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Ubiquinol Active CoQ10 100 mg

Natural Factors
4.8
★ ★ ★ ★ ★
(7141 ratings)
Coenzyme Q-10 100 mg
Product Image
Score81
100 mg of reduced-form ubiquinol offers focused CoQ10 support with an appropriate fat-soluble delivery format. The formula is simple and easy to assess.
How scoring works
Quantity:30 Softgel(s) • (30 servings)
Goals:
Heart Health
Energy
Cardiovascular Support
Anti-Aging
Metabolism Boost
Anti-Inflammatory Support

Score 81

100 mg of reduced-form ubiquinol offers focused CoQ10 support with an appropriate fat-soluble delivery format. The formula is simple and easy to assess.
How scoring works

Also available as

3 options
60 servings Flaxseed Oil 295 mg, Coenzyme Q-10 100 mg • 60 Softgel(s) • 60 servings $36.37 ($0.60 per serving) 200.00mg • 60 Softgel(s) servings Flaxseed Oil 340 mg, Coenzyme Q-10 200 mg • 60 Softgel(s) • 60 servings $62.97 ($1.04 per serving) 200.00mg • 30 Softgel(s) servings Flaxseed Oil 340 mg, Coenzyme Q-10 200 mg • 30 Softgel(s) • 30 servings $35.67 ($1.18 per serving)
$21.67($0.72 per serving)
iHerb
$ 21.67
Vitacost
$ 21.67
Amazon
$ 99.99
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Analysis

The serving supplies 100 mg of reduced-form ubiquinol. CoQ10 supports mitochondrial energy production and acts as a fat-soluble antioxidant, with the clearest practical value when intake, synthesis, or status is inadequate.

Ubiquinol offers strong absorption potential and may be especially practical for older adults or people who do not convert ubiquinone efficiently. The oil-based softgel, including organic flaxseed oil, provides a lipid environment for this fat-soluble ingredient.

The amount is well aligned with general maintenance or moderate targeted support. The single-active formula does not cover broader energy, lipid, inflammatory, or metabolic pathways, so it should be viewed as focused CoQ10 support.

Who is it for
  • Adults seeking maintenance-level CoQ10 support
  • Older adults or users who prefer reduced-form CoQ10
Best for
  • Supporting mitochondrial energy production
  • Foundational cardiovascular nutrient support

Pros

  • Uses reduced-form ubiquinol
  • Provides a clearly stated 100 mg amount
  • Includes organic flaxseed oil as a lipid carrier

Cons

  • Single-ingredient design provides narrow pathway coverage
  • Does not include broader mitochondrial cofactors
  • No complementary mitochondrial nutrients

Warnings

  • CoQ10 can reduce warfarin’s anticoagulant effect, so INR monitoring and prescriber coordination are important.
  • CoQ10 may add to the blood-pressure-lowering effect of antihypertensive medicines and can cause dizziness in susceptible users.
  • Digestive upset, headache, or sleep disturbance can occur; taking it earlier in the day with food may improve tolerance.

Nutrient quality

96 Highest impact

Reduced ubiquinol and lipid delivery provide strong ingredient quality. The amount fits meaningful daily maintenance use, and no obvious overdosing or unrelated actives are present.

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Ingredient transparency

80 Highest impact

The ubiquinol form and active amount are clearly disclosed without a hidden blend. Serving directions and inactive ingredients are not supplied.

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Customer satisfaction

72 High impact

The supplied average rating is strong and comes from a large rating pool. No firsthand experiences or recurring complaint details were provided, so consistency remains uncertain.

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Value for money

71 High impact

The active form and lipid delivery support quality, but the serving cost is relatively high. A maintenance-level amount limits category competitiveness.

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Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

Ubiquinol supplies the active reduced form of CoQ10 at a therapeutically useful amount. It directly supports cardiac cellular energy and is especially relevant when statin use lowers CoQ10 status.

Organic flaxseed oil provides a suitable lipid carrier for absorption. The compact formula is highly coherent but covers only the cardiac-energy pathway.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Energy
Energy
Impact
Highest effect
A Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

Ubiquinol directly supports mitochondrial electron transport, a core step in cellular energy production. The 100 mg amount provides practical maintenance support in one softgel.

The formula is focused on mitochondrial energy and does not address alertness or stress-resilience pathways. Organic flaxseed oil provides a compatible lipid carrier.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A Goal FitA Strength of SupportC- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports mitochondrial energy production in heart muscle and adds antioxidant protection. Human evidence is relevant for selected cardiovascular needs and statin-related depletion, but the single active does not cover lipids, vascular tone, or rhythm support.

The 100 mg amount falls within a researched range. The reduced ubiquinol form and an oil-based softgel support absorption. CoQ10 may reduce warfarin's anticoagulant effect, so users taking warfarin need the combination reviewed and monitored.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A Goal FitA Strength of SupportC- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports mitochondrial energy production and antioxidant defense, which are central to cellular aging. The disclosed 100 mg serving uses the better-absorbed ubiquinol form for meaningful targeted support.

Human evidence is strongest for selected cardiovascular and energy-related uses rather than broad life-extension outcomes. The focused formula provides depth in one pathway but does not cover structural, inflammatory, or neurological needs comprehensively.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
B- Goal FitA- Strength of SupportD CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

Ubiquinol supports mitochondrial energy production through a direct cellular mechanism. The 100 mg amount uses a well-absorbed CoQ10 form, although evidence for increasing whole-body metabolic rate or fat loss is limited.

The oil-based softgel is focused and provides good depth for one energy pathway. It does not address thermogenesis, thyroid support, glycemic control, or fatty-acid transport.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C+ Goal FitA- Strength of SupportC- CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

Ubiquinol provides antioxidant and mitochondrial support that may help manage inflammation-related oxidative stress. Its anti-inflammatory role remains supportive rather than a direct effect on inflammatory enzymes.

The 100 mg reduced CoQ10 form is well absorbed and delivered with flaxseed oil in a suitable softgel. The small oil amount mainly supports delivery and is too low to provide meaningful omega-3 pathway coverage.

Study evidence
Coenzyme Q-10 Supportive 46 studies

Ingredients

IngredientAmount per serving
CoQ10 (Ubiquinol)
 100 mg
organic Flaxseed Oil
295 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Coenzyme Q-10 (Ubiquinol) · 100 mg OverallScore88
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

Ubiquinol supplies the reduced, active form of CoQ10 with stronger absorption potential. 100 mg of ubiquinol falls within the researched therapeutic range. Cost per active amount is above typical collection levels.

View ingredientView products
Loading alternative details
87 Performance

Extra Strength Ubiquinol 200 mg

NOW
The reduced ubiquinol form at 200 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the ingredient list still does not provide independent testing or certification details.
85 Performance

Mega Ubiquinol CoQ10 100 mg

Qunol
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the ingredient list still does not provide independent testing or certification details.
85 Performance

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support 100 mg

Life Extension
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the added shilajit makes the formula less focused and may not suit people seeking CoQ10 alone.
87 Budget

Mega CoQ10 Ubiquinol 100 mg

Qunol
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
86 Budget

Ubiquinol 100 mg

NOW
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
87 Budget

QH-absorb 100 mg

Jarrow Formulas
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
87 Value

CoQ10 200 mg

California Gold Nutrition
A clearly stated ubiquinone dose at 200 mg provides a focused CoQ10 formula without unrelated active ingredients. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; Ubiquinone is the oxidized form, so people specifically seeking ubiquinol may prefer another option.
84 Value

High Absorption CoQ10 200 mg

Doctor's Best
Ubiquinone at 200 mg is paired with black pepper extract to support absorption, adding a practical feature to a focused CoQ10 formula. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; Black pepper extract can affect how some medicines are handled, so medication users should check suitability.
79 Value

Ubiquinol 100 mg

Qunol
Named Kaneka ubiquinol at 100 mg gives clear disclosure of the reduced CoQ10 form, which is often chosen for easier absorption. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; the ingredient list still does not provide independent testing or certification details.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  2. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  3. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  4. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  5. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  6. Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19.
    Sumbalova Z; Kucharska J; Palacka P; Rausova Z; Langsjoen PH; Langsjoen AM; Gvozdjakova A · Bratislavske lekarske listy · 2022
    Cross-sectional study25 participantsEnergy forCoenzyme Q-10
  7. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  8. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  9. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  10. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  11. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  12. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  13. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  14. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  15. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  16. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  17. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  18. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  19. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  20. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  21. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  22. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  23. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  24. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  25. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  26. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  27. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  28. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  29. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  30. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  31. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10