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FemGuard + Balance

Designs for Health
4.8
★ ★ ★ ★ ★
(85 ratings)
Rosemary
Vitamin B12 400 mcg
Vitamin B6 30 mg
Resveratrol 20 mg
Folate 400 mcg
Green Tea 100 mg
Turmeric 50 mg
Product Image
Score66
A broad hormone-focused blend with useful B vitamins and several relevant botanicals, but many supporting ingredients are light or incompletely disclosed. The four-capsule serving and multiple safety considerations narrow its audience.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:

Score 66

A broad hormone-focused blend with useful B vitamins and several relevant botanicals, but many supporting ingredients are light or incompletely disclosed. The four-capsule serving and multiple safety considerations narrow its audience.
How scoring works
$65.49($2.18 per serving)
iHerb
$ 65.49
Pure Formulas
$ 65.49
Report prices

Analysis

The formula is chiefly designed around estrogen metabolism and menopausal support, using calcium D-glucarate, diindolylmethane, black cohosh, chaste tree, and several antioxidant botanicals. Methylcobalamin and folate add useful nutritional support, but the blend is much less convincing for broad goals such as heart health, hair, or mental focus.

Vitamin B6 is supplied at a substantial amount, while magnesium, turmeric, resveratrol, and several other actives are modest for targeted use. Some extracts name marker compounds, yet missing standardization percentages and an unspecified folate form make potency and bioavailability harder to judge.

A four-capsule serving may suit adults seeking a broad hormone-focused formula and comfortable managing a complex ingredient list. It is a poor match for pregnancy, hormone-sensitive conditions, liver concerns, or anyone wanting a simple multivitamin or a focused single-ingredient supplement.

Who is it for
  • Adults seeking broad nutritional and botanical support around hormonal transitions
  • People who prefer a multi-pathway formula over separate supplements
Best for
  • Hormone-focused botanical support
  • Combining B vitamins with estrogen-metabolism ingredients

Pros

  • Uses methylcobalamin as the vitamin B12 form
  • Includes meaningful calcium D-glucarate and phosphatidylcholine amounts
  • Names several botanical marker compounds
  • Covers multiple hormone-related pathways

Cons

  • Requires four capsules per serving
  • Folate form is not disclosed
  • Many botanicals are modest for focused use
  • Caffeine content from green tea is not stated
  • Complex formula makes individual tolerance harder to assess

Warnings

  • Vitamin B6 at 30 mg may raise the risk of nerve symptoms with prolonged daily use, especially when combined with other B6 supplements.
  • Black cohosh may not suit people with liver disease, and new liver-related symptoms warrant stopping use.
  • Black cohosh and chaste tree may be unsuitable during pregnancy or with hormone-sensitive conditions or treatments.
  • Chaste tree may interact with dopamine-related medicines, while undisclosed caffeine from green tea may affect sleep or cause jitteriness.

Nutrient quality

65 High impact

Several bioactive forms strengthen the formula, but many botanicals are too lightly dosed for focused use. The daily vitamin B6 amount also deserves care during prolonged use.

Ingredient transparency

77 High impact

Nearly every active has a stated amount, which makes the complex formula unusually easy to inspect. Folate form, usage detail, and inactive ingredients remain incompletely disclosed.

Customer satisfaction

66 High impact

The aggregate rating is strong, but the feedback volume is only moderate. No detailed comments are supplied to show recurring benefits or complaints.

Value for money

53 Moderate impact

The broad active panel partly supports the premium positioning. Many modest doses and the high serving cost weaken practical value.

Report analysis

Goals

General Health
Daily Energy Vitality
General Health
Impact
Moderate effect
C Goal FitC+ Strength of SupportC CoverageC Formula Quality
Folate · 400 mcgVitamin B12 · 400 mcgMagnesium · 50 mg

Methylcobalamin and a routine folate amount provide some foundational micronutrient support. The broader formula is centered on female hormone-related botanicals rather than general nutritional coverage.

Several specialized compounds are present at modest amounts, and the folate blend does not reveal its chemical form. The product may fit its narrower intended use, but it is not a balanced general-health supplement.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Mood Support
Mood Support
Impact
Moderate effect
D+ Goal FitC Strength of SupportC CoverageC- Formula Quality
Folate · 400 mcgVitamin B6 · 30 mgVitamin B12 · 400 mcgMagnesium · 50 mg

B vitamins, chaste tree, and black cohosh may support mood when symptoms track hormonal changes. The formula is primarily designed for hormone metabolism and menopausal support rather than general mood regulation.

B6 is meaningfully dosed, while magnesium and many antioxidant botanicals are modest for mood use. Black cohosh warrants care with liver disease, and chaste tree may conflict with dopamine-related or hormone-sensitive treatments.

Study evidence
Folate Supportive 84 studies
Magnesium Supportive 60 studies
Vitamin B12 Supportive 29 studies
Vitamin B6 Supportive 19 studies
Energy
Essential Energy Nutrients
Energy
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD+ CoverageC- Formula Quality
Magnesium · 50 mgVitamin B12 · 400 mcg

Methylcobalamin and vitamin B6 offer some metabolic support within a hormone-focused botanical formula. Green tea extract could influence alertness, but its caffeine content is not stated.

Most of the formula targets estrogen metabolism and menopausal balance rather than energy, and magnesium is modest. Vitamin B6 at 30 mg may raise nerve-toxicity concerns with prolonged daily exposure, especially when combined with other B6 sources.

Study evidence
Magnesium Supportive 4 studies
Vitamin B12 Disputed 14 studies
Heart Health
Heart Health
Impact
Moderate effect
C- Goal FitC- Strength of SupportC- CoverageD+ Formula Quality
Magnesium · 50 mgVitamin B12 · 400 mcgVitamin B6 · 30 mgGreen Tea · 100 mgFolate · 400 mcg

B vitamins, folate, magnesium, green tea, and resveratrol touch homocysteine, vascular, and antioxidant pathways. Methylcobalamin and standardized botanical markers improve parts of the formula.

Magnesium and resveratrol are far below focused cardiovascular amounts, while the botanical stack is primarily designed for hormonal balance. Many ingredients broaden the label without providing strong heart-specific potency.

Study evidence
Folate Supportive 116 studies
Green Tea Supportive 84 studies
Magnesium Supportive 158 studies
Resveratrol Supportive 66 studies
Vitamin B12 No effect 42 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
D+ Goal FitC- Strength of SupportC- CoverageF Formula Quality
Magnesium · 50 mgVitamin B12 · 400 mcgVitamin B6 · 30 mgFolate · 400 mcg

B6, folate, B12, green tea, resveratrol, turmeric, and grape seed provide homocysteine and antioxidant connections. The hormone-balance formula does not supply cardiovascular doses of most botanicals and lacks omega-3s, magnesium, CoQ10, or nitric-oxide actives.

Methylcobalamin is a strong form and several botanical standards are disclosed. The four-capsule blend remains better suited to hormone support than cardiovascular use.

Study evidence
Folate Supportive 93 studies
Green Tea Supportive 95 studies
Magnesium Supportive 123 studies
Resveratrol Supportive 73 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Vitamin B6
30 mg
NatureFolate Blend
400 mcg
Vitamin B12 (Methylcobalamin)
 400 mcg
Calcium (Calcium D-Glucarate, DimaCal Di-Calcium Malate, TRAACS(R) Calcium Glycinate Chelate)
 124 mg
Magnesium (DiMagnesium Malate, TRAACS Magnesium Glycinate Chelate buffered)
 50 mg
Calcium D-Glucarate
200 mg
Phosphatidylcholine (Soy Lecithin)
 200 mg
Chrysin
200 mg
Green Tea Extract (EGCG, Polyphenols)
 100 mg
BroccoRaphanin(R) (Sulforaphane Glucosinolate)
 100 mg
Diindolylmethane
100 mg
Black Cohosh extract (Triterpene Glycosides)
 100 mg
Chaste Tree extract (agnusides)
 100 mg
Turmeric (Curcuminoids)
 50 mg
Rosemary Extract (Carnosic Acid)
 50 mg
Trans Resveratrol
20 mg
Grape seed extract (Proanthocyanidins)
 25 mg
Gluten Free Adults 18–50
Report overview
Rosemary (Carnosic Acid) · 50 mg OverallScore67
C- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

The 50 mg rosemary extract meets the stated threshold for a multi-ingredient blend and identifies carnosic acid as its form. The label does not disclose a standardization percentage, extraction method, or plant part, which limits confidence in active strength. A broad set of other quantified actives adds formula value, but the high serving cost makes it inefficient for rosemary-focused use.

View ingredientView products
Vitamin B12 (Methylcobalamin) · 400 mcg OverallScore62
A- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

Bioactive methylcobalamin is clearly identified, while the swallowed capsule provides standard rather than optimized absorption. The 400 mcg amount provides moderate potency but remains below a high-need level. Cost per active amount remains unfavorable despite use of the preferred form.

View ingredientView products
Vitamin B6 · 30 mg OverallScore54
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

The B6 amount is well aligned with the preferred range, but its chemical form is not disclosed. A four-capsule serving reduces practicality and makes the label less useful for comparing bioavailability. The comprehensive formula carries a premium serving cost.

View ingredientView products
Loading alternative details
82 Performance

BioActive Vitamin B

Terry Naturally
<p>P-5-P, methylcobalamin, and methylfolate provide clearer active B-vitamin forms than the original, whose B6 and folate details are incomplete. The compact formula removes the botanical hormone-support ingredients, so its advantage is nutrient quality rather than comparable breadth.</p>
77 Performance

Telomeron

Source Naturals
<p>Substantial turmeric, green tea, and trans-resveratrol amounts provide deeper antioxidant coverage than the original’s modest botanical doses. NAC, carnosine, and astragalus broaden the formula, but DIM, calcium D-glucarate, black cohosh, chaste tree, and active folate are absent.</p>
82 Performance

EstroSense

Natural Factors WS WomenSense
<p>DIM, indole-3-carbinol, calcium D-glucarate, green tea, turmeric, milk thistle, rosemary, and sulforaphane create a more focused hormone-metabolism blend. It omits the original’s B vitamins, black cohosh, chaste tree, and resveratrol, while several extract details remain incomplete.</p>
73 Budget

Kyolic B6 B12 Folic Acid & L-Argininge

Kyolic
<p>The lower serving cost retains vitamin B6, folate, and B12 while adding aged garlic and arginine for cardiovascular support. It drops the original’s DIM, calcium D-glucarate, black cohosh, chaste tree, green tea, turmeric, rosemary, and resveratrol, so it is not a close hormone-balance replacement.</p>
74 Budget

D-Flame

NOW
<p>Turmeric, green tea, resveratrol, ginger, holy basil, and boswellia preserve part of the original’s botanical and antioxidant focus at a lower serving cost. It lacks the B vitamins, DIM, calcium D-glucarate, black cohosh, and chaste tree that make the original more hormone focused.</p>
75 Budget

AndroSense T-Correct

Natural Factors
<p>DIM, indole-3-carbinol, calcium D-glucarate, green tea, turmeric, milk thistle, rosemary, and sulforaphane closely match the original’s hormone-metabolism strategy at a lower serving cost. The formula is marketed for a different population and omits the original’s active B12, folate, black cohosh, chaste tree, and resveratrol.</p>
82 Value

BioActive Vitamin B

Terry Naturally
<p>Active B6, B12, and folate provide high form quality with strong serving value and a much simpler label. It does not cover the original’s hormone-focused botanicals, and the vitamin B6 amount may still be more than many users need long term.</p>
81 Value

EstroSense

Natural Factors WS WomenSense
<p>The focused combination of DIM, indole-3-carbinol, calcium D-glucarate, green tea, turmeric, milk thistle, and rosemary matches much of the original’s core strategy with better practical value. Missing B vitamins, black cohosh, chaste tree, and resveratrol narrow the coverage.</p>
74 Value

D-Flame

NOW
<p>A readable botanical blend supplies turmeric, green tea, resveratrol, ginger, holy basil, and boswellia at a lower serving cost. The formula is broader for inflammatory support but less aligned with hormone balance because it lacks DIM, calcium D-glucarate, black cohosh, and chaste tree.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  2. Nonlinear associations of serum cobalamin with risk of all-cause and cardiovascular mortality in hypertensive adults.
    Zhu X; Tang Y; Cheang I; Gao R; Liao S; Yao W; Zhou Y; Zhang H; Li X · Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Cohort study9,934 participantsHeart Health forVitamin B12
  3. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  4. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
    Bennett DA; Parish S; Millwood IY; Guo Y; Chen Y; Turnbull I; Yang L; Lv J; Yu C; Davey Smith G; Wang Y; Wang Y; Peto R; Collins R; Walters RG; Li L; Chen Z; Clarke R; China Kadoorie Biobank (CKB) Study Collaborative Group · International journal of epidemiology · 2023
    Cohort study156,253 participantsHeart Health forFolate
  5. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsMental Focus forVitamin B12
  6. Child plasma vitamin B12 concentrations and executive functions at age 7-11 years: the GUSTO study.
    Loh J; Chan SY; Toh JY; Tan KML; Godfrey KM; Yap F; Chong YS; Eriksson JG; Chong MFF; Tan AP; Law E; Lai JS · European journal of nutrition · 2025
    Cohort study304 participantsMental Focus forVitamin B12
  7. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsMental Focus forFolate
  8. Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
    Surman C; Ceranoglu A; Vaudreuil C; Albright B; Uchida M; Yule A; Spencer A; Boland H; Grossman R; Rhodewalt L; Fitzgerald M; Biederman J · Journal of clinical psychopharmacology · 2019
    Randomized trial44 participantsMental Focus forFolate
  9. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  10. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
    Karakoyun Ö; Ayhan E; Yıldız İ · Journal of cosmetic dermatology · 2025
    Cohort study2,851 participantsHair Health forVitamin B12
  11. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  12. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  13. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  14. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  15. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  16. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  17. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  18. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.
    Nagao T; Hase T; Tokimitsu I · Obesity (Silver Spring, Md.) · 2007
    Randomized trial240 participantsCardiovascular Support forGreen Tea
  19. The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis.
    Zamani M; Kelishadi MR; Ashtary-Larky D; Amirani N; Goudarzi K; Torki IA; Bagheri R; Ghanavati M; Asbaghi O · Frontiers in nutrition · 2023
    Meta-analysis55 studies pooledCardiovascular Support forGreen Tea
  20. Effect of Green Tea on Blood Pressure in Healthy Individuals: A Meta-Analysis.
    Yıldırım Ayaz E; Dincer B; Mesci B · Alternative therapies in health and medicine · 2023
    Meta-analysis680 participants9 studies pooledCardiovascular Support Heart Health forGreen Tea
  21. Effects of green tea on lipid profile in overweight and obese women.
    Li A; Wang Q; Li P; Zhao N; Liang Z · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2024
    Meta-analysis1,818 participants15 studies pooledCardiovascular Support Heart Health forGreen Tea
  22. Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis.
    Pang J; Zhang Z; Zheng TZ; Bassig BA; Mao C; Liu X; Zhu Y; Shi K; Ge J; Yang YJ; Dejia-Huang; Bai M; Peng Y · International journal of cardiology · 2016
    Meta-analysis259,267 participants9 studies pooledCardiovascular Support forGreen Tea
  23. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  24. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  25. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  26. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  27. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  28. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; García-Almagro FJ; Avilés-Plaza F; Parra S; Yáñez-Gascón MJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · Molecular nutrition & food research · 2012
    Randomized trial75 participantsCardiovascular Support forResveratrol
  29. Resveratrol improves lipid profile and recovers heart function in postoperative CABG patients.
    Ahmadi P; Akbarzadeh S; Alizadeh M; Mohammadi N; Mahmoodi M; Amini A; Netticadan T; Rezaei M; Movahed A · Molecular and cellular biochemistry · 2025
    Randomized trial60 participantsCardiovascular Support forResveratrol
  30. Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases.
    Shen CY; Li CP; Yu JT; Ho YJ; Tsai RY · In vivo (Athens, Greece) · 2026
    Meta-analysis2,551 participants40 studies pooledCardiovascular Support forResveratrol
  31. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.
    Wong RH; Berry NM; Coates AM; Buckley JD; Bryan J; Kunz I; Howe PR · Journal of hypertension · 2014
    Randomized trial28 participantsCardiovascular Support Heart Health forResveratrol
  32. Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.
    Simental-Mendía LE; Guerrero-Romero F · Nutrition (Burbank, Los Angeles County, Calif.) · 2020
    Randomized trial71 participantsCardiovascular Support forResveratrol
  33. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  34. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  35. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  36. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  37. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  38. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  39. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  40. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  41. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  42. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  43. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  44. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  45. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  46. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  47. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  48. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  49. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  50. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  51. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  52. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  53. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  54. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  55. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  56. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  57. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  58. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  59. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  60. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  61. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  62. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  63. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate
  64. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  65. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  66. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials.
    Khalesi S; Sun J; Buys N; Jamshidi A; Nikbakht-Nasrabadi E; Khosravi-Boroujeni H · European journal of nutrition · 2015
    Meta-analysis13 studies pooledHeart Health forGreen Tea
  67. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.
    Bogdanski P; Suliburska J; Szulinska M; Stepien M; Pupek-Musialik D; Jablecka A · Nutrition research (New York, N.Y.) · 2012
    Randomized trial56 participantsHeart Health forGreen Tea
  68. Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials.
    Zheng XX; Xu YL; Li SH; Liu XX; Hui R; Huang XH · The American journal of clinical nutrition · 2011
    Meta-analysis1,136 participants14 studies pooledHeart Health forGreen Tea
  69. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  70. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  71. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  72. A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy.
    Nyambuya TM; Nkambule BB; Mazibuko-Mbeje SE; Mxinwa V; Mokgalaboni K; Orlando P; Silvestri S; Louw J; Tiano L; Dludla PV · Molecules (Basel, Switzerland) · 2021
    Meta-analysis388 participants5 studies pooledHeart Health forResveratrol
  73. Resveratrol Improves Heart Function by Moderating Inflammatory Processes in Patients with Systolic Heart Failure.
    Gal R; Deres L; Horvath O; Eros K; Sandor B; Urban P; Soos S; Marton Z; Sumegi B; Toth K; Habon T; Halmosi R · Antioxidants (Basel, Switzerland) · 2024
    Randomized trial60 participantsHeart Health forResveratrol
  74. Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus.
    Wong RH; Nealon RS; Scholey A; Howe PR · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial36 participantsHeart Health forResveratrol
  75. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment.
    Fujitaka K; Otani H; Jo F; Jo H; Nomura E; Iwasaki M; Nishikawa M; Iwasaka T; Das DK · Nutrition research (New York, N.Y.) · 2012
    Randomized trial34 participantsHeart Health forResveratrol
  76. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  77. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  78. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  79. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.
    Firth J; Teasdale SB; Allott K; Siskind D; Marx W; Cotter J; Veronese N; Schuch F; Smith L; Solmi M; Carvalho AF; Vancampfort D; Berk M; Stubbs B; Sarris J · World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Systematic review10,951 participants33 studies pooledMood Support forFolate
  80. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis.
    Jin X; Cheng Z; Yu X; Tao Q; Huang R; Wang S · Journal of affective disorders · 2022
    Meta-analysis26,275 participants15 studies pooledMood Support forFolate
  81. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forFolate Mood Support forVitamin B12
  82. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
    Gao S; Khalid A; Amini-Salehi E; Radkhah N; Jamilian P; Badpeyma M; Zarezadeh M · Food science & nutrition · 2024
    Meta-analysis11 studies pooledMood Support forFolate
  83. Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.
    Passeri M; Cucinotta D; Abate G; Senin U; Ventura A; Stramba Badiale M; Diana R; La Greca P; Le Grazie C · Aging (Milan, Italy) · 1993
    Randomized trial96 participantsMood Support forFolate
  84. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  85. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support forMagnesium
  86. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  87. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  88. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  89. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
    Cohort study391 participantsMood Support forVitamin B12
  90. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Arija V · Journal of reproductive and infant psychology · 2025
    Cohort study336 participantsMood Support forVitamin B12
  91. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
    Soriano-Gonzalez R; Ramirez-Olea H; Gonzalez-Soltero R; Chavez-Santoscoy RA · Frontiers in nutrition · 2025
    Systematic review24 studies pooledMood Support forVitamin B12
  92. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  93. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  94. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  95. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  96. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6