Product Image

Ultra Strength One-per-Day RxOmega-3 with Vitamin D3 25 mcg (1000IU)

Natural Factors
4.9
★ ★ ★ ★ ★
(1724 ratings)
DHA 300 mg
Fish Oil 1407 mg
Omega-3 900 mg
Product Image
Score83
Concentrated omega-3 and vitamin D in one softgel are convenient, but duplicate DHA labeling and ethyl ester delivery weaken transparency.
How scoring works
Quantity:150 Softgel(s) • (150 servings)
Goals:
Anti-Inflammatory Support
Skin Health
Cardiovascular Support

Score 83

Concentrated omega-3 and vitamin D in one softgel are convenient, but duplicate DHA labeling and ethyl ester delivery weaken transparency.
How scoring works
$49.67($0.33 per serving)
iHerb
$ 49.67
Vitacost
$ 49.67
Report prices

Analysis

One softgel supplies 900 mg total omega-3 from concentrated fish oil and adds 25 mcg of vitamin D3. The active concentration is useful for daily cardiovascular, inflammatory-balance, and skin-barrier support.

Two entries are both labeled DHA ethyl ester, one at 600 mg and one at 300 mg, so the expected EPA component is not separately identifiable. Ethyl ester delivery also offers less efficient absorption than preferred triglyceride forms.

Anchovy, mackerel, and sardine sources are named, and the one-per-day format is convenient. No antioxidant protection, oxidation result, or independent contaminant testing is stated in the supplied details.

Who is it for
  • Adults wanting omega-3 and vitamin D together
  • People preferring a one-softgel daily serving
  • Users seeking a concentrated maintenance formula
Best for
  • Convenient daily cardiovascular support
  • Inflammatory-balance support
  • Combined omega-3 and vitamin D intake

Pros

  • Provides 900 mg total omega-3
  • Includes 25 mcg vitamin D3
  • Uses named small-fish sources

Cons

  • Does not clearly identify a separate EPA amount
  • Uses ethyl ester fatty acids
  • No stated antioxidant or independent purity testing

Warnings

  • Avoid with fish allergy due to anchovy, mackerel, and sardine oil
  • Account for the added vitamin D when combining with other high-dose vitamin D products
  • Fish oil can add to bleeding risk with anticoagulant or antiplatelet medicines

Nutrient quality

90 Highest impact

The concentrated omega amount and vitamin D3 provide substantial one-softgel support. Ethyl-ester delivery and an ambiguous EPA-to-DHA split limit quality.

Ingredient transparency

74 High impact

Important active-label details are incomplete or ambiguous. Complete use directions and inactive-ingredient details are not available.

Customer satisfaction

73 High impact

The aggregate satisfaction measure is favorable, with response volume determining how much confidence it deserves. Comment-level evidence is absent, so recurring complaints and purpose fit cannot be verified.

Value for money

96 Highest impact

A large supply and concentrated active profile create excellent value. Form and labeling weaknesses are notable but do not erase the strong active return.

Report analysis

Goals

Anti-Inflammatory Support
Impact
High effect
A- Goal FitC+ Strength of SupportC+ CoverageA- Formula Quality
Vitamin D · 25 mcgFish Oil · 1407 mg

Omega-3 fatty acids and vitamin D3 provide complementary lipid-resolving and immune-modulating support. The 900 mg omega-3 amount approaches the stated minimum, but the supplied label data do not clearly separate EPA from DHA.

Vitamin D3 is fully disclosed and the fish sources are named. The one-per-day combination is coherent, although ambiguous fatty-acid labeling limits precision.

Study evidence
Fish Oil Supportive 68 studies
Vitamin D Supportive 101 studies
Skin Health
Impact
High effect
B+ Goal FitB- Strength of SupportC+ CoverageB+ Formula Quality
Omega-3 · 900 mg

A concentrated omega-3 amount may support skin-barrier lipids and balanced inflammatory signaling. Added vitamin D provides a useful nutrient for people with inadequate status but is not a primary skin active here.

Ethyl ester delivery offers moderate absorption. Repeated DHA labeling without a clearly stated EPA amount and absent oxidation or purity details reduce confidence in the active profile.

Study evidence
Omega-3 Supportive 35 studies
Cardiovascular Support
Impact
High effect
A Goal FitC Strength of SupportC CoverageA- Formula Quality
Vitamin D · 25 mcgFish Oil · 1407 mg

Concentrated marine omega fats directly support triglycerides, vascular function, and inflammatory balance. Vitamin D adds general cardiometabolic support. The total omega-fat amount is practical for daily cardiovascular support.

The ethyl ester form is less efficiently absorbed than triglyceride forms. EPA is not separately identified and two DHA entries create label ambiguity, so the active profile cannot be fully assessed.

Study evidence
Vitamin D Mixed 170 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
1.5 Gram(s)
Cholesterol
5 mg
Vitamin D3
25 mcg
pharmaceutical grade Fish Oil concentrate
1407 mg
Omega-3 Fatty Acids
900 mg
Docosahexaenoic Acid Ethyl Ester
300 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
DHA · 300 mg OverallScore73
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The label identifies DHA as an ethyl ester, a less bioavailable form than triglyceride DHA. The 900 mg DHA serving reaches a high-potency amount. No protective antioxidant is listed, while pharmaceutical-grade anchovy, mackerel, and sardine oil strengthens contaminant transparency and value is strong.

Fish Oil · 1407 mg OverallScore60
D+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyA+ Value

Small-fish sourcing and pharmaceutical-grade oil support quality, but the ethyl ester form is less efficiently absorbed. The active amount is reasonably concentrated, yet EPA is not separately disclosed and the two DHA entries create ambiguity. Cost efficiency appears excellent, although antioxidant protection is not shown.

Omega-3 · 900 mg OverallScore51
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value

The ethyl ester form provides moderate absorption and a concentrated active omega-3 serving. The label repeats DHA entries without clearly identifying EPA, and no antioxidant protection or independent testing is supplied. The low cost per disclosed active amount offers strong value, with vitamin D3 adding a useful cofactor for people who need it.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
    Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
    Randomized trial25,871 participantsCardiovascular Support forFish Oil
  2. Effect of fish oil supplement in maintenance hemodialysis patients: a systematic review and meta-analysis of published randomized controlled trials.
    He L; Li MS; Lin M; Zhao TY; Gao P · European journal of clinical pharmacology · 2016
    Meta-analysis916 participants13 studies pooledAnti-Inflammatory Support forFish Oil
  3. The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial.
    Ando N; Nosaka N; Arai C; Kato K · The Journal of nutrition · 2025
    Randomized trial120 participantsSkin Health forOmega-3
  4. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  5. No effect of fish oil supplementation on serum inflammatory markers and their interrelationships: a randomized controlled trial in healthy, middle-aged individuals.
    Pot GK; Brouwer IA; Enneman A; Rijkers GT; Kampman E; Geelen A · European journal of clinical nutrition · 2010
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  6. Dietary supplementation with very long-chain n-3 fatty acids in patients with atopic dermatitis. A double-blind, multicentre study.
    Søyland E; Funk J; Rajka G; Sandberg M; Thune P; Rustad L; Helland S; Middelfart K; Odu S; Falk ES · The British journal of dermatology · 1994
    Randomized trial145 participantsSkin Health forOmega-3
  7. Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months.
    Berman D; Clinton C; Limb R; Somers EC; Romero V; Mozurkewich E · Insights in allergy, asthma & bronchitis · 2020
    Randomized trial84 participantsSkin Health forOmega-3
  8. Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects.
    Janowitz P; Swobodnik W; Wechsler JG; Janowitz A; Saal D; Ditschuneit H · Klinische Wochenschrift · 1991
    Non-randomized trial24 participantsCardiovascular Support forFish Oil
  9. Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial.
    Quan C; Tang W; Qin Y; Nian Z; Li Z; Mao L · Food & function · 2026
    Randomized trial240 participantsAnti-Inflammatory Support forFish Oil
  10. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  11. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  12. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  13. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  14. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  15. Randomized controlled trial of oral omega-3 PUFA in solar-simulated radiation-induced suppression of human cutaneous immune responses.
    Pilkington SM; Massey KA; Bennett SP; Al-Aasswad NM; Roshdy K; Gibbs NK; Friedmann PS; Nicolaou A; Rhodes LE · The American journal of clinical nutrition · 2013
    Randomized trial79 participantsSkin Health forOmega-3
  16. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  17. Efficacy of fish oil and its components in the management of psoriasis: a systematic review of 18 randomized controlled trials.
    Chen X; Hong S; Sun X; Xu W; Li H; Ma T; Zheng Q; Zhao H; Zhou Y; Qiang Y; Li B; Li X · Nutrition reviews · 2021
    Meta-analysis927 participants18 studies pooledAnti-Inflammatory Support forFish Oil
  18. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsSkin Health forOmega-3
  19. Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study.
    Li ZH; Zhong WF; Liu S; Kraus VB; Zhang YJ; Gao X; Lv YB; Shen D; Zhang XR; Zhang PD; Huang QM; Chen Q; Wu XB; Shi XM; Wang D; Mao C · BMJ (Clinical research ed.) · 2020
    Cohort study427,678 participantsCardiovascular Support forFish Oil
  20. The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients.
    Deike E; Bowden RG; Moreillon JJ; Griggs JO; Wilson RL; Cooke M; Shelmadine BD; Beaujean AA · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2013
    Randomized trial31 participantsAnti-Inflammatory Support forFish Oil
  21. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  22. Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study.
    Chen G; Qian ZM; Zhang J; Zhang S; Zhang Z; Vaughn MG; Aaron HE; Wang C; Lip GY; Lin H · BMJ medicine · 2024
    Cohort study415,737 participantsCardiovascular Support forFish Oil
  23. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  24. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  25. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  26. A systematic review and meta-analysis of the n-3 polyunsaturated fatty acids effects on inflammatory markers in colorectal cancer.
    Mocellin MC; Camargo CQ; Nunes EA; Fiates GMR; Trindade EBSM · Clinical nutrition (Edinburgh, Scotland) · 2017
    Meta-analysis475 participants9 studies pooledAnti-Inflammatory Support forFish Oil
  27. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3
  28. Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China.
    Lin Z; Chen R; Jiang Y; Xia Y; Niu Y; Wang C; Liu C; Chen C; Ge Y; Wang W; Yin G; Cai J; Clement V; Xu X; Chen B; Chen H; Kan H · Journal of the American College of Cardiology · 2020
    Randomized trial65 participantsCardiovascular Support forFish Oil
  29. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  30. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation.
    Furuhjelm C; Warstedt K; Fagerås M; Fälth-Magnusson K; Larsson J; Fredriksson M; Duchén K · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011
    Randomized trial145 participantsSkin Health forOmega-3
  31. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  32. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  33. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  34. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  35. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  36. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  37. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forVitamin D
  38. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  39. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  40. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  41. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support forVitamin D