concentrated active omega-3 serving. The label repeats DHA entries without clearly identifying EPA, and no antioxidant protection or independent testing is supplied. The cost per disclosed active amount offers strong value despite the incomplete fatty-acid labeling.

View ingredientView products
Loading alternative details
85 Performance

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
Triglyceride fish oil delivers a highly concentrated EPA-led omega-3 serving with clear fatty-acid amounts and favorable value. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and stronger formulation depth make it a better quality-focused match.
83 Performance

Ultra Strength One-per-Day RxOmega-3 with Vitamin D3 25 mcg (1000IU)

Natural Factors
A concentrated omega-fatty-acid amount and useful vitamin D3 addition provide strong one-softgel value. Ethyl-ester delivery is less absorbable than triglyceride oil, while duplicated DHA lines leave the EPA amount unclear. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and stronger formulation depth make it a better quality-focused match.
86 Performance

Purified & Clear Omega 3 Fish Oil 1000 mg

Doctor's Best
A substantial, clearly separated EPA and DHA serving offers strong potency and active value. The ethyl-ester form is less readily absorbed than triglyceride oil, and oxidation protection plus independent purity testing are not supplied. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and stronger formulation depth make it a better quality-focused match.
86 Budget

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
Triglyceride fish oil delivers a highly concentrated EPA-led omega-3 serving with clear fatty-acid amounts and especially favorable package value. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps. Compared with the original, its lower serving cost improves affordability while retaining Omega-3 and DHA and Fish Oil support.
82 Budget

Ultra Strength One-per-Day RxOmega-3

Natural Factors
A concentrated omega-fatty-acid amount and large supply create strong one-softgel value. Ethyl-ester delivery remains less absorbable than triglyceride oil, and duplicated DHA lines obscure the EPA amount. Compared with the original, its lower serving cost improves affordability while retaining Omega-3 and DHA and Fish Oil support.
84 Budget

Fish Oil 1400 mg

Nature's Bounty
A meaningful EPA-led amount and strong oil concentration provide good active value. The ethyl-ester form is less readily absorbed, while fish source, antioxidant protection, and independent purity testing are not stated. Compared with the original, its lower serving cost improves affordability while retaining Omega-3 and DHA and Fish Oil support.
82 Value

RxOmega-3

Natural Factors
A substantial omega-fatty-acid amount from named small fish and a bulk supply create exceptional recurring value. Ethyl-ester delivery and duplicated DHA lines still limit absorption and label clarity. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and balance of formula depth and serving cost provide better practical value.
84 Value

Omega 3 Platinum + D 2000 mg

Advanced Nutrition by Zahler
Triglyceride-form oil, clearly separated EPA and DHA, and a meaningful vitamin D3 amount create a coherent formula. Moderate oil concentration plus missing source, oxidation, and independent purity details remain the main limitations. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and balance of formula depth and serving cost provide better practical value.
83 Value

Wild Alaskan Fish Oil Summit DHA Natural Lime Flavor

Wiley's Finest
A very high DHA-led serving provides substantial retinal and omega-fat support with clear active amounts. The concentrated intake deserves care with anticoagulant or antiplatelet medicines, while oxidation, molecular-form, and purity details are not supplied. Compared with the original, its Omega-3 and DHA and Fish Oil coverage and balance of formula depth and serving cost provide better practical value.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  2. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  3. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  4. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  5. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  6. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  7. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  8. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsSkin Health forOmega-3
  9. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  10. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3