5-HTP with Vitamin B6 100 mg

5-HTP with Vitamin B6 100 mg

The Vitamin Shoppe4.9 (19 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$29.99 $0.24 per serving
iHerb$29.99

About this product

The capsule provides 100 mg of 5-HTP plus 20 mg of vitamin B6 as pyridoxine hydrochloride. Vitamin B6 participates in neurotransmitter metabolism, although the supplied data do not show that this added amount improves results over 5-HTP alone.

Sleep, mood, and stress support are more direct uses than weight management. No ingredient addresses circadian timing, relaxation, or appetite through a separate pathway.

Griffonia seed extract is identified without a standardization percentage, and the supplied label information lacks the key serotonin-medication warning. The added B6 also deserves attention when several supplements or fortified products are used together.

Who is it for
  • People seeking 5-HTP with added vitamin B6
  • Users targeting mood or sleep support
Best for
  • One-capsule 5-HTP and B6 use
  • Standard-strength serotonin-pathway support

Pros

  • Provides 100 mg of 5-HTP
  • Names Griffonia seed extract
  • Includes vitamin B6 as a relevant cofactor

Cons

  • No extract standardization
  • Added B6 may duplicate other supplements
  • No broader relaxation or circadian support

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines without medical supervision.
  • 5-HTP may cause nausea, digestive discomfort, drowsiness, or vivid dreams.
  • Count the 20 mg of vitamin B6 with other supplements because unnecessary long-term cumulative intake may cause nerve-related symptoms.

Product analysis

75 out of 100
Standard 5-HTP dosing plus vitamin B6 creates a relevant but not clearly superior combination. Cumulative B6 exposure and missing interaction guidance are the main concerns.

AI assessment of the formula, label and price. How scoring works

Nutrient quality77

The named Griffonia seed extract gives the active a clear botanical source, although no standardization percentage is supplied. The 100 mg 5-HTP serving is well aligned with common supplemental use, while the added nutrients provide mixed additional value.

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Ingredient transparency84

All supplied active ingredients have specific amounts, and no proprietary blend hides key doses. Serving count is available, but full intake directions, excipients, and a serotonin-medication warning are absent from the supplied label details.

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Customer satisfaction58

The supplied aggregate rating is strong, though its reliability depends heavily on the available review volume. No review text is provided to identify repeated complaints or firsthand experiences tied to the intended uses.

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Value for money77

Cost efficiency per equivalent active amount appears good, with the standard dose shaping practical value. Vitamin B6 has a cofactor role, but calcium and phosphorus add little to the main purpose.

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Format
Capsule
Container
120 Capsule(s)
Per serving
$0.24
Customer rating
4.9 · 19 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
B Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 20 mg5-HTP · 100 mg

Vitamin B6 may help with depressed mood when you're low in this nutrient. A deficiency can also cause confusion, so correcting it has a clearer purpose than expecting a general lift in mood. The accompanying 5-HTP is a precursor to serotonin, a chemical involved in mood, but that role alone doesn't tell you whether taking it improves everyday emotional well-being.

How this product is rated for Mood Support

Ingredient fit77

The declared ingredients provide a concrete connection to mood, with benefits depending on the conditions described above.
Goal fit
Several ingredients relate to mood, while their practical value depends on their individual roles and preparation.
Dose adequacy
Vitamin B6 20 mg; 5-HTP 100 mg. These are serving amounts, not necessarily daily amounts.

Pathways60

Mood-related ingredient roles are identified, but mechanisms alone do not tell you how your mood will change.
Depth
The ingredients relate most directly to calming; a calming role alone does not guarantee a change in mood.
Breadth
These ingredient roles do not show that every aspect of emotional well-being will improve.

Evidence96

Vitamin B6 may help with depressed mood when you're low in this nutrient. A deficiency can also cause confusion, so correcting it has a clearer purpose than expecting a general lift in mood.
Evidence strength
Vitamin B6 may help with depressed mood when you're low in this nutrient.
Studied preparation
The ingredient identity is available, but its relevance to everyday mood still depends on the population and purpose of use.

Formulation logic100

No particular ingredient conflict or missing required companion is identified. Known amounts do not by themselves guarantee a mood benefit.
Partner coverage
No required companion ingredient is missing for the identified ingredients.
Conflicts
No particular conflict between the declared ingredients is identified.
Effective doses
The individual amounts are available; this does not make the serving a recommended dose for mood.
Study evidence
5-HTP Supportive 9 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
Moderate effect
B Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic

5-HTP may offer some support through the serotonin–melatonin precursor route, but the supplied context points to a limited role, mainly for poor sleepers. It doesn't establish a broad sleep benefit across adults.

Vitamin B6 supports normal neurotransmitter metabolism, but that role alone doesn't show that extra B6 improves sleep. The product's possible sleep contribution therefore rests mainly on 5-HTP.

How this product is rated for Sleep Support

Ingredient fit77

5-HTP supplies the clearest sleep link; B6 is included but doesn't establish an independent sleep benefit.
Goal fit
5-HTP is the main sleep-oriented ingredient; Calcium and Phosphorus have no described sleep role in these facts.
Dose adequacy
One serving lists 100 mg of 5-HTP and 20 mg of B6; the amounts are clear, though B6's amount doesn't establish extra sleep support.

Pathways60

The formula centers on precursor metabolism and does not cover separate timing or calming routes.
Depth
5-HTP provides the strongest route through serotonin–melatonin precursors; B6's normal metabolic role doesn't prove better sleep.
Breadth
The product's possible pathway contribution stays with precursors rather than covering several sleep processes.

Evidence58

5-HTP has a limited, context-specific possible role, while B6 does not add a separately established sleep benefit.
Evidence strength
5-HTP may help some poor sleepers, but the supplied context doesn't establish broad benefit for other adults.
Studied preparation
The 5-HTP and B6 forms are identified, but B6's normal metabolic role doesn't establish an independent sleep benefit.

Formulation logic100

Neither ingredient needs a partner for its described role, and the supplied ingredients show no configured sleep conflict.
Partner coverage
The possible 5-HTP contribution can stand alone; B6 isn't required as a sleep partner.
Conflicts
Neither 5-HTP nor B6 is a configured sleep conflict in the supplied ingredient list.
Effective doses
The 100 mg 5-HTP and 20 mg B6 amounts are recognized here, but neither amount proves that sleep will improve.
Study evidence
5-HTP Supportive 1 study
Vitamin B6 Disputed 7 studies
Stress Relief
Stress Relief
Impact
High effect
C+ Ingredient FitD+ PathwaysB- EvidenceA Formulation Logic
Vitamin B6 · 20 mg

5-HTP may help with anxiety or stress in selected circumstances, but whether that translates into everyday relief is uncertain. Vitamin B6 also has some anxiety-related relevance, although its individual contribution to stress relief is difficult to separate from combinations. Having both ingredients does not by itself tell you that they provide an added calming effect together.

How this product is rated for Stress Relief

Ingredient fit66

5-HTP and B6 provide relevant connections within a mixture also containing calcium and phosphorus. The serving supplies 100 mg of 5-HTP and 20 mg of B6; B6 is below its 50 mg comparison amount.
Goal fit
5-HTP and B6 provide relevant connections within a mixture also containing calcium and phosphorus.
Dose adequacy
The serving supplies 100 mg of 5-HTP and 20 mg of B6; B6 is below its 50 mg comparison amount.

Pathways54

The relevant ingredients connect most closely with mood and neurotransmitter synthesis. These links do not predict how much calmer you will feel.
Depth
The strongest ingredient connection here concerns mood and neurotransmitter synthesis, without predicting the amount of stress relief.
Breadth
One main connection is present, without implying broad stress relief.

Evidence70

B6 has some anxiety-related support, while 5-HTP’s everyday stress applicability remains conditional. The 5-HTP and B6 declarations are identified without unresolved preparation information.
Evidence strength
B6 has some anxiety-related support, while 5-HTP’s everyday stress applicability remains conditional.
Studied preparation
The 5-HTP and B6 declarations are identified without unresolved preparation information.

Formulation logic90

B6 lacks its relevant combination partner; the presence of 5-HTP alone does not demonstrate that partnership. No particular ingredient conflict is identified.
Partner coverage
B6 lacks its relevant combination partner; the presence of 5-HTP alone does not demonstrate that partnership.
Conflicts
No particular ingredient conflict is identified in these facts.
Effective doses
Both 5-HTP and B6 have declared amounts, with B6 below its comparison quantity.
Study evidence
5-HTP Supportive 18 studies
Vitamin B6 Supportive 10 studies
Weight Loss
Appetite and Craving Control
Weight Loss
Impact
Moderate effect
D Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
Vitamin B6 (Pyridoxine Hydrochloride)
 20 mg
Calcium (Dicalcium Phosphate)
 70 mg
Phosphorus (Dicalcium Phosphate)
 54 mg
5-HTP (Griffonia simplicifolia Seed Extract)
 100 mg 85
Gluten Free Adults 18–50 Dairy Free Women
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 100 mg OverallScore85
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value
5-HTP with Vitamin B6 100 mg names Griffonia simplicifolia and lists 100 mg 5-HTP per serving. A specific warning about SSRIs or other serotonin-modulating medicines is recorded, but no standardization percentage is given. Its cost per 100 mg 5-HTP is moderate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia simplicifolia is named as the source, but the 5-HTP standardization percentage isn't stated.
Botanical Source & Standardization
The label names Griffonia simplicifolia but doesn't state a 5-HTP standardization percentage.

Dose, Safety & Label Transparency100

The label states 100 mg 5-HTP per serving and includes a specific medication warning.
Dosage Potency & Range
It provides 100 mg 5-HTP per serving.
Safety Warnings & Label Clarity
A specific warning about SSRIs, antidepressants, or serotonin-modulating medicines is recorded.

Value85

The cost per 100 mg 5-HTP is moderate.
Price per 100mg 5-HTP
The cost per 100 mg 5-HTP is moderate.
View ingredientView products
Loading alternative details
85 Performance

5-HTP 100 mg

NOW
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and strong formula value make this a practical value alternative. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  3. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  4. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  5. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  6. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  7. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  8. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  9. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  10. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  11. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  12. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  13. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  14. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  15. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  16. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  17. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  18. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  19. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  20. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  21. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  22. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  23. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  24. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  25. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  26. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  27. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  28. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  29. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  30. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  31. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  32. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  33. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP