2-in-1 Kidney & Liver Super Cleanse

2-in-1 Kidney & Liver Super Cleanse

Irwin Naturals4.5 (1,347 ratings)
Format:Softgel Quantity: 60 Liquid(s) · 20 servings
Goals
$18.95 $0.94 per serving

Product analysis

44 out of 100

2-in-1 Kidney & Liver Super Cleanse combines plant ingredients and nutrients, with milk thistle providing its main liver-related rationale. The evidence is tied to particular health settings and preparations, leaving routine cleansing benefits uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

Most preparations are unspecified, limiting comparison of the herbs and omega-3 ingredients. Ingredient identity is also unclear in part of the description, so a full quality judgment remains uncertain.

Ingredient Transparency66

Most amounts are stated, but nearly all preparation forms are unspecified. Most applicable composition details are available, with one part still unresolved.

Value For Money28

The EPA and DHA contributions are costly relative to their amounts, limiting price appeal. Stinging nettle also offers weak value, while several other contributions remain uncertain.

Customer Satisfaction79

Customer feedback is positive. More than a thousand ratings provide a substantial base for judging satisfaction.

Product Focus45

Milk thistle provides the main liver-related rationale, but preparation-specific findings do not establish a general cleanse benefit. The small EPA and DHA contributions also fall short of the larger daily exposures behind the relevant blood-fat findings.

Format
Softgel
Container
60 Liquid(s)
Per serving
$0.94
Customer rating
4.5 · 1,347 ratings
Report analysis

Goals

Liver & Detox
Impact
High effect
D+ Ingredient FitB PathwaysA- EvidenceA+ Formulation Logic
Vitamin B12 · 250 mcgVitamin B6 · 15 mgSelenium · 50 mcgMagnesium · 12.5 mgMilk Thistle · 270 mgZinc · 7.5 mgVitamin C · 50 mg
Study evidence
Magnesium Supportive 19 studies
Selenium Supportive 10 studies
Vitamin C Supportive 9 studies
Zinc Supportive 30 studies
Inflammation
Impact
Lower effect
F Ingredient FitF PathwaysC- EvidenceA Formulation Logic
Vitamin D · 4 mcgFish Oil · 1600 mgVitamin C · 50 mg
Study evidence
Fish Oil Supportive 68 studies
Ginger Supportive 30 studies
Magnesium Supportive 41 studies
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin D Supportive 101 studies
Zinc Supportive 64 studies
Cardiovascular Support
Impact
High effect
D+ Ingredient FitB PathwaysB+ EvidenceA+ Formulation Logic
Potassium · 25 mgMagnesium · 12.5 mgVitamin D · 4 mcgFish Oil · 1600 mgSelenium · 50 mcgVitamin B12 · 250 mcgVitamin B6 · 15 mgVitamin C · 50 mg
Study evidence
Fish Oil Supportive 185 studies
Magnesium Supportive 123 studies
Potassium Supportive 117 studies
Selenium Supportive 107 studies
Vitamin B6 Supportive 35 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies

Ingredients

IngredientAmount per servingScore
Calories
30 Calorie(s)
Total Fat
2 Gram(s)
Saturated Fat
0.5 Gram(s)
Cholesterol
15 mg
Total Carbohydrates
3 Gram(s)
Protein
1 Gram(s)
Vitamin C (Ascorbic Acid)
50 mg
Vitamin D (Cholecalciferol)
4 mcg
Vitamin B6 (Pyridoxine Hydrochloride)
15 mg 70
Vitamin B12 (Methylcobalamin)
250 mcg 67
Magnesium (Magnesium Citrate)
12.5 mg
Zinc (Zinc Citrate)
7.5 mg
Selenium (L-Selenomethionine)
50 mcg
Potassium (Potassium Citrate)
25 mg
Fish Oil
1600 mg 25
Eicosapentaenoic Acid
288 mg 40
Docosahexaenoic Acid
192 mg 19
Milk Thistle seed extract
270 mg 56
Silymarin
121.5 mg
Pacran SP Cranberry (Vaccinium macrocarpon) powder (Proanthocyanidins)
250 mg
Artichoke leaf extract
187.5 mg
Stinging Nettle leaf extract
150 mg 86
Barberry Root Extract
100 mg
Corn Silk extract
100 mg
European Elder fruit extract
65 mg 85
Dandelion Leaf Extract (Taraxacum mongolicum Leaf Extract)
50 mg
Uva Ursi leaf extract
50 mg
N-Acetyl-Cysteine
45 mg
Reishi Mushroom Fruiting Body Extract
15 mg
BioPerine Complex
3 mg
Bioperine (Black Pepper Fruit Extract)
0 NP
Ginger Rhizome Extract (Gingerols)
0 NP
Adults 18–50 Women
Report overview
D- Composition And Label DisclosureA+ Composition And Label DisclosureF Commercial Price And Usability
The serving provides 270 mg of milk thistle seed extract at a high whole-product serving cost. It lists 45% silymarin and 121.5 mg silymarin.
How this ingredient is rated

Composition and Label Disclosure40

The milk thistle seed extract has a stated 45% silymarin.
Declared Silymarin Concentration
The milk thistle seed extract has a stated 45% silymarin.

Composition and Label Disclosure100

The 270 mg of milk thistle seed extract includes 121.5 mg silymarin.
Extract and Marker Amount Disclosure
The 270 mg of milk thistle seed extract includes 121.5 mg silymarin.

Commercial Price and Usability0

The whole-product serving cost is high for the stated milk thistle details.
Selected-Serving Price Comparison
The whole-product serving cost is high for the stated milk thistle details.
A+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value
Each serving provides 250 mcg of B12, with a high cost relative to the amount of B12. The form is Methylcobalamin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses Methylcobalamin, a bioactive form.
Bioactive B12 Form Selection
It uses Methylcobalamin, a bioactive form.

Dose, Safety & Label Transparency58

The serving provides 250 mcg of B12. The amount and Methylcobalamin form are stated.
Therapeutic Dosage Level
Each serving provides 250 mcg of B12.
Label and Form Transparency
The amount and Methylcobalamin form are stated.

Value20

The cost relative to the B12 amount is high.
Price per 1,000 mcg B12
The cost relative to the B12 amount is high.
A+ Composition And Label DisclosureA+ Composition And Label DisclosureF Commercial Price And Usability
A serving lists 150 mg of Nettle Leaf Extract at a higher cost per serving. The nettle source is leaf. The exact standardization or ratio detail is unavailable.
How this ingredient is rated

Composition and Label Disclosure100

The nettle source is leaf. The extract has additional standardization or ratio detail, but the exact detail is unavailable.
Root or Leaf Identity Disclosure
The nettle source is leaf.
Nettle Preparation and Marker Detail
The extract has additional standardization or ratio detail, but the exact detail is unavailable.

Composition and Label Disclosure100

The serving lists 150 mg of Nettle Leaf Extract.
Nettle Amount Disclosure
The serving lists 150 mg of Nettle Leaf Extract.

Commercial Price and Usability30

The cost per serving is higher.
Selected-Serving Price Comparison
The cost per serving is higher.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  2. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  3. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  4. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  5. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  6. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  7. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  8. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support forMagnesium
  9. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forMagnesium Cardiovascular Support forVitamin D
  10. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  11. Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies.
    Gan L; Zhao B; Inoue-Choi M; Liao LM; Graubard BI; Weinstein SJ; Albanes D; Huang J · BMC medicine · 2024
    Meta-analysis416,104 participantsCardiovascular Support forPotassium
  12. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledCardiovascular Support forPotassium
  13. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.
    Geleijnse JM; Kok FJ; Grobbee DE · Journal of human hypertension · 2003
    Meta-analysis27 studies pooledCardiovascular Support forPotassium
  14. Twenty-Four-Hour Urinary Sodium and Potassium Excretion and Their Associations With Blood Pressure Among Adults in China: Baseline Survey of Action on Salt China.
    Li Y; Zhang P; Wu J; Ma J; Xu J; Zhang X; Luo R; Liu M; Sun Y; Li X; Tan M; He FJ; MacGregor GA; Li X · Hypertension (Dallas, Tex. : 1979) · 2021
    Cross-sectional study5,353 participantsCardiovascular Support forPotassium
  15. Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program.
    Wang DD; Li Y; Nguyen XT; Song RJ; Ho YL; Hu FB; Willett WC; Wilson PWF; Cho K; Gaziano JM; Djoussé L; On Behalf Of The Va Million Veteran Program · Nutrients · 2022
    Cohort study180,156 participantsCardiovascular Support forPotassium
  16. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support forSelenium
  17. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  18. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support forSelenium
  19. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  20. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support forSelenium