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Extreme Omega 2400 mg Lemon Natural Flavor

Natrol
4.8
★ ★ ★ ★ ★
(795 ratings)
EPA (Eicosapentaenoic Acid) 646 mg
Fish Oil 2400 mg
DHA 430 mg
Product Image
Score82
A concentrated EPA-and-DHA serving is clearly disclosed, but missing form and testing details limit confidence in oil quality.
How scoring works
Quantity:60 Softgel(s) • (30 servings)
Goals:
Heart Health
Cardiovascular Support
Anti-Inflammatory Support
Mental Focus

Score 82

A concentrated EPA-and-DHA serving is clearly disclosed, but missing form and testing details limit confidence in oil quality.
How scoring works
$11.99($0.39 per serving)
iHerb
$ 11.99
Vitacost
$ 11.99
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Analysis

The formula supplies 646 mg EPA and 430 mg DHA per serving, giving a high omega-3 dose. Both key omega-3s are quantified, so the active amount is easy to assess.

The concentrated serving fits adults seeking meaningful omega-3 intake for heart health and cardiovascular support. Added vitamin E provides antioxidant support for the oil. The amount of active omega-3 provided per serving also compares favorably with the product cost.

The label does not identify the omega-3 molecular form or provide independent purity and oxidation test results, so important quality details remain uncertain. The softgel(s) format may be convenient for routine use, but the disclosed facts do not establish freshness or contaminant control.

Who is it for
  • Adults seeking a concentrated daily fish-oil serving
  • People focused on cardiovascular or inflammatory support
Best for
  • Heart Health
  • Cardiovascular Support
  • Anti-Inflammatory Support

Pros

  • EPA and DHA are listed separately at 646 mg and 430 mg per serving
  • Concentrated active omega-3 amount per serving
  • Includes antioxidant vitamin E

Cons

  • Omega-3 molecular form is not identified
  • Independent purity and oxidation testing is not provided
  • Fish source or processing details are limited

Warnings

  • Avoid if you have a fish allergy because the active oil is fish-derived.
  • The 1076 mg combined EPA, DHA serving may add to bleeding risk with anticoagulant or antiplatelet medicines; discuss this dose with the prescribing clinician.
  • Fish oil can cause burping or stomach upset; taking it with a meal may improve tolerance.

Nutrient quality

86 Highest impact

A substantial EPA-forward dose and natural vitamin E create a focused, useful formula. Unknown oil form, fish source, purification, and independent testing remain meaningful gaps.

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Ingredient transparency

81 Highest impact

Active amounts are individually disclosed, and no proprietary blend hides the supplied doses. Complete use directions, excipients, and some source or quality details remain unavailable.

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Customer satisfaction

70 High impact

Supplied aggregate data indicate very strong satisfaction with a solid response base. Specific comments are absent, so recurring complaints and purpose-specific experiences cannot be verified.

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Value for money

91 Highest impact

A substantial active dose and focused antioxidant support provide strong value. Limited sourcing and testing information are the main value trade-off.

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Goals

Heart Health
Heart Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 646 mg

Clearly disclosed EPA and DHA provide direct support for triglyceride management and cardiovascular inflammation. The combined amount is substantial enough to make this a focused and evidence-based heart-health option.

The formula concentrates on one major lipid pathway rather than vascular tone, cardiac energy, or homocysteine support. EPA and DHA can increase bleeding tendency when combined with anticoagulants or antiplatelet medicines, especially at higher total daily omega-3 intakes.

Study evidence
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A Goal FitA Strength of SupportC CoverageA Formula Quality
Fish Oil · 2400 mgVitamin E · 20.1 mg

EPA and DHA provide meaningful triglyceride and inflammatory support, while vitamin E helps protect the oil from oxidation. The combined active fatty-acid dose is useful but lower than the strongest high-dose fish-oil option in this batch.

EPA, DHA, total oil, and vitamin E are clearly disclosed. Fish-derived oil can trigger an allergic reaction in people with fish allergy, and higher-dose use warrants attention with anticoagulant or antiplatelet therapy.

Study evidence
Fish Oil Supportive 185 studies
Vitamin E Mixed 79 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
A Goal FitB Strength of SupportC CoverageA+ Formula Quality
Fish Oil · 2400 mgVitamin E · 20.1 mg

EPA and DHA are clearly disclosed at a meaningful combined amount for inflammation-resolving pathways. Vitamin E helps protect the oil from oxidation.

The formula is focused and provides good depth, but its molecular form, fish source, purification, and independent testing are not stated. These omissions limit confidence in absorption and contaminant control.

Study evidence
Fish Oil Supportive 68 studies
Vitamin E Supportive 20 studies
Mental Focus
Mental Focus
Impact
High effect
C Goal FitB+ Strength of SupportD CoverageB+ Formula Quality

EPA and DHA provide long-term support for brain structure and a healthy inflammatory balance, but they are not direct acute focus enhancers. The disclosed amounts are substantial and may support the conditions needed for steady cognition over time.

The formula does not address alertness, neurotransmitter production, or stress resilience with dedicated focus ingredients. Exact fatty-acid amounts are helpful, although the oil form and oxidation-quality details are not provided.

Study evidence

Ingredients

IngredientAmount per serving
Calories
30 Calorie(s)
Total Fat
3 Gram(s)
Saturated Fat
0 Gram(s)
Trans Fat
0 Gram(s)
Polyunsaturated Fat
2 Gram(s)
Monounsaturated Fat
0 Gram(s)
Cholesterol
20 mg
Vitamin E
20.1 mg
Omega-3 Fish Oil
2400 mg
Eicosapentaenoic Acid
646 mg
Docosahexaenoic Acid
430 mg
Adults 18–50 Dairy Free
Report overview
EPA (Eicosapentaenoic Acid) · 646 mg OverallScore64
D+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB+ Value

The molecular form is unspecified; ePA density is modest, and only one protective antioxidant is evident. The serving provides a strong EPA amount with a clearly EPA-centric ratio. No purification or third-party verification is shown, while normalized cost is favorable.

View ingredientView products
Fish Oil · 2400 mg OverallScore55
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value

Molecular form, purification, and fish source are not disclosed. EPA and DHA provide an effective dose at standard concentration with clear individual amounts. D-alpha tocopherol protects the oil and active-dose value is excellent.

View ingredientView products
DHA · 430 mg OverallScore52
D+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyB+ Value

The DHA chemical form is not identified, leaving bioavailability uncertain. The 430 mg DHA serving provides a moderate amount. Oxidation protection is present, and generic fish oil provides favorable DHA-specific value despite limited purity verification.

View ingredientView products
Loading alternative details
87 Performance

Omega-3

Solgar
<p>A more concentrated serving provides 1,008 mg EPA and 756 mg DHA, giving greater omega-3 depth than the original's 646 mg EPA and 430 mg DHA. Mixed tocopherols aid oxidation control, but molecular form, fish source, purification method, and independent testing remain unclear.</p>
85 Performance

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
<p>A molecularly distilled triglyceride fish oil with 729 mg EPA and 275 mg DHA provides more specific form and processing detail than the original. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps.</p>
86 Performance

Purified & Clear Omega 3 Fish Oil 1000 mg

Doctor's Best
<p>A clearly quantified serving of 800 mg EPA and 400 mg DHA offers a more focused EPA-and-DHA profile than the original. The ethyl-ester form is less readily absorbed than triglyceride oil, and oxidation protection plus independent purity testing are not supplied.</p>
86 Budget

Omega-3 Triglyceride Fish Oil 1100 mg

NATURELO Premium Supplements
<p>A lower recurring cost provides 729 mg EPA and 275 mg DHA, compared with the original's 646 mg EPA and 430 mg DHA. Molecular distillation adds some purity assurance, while missing independent testing, fish species, and antioxidant protection leave smaller quality gaps.</p>
84 Budget

Mega EPA/DHA

Life Extension
<p>A lower recurring cost provides 720 mg EPA and 480 mg DHA, compared with the original's 646 mg EPA and 430 mg DHA. The oil molecular form, fish species, purification, and independent testing remain undisclosed.</p>
84 Budget

Fish Oil 1400 mg

Nature's Bounty
<p>A lower recurring cost provides 647 mg EPA and 253 mg DHA, compared with the original's 646 mg EPA and 430 mg DHA. The ethyl-ester form is less readily absorbed, while fish source, antioxidant protection, and independent purity testing are not stated.</p>
84 Value

Alaska Wild Fish Oil Mega Omega-3

21st Century
<p>A favorable balance of active dose and recurring cost provides 965 mg EPA and 385 mg DHA with better practical value than the original. Molecular form, antioxidant protection, fish species, and independent purity testing are not disclosed.</p>
83 Value

Super Omega-3

Life Extension
<p>A favorable balance of active dose and recurring cost provides 700 mg EPA and 500 mg DHA with better practical value than the original. The large package provides strong active value, though the four-softgel serving is less convenient and oil-quality documentation remains incomplete.</p>
84 Value

Omega 3 Platinum + D 2000 mg

Advanced Nutrition by Zahler
<p>A favorable balance of active dose and recurring cost provides 600 mg EPA and 400 mg DHA with better practical value than the original. Moderate oil concentration plus missing source, oxidation, and independent purity details remain the main limitations.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  2. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  3. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  4. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  5. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  6. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  7. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  8. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  9. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  10. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  11. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  12. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  13. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  14. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  15. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  16. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  17. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  18. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  19. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  20. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  21. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  22. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  23. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  24. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  25. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  26. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  27. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  28. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  29. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)