Gluthathione
Glutathione is a tripeptide composed of three amino acids: cysteine, glycine, and glutamic acid. It exists in two forms: reduced (GSH), which is active and capable of neutralizing free radicals, and oxidized (GSSG), which occurs after it has performed its antioxidant function. Maintaining a healthy balance of GSH to GSSG is vital for cellular health. This essential molecule is integral to numerous biological processes, including DNA synthesis and repair, protein synthesis, enzyme activation, and regulating cell growth and death. Its primary role in detoxification pathways makes it critical for neutralizing toxins, heavy metals, and carcinogens in the liver and other organs. Beyond its direct antioxidant activity, glutathione supports the immune system by influencing immune cell function and acts as a key component of the body's natural defense against oxidative stress and inflammation. Supplementation is often used to support overall health, liver function, and antioxidant status.
AsparagusAvocadosSpinachBroccoliBrussels sproutsGarlicOnions
Minimum50 mg
Maximum200 mg
Toxicity Threshold1000 mg
Toxicity EffectLiver toxicity, kidney damage
Impact
High effect
Typical dose:500–1000 mg
As the body's master antioxidant, glutathione protects skin cells from oxidative damage caused by UV radiation and pollutants. It also plays a role in detoxification pathways and may influence melanin synthesis by inhibiting the tyrosinase enzyme, potentially leading to a brighter, more even skin tone. Oral bioavailability can be a concern, with S-acetyl or liposomal forms often preferred.
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Impact
Lower effect
Typical dose:250–1000 mg
Standard oral glutathione is broken down by digestive enzymes into its constituent amino acids before it can be absorbed, preventing it from raising cellular glutathione levels effectively. For direct supplementation, specialized forms like S-Acetyl-Glutathione or Liposomal Glutathione are necessary for absorption. A more efficient and cost-effective strategy is to supplement with precursors like N-Acetylcysteine (NAC) and Glycine, which the body can use to synthesize its own glutathione.
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Impact
Lower effect
Typical dose:250–500 mg
Glutathione is vital for detoxification and neutralizing free radicals. However, when taken orally, standard glutathione is largely broken down in the digestive system before it can be absorbed effectively. For raising systemic levels, liposomal forms offer modest improvement, but precursor supplements like N-acetylcysteine (NAC) are generally considered more reliable and cost-effective.
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Cysteine
A direct amino acid precursor necessary for the body's synthesis of glutathione.
Glycine
A direct amino acid precursor necessary for the body's synthesis of glutathione.
Glutamic Acid
A direct amino acid precursor necessary for the body's synthesis of glutathione.
Vitamin C
Helps regenerate and recycle oxidized glutathione back to its active, reduced form.
Selenium
A vital cofactor for glutathione peroxidase, a key enzyme in the glutathione antioxidant system.
Milk Thistle
Supports liver health and is known to enhance the body's production and levels of glutathione.
Vitamin E
Works synergistically as an antioxidant, helping to protect cells from oxidative damage alongside glutathione.
Zinc
Plays a role in the activity of several antioxidant enzymes that interact with glutathione pathways.
Riboflavin
As a component of FAD, it is a necessary cofactor for glutathione reductase, which regenerates reduced glutathione.
Niacin
As a component of NAD(P)H, it is essential for the activity of glutathione reductase, which reduces oxidized glutathione.
96 Best 
Mega-Liposomal Glutathione+ 750 mg Organic Fruit Flavor
Aurora NutraScience
4.6
★★★★★
(9935 ratings)
Gluthathione: 750 mg
A high-potency, 750mg liposomal L-Glutathione liquid supplement, featuring added Vitamin C and an organic fruit flavor, designed for potentially improved absorption and broad wellness support.
88 Best 
Optimal Liposomal Glutathione Plus
Seeking Health
4.7
★★★★★
(98 ratings)
Gluthathione: 350 mg
This liposomal liquid supplement offers well-absorbed glutathione with key cofactors like active Riboflavin, Selenium, Molybdenum, and PQQ, aiming to support cellular energy, detoxification, and overall antioxidant health.
75 Value 
Chem-Defense Orange Flavored
Source Naturals
4.6
★★★★★
(278 ratings)
Gluthathione: 50 mg
This tablet supplement combines L-Glutathione for antioxidant benefits with Riboflavin for energy and Molybdenum for enzyme support, all in an orange-flavored format.
30 Value 
Reduced Glutathione 50 mg
Source Naturals
4.5
★★★★★
(2 ratings)
Gluthathione: 50 mg
This supplement offers a very low 50mg dose of reduced L-Glutathione with added calcium, likely too small for meaningful daily support.
40 Value 
Reduced Glutathione Complex 50 mg Orange Flavored
Source Naturals
4.5
★★★★★
(6 ratings)
Gluthathione: 50 mg
This is an orange-flavored liquid offering a very low 50mg dose of reduced L-Glutathione alongside minor cofactors, designed for easy but modest antioxidant support.
91 Value 
Advanced Liver Support
Super Nutrition
4.8
★★★★★
(3852 ratings)
Gluthathione: 100 mg
Super Nutrition's Advanced Liver Support offers a comprehensive blend of milk thistle, glutathione precursors, various antioxidants, and botanicals, featuring strong dosages of key ingredients at a very competitive price.
82 Value 
Kyolic AC E & Herbal Antioxidants
Kyolic
4.7
★★★★★
(811 ratings)
Gluthathione: 25 mg
This product provides a focused blend of antioxidant vitamins and a mix of herbal extracts, including Kyolic Aged Garlic, to support general well-being and cellular protection.
68 Value 
Healthy Eyes Extra
21st Century
4.7
★★★★★
(5538 ratings)
Gluthathione: 5 mg
This supplement combines vitamins, minerals, and Lutein to support vision health and general antioxidant status in a budget-friendly tablet form.
78 Budget 
Liver Refresh
NOW
4.8
★★★★★
(21119 ratings)
Gluthathione: 100 mg
Liver Refresh is a multi-ingredient blend featuring milk thistle, glutathione precursors, and other antioxidants, designed to support various bodily functions and general wellness.
85 Best 
L-Glutathione 500 mg
AN Amazing Nutrition Amazing Formulas
4.7
★★★★★
(58 ratings)
Gluthathione: 500 mg
This L-Glutathione product delivers a robust 500mg dose per capsule, offering a generous 120-serving supply at a very economical price per serving.
55 Best 
Reduced L-Glutathione 100 mg
Kirkman
5.0
★★★★★
(1 ratings)
Gluthathione: 100 mg
This supplement offers a modest 100mg dose of L-Glutathione with added calcium and phosphorus, at a higher price per serving for its strength.
75 Best 
Clinical Glutathione
EuroMedica
5.0
★★★★★
(4 ratings)
Gluthathione: 300 mg
This supplement delivers a straightforward 300mg dose of L-Glutathione per tablet, providing a moderate and focused approach to antioxidant support.
85 Best 
Glutathione 500 mg
Nutricost
4.7
★★★★★
(906 ratings)
Gluthathione: 500 mg
This supplement delivers a high 500mg dose of L-Glutathione, offering excellent value with a large quantity and low price per serving.
98 Best 
L-Glutathione (Reduced) 500 mg
California Gold Nutrition
4.6
★★★★★
(15286 ratings)
Gluthathione: 500 mg
This product delivers an excellent 500mg dose of 'reduced' L-Glutathione, offering premium quality for targeted antioxidant support in a convenient capsule.
75 Value 
Reduced Glutathione Complex 50 mg Orange Flavored
Source Naturals
4.5
★★★★★
(1654 ratings)
Gluthathione: 50 mg
This liquid supplement provides L-Glutathione for antioxidant support, along with Riboflavin for energy metabolism and Molybdenum for enzyme function, all in an orange-flavored formula.
45 Best 
Reduced Glutathione 250 mg
Source Naturals
4.6
★★★★★
(591 ratings)
Gluthathione: 250 mg
This supplement provides a moderate 250mg dose of reduced L-Glutathione, but its value is diminished by the added calcium and a higher price per serving.
92 Budget 
Kyolic AC E & Herbal Antioxidants
Kyolic
5.0
★★★★★
(2 ratings)
Gluthathione: 25 mg
This supplement combines a rich array of vitamins, minerals, and herbal extracts like aged garlic and milk thistle to provide comprehensive antioxidant support for general health.
85 Best 
L-Glutathione 500 mg
AN Amazing Nutrition Amazing Formulas
4.7
★★★★★
(58 ratings)
Gluthathione: 500 mg
This is a direct and well-dosed L-Glutathione supplement, providing 500mg per serving in a vegetarian capsule, suitable for focused support.
98 Best 
L-Glutathione (Reduced) 500 mg
California Gold Nutrition
4.6
★★★★★
(15277 ratings)
Gluthathione: 500 mg
This is an exceptional supplement, offering a high 500mg dose of premium 'reduced' L-Glutathione in a large quantity, providing superb value for consistent use.
Average$31.20
Median$28.76
Average$0.77
Median$0.58