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Ortho Prostate

Protocol For Life Balance
4.8
★ ★ ★ ★ ★
(65 ratings)
Stinging Nettle 300 mg
Zinc 15 mg
Saw Palmetto 160 mg
Lycopene 3 mg
Product Image
Score76
A coherent prostate blend led by nettle root and zinc, but saw palmetto and lycopene are less compelling than the ingredient count suggests.
How scoring works
Quantity:90 Softgel(s) • (45 servings)
Goals:
Anti-Inflammatory Support
General Health

Score 76

A coherent prostate blend led by nettle root and zinc, but saw palmetto and lycopene are less compelling than the ingredient count suggests.
How scoring works
$32.00($0.71 per serving)
iHerb
$ 32.00
Pure Formulas
$ 32.00
Vitacost
$ 32.00
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Analysis

Nettle root is the clearest strength, with 300 mg of extract supported by pumpkin seed oil, zinc, and saw palmetto. The ingredients form a coherent prostate-focused combination rather than a broad daily supplement.

Saw palmetto is supplied at 160 mg and the label does not state a fatty-acid percentage or extraction method. Lycopene is also modest at 3 mg, so neither ingredient anchors the formula as strongly as the ingredient list may suggest.

The softgel and oil base suit the fat-soluble components, while individual active amounts are easy to identify. Value is less convincing for the depth of the formula, especially when saw palmetto standardization is not shown.

Who is it for
  • Adults seeking targeted prostate support
  • People who prefer an oil-based softgel
Best for
  • Nettle-root-centered prostate support
  • Combining zinc with prostate-focused botanicals

Pros

  • 300 mg nettle root extract
  • Clearly disclosed active amounts
  • Oil base suits fat-soluble ingredients
  • Useful 15 mg zinc amount

Cons

  • Saw palmetto is only 160 mg
  • No fatty-acid standardization is stated
  • Lycopene is modest at 3 mg
  • Limited value for the formula depth

Warnings

  • Saw palmetto may affect interpretation of prostate-specific antigen testing; disclose its use before the test.
  • Saw palmetto may add to bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Nutrient quality

82 Highest impact

The blend fits prostate support and uses practical amounts of zinc, nettle root, and pumpkin seed oil. Modest saw palmetto and lycopene amounts plus limited extract standardization reduce confidence in dose quality.

Ingredient transparency

81 Highest impact

Every listed active has a specific amount, and no proprietary blend conceals key doses. Botanical standardization, full usage directions, and non-active ingredients are not available in the supplied label details.

Customer satisfaction

67 High impact

The high average rating is supported by a moderate review count. No specific review comments are supplied, so repeated complaints and fit with the intended use cannot be judged confidently.

Value for money

69 High impact

The coherent multi-ingredient blend and reasonable serving count support acceptable value. Modest amounts and incomplete standardization for key botanicals keep it from comparing especially well on formula quality.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C Goal FitC+ Strength of SupportC+ CoverageB+ Formula Quality

Stinging nettle root, pumpkin seed oil, saw palmetto, zinc, and lycopene provide a prostate-focused mix with some local inflammatory relevance. The formula is less applicable to broad systemic anti-inflammatory support.

Nettle root and saw palmetto have meaningful amounts, while lycopene is modest and extract markers are incomplete. Saw palmetto may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Lycopene Supportive 15 studies
Stinging Nettle Supportive 5 studies
Zinc Supportive 64 studies
General Health
General Health
Impact
High effect
D+ Goal FitB Strength of SupportC- CoverageA- Formula Quality
Zinc · 15 mg

The formula is designed for prostate support rather than broad daily wellness. Zinc gluconate supplies a useful maintenance amount, while saw palmetto, nettle, pumpkin seed oil, and lycopene form a coherent targeted blend.

Its narrow focus leaves most foundational vitamin, mineral, fatty-acid, and energy pathways uncovered. It may fit an adult seeking prostate-focused support but is not a comprehensive general-health supplement.

Study evidence
Zinc Supportive 60 studies
Hair Health
Healthy Hair Growth Cycle
Hair Health
Impact
Moderate effect
C Goal FitC- Strength of SupportC- CoverageB- Formula Quality
Zinc · 15 mg

Saw palmetto, pumpkin seed oil, nettle, and zinc provide a plausible androgen and nutrient pathway relevant to some forms of hair shedding. The oil-based softgel suits the fat-soluble botanicals, but saw palmetto is only half the usual daily target and lacks fatty-acid standardization.

The formula does not provide structural proteins, iron, vitamin D, or meaningful antioxidant breadth. Its primary prostate positioning also makes hair benefits more indirect and less certain.

Study evidence
Saw Palmetto Supportive 5 studies
Zinc Supportive 22 studies
Testosterone Support
Natural Hormone Production
Testosterone Support
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageD Formula Quality
Zinc · 15 mg

Zinc and nettle root provide some endocrine relevance, but the formula is designed around prostate and androgen metabolism. It does not directly establish support for testosterone production.

Relevant amounts are disclosed, while botanical standardization is limited. Saw palmetto may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Study evidence
Zinc Disputed 7 studies
Immunity
Immunity
Impact
Moderate effect
D Goal FitC+ Strength of SupportD- CoverageC Formula Quality
Zinc · 15 mg

Zinc gluconate provides a meaningful immune-relevant nutrient, but the formula is designed for prostate support. Saw palmetto, nettle, pumpkin seed oil, and lycopene do not create broad immune coverage.

The zinc amount and form are practical and clearly disclosed. Immune value remains narrow and incidental to the main formulation purpose.

Study evidence
Zinc Supportive 73 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Fat
1 Gram(s)
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
Zinc (Zinc Gluconate)
 15 mg
Saw Palmetto extract (Fatty Acids)
 160 mg
Stinging Nettle root extract
300 mg
Pumpkin seed Oil
1 Gram(s)
Lycopene
3 mg
Gluten Free Men 18–50 Dairy Free
Report overview
Stinging Nettle · 300 mg OverallScore86
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

A 300 mg stinging nettle root extract is well aligned with the prostate-focused combination of saw palmetto, pumpkin seed oil, zinc, and lycopene. The serving reaches an effective extract range and is individually disclosed, though no concentration ratio or active marker is provided. Near-median cost supports reasonable value for a multi-ingredient formula.

View ingredientView products
Zinc (Zinc Gluconate) · 15 mg OverallScore73
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Zinc gluconate provides an effective organic salt in a swallowed softgel. The clearly disclosed 15 mg amount suits daily maintenance, and copper imbalance risk is low at this level despite no added copper. Value is weak because the prostate-support formula is costly per serving.

View ingredientView products
Saw Palmetto (Fatty Acids) · 160 mg OverallScore49
D Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD- Value

The oil-based softgel is well suited to saw palmetto actives, but the label does not give a fatty-acid percentage or extraction method. Its extract amount is only half of the usual daily target. Pumpkin seed oil and nettle add breadth, yet value remains limited without stronger saw palmetto standardization.

View ingredientView products
Loading alternative details
81 Performance

Prostate Wellness

Bio Nutrition
<p>A coherent prostate blend combines saw palmetto, nettle, pygeum, pumpkin seed, beta-sitosterol, and lycopene at disclosed amounts. More focused or better-disclosed prostate ingredients strengthen the comparison with the original, although the label still leaves some extract or mineral-form uncertainty.</p>
79 Performance

Gold Specifics Prostate Support

Solgar
<p>Well-chosen mineral forms and several standardized botanicals create a focused prostate-support formula. More focused or better-disclosed prostate ingredients strengthen the comparison with the original, although the label still leaves some extract or mineral-form uncertainty.</p>
75 Performance

Pros-T

LifeSeasons
<p>Saw palmetto, beta-sitosterol, nettle root, vitamin D, zinc, and selenium form a broad, well-aligned prostate and androgen-pathway formula. More focused or better-disclosed prostate ingredients strengthen the comparison with the original, although the label still leaves some extract or mineral-form uncertainty.</p>
77 Budget

Prostate Essentials Plus

Swanson
<p>The formula pairs zinc picolinate and selenium with prostate botanicals, but saw palmetto, nettle, beta-sitosterol, and amino acids remain modest or incompletely standardized. The lower serving cost improves accessibility compared with the original, while incomplete extract standardization means potency still needs cautious interpretation.</p>
81 Budget

Saw Palmetto 450 mg

21st Century
<p>Saw-palmetto powder and zinc form an inexpensive, focused male-health supplement. The lower serving cost improves accessibility compared with the original, while incomplete extract standardization means potency still needs cautious interpretation.</p>
80 Budget

Saw Palmetto Extract

NOW
<p>Saw-palmetto extract, pumpkin-seed oil, and zinc create a simple, coherent formula at a low recurring cost. The lower serving cost improves accessibility compared with the original, while incomplete extract standardization means potency still needs cautious interpretation.</p>
77 Value

Prostate Essentials

Swanson
<p>Absorbable zinc supports a coherent prostate-focused formula, but saw palmetto, nettle, amino acids, and beta-sitosterol are modest or poorly characterized. A lower recurring cost and relevant prostate ingredients improve practical value versus the original, with narrower coverage or incomplete botanical standardization as the trade-off.</p>
69 Value

Saw Palmetto With Lycopene

Natural Factors HerbalFactors
<p>The softgel format suits saw palmetto, but the extract lacks fatty-acid standardization and the lycopene source is not identified. A lower recurring cost and relevant prostate ingredients improve practical value versus the original, with narrower coverage or incomplete botanical standardization as the trade-off.</p>
80 Value

Saw Palmetto 450 mg

21st Century
<p>Saw-palmetto powder and zinc form an inexpensive, focused male-health supplement. A lower recurring cost and relevant prostate ingredients improve practical value versus the original, with narrower coverage or incomplete botanical standardization as the trade-off.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Carotenoids supplementation and inflammation: a systematic review and meta-analysis of randomized clinical trials.
    Hajizadeh-Sharafabad F; Zahabi ES; Malekahmadi M; Zarrin R; Alizadeh M · Critical reviews in food science and nutrition · 2022
    Meta-analysis26 studies pooledAnti-Inflammatory Support forLycopene
  2. Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men.
    Kim JY; Paik JK; Kim OY; Park HW; Lee JH; Jang Y; Lee JH · Atherosclerosis · 2011
    Randomized trial126 participantsAnti-Inflammatory Support forLycopene
  3. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals.
    McEneny J; Wade L; Young IS; Masson L; Duthie G; McGinty A; McMaster C; Thies F · The Journal of nutritional biochemistry · 2013
    Randomized trial54 participantsAnti-Inflammatory Support forLycopene
  4. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept.
    Wood LG; Garg ML; Powell H; Gibson PG · Free radical research · 2008
    Randomized trial32 participantsAnti-Inflammatory Support forLycopene
  5. Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease.
    Chandra RV; Srinivas G; Reddy AA; Reddy BH; Reddy C; Nagarajan S; Naveen A · Journal of periodontal & implant science · 2013
    Randomized trial31 participantsAnti-Inflammatory Support forLycopene
  6. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial.
    Namazi N; Esfanjani AT; Heshmati J; Bahrami A · Pakistan journal of biological sciences : PJBS · 2012
    Randomized trial50 participantsAnti-Inflammatory Support forStinging Nettle
  7. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.
    Akbar Karami A; Sheikhsoleimani M; Reza Memarzadeh M; Haddadi E; Bakhshpour M; Mohammadi N; Mehdi Mirhashemi S · Pakistan journal of biological sciences : PJBS · 2021
    Randomized trial60 participantsAnti-Inflammatory Support forStinging Nettle
  8. Safety, Tolerability, and Efficacy of Hox Alpha, a Dry Extract from Stinging Nettle Leaves versus OTC NSAIDs in Osteoarthritis: A Retrospective, Propensity-Matched 12-Week Analysis from the German Pain e-Registry (SIPHARO Study).
    Überall MA; Küster MA; Müller-Schwefe PCG; Müller-Schwefe GHH · Journal of pain research · 2026
    Cohort study2,146 participantsAnti-Inflammatory Support forStinging Nettle
  9. [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].
    Keyßer G; Seifert O; Frohne I; Michalsen A; Pfeil A; Reuß-Borst M; Sander O · Zeitschrift fur Rheumatologie · 2025
    Guideline / consensusAnti-Inflammatory Support forStinging Nettle
  10. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
    C Randall, H Randall, F Dobbs, C Hutton, H Sanders · Journal of the Royal Society of Medicine · 2000
    Randomized trial27 participantsAnti-Inflammatory Support forStinging Nettle
  11. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  12. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  13. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  14. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  15. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  16. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  17. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  18. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  19. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  20. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  21. The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto (Serenoa repens) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self-Perceived Thinning Hair: 90-Day Results.
    Ablon G · Journal of cosmetic dermatology · 2025
    Randomized trial60 participantsHair Health forSaw Palmetto
  22. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
    Zhou L; Zhu W; Chen Y · Frontiers in nutrition · 2026
    Meta-analysis1,658 participants19 studies pooledHair Health forSaw Palmetto
  23. The Safety and Efficacy of a Novel Saw Palmetto (Serenoa repens) Extract for Promoting Hair Growth in Adults With Self-Perceived Thinning Hair: 180-Day Results.
    Ablon G · Journal of cosmetic dermatology · 2026
    Randomized trial60 participantsHair Health forSaw Palmetto
  24. Beyond Minoxidil: Off-Label Therapies for Male Androgenetic Alopecia-A Systematic Review with Network Meta-Analyses.
    Gupta AK; Compton SAH; Liddy A; Talukder M; Wang T; Bamimore MA · Medicina (Kaunas, Lithuania) · 2026
    Meta-analysis50 participants23 studies pooledHair Health forSaw Palmetto
  25. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.
    Rossi A; Mari E; Scarno M; Garelli V; Maxia C; Scali E; Iorio A; Carlesimo M · International journal of immunopathology and pharmacology · 2013
    Non-randomized trial100 participantsHair Health forSaw Palmetto
  26. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  27. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  28. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  29. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  30. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  31. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  32. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  33. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  34. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  35. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  36. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  37. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  38. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  39. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  40. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc