Product Image

Choline Cocktail

Twinlab
4.4
★ ★ ★ ★ ★
(31 ratings)
Vitamin E 400 IU
Deanol 100 mg
Vitamin A 11000 IU
Ginkgo
Guarana
L-Carnitine 100 mg
Product Image
Score59
A choline-heavy energy and focus blend with broad vitamin support, but uncertain caffeine exposure and several underdosed secondary actives reduce precision.
How scoring works
Quantity:13 Liquid(s) • (9 servings)
Goals:
Energy

Score 59

A choline-heavy energy and focus blend with broad vitamin support, but uncertain caffeine exposure and several underdosed secondary actives reduce precision.
How scoring works
$26.39($2.93 per serving)
Pure Formulas
$ 26.39
Pure Formulas
$ 26.39
iHerb
$ 32.99
Vitacost
$ 35.43
Report prices

Analysis

Choline at 1,500 mg anchors the formula and is joined by guarana, ginkgo, DMAE, and B vitamins for alertness and cognitive support. Vitamin C and natural-form vitamin E add meaningful antioxidant coverage.

The supporting actives are uneven: carnitine and CoQ10 are low, while ginkgo standardization and guarana caffeine yield are not stated. That makes both expected potency and stimulant exposure harder to judge.

A four-tablespoon serving supplies 32 g of carbohydrate and 7 g of sugar, which may not fit people seeking a lean supplement. It suits users who want a broad, stimulating liquid more than those seeking a focused choline, ginkgo, or carnitine product.

Who is it for
  • Adults seeking a stimulating liquid for alertness
  • People who want choline plus broad vitamin support
  • Users comfortable with a large sweetened serving
Best for
  • Short-term energy support
  • Choline intake
  • Broad antioxidant coverage

Pros

  • Provides 1,500 mg choline
  • Includes substantial vitamin C and natural vitamin E
  • Covers several alertness and cognitive pathways
  • Clearly lists most ingredient amounts

Cons

  • Guarana caffeine yield is not disclosed
  • Carnitine and CoQ10 amounts are modest
  • Large serving contains 32 g carbohydrate
  • Poor value for several targeted ingredients

Warnings

  • The 750 mg guarana extract has an unknown caffeine yield and may cause jitteriness, sleep disruption, or a faster heartbeat
  • Ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines
  • Concentrated beta-carotene may be unsuitable for current or former smokers

Nutrient quality

59 Moderate impact

A substantial choline dose is the clearest strength, with guarana and ginkgo supporting the intended use. High fat-soluble vitamin amounts and several modest add-ons make the formula less balanced.

.

Ingredient transparency

70 High impact

The main active amounts are generally available and no broad proprietary blend obscures the formula. Complete usage directions and non-active ingredients are not supplied, while any noted duplicate or vague entries reduce clarity.

.

Customer satisfaction

60 Moderate impact

Aggregate satisfaction is strong but comes from a fairly limited evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment cannot be checked.

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Value for money

44 Lower impact

The substantial choline dose adds value, but the bottle provides few servings. Several low-impact additions and aggressive vitamin amounts reduce the quality received for the cost.

.
Report analysis

Goals

Energy
Mental AlertnessEssential Energy Nutrients
Energy
Impact
High effect
B Goal FitC Strength of SupportB CoverageC+ Formula Quality
Vitamin B5 · 100 mgRiboflavin · 1.9 mgThiamin · 1.5 mgVitamin B12 · 1000 mcgCoenzyme Q-10 · 15 mg

Guarana, 1,000 mcg vitamin B12, choline, a broad vitamin base, and carbohydrate provide several plausible routes to short-term and metabolic energy. The 750 mg guarana amount could be strongly stimulating, but its caffeine yield is not stated.

Choline is substantial, while carnitine and CoQ10 are too modest to carry mitochondrial support. People sensitive to caffeine should treat the unknown stimulant exposure cautiously because it may cause jitteriness, sleep disruption, or a faster heartbeat.

Study evidence
Guarana No effect 8 studies
Cognitive Support
Mental Energy
Cognitive Support
Impact
Moderate effect
C+ Goal FitC- Strength of SupportB- CoverageC- Formula Quality
Choline · 1500 mgThiamin · 1.5 mgVitamin B6 · 2 mgFolate · 400 mcgVitamin B12 · 1000 mcg

Choline, guarana, ginkgo, and DMAE give the formula several direct cognitive mechanisms. Choline and stimulant alertness have credible support, while evidence for DMAE and the exact combination is weaker.

Choline is substantial, but ginkgo and DMAE are modest and guarana caffeine yield is unknown. Neurotransmitter support, alertness, circulation, and cellular energy are represented.

Study evidence
Choline Supportive 76 studies
Deanol No effect 2 studies
Ginkgo Supportive 87 studies
Guarana Supportive 11 studies
Skin Health
Skin Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC+ CoverageD- Formula Quality
Vitamin C · 1000 mgVitamin E · 400 IU

Vitamin A, vitamin C, and natural vitamin E provide relevant support for skin renewal, collagen production, and antioxidant defense. Coenzyme Q10 is present only in a small amount, while most of the formula targets energy and general nutrition.

The clearly stated vitamin doses make its useful contributions easy to judge. A broad stimulant-heavy blend and substantial sugar keep it from being a focused skin formula.

Study evidence
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Anti-Inflammatory Support
Cellular Defense
Anti-Inflammatory Support
Impact
Moderate effect
D Goal FitB- Strength of SupportD+ CoverageC+ Formula Quality
Coenzyme Q-10 · 15 mgVitamin E · 400 IUVitamin C · 1000 mg

Vitamin C and natural-form vitamin E provide complementary antioxidant support that may help moderate oxidative inflammatory signaling. The formula does not contain a direct pathway-targeting botanical or omega-3 fatty acid.

Both vitamins are supplied at substantial amounts, although vitamin E lacks mixed tocopherols and tocotrienols. It is a focused antioxidant product with only indirect anti-inflammatory reach.

Study evidence
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Cardiovascular Support
Arterial Integrity and Protection
Cardiovascular Support
Impact
Moderate effect
C- Goal FitD+ Strength of SupportD+ CoverageD Formula Quality
Coenzyme Q-10 · 15 mgL-Carnitine · 100 mgVitamin B12 · 1000 mcgVitamin B6 · 2 mgVitamin E · 400 IUFolate · 400 mcgNiacin · 20 mgVitamin C · 1000 mg

Vitamin E, vitamin C, B vitamins, choline, carnitine, and CoQ10 create several cardiovascular links. The strongest heart-energy actives are present only in small amounts, while guarana shifts the formula toward stimulation.

Natural vitamin E and substantial vitamin C support antioxidant defense, but carnitine and CoQ10 are underdosed for targeted use. Guarana can raise heart rate or blood pressure in caffeine-sensitive users and may not suit people with rhythm concerns.

Study evidence
L-Carnitine Supportive 73 studies
Vitamin C Supportive 101 studies
Vitamin E Mixed 79 studies

Ingredients

IngredientAmount per serving
Calories
130 {Calories}
Total Carbohydrates
32 g
Sugar
7 g
Vitamin A (Beta-Carotene)
 11000 IU
Vitamin C (Ascorbic Acid)
 1000 mg
Vitamin E (D-Alpha-Tocopheryl Acetate)
 400 IU
Thiamine (Thiamine Mononitrate)
 1.5 mg
Riboflavin
1.9 mg
Niacin (Niacinamide)
 20 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
Folic Acid
400 mcg
Vitamin B12 (Cyanocobalamin)
 1000 mcg
Biotin
300 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 100 mg
Chromium (Chromium Picolinate)
 100 mcg
Choline (Choline Dihydrogen Citrate)
 1500 mg
Guarana Seed Extract
750 mg
DMAE (2-Dimethylaminoethanol Bitartrate)
 100 mg
L-Carnitine
100 mg
Ginkgo biloba leaf extract (Ginkgo Flavone Glycosides, Terpene Lactones)
 60 mg
Co-Enzyme Q10
15 mg
Adults 18–50
Report overview
Vitamin E (D-Alpha-Tocopheryl Acetate) · 400 IU OverallScore63
D Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

Natural d-alpha-tocopheryl acetate provides a well-absorbed form at the top of the preferred range. The formula contains neither mixed tocopherols nor tocotrienols, so vitamin E diversity is limited. Its serving cost is high for an alpha-only formula.

View ingredientView products
Deanol (2-Dimethylaminoethanol Bitartrate) · 100 mg OverallScore62
B- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyC Value

DMAE bitartrate is explicitly identified, but only the total salt weight is given and the active Deanol yield must be estimated. The calculated 37 mg active amount is modest, while the four-tablespoon liquid serving is relatively cumbersome. No Deanol-specific safety warning appears in the supplied data, and value is neutral because DMAE is secondary within a broad formula.

View ingredientView products
Vitamin A (Beta-Carotene) · 11000 IU OverallScore55
D+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

The vitamin A form provides only moderate quality assurance. Absorption depends largely on taking the product with dietary fat. The low dose and weak cost efficiency limit its fit for focused vitamin A use.

View ingredientView products
Loading alternative details
75 Performance

Brain Cell Support

Metabolic Maintenance
<p>A more coherent cognitive formula combines citicoline, acetyl-L-carnitine, phosphatidylserine, DMAE, ginkgo, and gotu kola at clearly listed amounts. Its serving value is weaker, but the ingredient profile is more directly aligned with cognitive support and avoids guarana.</p>
73 Performance

Skin Eternal

Source Naturals
<p>A focused antioxidant and skin-support blend uses vitamin C, natural-form vitamin E, alpha-lipoic acid, grape-seed extract, and DMAE. It offers much less energy and cognitive breadth, but its disclosed formula is more balanced for skin and antioxidant goals.</p>
66 Performance

Only One Liquid-Gel Multi

Irwin Naturals
<p>A broad multivitamin provides vitamin D3, methylcobalamin, selenium, chelated iron, and a wide nutrient base without the original’s high sugar and guarana. Magnesium and zinc use less desirable oxide forms, and the small proprietary blends remain difficult to assess.</p>
71 Budget

Norwegian Cod Liver Oil 1000 mg Fresh Orange Flavor

AN Amazing Nutrition Amazing Omega
<p>A very economical serving supplies vitamins A, D, and E from a short ingredient list. It does not replace the original’s choline, ginkgo, guarana, or B-vitamin coverage, so it fits only when fat-soluble vitamins are the priority.</p>
73 Budget

Flintstones Gummies + Immunity Support

Bayer
<p>A low-cost vitamin gummy avoids the original’s added guarana and unusually high choline dose while covering vitamins A, C, D, E, and several B vitamins. The formula is designed as basic children’s nutrition and does not provide targeted cognitive ingredients.</p>
78 Budget

Eye Wellness With Zeaxanthin

Bio Nutrition
<p>A lower-cost serving gives a more focused mix of ginkgo, lutein, zeaxanthin, taurine, and vitamin A for vision support. It omits choline and most B vitamins, so the trade-off is narrower coverage rather than a direct replacement.</p>
70 Value

Poly-Vi-Sol

Enfamil
<p>A simple liquid vitamin formula offers a long supply and strong serving value with clearly listed amounts. It lacks minerals, choline, ginkgo, and other cognitive ingredients, so it suits basic vitamin coverage rather than the original’s main purpose.</p>
59 Value

Daily Total One

Country Life
<p>A broad vitamin-and-mineral profile adds methylcobalamin, active vitamin B6 and riboflavin forms, selenium, and natural-form vitamin E at favorable serving value. Several nutrients appear more than once in the supplied data, and some totals may be high or ambiguous.</p>
58 Value

Premium Adult Multi-Vitamin Mineral

Tropical Oasis
<p>A lower-cost liquid multi keeps broad vitamin coverage and includes methylcobalamin with modest iron. Vitamin D2, conventional folic acid, and an undisclosed herbal blend limit the quality advantage, while cognitive ingredients are largely absent.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary supplements and fatigue in patients with breast cancer: a systematic review.
    Pereira PTVT; Reis AD; Diniz RR; Lima FA; Leite RD; da Silva MCP; Guerra RNM; de Moraes Vieira ÉB; Garcia JBS · Breast cancer research and treatment · 2019
    Systematic review932 participants8 studies pooledEnergy forGuarana
  2. Purified dry extract of Paullinia cupana (guaraná) (PC-18) for chemotherapy-related fatigue in patients with solid tumors: an early discontinuation study.
    del Giglio AB; Cubero Dde I; Lerner TG; Guariento RT; de Azevedo RG; Paiva H; Goldman C; Carelli B; Cruz FM; Schindler F; Pianowski L; de Matos LL; del Giglio A · Journal of dietary supplements · 2014
    Randomized trial40 participantsEnergy forGuarana
  3. Effects of Acute Guarana (Paullinia cupana) Ingestion on Mental Performance and Vagal Modulation Compared to a Low Dose of Caffeine.
    Talik TN; Penna EM; Hack BP; Harp A; Millard-Stafford M · Nutrients · 2024
    Randomized trial20 participantsCognitive Support Energy forGuarana
  4. Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
    von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
    Meta-analysis1,628 participants4 studies pooledCognitive Support forGinkgo
  5. Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
    Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
    Meta-analysis782 participants4 studies pooledCognitive Support forGinkgo
  6. Ginkgo biloba for cognitive impairment and dementia.
    Wieland LS; Ludeman E; Chi Y; Feinberg TM; Chen IH; Chen KH; Zhu Y; Wolverson E; Amri H · The Cochrane database of systematic reviews · 2026
    Meta-analysis10,613 participants82 studies pooledCognitive Support forGinkgo
  7. Ginkgo biloba Extract (EGb761), Cholinesterase Inhibitors, and Memantine for the Treatment of Mild-to-Moderate Alzheimer's Disease: A Network Meta-Analysis.
    Thancharoen O; Limwattananon C; Waleekhachonloet O; Rattanachotphanit T; Limwattananon P; Limpawattana P · Drugs & aging · 2019
    Meta-analysisCognitive Support forGinkgo
  8. The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
    Feng X; Fan S; Wei F · Frontiers in pharmacology · 2026
    Meta-analysis1,861 participants25 studies pooledCognitive Support forGuarana
  9. Cognitive effects of guarana supplementation with maximal intensity cycling.
    Gurney T; Bradley N; Izquierdo D; Ronca F · The British journal of nutrition · 2023
    Randomized trial25 participantsCognitive Support forGuarana
  10. Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis.
    Hack B; Penna EM; Talik T; Chandrashekhar R; Millard-Stafford M · Nutrients · 2023
    Meta-analysis328 participants8 studies pooledCognitive Support forGuarana
  11. Senile dementia: treatment with deanol.
    Ferris SH; Sathananthan G; Gershon S; Clark C · Journal of the American Geriatrics Society · 1977
    Single-arm trial14 participantsCognitive Support forDeanol
  12. The Effects of L-Carnitine on Echocardiographic Changes in Patients With β-Thalassemia Major and Intermedia.
    Shahidi M; Hashemi SR; Fattahi N; Roshani D; Vahedi S; Sharifi P; Moradveisi B · Journal of pediatric hematology/oncology · 2020
    Randomized trial60 participantsCardiovascular Support forL-Carnitine
  13. L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Choi M; Park S; Lee M · Nutrients · 2021
    Meta-analysis9 studies pooledCardiovascular Support forL-Carnitine
  14. The Effects of L-Carnitine Supplementation on Serum Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Fathizadeh H; Milajerdi A; Reiner Ž; Kolahdooz F; Chamani M; Amirani E; Asemi Z · Current pharmaceutical design · 2020
    Meta-analysis67 studies pooledCardiovascular Support forL-Carnitine
  15. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis.
    Shang R; Sun Z; Li H · BMC cardiovascular disorders · 2015
    Meta-analysis3,108 participants5 studies pooledCardiovascular Support forL-Carnitine
  16. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
    Koeth RA; Wang Z; Levison BS; Buffa JA; Org E; Sheehy BT; Britt EB; Fu X; Wu Y; Li L; Smith JD; DiDonato JA; Chen J; Li H; Wu GD; Lewis JD; Warrier M; Brown JM; Krauss RM; Tang WH; Bushman FD; Lusis AJ; Hazen SL · Nature medicine · 2013
    Other2,595 participantsCardiovascular Support forL-Carnitine
  17. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  18. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  19. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  20. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  21. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  22. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  23. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  24. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  25. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  26. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  27. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes.
    Malaguarnera M; Vacante M; Avitabile T; Malaguarnera M; Cammalleri L; Motta M · The American journal of clinical nutrition · 2009
    Randomized trial81 participantsCardiovascular Support forL-Carnitine
  28. The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-response Meta-Analysis of Randomized Controlled Trials.
    Mirrafiei A; Jayedi A; Shab-Bidar S · Clinical therapeutics · 2024
    Meta-analysis2,041 participants21 studies pooledCardiovascular Support forL-Carnitine
  29. Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus.
    Solfrizzi V; Capurso C; Colacicco AM; D'Introno A; Fontana C; Capurso SA; Torres F; Gadaleta AM; Koverech A; Capurso A; Panza F · Atherosclerosis · 2007
    Randomized trial52 participantsCardiovascular Support forL-Carnitine
  30. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  31. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  32. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  33. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  34. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  35. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  36. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  37. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  38. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  39. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  40. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  41. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  42. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  43. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  44. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  45. Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies.
    Blin O; Audebert C; Pitel S; Kaladjian A; Casse-Perrot C; Zaim M; Micallef J; Tisne-Versailles J; Sokoloff P; Chopin P; Marien M · Psychopharmacology · 2010
    Randomized trial24 participantsCognitive Support forDeanol
  46. Efficacy of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke: a predefined exploratory analysis of a multicenter, double-blind, randomized controlled trial.
    Tian X; Xu Q; Xia X; Zhang Y; Meng X; Wang A · Journal of neurology · 2024
    Randomized trial3,163 participantsCognitive Support forGinkgo
  47. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
    Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
    Randomized trial309 participantsCognitive Support forGinkgo
  48. Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.
    Bachinskaya N; Hoerr R; Ihl R · Neuropsychiatric disease and treatment · 2011
    Randomized trial410 participantsCognitive Support forGinkgo
  49. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial.
    Ihl R; Bachinskaya N; Korczyn AD; Vakhapova V; Tribanek M; Hoerr R; Napryeyenko O; GOTADAY Study Group · International journal of geriatric psychiatry · 2013
    Randomized trial410 participantsCognitive Support forGinkgo
  50. Cognitive Performance Enhancement Induced by Caffeine, Carbohydrate and Guarana Mouth Rinsing during Submaximal Exercise.
    Pomportes L; Brisswalter J; Casini L; Hays A; Davranche K · Nutrients · 2018
    Randomized trial24 participantsCognitive Support forGuarana
  51. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng.
    Kennedy DO; Haskell CF; Wesnes KA; Scholey AB · Pharmacology, biochemistry, and behavior · 2005
    Non-randomized trial28 participantsCognitive Support forGuarana
  52. Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life.
    Martins SPDS; Ferreira CL; Del Giglio A · Journal of dietary supplements · 2019
    Randomized trial60 participantsEnergy forGuarana
  53. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study.
    da Costa Miranda V; Trufelli DC; Santos J; Campos MP; Nobuo M; da Costa Miranda M; Schlinder F; Riechelmann R; del Giglio A · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Randomized trial36 participantsEnergy forGuarana
  54. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  55. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  56. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  57. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  58. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  59. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  60. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  61. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  62. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  63. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  64. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  65. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  66. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E
  67. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  68. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E