Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
Randomized trial30 participantsflagSleep Support forscience5-HTP
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
Randomized trial45 participantsflagStress Relief forscience5-HTP
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
Randomized trial48 participantsflagStress Relief forscience5-HTP
- An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
Single-arm trial15 participantsflagStress Relief forscience5-HTP
- Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
Clinical trial120 participantsflagStress Relief forscience5-HTP
- Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
Systematic review2,023 participants13 studies pooledflagStress Relief forscience5-HTP
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
Randomized trialflagStress Relief forscience5-HTP
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
Randomized trial70 participantsflagMood Support forscience5-HTP
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
Meta-analysis13 studies pooledflagMood Support forscience5-HTP
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
Randomized trial30 participantsflagMood Support forscience5-HTP
- Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
Randomized trial166 participantsflagMood Support forscience5-HTP
- Tryptophan and 5-hydroxytryptophan for depression.
Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
Systematic review64 participants2 studies pooledflagMood Support forscience5-HTP
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
Non-randomized trial30 participantsflagMood Support forscience5-HTP
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
Randomized trialflagStress Relief forscience5-HTP
- The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
Randomized trial48 participantsflagWeight Loss forscience5-HTP
- Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
Randomized trial25 participantsflagWeight Loss forscience5-HTP
- The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
Clinical trial19 participantsflagWeight Loss forscience5-HTP
- Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
Narrative reviewflagWeight Loss forscience5-HTP
- Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
Randomized trial20 participantsflagWeight Loss forscience5-HTP