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Adrenotone

Designs for Health
4.7
★ ★ ★ ★ ★
(26 ratings)
Eleuthero 250 mg
Ashwagandha 100 mg
Rhodiola
Product Image
Score68
A thoughtful mix of active B vitamins and adaptogens may support daytime resilience. Modest botanical depth and premium cost are the main trade-offs.
How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:
Energy
Mental Focus
Cognitive Support

Score 68

A thoughtful mix of active B vitamins and adaptogens may support daytime resilience. Modest botanical depth and premium cost are the main trade-offs.
How scoring works
$35.99($1.19 per serving)
Pure Formulas
$ 35.99
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Analysis

Active riboflavin and vitamin B6 forms join a large pantothenic-acid amount to support basic energy metabolism. Eleuthero, American ginseng, ashwagandha, rhodiola, tyrosine, and licorice add several stress-response pathways.

Eleuthero is present at a moderate amount, while ashwagandha and rhodiola sit below stronger stand-alone doses. Active markers are named, but their percentages and several extract details are missing, limiting potency comparisons.

The blend may suit people seeking daytime resilience rather than a strong acute stimulant. Three capsules per serving and premium cost reduce convenience and value, especially for users focused on one adaptogen.

Who is it for
  • Adults seeking daytime stress and energy support
  • Users comfortable with multi-adaptogen capsules
  • People who value active B-vitamin forms
Best for
  • Stress-related fatigue
  • Daytime adaptogen routines
  • Broad energy-metabolism support

Pros

  • Uses active forms of riboflavin and vitamin B6
  • Combines several relevant adaptogens
  • Most active amounts are disclosed

Cons

  • Ashwagandha and rhodiola amounts are modest
  • Marker percentages are incomplete
  • Three-capsule serving is costly

Warnings

  • Ashwagandha warrants professional guidance during pregnancy or when thyroid or liver concerns are present.
  • Rhodiola, eleuthero, or ginseng may feel stimulating and can be a poor fit near bedtime or with other stimulants.
  • Introduce multi-herb adaptogen blends cautiously because sensitivity to one ingredient can be difficult to identify.
  • Licorice may be unsuitable for people who need to closely manage blood pressure or potassium.

Nutrient quality

75 High impact

Active B-vitamin forms and named botanical markers improve form quality, though several marker strengths and species details are missing. Eleuthero is moderately dosed, while ashwagandha, rhodiola, and N-acetyl tyrosine are modest for primary use.

Ingredient transparency

74 High impact

Specific amounts are provided for every listed active ingredient. Excipients and other non-active ingredients are not provided.

Customer satisfaction

63 Moderate impact

The supplied average rating is very strong. The small rating sample limits confidence in the average.

Value for money

55 Moderate impact

The broad formula offers useful variety, but uneven botanical characterization limits the quality delivered for the cost. The relatively high serving cost is difficult to justify when several core actives are modestly dosed.

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Goals

Energy
Essential Energy Nutrients
Energy
Impact
High effect
B+ Goal FitC+ Strength of SupportB- CoverageB+ Formula Quality
Vitamin B5 · 250 mgRiboflavin · 5 mg

Rhodiola, eleuthero, ashwagandha, American ginseng, active B6, riboflavin, and pantothenic acid create a coherent stress-resilience formula. The adaptogens are individually quantified and several active markers are named.

Rhodiola and ashwagandha are modest for primary use, while marker percentages and exact species details are incomplete. Licorice may raise blood pressure or lower potassium in susceptible users, particularly with sustained use or alongside diuretics.

Study evidence
Ashwagandha Supportive 9 studies
Eleuthero Disputed 3 studies
Rhodiola Supportive 18 studies
Riboflavin Mixed 6 studies
Mental Focus
Mental Focus
Impact
High effect
C+ Goal FitC Strength of SupportB- CoverageB- Formula Quality
Vitamin B6 · 5 mg

Several adaptogens and N-acetyl tyrosine may support mental stamina when stress is the main source of poor concentration. Eleuthero has a useful amount, while the rhodiola, ashwagandha, and tyrosine contributions are modest or incompletely characterized.

Active B-vitamin forms add metabolic support, but the formula lacks a well-developed acute attention pathway. Exact ingredient amounts are disclosed, although missing botanical species or marker percentages limit confidence in potency.

Study evidence
Ashwagandha Supportive 12 studies
Eleuthero Disputed 3 studies
Rhodiola Supportive 15 studies
Cognitive Support
Cognitive Support
Impact
High effect
C+ Goal FitC Strength of SupportC+ CoverageB Formula Quality
Vitamin B6 · 5 mgAshwagandha · 100 mg

The adaptogen blend may support clearer thinking when stress and fatigue are the main barriers. Rhodiola, eleuthero, ashwagandha, and N-acetyl tyrosine cover stress resilience and neurotransmitter support.

Most of the cognitive contribution is indirect, and several key amounts are below commonly studied ranges. Clear ingredient amounts and useful extract markers help, but missing marker strengths leave potency uncertain.

Study evidence
Ashwagandha Supportive 17 studies
Eleuthero No effect 1 study
Rhodiola Supportive 7 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 100 mg
Riboflavin (Riboflavin 5-Phosphate, Vitamin B2)
 5 mg
Vitamin B-6 (Pyridoxal 5-Phosphate)
 5 mg
Pantothenic Acid (D-Calcium Pantothenate)
 250 mg
Eleuthero (Eleutherosides)
 250 mg
American Ginseng (Ginsenosides)
 100 mg
Ashwaganda (Withanolides)
 100 mg
Rhodiola (Rosavins, Salidroside)
 100 mg
N-Acetyl Tyrosine
75 mg
Licorice
20 mg
Gluten Free Adults 18–50
Report overview
Eleuthero (Eleutherosides) · 250 mg OverallScore59
C- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Eleutherosides are identified, but the label does not state their concentration or the plant part used. The 250 mg amount is clearly disclosed and provides a moderate extract-level dose in one capsule. A relatively high cost per serving weakens the value.

View ingredientView products
Ashwagandha (Withanolides) · 100 mg OverallScore58
C Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

A withanolide-marked extract offers some quality detail, but no clinically studied brand or absorption aid is identified. The clearly listed 100 mg amount is modest for a primary ashwagandha option. A relatively high cost and the emphasis on a broader adaptogen blend limit its fit for shoppers focused on ashwagandha.

View ingredientView products
Rhodiola (Rosavins, Salidroside) · 100 mg OverallScore54
D Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Both rosavins and salidroside are named, but the Rhodiola species and marker percentages are not provided. The disclosed amount is useful for a blend yet sits below the main evidence-based range. High cost per standardized dose and missing additive details weaken its fit.

View ingredientView products
Loading alternative details
81 Performance

Adrenal Serenity

Natural Factors Stress-Relax
Stronger supplied quality or collection-fit evidence makes this a more compelling option than the original formula. It provides 250.00mg of Sensoril Ashwagandha extract with good alignment with the stated cognitive support goal, while the input does not supply certification or testing details.
81 Performance

AdrenaSense

Natural Factors WS WomenSense
Stronger supplied quality or collection-fit evidence makes this a more compelling option than the original formula. It provides 200.00mg of Rhodiola extract as Rosavins with good alignment with the stated mood support goal, while the input does not supply certification or testing details.
73 Performance

HPA Adapt

Integrative Therapeutics
Stronger supplied quality or collection-fit evidence makes this a more compelling option than the original formula. It provides 200.00mg of Holy Basil (Ocimum sanctum) leaf extract as Ursolic Acid with good alignment with the stated stress relief goal, while the input does not supply certification or testing details.
79 Budget

Dual Ginseng Plus

Swanson Superior Herbs
Lower serving cost makes this a more economical choice than the original formula. It still provides a clearly listed 200.00mg of American Ginseng root extract as Ginsenosides, retaining a relevant active rather than cutting cost through an unrelated product.
67 Budget

Adrenal Optimizer

Jarrow Formulas
Lower serving cost makes this a more economical choice than the original formula. It still provides a clearly listed 100.00mg of Vitamin C as Calcium Ascorbate, retaining a relevant active rather than cutting cost through an unrelated product.
62 Budget

Yohimbe-Plus Maximum Enhancement

Irwin Naturals
Lower serving cost makes this a more economical choice than the original formula. It still provides a clearly listed 20.00Calorie(s) of Calories, retaining a relevant active rather than cutting cost through an unrelated product.
77 Value

Energy Xtra

Pure Encapsulations
A clearly listed 200.00mg of Ashwagandha (Withania somnifera) extract as Withanolides pairs useful collection fit with a lower serving cost, creating a balanced quality-to-cost trade-off. Its supplied analyses show good alignment with the stated cognitive support goal, though the available data do not document certification or testing.
78 Value

Saffron

youtheory
A clearly listed 350.00mg of Rhodiola (root) extract pairs useful collection fit with a lower serving cost, creating a balanced quality-to-cost trade-off. Its supplied analyses show good alignment with the stated productivity boost goal, though the available data do not document certification or testing.
68 Value

Stress Remedy

Pure Synergy
A clearly listed 600.00mg of SuperPure Ashwagandha root extract pairs useful collection fit with a lower serving cost, creating a balanced quality-to-cost trade-off. Its supplied analyses show good alignment with the stated general health goal, though the available data do not document certification or testing.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsCognitive Support Mental Focus forAshwagandha
  2. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsCognitive Support Energy forAshwagandha
  3. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive Support Mental Focus forAshwagandha
  4. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsCognitive Support Mental Focus forAshwagandha
  5. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsCognitive Support forAshwagandha
  6. No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
    Schaffler K; Wolf OT; Burkart M · Pharmacopsychiatry · 2014
    Randomized trial144 participantsCognitive Support Mental Focus forEleuthero
  7. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewCognitive Support Mental Focus forRhodiola Energy Mental Focus forEleuthero
  8. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsCognitive Support forRhodiola
  9. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  10. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledCognitive Support forRhodiola
  11. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsCognitive Support forRhodiola
  12. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsEnergy forAshwagandha
  13. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy forAshwagandha
  14. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy forAshwagandha
  15. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsEnergy forAshwagandha
  16. Randomized controlled trial of Siberian ginseng for chronic fatigue.
    Hartz AJ; Bentler S; Noyes R; Hoehns J; Logemann C; Sinift S; Butani Y; Wang W; Brake K; Ernst M; Kautzman H · Psychological medicine · 2004
    Randomized trial96 participantsEnergy forEleuthero
  17. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
    J Kuo, K W Chen, I S Cheng, P H Tsai, Y J Lu, N Y Lee · Chinese Journal of Physiology · 2010
    Randomized trial9 participantsEnergy forEleuthero
  18. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  19. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy Mental Focus forRhodiola
  20. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  21. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsEnergy forRhodiola
  22. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  23. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  24. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  25. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  26. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  27. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  28. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.
    Choudhary D; Bhattacharyya S; Bose S · Journal of dietary supplements · 2018
    Randomized trial50 participantsMental Focus forAshwagandha
  29. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsMental Focus forAshwagandha
  30. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.
    Panossian A; Wagner H · Phytotherapy research : PTR · 2005
    Narrative reviewMental Focus forEleuthero
  31. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
    Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Systematic review11 studies pooledMental Focus forRhodiola
  32. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsMental Focus forRhodiola
  33. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsMental Focus forRhodiola