Format:
Goals
$35.16 $1.17 per serving
Product analysis
Ortho Sleep combines melatonin, calming herbs and other ingredients in a formula aimed at sleep support. Unspecified forms for most ingredients and weak value for several of them make it harder to compare with simpler options.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality23
Most ingredient forms are unspecified. That limits a confident comparison of their quality, even though a source is named for 5-HTP.
Ingredient Transparency68
All amounts are listed, which helps compare serving sizes. Most ingredient forms are missing, leaving uncertainty about what those amounts represent.
Value For Money31
Value is weak for several ingredients, especially valerian and 5-HTP. Theanine offers a more balanced price comparison, while value for some herbs remains uncertain.
Customer Satisfaction62
Customer ratings are positive, though less consistently high than the strongest-rated options. The relatively limited review base also narrows the picture of satisfaction.
Product Focus69
The combination appears well aligned with its sleep-focused purpose. Its many ingredients and broader intended uses make it less concentrated than a simple sleep supplement.
- Format
Capsule - Container
- 60 Capsule(s)
- Per serving
- $1.17
- Customer rating
- 4.2 · 149 ratings
Goals
Impact
Highest effect
Melatonin · 3 mgTheanine · 200 mg
Impact
High effect
Impact
Highest effect
5-HTP · 100 mg
Impact
Lower effect
Theanine · 200 mg
Impact
Moderate effect
Theanine Not classified
No linked studies yet.
Impact
High effect
Theanine · 200 mg
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Lemon Balm (Melissa officinalis L.) aerial parts extract | 300 mg | |
L-Theanine | 200 mg | |
Valerian (Valeriana officinalis L.) root extract | 150 mg | |
GABA | 100 mg | |
L-5-Hydroxytryptophan (Griffonia) | 100 mg | |
Passionflower (Passiflora incarnata L.) aerial parts extract | 32 mg | |
Melatonin | 3 mg |
Theanine · 200 mg OverallScore82
Ortho Sleep provides 200 mg of L-Theanine per serving, with a fairly high cost for the amount of theanine. The amount is associated with supporting relaxation and focus. The amount and form are clear, but no added purity claim is specified.
How this ingredient is rated
Active Ingredient Quality & Bioavailability80
The ingredient is L-Theanine, the form associated with calming and focus. No branded source or added purity claim is specified in the available details.
Isomer Specificity (L-Theanine)
L-Theanine is the form associated with calming and focus.
Branded Forms & Purity Standards
No branded source or added purity claim is specified in the available details.
Dose, Safety & Label Transparency100
Each serving provides 200 mg, an amount associated with supporting relaxation and focus. The amount is individually disclosed.
Theanine Dosage Efficacy
Each serving provides 200 mg, an amount associated with supporting relaxation and focus.
Label Transparency & Blends
The L-Theanine amount is individually disclosed.
Value50
The cost is fairly high for the amount of theanine provided.
Price per 100mg L-Theanine
The cost is fairly high for the amount of theanine provided.
GABA · 100 mg OverallScore69
The serving declares 100 mg of GABA. The cost per serving is high. GABA is named without a specific source or production method. The Other Ingredients panel lists at least one flow aid.
How this ingredient is rated
Active Ingredient Quality & Bioavailability70
GABA is named without a specific source or production method.
GABA Source & Production Method
GABA is named without a specific source or production method.
Dose, Safety & Label Transparency82
The serving declares 100 mg of GABA. The Other Ingredients panel lists at least one flow aid.
GABA Dosage Adequacy & Transparency
The serving declares 100 mg of GABA.
Label Purity & Excipient Quality
The Other Ingredients panel lists at least one flow aid.
Value40
The cost per serving is high.
Price per Effective Dose
The cost per serving is high.
5-HTP (Griffonia) · 100 mg OverallScore51
Each serving provides 100 mg of 5-HTP at a high cost per amount of 5-HTP. The botanical source of the 5-HTP is not specified. General warnings are included, but a specific warning about serotonin-modulating medicines is not apparent.
How this ingredient is rated
Active Ingredient Quality & Bioavailability40
The botanical source of the 5-HTP is not specified.
Botanical Source & Standardization
The botanical source of the 5-HTP is not specified.
Dose, Safety & Label Transparency88
Each serving provides 100 mg of 5-HTP. General warnings are included, but a specific warning about serotonin-modulating medicines is not apparent.
Dosage Potency & Range
Each serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
General warnings are included, but a specific warning about serotonin-modulating medicines is not apparent.
Value0
The cost per amount of 5-HTP is high.
Price per 100mg 5-HTP
The cost per amount of 5-HTP is high.
Alternative products
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
- Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
- Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
- Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
- Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
- Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
- Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
- The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.