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Kyolic B6 B12 Folic Acid & L-Argininge

Kyolic
4.7
★ ★ ★ ★ ★
(659 ratings)
Vitamin B6 25 mg
Arginine 200 mg
Folate 600 mcg
Vitamin B12 200 mcg
Product Image
Score73
A practical B-vitamin and aged-garlic blend with useful cardiovascular relevance, but weak arginine dosing and incomplete form disclosure hold it back.
How scoring works
Quantity:100 Capsule(s) • (50 servings)
Goals:
Heart Health
Cardiovascular Support
General Health

Score 73

A practical B-vitamin and aged-garlic blend with useful cardiovascular relevance, but weak arginine dosing and incomplete form disclosure hold it back.
How scoring works
$15.37($0.30 per serving)
Vitacost
$ 16.12
Pure Formulas
$ 15.37
Pure Formulas
$ 15.37
iHerb
$ 16.12
Amazon
$ 16.07
Walmart
$ 16.07
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Analysis

The B6, folate, and B12 combination supports energy metabolism and normal homocysteine processing. Aged garlic adds a distinct cardiovascular angle rather than simply duplicating the vitamin blend.

Ingredient quality is uneven because the B6 and B12 forms are not named and the folate is folic acid. L-arginine is present, but 200 mg is too little to serve as a meaningful standalone circulation dose.

The capsule format and serving value make the formula practical for someone who wants several related nutrients together. Aged garlic and arginine also create relevant medication interactions that deserve attention before routine use.

Who is it for
  • Adults seeking a combined B-vitamin and garlic supplement
  • People who value broad cardiovascular nutrient coverage in capsules
Best for
  • Homocysteine-related nutrient support
  • General cardiovascular wellness

Pros

  • Combines B6, folate, and B12 in meaningful amounts
  • Includes 500 mg of aged garlic extract
  • Good serving value for a multi-ingredient formula

Cons

  • B6 and B12 chemical forms are not disclosed
  • Uses folic acid rather than an active folate form
  • Arginine amount is too small for focused circulation support

Warnings

  • Aged garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines
  • Garlic and L-arginine may add to the effects of nitrates or blood-pressure medicines

Nutrient quality

63 Moderate impact

Folate is identified, but the forms of vitamin B6 and vitamin B12 are not specified. Aged garlic is substantial, while the arginine amount is modest for its usual intended role.

Ingredient transparency

76 High impact

Specific amounts are supplied for every listed active ingredient. Inactive ingredients are not identified in the supplied label data.

Customer satisfaction

69 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

85 Highest impact

The accessible cost is supported by a focused garlic-and-vitamin formula. The serving cost appears favorable for the disclosed active amounts.

Report analysis

Goals

Heart Health
Heart Health
Impact
High effect
B+ Goal FitC+ Strength of SupportB CoverageA- Formula Quality
Vitamin B12 · 200 mcgVitamin B6 · 25 mgFolate · 600 mcg

Folate, vitamin B6, and vitamin B12 form a coherent homocysteine-support trio, while aged garlic adds vascular relevance. L-arginine is present at too little an amount to add meaningful nitric-oxide support.

Synthetic folic acid and undisclosed B6 and B12 forms reduce the quality of an otherwise well-targeted formula. Long-term use of the high B6 amount may raise nerve-injury risk, and aged garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B+ Goal FitC- Strength of SupportB CoverageB+ Formula Quality
Arginine · 200 mgVitamin B12 · 200 mcgVitamin B6 · 25 mgFolate · 600 mcg

Vitamin B6, folate, and vitamin B12 form a coherent combination for homocysteine metabolism. Aged garlic adds vascular support, while L-arginine supplies a relevant nitric oxide pathway.

The B-vitamin amounts are meaningful, but the B6 and B12 forms are unspecified and folic acid is less direct than methylfolate. The 200 mg L-arginine amount is far below common circulation-support doses, and combining arginine and garlic with nitrates or blood-pressure medicines may cause excessive blood-pressure lowering.

Study evidence
Arginine Supportive 47 studies
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
General Health
General Health
Impact
High effect
B- Goal FitD+ Strength of SupportC+ CoverageB- Formula Quality
Folate · 600 mcgVitamin B12 · 200 mcg

B6, folate, and B12 support methylation, blood-cell formation, and energy metabolism, while aged garlic and arginine broaden the formula toward circulatory support. The combination is relevant to general wellness, but ingredient quality and dose strength vary.

Folic acid requires conversion, and the B12 chemical form is not disclosed. The arginine amount is small for a meaningful standalone effect, so the broad-looking formula has uneven functional depth.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies

Ingredients

IngredientAmount per serving
Vitamin B6
25 mg
Folic Acid (Folate)
 600 mcg
Vitamin B12
200 mcg
Aged Garlic extract powder
500 mg
L-Arginine
200 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Vitamin B6 · 25 mg OverallScore67
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

The 25 mg dose is well aligned with the intended range, but the undisclosed chemical form leaves its metabolic readiness uncertain. Its low serving cost and broader nutrient formula provide strong value. Aged garlic and L-arginine may lower blood pressure, while garlic may increase bleeding tendency with anticoagulant or antiplatelet drugs.

View ingredientView products
Arginine · 200 mg OverallScore42
C+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The L-isomer is clearly identified, but the amount is far below the range commonly used for circulation or fitness support. Reaching a meaningful arginine intake would require many capsules, which weakens convenience and value. L-arginine and aged garlic may add to the effects of nitrates or antihypertensive medicines and could cause dizziness or an excessive drop in blood pressure.

View ingredientView products
Folate · 600 mcg OverallScore40
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD- Value

Synthetic folic acid requires conversion and lacks active-isomer purity markers. The estimated dietary folate equivalent is above the preferred range but below the highest-dose band. Vitamin B12 supports the safety logic, while the serving cost offers moderate value for the folate form provided.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Methylcobalamin and branded methylfolate provide a high-quality active-form pairing. The ingredient focus improves on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although the concentrated B12 amount is better suited to targeted use than basic maintenance.</p>
86 Performance

B-6 B-12 Methyl Folate Mixed Berry

KAL
<p>Active B6, methylfolate, and methylcobalamin create a focused three-nutrient formula. The ingredient focus improves on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although the concentrated B12 amount may exceed basic maintenance needs.</p>
82 Performance

BioActive Vitamin B

Terry Naturally
<p>Active forms of B6, B12, and folate create a compact formula with broad heart, energy, and cognitive alignment. The ingredient focus improves on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although the B6 amount may be more than many users need over the long term.</p>
77 Budget

Vitamin B12 & Folic Acid Natural Raspberry Flavor

Bluebonnet EarthSweet Chewables
<p>A higher serving cost means this is not a true cheaper option, although meaningful B12 and folate amounts provide convenient chewable coverage. Cyanocobalamin, synthetic folic acid, and the carbohydrate base reduce form quality.</p>
75 Budget

Vitamin B12 With Folic Acid 500 mcg Cherry Flavor

Country Life
<p>A higher serving cost means this is not a true cheaper option, although practical B12 and folate amounts come in an oral-dissolving format. Cyanocobalamin and synthetic folic acid are less preferred than active cobalamins and methylfolate.</p>
81 Budget

Folic Acid B6 & B12

Mason Natural
<p>A higher serving cost means this is not a true cheaper option, although a simple B6, folate, and B12 combination provides inexpensive nutrient coverage. Older forms and an aggressive pyridoxine amount weaken quality and long-term suitability.</p>
81 Value

Tri-B

Carlson
<p>B6, folate, and B12 create a simple cardiovascular-support combination with a long supply at a higher serving cost. The quality-to-cost balance may improve on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although conventional forms, high folate, and elevated pyridoxine reduce long-term suitability.</p>
78 Value

Homocysteine Defense

Source Naturals
<p>A meaningful betaine amount gives the B-vitamin formula a clear homocysteine focus at a higher serving cost. The quality-to-cost balance may improve on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although older vitamin forms, high folate, and elevated pyridoxine reduce long-term suitability.</p>
79 Value

Homocysteine Modulators

Solgar
<p>Betaine and an active B6 addition give the homocysteine formula a clear cardiovascular purpose at a higher serving cost. The quality-to-cost balance may improve on the original’s modest arginine, unspecified nutrient forms, and relatively high B6, although most vitamins use older forms and the B6 amount is aggressive for long-term use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials.
    Li Y; Huang T; Zheng Y; Muka T; Troup J; Hu FB · Journal of the American Heart Association · 2018
    Meta-analysis82,334 participants30 studies pooledCardiovascular Support Heart Health forFolate
  2. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  3. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forVitamin B6 Heart Health forVitamin B12 Heart Health forFolate
  4. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.
    Khan SU; Khan MU; Riaz H; Valavoor S; Zhao D; Vaughan L; Okunrintemi V; Riaz IB; Khan MS; Kaluski E; Murad MH; Blaha MJ; Guallar E; Michos ED · Annals of internal medicine · 2020
    Meta-analysis992,129 participants277 studies pooledHeart Health forVitamin B6
  5. Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Rodrigues-Krause J; Krause M; Rocha IMGD; Umpierre D; Fayh APT · Nutrients · 2019
    Meta-analysis13 studies pooledCardiovascular Support forArginine
  6. Nonlinear associations of serum cobalamin with risk of all-cause and cardiovascular mortality in hypertensive adults.
    Zhu X; Tang Y; Cheang I; Gao R; Liao S; Yao W; Zhou Y; Zhang H; Li X · Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Cohort study9,934 participantsHeart Health Cardiovascular Support forVitamin B12
  7. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes.
    Liu Y; Geng T; Wan Z; Lu Q; Zhang X; Qiu Z; Li L; Zhu K; Liu L; Pan A; Liu G · JAMA network open · 2022
    Cohort study4,860 participantsCardiovascular Support forFolate Cardiovascular Support forVitamin B12
  8. Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease.
    Bleie Ø; Semb AG; Grundt H; Nordrehaug JE; Vollset SE; Ueland PM; Nilsen DW; Bakken AM; Refsum H; Nygård OK · Journal of internal medicine · 2007
    Randomized trial90 participantsCardiovascular Support forVitamin B6
  9. Subclinical atherosclerosis and impaired cardiac autonomic control in pediatric patients with Vitamin B12 deficiency.
    Celik SF; Celik E · Nigerian journal of clinical practice · 2018
    Case-control study100 participantsHeart Health forVitamin B12
  10. The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK).
    Zuo H; Tell GS; Ueland PM; Nygård O; Vollset SE; Midttun Ø; Meyer K; Ulvik A · The American journal of clinical nutrition · 2019
    Cohort study6,891 participantsCardiovascular Support Heart Health forVitamin B6
  11. MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
    Klerk M; Verhoef P; Clarke R; Blom HJ; Kok FJ; Schouten EG; MTHFR Studies Collaboration Group · JAMA · 2002
    Meta-analysis23,920 participants40 studies pooledHeart Health forFolate
  12. The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials.
    Hadi A; Arab A; Moradi S; Pantovic A; Clark CCT; Ghaedi E · The British journal of nutrition · 2020
    Meta-analysis12 studies pooledCardiovascular Support forArginine
  13. Effect of Folate-Based Supplementation in Kidney Disease: A Systematic Review and Meta-analysis of Kidney, Cardiovascular, and Mortality Outcomes.
    Chan WL; Jiao Y; Chim KCY; Lederman Z; Tang SCW; Rainer TH · Nutrition reviews · 2026
    Meta-analysis8,625 participants37 studies pooledCardiovascular Support forFolate
  14. Dietary Intake and Plasma Concentration of B Vitamins in Relation to Incident Coronary Artery Disease in African-American Adults: The Jackson Heart Study.
    Huo C; Thiagarajah K; Tekwe CD; Tucker KL; Bidulescu A · The Journal of nutrition · 2026
    Cohort study4,906 participantsHeart Health forFolate
  15. Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study.
    Minović I; Kieneker LM; Gansevoort RT; Eggersdorfer M; Touw DJ; Voerman AJ; Connelly MA; Boer RA; Hak E; Bos J; Dullaart RPF; Kema IP; Bakker SJL · Nutrients · 2021
    Cohort study6,249 participantsHeart Health forVitamin B6
  16. Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review.
    Goh JK; Koh L · Diabetology international · 2024
    Systematic review724 participants13 studies pooledHeart Health Cardiovascular Support forVitamin B12
  17. Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study.
    Vogl L; Pohlhammer J; Meinitzer A; Rantner B; Stadler M; Peric S; Hammerer-Lercher A; Klein-Weigel P; Fraedrich G; Kronenberg F; Kollerits B · Atherosclerosis · 2015
    Cohort study478 participantsCardiovascular Support forArginine
  18. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health Cardiovascular Support forFolate
  19. Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials.
    Asbaghi O; Ashtary-Larky D; Bagheri R; Nazarian B; Pourmirzaei Olyaei H; Rezaei Kelishadi M; Nordvall M; Wong A; Dutheil F; Naeini AA · Critical reviews in food science and nutrition · 2022
    Meta-analysis21,787 participants34 studies pooledCardiovascular Support Heart Health forFolate
  20. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  21. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  22. Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study.
    Guo J; Liu X; Wang Z; Lu R; Liu Y; Zhang Y; Tian W; Fang S; Wang S; Yu B · Nutrition journal · 2023
    Cohort study1,755 participantsHeart Health Cardiovascular Support forVitamin B12
  23. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  24. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  25. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsHeart Health Cardiovascular Support forVitamin B6
  26. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  27. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  28. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  29. A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia.
    Wang WW; Wang XS; Zhang ZR; He JC; Xie CL · Frontiers in pharmacology · 2020
    Meta-analysis7,887 participants65 studies pooledHeart Health forFolate
  30. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health Cardiovascular Support forVitamin B6
  31. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6 Cardiovascular Support forFolate
  32. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  33. Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial.
    van Dijk SC; Enneman AW; Swart KM; van Wijngaarden JP; Ham AC; Brouwer-Brolsma EM; van der Zwaluw NL; Blom HJ; Feskens EJ; Geleijnse JM; van Schoor NM; Dhonukshe-Rutten RA; de Jongh RT; Lips P; de Groot LC; Uitterlinden AG; Smulders YM; van den Meiracker AH; Mattace Raso FU; van der Velde N · Journal of hypertension · 2016
    Randomized trial2,919 participantsHeart Health forVitamin B12
  34. The independent and joint associations of vitamin B12 and methylmalonic acid on the risk of mortality in individuals with metabolic dysfunction-associated steatotic liver disease.
    Wang P; Yu J; Zhao Y; Simayi R; Shi D · European journal of nutrition · 2024
    Cohort study6,797 participantsCardiovascular Support forVitamin B12
  35. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
    Shirodaria C; Antoniades C; Lee J; Jackson CE; Robson MD; Francis JM; Moat SJ; Ratnatunga C; Pillai R; Refsum H; Neubauer S; Channon KM · Circulation · 2007
    Randomized trial56 participantsCardiovascular Support forFolate
  36. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  37. Dietary Vitamin B6 Intake Associated with a Decreased Risk of Cardiovascular Disease: A Prospective Cohort Study.
    Jeon J; Park K · Nutrients · 2020
    Cohort study9,142 participantsCardiovascular Support forVitamin B6
  38. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  39. Atorvastatin but not L-arginine improves endothelial function in type I diabetes mellitus: a double-blind study.
    Mullen MJ; Wright D; Donald AE; Thorne S; Thomson H; Deanfield JE · Journal of the American College of Cardiology · 2000
    Randomized trial84 participantsCardiovascular Support forArginine
  40. Intraoperative Versus Postoperative Hydroxocobalamin for Vasoplegic Shock in Cardiothoracic Surgery.
    Khandekar DA; Seelhammer TG; Mara KC; Stephens EH; Wittwer ED; Wieruszewski PM · Journal of cardiothoracic and vascular anesthesia · 2023
    Cohort study112 participantsCardiovascular Support forVitamin B12
  41. The effects of folic acid supplementation on endothelial function in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.
    Zamani M; Rezaiian F; Saadati S; Naseri K; Ashtary-Larky D; Yousefi M; Golalipour E; Clark CCT; Rastgoo S; Asbaghi O · Nutrition journal · 2023
    Meta-analysis2,025 participants21 studies pooledCardiovascular Support forFolate
  42. Efficacy of folic acid supplementation on endothelial function and plasma homocysteine concentration in coronary artery disease: A meta-analysis of randomized controlled trials.
    Yi X; Zhou Y; Jiang D; Li X; Guo Y; Jiang X · Experimental and therapeutic medicine · 2021
    Meta-analysis377 participantsHeart Health forFolate
  43. Dietary folate and vitamin b6 and B12 intake in relation to mortality from cardiovascular diseases: Japan collaborative cohort study.
    Cui R; Iso H; Date C; Kikuchi S; Tamakoshi A; Japan Collaborative Cohort Study Group · Stroke · 2010
    Cohort study58,730 participantsHeart Health forVitamin B6
  44. Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography.
    Sourij H; Meinitzer A; Pilz S; Grammer TB; Winkelmann BR; Boehm BO; März W · Atherosclerosis · 2012
    Cohort study2,236 participantsCardiovascular Support forArginine
  45. Prevalence of Functional Cobalamin Deficiency and Relevant Mortality Risk in the General Population: An Unheeded Phenotype Distinct from Cobalamin Deficiency.
    Liu Y; Gao Y; Liu Y; Zhang Y; Wang S; Yu B · Journal of the American Nutrition Association · 2025
    Cohort study22,513 participantsCardiovascular Support forVitamin B12
  46. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  47. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  48. Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.
    Van den Eynde MDG; Houben AJHM; Scheijen JLJM; Linkens AMA; Niessen PM; Simons N; Hanssen NMJ; Kusters YHAM; Eussen SJMP; Miyata T; Stehouwer CDA; Schalkwijk CG · Diabetes, obesity & metabolism · 2023
    Randomized trial108 participantsCardiovascular Support forVitamin B6
  49. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  50. Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study.
    Yang D; Liu Y; Wang Y; Ma Y; Bai J; Yu C · Nutrients · 2021
    Cohort study12,190 participantsHeart Health forVitamin B6
  51. Methylmalonic acid and vitamin B12 in patients with heart failure.
    Polytarchou K; Dimitroglou Y; Varvarousis D; Christodoulis N; Psachoulia C; Pantziou C; Mourouzis I; Pantos C; Manolis AS · Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese · 2021
    Case-control study156 participantsHeart Health forVitamin B12
  52. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsCardiovascular Support General Health forVitamin B12
  53. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
    Bennett DA; Parish S; Millwood IY; Guo Y; Chen Y; Turnbull I; Yang L; Lv J; Yu C; Davey Smith G; Wang Y; Wang Y; Peto R; Collins R; Walters RG; Li L; Chen Z; Clarke R; China Kadoorie Biobank (CKB) Study Collaborative Group · International journal of epidemiology · 2023
    Cohort study156,253 participantsHeart Health forFolate
  54. Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy of the VITATOPS trial.
    Dusitanond P; Eikelboom JW; Hankey GJ; Thom J; Gilmore G; Loh K; Yi Q; Klijn CJ; Langton P; van Bockxmeer FM; Baker R; Jamrozik K · Stroke · 2005
    Randomized trial285 participantsHeart Health forVitamin B6
  55. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure.
    Bennett-Richards KJ; Kattenhorn M; Donald AE; Oakley GR; Varghese Z; Bruckdorfer KR; Deanfield JE; Rees L · Kidney international · 2003
    Randomized trial21 participantsCardiovascular Support forArginine
  56. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  57. Dietary Folate, Vitamin B6, and Vitamin B12 and Risk of Cardiovascular Diseases among Individuals with Type 2 Diabetes: A Case-Control Study.
    Wu S; Feng P; Li W; Zhuo S; Lu W; Chen P; Sui Y; Fang S; Yang Z; Ye Y · Annals of nutrition & metabolism · 2023
    Case-control study838 participantsCardiovascular Support forVitamin B12
  58. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  59. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  60. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  61. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  62. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  63. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  64. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  65. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  66. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  67. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  68. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  69. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  70. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  71. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  72. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  73. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  74. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  75. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  76. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  77. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  78. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6