5-HTP
Nature's Way
5-HTP
4.5
★ ★ ★ ★ ★
(829 ratings)
5-HTP 100 mg
Score 86.0
A well-formulated 100mg 5-HTP with added B6 and C to enhance efficacy, though it comes at a higher price per serving.
Quantity: 30 Tablet(s)Servings size: 1 Tablet(s) (15 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
leaderboard Score 86.0
A well-formulated 100mg 5-HTP with added B6 and C to enhance efficacy, though it comes at a higher price per serving.
insights Analysis
This Nature's Way 5-HTP product stands out by including Vitamin B6 and Vitamin C alongside its 100mg 5-HTP from Griffonia. Nutritionists often recommend these cofactors as they are crucial for the efficient conversion of 5-HTP into serotonin and subsequently, melatonin, potentially enhancing the supplement's effectiveness for mood, stress, and sleep. While the inclusion of these beneficial vitamins is a significant advantage, the price per serving is relatively high compared to some other 100mg 5-HTP options, especially those without the added vitamins. Despite the higher cost, the thoughtful formulation makes it a more comprehensive approach.
- Includes Vitamin B6 and C, essential cofactors for 5-HTP conversion and enhanced efficacy.
- Provides a good 100mg dose of 5-HTP.
- From a reputable brand.
- Higher price per serving compared to basic 5-HTP products.
- As with all 5-HTP, individuals on SSRIs or other psychiatric medications should consult a doctor due to the risk of serotonin syndrome.
$10.99($0.73 per serving)
 iHerb | $ 10.99 | |
 Vitacost | $ 10.99 | |
 Amazon | $ 10.99 |
bolt Effectiveness for goals
5-HTP is a precursor to serotonin, a neurotransmitter that plays a key role in mood regulation. Some studies suggest that 5-HTP supplementation may help support a balanced mood, particularly in individuals with lower serotonin levels. However, it is not a treatment for mood disorders and should not replace professional medical advice.
As 5-HTP converts to serotonin, which can then be converted into melatonin, it is thought to play a role in sleep regulation. Some research indicates that 5-HTP may help improve sleep quality and reduce the time it takes to fall asleep for certain individuals. Consistent evidence across all populations is still being gathered.
5-Hydroxytryptophan (5-HTP) is a precursor to serotonin, a neurotransmitter involved in mood, sleep, and appetite. Some research suggests it may help support these functions by increasing serotonin levels, but more definitive studies are needed to establish broad effectiveness across all individuals. Individual results can vary depending on various factors.
Some research suggests that 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in feelings of well-being and happiness. However, more extensive research is needed to fully understand its effects.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Some studies indicate that 5-HTP may contribute to improved sleep quality and duration. Individual responses can vary.
schedule Dosage, timing & forms
Many sources suggest beginning with a low dose, such as 50 mg, taken once or twice daily. This approach allows individuals to assess their tolerance and response. Doses can be gradually increased if needed, often under professional guidance.
5-HTP is often taken in the evening, sometimes 30-60 minutes before bedtime, particularly if supporting sleep is a goal. For other uses, it may be taken throughout the day, often divided into multiple doses. Timing can vary based on individual response and desired effects.
5-HTP is often taken in the evening, particularly if used for sleep support. For other purposes, it can be taken throughout the day, sometimes with meals to help minimize potential stomach upset.
While specific recommendations vary, dosages beyond 300-500 mg per day are generally not advised without professional guidance. Higher doses may increase the risk of side effects. It is important to adhere to recommended serving sizes or consult a healthcare provider.
Taking 5-HTP with food may help reduce gastrointestinal side effects like nausea, which some individuals experience. However, some sources suggest taking it on an empty stomach might enhance absorption for specific uses. Following product label instructions is generally recommended.
health_and_safety Safety & interactions
Yes, 5-HTP can have significant interactions with antidepressant medications, including SSRIs (Selective Serotonin Reuptake Inhibitors) and MAOIs (Monoamine Oxidase Inhibitors). Combining 5-HTP with these drugs can elevate serotonin levels excessively, increasing the risk of serotonin syndrome. Consultation with a healthcare provider is essential before combining them.
No, combining 5-HTP with antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs) is not recommended. This combination can significantly increase serotonin levels, potentially leading to serotonin syndrome. It is crucial to consult a healthcare professional before combining supplements with prescription drugs.
Yes, 5-HTP can potentially contribute to serotonin syndrome, especially when taken with other medications that increase serotonin levels. Serotonin syndrome is a serious condition caused by excessive serotonin activity in the brain. It is crucial to avoid combining 5-HTP with such medications without professional guidance.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin activity in the brain. Taking 5-HTP, which increases serotonin levels, especially with other serotonergic medications, may elevate this risk. Symptoms can include agitation, rapid heart rate, confusion, and muscle rigidity.
Yes, 5-HTP may interact with other substances that affect serotonin levels, including triptans for migraines, dextromethorphan (found in cough medicines), and certain herbal supplements like St. John's Wort. Combining these can increase the risk of serotonin syndrome. Always discuss all current medications and supplements with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Total Carbohydrates | 1 NP |
Vitamin C | 120 mg |
Vitamin B6 | 8 mg |
5-HTP | 100 mg |
Categories
5-HTP 87.0
This product is a strong contender in the 5-HTP category due to its inclusion of essential cofactors (B6 and C) which optimize the 5-HTP pathway, making it a more thoughtfully formulated and potentially more effective option than many plain 5-HTP supplements.
Goals
Mood Support 88.0
The synergistic effect of 5-HTP with B6 and C is excellent for mood support, as these vitamins facilitate optimal serotonin synthesis. This makes it a highly effective choice for improving mood.
Stress Relief 85.0
The combination of 100mg 5-HTP with B6 and C offers enhanced support for stress relief by optimizing serotonin production, making it more effective than basic 5-HTP formulations, despite the higher cost.
Sleep Support 85.0
By supporting the conversion of 5-HTP to serotonin and then melatonin, the added B6 and C make this product more potent for sleep support compared to 5-HTP alone, justifying its inclusion.
Recommended Alternatives
88 Value 
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
This alternative offers a superior blend of 5-HTP with B6 and C, similar to the Nature's Way product, but typically provides a better price per serving with more capsules, delivering enhanced efficacy and better overall value.
86 Value 
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Provides 100mg of 5-HTP along with the beneficial cofactors Vitamin B6 and Vitamin C, offering a similar high-quality formulation to Nature's Way but often at a more attractive price per serving for a larger supply.
78 Value 
5-HTP 100 mg
Nature's Bounty
4.4
★★★★★
(1465 ratings)
While it doesn't include B6/C, it offers a solid 100mg dose at a significantly lower price per serving and a high review count, making it a strong value for a basic higher-dose 5-HTP if cofactors are not a priority.
90 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While similar in concept, this product from Doctor's Best offers a slightly higher quantity of servings (120 vs 30) for a comparable dose of 5-HTP plus B6 and C, often at a competitive price, making it a slightly better long-term option.
88 Performance
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offers a well-balanced blend of 100mg 5-HTP with optimal amounts of B6 and C, similar to Nature's Way, but often provides better price per serving due to more servings, making it a superior value for the comprehensive formulation.
87 Performance 
Advanced Sleep Melatonin + 5-HTP Time Release
Natrol
4.5
★★★★★
(8298 ratings)
This product offers 50mg of 5-HTP plus B6 and a time-release melatonin component, providing a more direct and enhanced approach to sleep support, which is one of the stated goals, making it potentially more effective for sleep-specific issues.
83 Budget 
5-HTP 100 mg
NOW
4.7
★★★★★
(40188 ratings)
Offers a solid 100mg of 5-HTP at a significantly lower price per serving, providing a more economical option if the added B6 and C are not deemed essential for the user.
79 Budget 
5-HTP 100 mg Extra Strength
Swanson
4.8
★★★★★
(3247 ratings)
Delivers a 100mg dose of 5-HTP at a much lower price per serving, making it a highly cost-effective choice for those prioritizing pure 5-HTP over cofactors.
85 Budget 
5-HTP 100 mg
Doctor's Best
4.7
★★★★★
(12256 ratings)
Provides 100mg of 5-HTP at an exceptionally low price per serving, representing significant savings for individuals seeking a high-dose 5-HTP without the added vitamins.
88 Value
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
This alternative offers a superior blend of 5-HTP with B6 and C, similar to the Nature's Way product, but typically provides a better price per serving with more capsules, delivering enhanced efficacy and better overall value.
86 Value
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Provides 100mg of 5-HTP along with the beneficial cofactors Vitamin B6 and Vitamin C, offering a similar high-quality formulation to Nature's Way but often at a more attractive price per serving for a larger supply.
78 Value
5-HTP 100 mg
Nature's Bounty
4.4
★★★★★
(1465 ratings)
While it doesn't include B6/C, it offers a solid 100mg dose at a significantly lower price per serving and a high review count, making it a strong value for a basic higher-dose 5-HTP if cofactors are not a priority.
90 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While similar in concept, this product from Doctor's Best offers a slightly higher quantity of servings (120 vs 30) for a comparable dose of 5-HTP plus B6 and C, often at a competitive price, making it a slightly better long-term option.
88 Performance
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offers a well-balanced blend of 100mg 5-HTP with optimal amounts of B6 and C, similar to Nature's Way, but often provides better price per serving due to more servings, making it a superior value for the comprehensive formulation.
87 Performance
Advanced Sleep Melatonin + 5-HTP Time Release
Natrol
4.5
★★★★★
(8298 ratings)
This product offers 50mg of 5-HTP plus B6 and a time-release melatonin component, providing a more direct and enhanced approach to sleep support, which is one of the stated goals, making it potentially more effective for sleep-specific issues.