Melatonin plus 5-HTP & Rhodiola

Melatonin plus 5-HTP & Rhodiola

Irwin Naturals4.6 (365 ratings)
Format:Softgel Quantity: 54 Liquid(s) · 18 servings
Goals

Product analysis

40 out of 100

Melatonin plus 5-HTP & Rhodiola is most clearly suited to sleep timing and falling asleep, with more limited support for relaxation. Melatonin can cause sleepiness and slower reactions after taking it, making daytime use a poor fit for alertness.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality27

Ingredient quality is difficult to compare because most preparation details are unspecified. The partly unidentified herbal blend adds uncertainty about what each component contributes.

Ingredient Transparency57

Declared ingredient amounts are available, but most forms and the herbal blend components are not identified. The blend total cannot reveal each constituent contribution.

Value For Money32

The melatonin, theanine, rhodiola and 5-HTP contributions are relatively costly. Value for the remaining ingredients is uncertain, so the larger combination does not establish a price advantage.

Customer Satisfaction73

Customers generally report favorable satisfaction. Several hundred ratings give the average context, without demonstrating sleep or stress benefits.

Product Focus22

The clearest fit is sleep support, with more limited findings for tension and calm focus. The many ingredients and partly unidentified blend make its wider range of aims harder to judge.

Format
Softgel
Container
54 Liquid(s)
Per serving
$1.11
Customer rating
4.6 · 365 ratings
Report analysis

Goals

Impact
Highest effect
C Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 100 mgMelatonin · 3 mgTheanine · 100 mg
Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Vitamin D Supportive 55 studies
Stress Relief
Impact
High effect
C Ingredient FitB+ PathwaysB EvidenceA+ Formulation Logic
Vitamin D · 25 mcgAshwagandha · 50 mgMagnesium · 100 mgVitamin B6 · 10 mgTheanine · 100 mg
Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Melatonin Supportive 21 studies
Rhodiola Supportive 16 studies
Theanine Supportive 16 studies
Vitamin D Supportive 41 studies
Mood Support
Impact
High effect
C- Ingredient FitD PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 100 mgVitamin D · 25 mcg5-HTP · 50 mgAshwagandha · 50 mg
Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Rhodiola Supportive 15 studies
Theanine Supportive 12 studies
Vitamin B6 Supportive 19 studies
Vitamin D Supportive 163 studies
Brain Health
Impact
High effect
C- Ingredient FitB- PathwaysA EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgVitamin D · 25 mcgMagnesium · 100 mgAshwagandha · 50 mg
Study evidence
Magnesium Supportive 86 studies
Melatonin Supportive 29 studies
Rhodiola Supportive 8 studies
Theanine Supportive 17 studies
Vitamin B6 Supportive 29 studies
Vitamin D Supportive 94 studies
Cognitive Support
Impact
Moderate effect
D+ Ingredient FitF PathwaysA+ EvidenceB+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 100 mgVitamin D · 25 mcgAshwagandha · 50 mgTheanine · 100 mg
Study evidence
Magnesium Supportive 24 studies
Rhodiola Supportive 7 studies
Theanine Supportive 25 studies
Vitamin B6 Supportive 17 studies
Vitamin D Supportive 118 studies
Productivity Boost
Impact
Lower effect
D- Ingredient FitD- PathwaysA+ EvidenceA Formulation Logic
Vitamin B6 · 10 mgMagnesium · 100 mgTheanine · 100 mg
Study evidence
Magnesium Supportive 10 studies
Rhodiola Supportive 7 studies
Theanine Supportive 5 studies

Ingredients

IngredientAmount per servingScore
Calories
30 Calorie(s)
Total Fat
1.5 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin D3 (Cholecalciferol)
25 mcg
Vitamin B6 (Pyridoxine Hydrochloride)
10 mg
Magnesium (Magnesium Citrate)
100 mg
Flaxseed Oil
1650 mg
Chamomile flower extract
150 mg
L-Theanine
100 mg 76
Passionflower extract
100 mg
Rhodiola root extract
100 mg 57
Ashwagandha, Powder
50 mg 50
5-HTP (Griffonia simplicifolia)
50 mg 60
Lemon Balm extract
50 mg
Melatonin
3 mg 46
BioPerine Complex
6 mg
Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
The serving supplies 100 mg of L-Theanine at a high cost per 100 mg. That's an amount associated with relaxation and focus. The available information does not identify a branded source or a purity claim.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

The ingredient is specified as L-Theanine. The available information does not identify a branded source or a purity claim.
Isomer Specificity (L-Theanine)
The label specifies L-Theanine, the active form associated with calming and focus.
Branded Forms & Purity Standards
The available information does not identify a branded source or a purity claim.

Dose, Safety & Label Transparency100

The label clearly lists 100 mg per serving, an amount associated with relaxation and focus.
Theanine Dosage Efficacy
The serving provides 100 mg, an amount associated with relaxation and focus.
Label Transparency & Blends
The theanine amount and source are individually disclosed.

Value20

The cost per 100 mg of theanine is high.
Price per 100mg L-Theanine
The cost per 100 mg of theanine is high.
Melatonin · 3 mg OverallScore46
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
The serving provides 3 mg melatonin. The whole-product cost per serving is high. No certification details are available in the information.
How this ingredient is rated

Active Ingredient Quality & Bioavailability0

No certification details are available in the information.
Third-Party Purity Verification
No certification details are available in the information.

Dose, Safety & Label Transparency100

The serving provides 3 mg melatonin.
Physiological Dosing Alignment
The serving provides 3 mg melatonin.

Value30

The whole-product cost per serving is high.
Price Per Serving Efficiency
The whole-product cost per serving is high.
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
A serving provides 50 mg of 5-HTP, at a very high cost per 100 mg. The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated. The label includes a warning about serotonin-related medication interactions. The serving also contains 100 mg of L-theanine and 3 mg of melatonin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.

Dose, Safety & Label Transparency79

The serving contains 50 mg of 5-HTP. The serving also contains 100 mg of L-theanine and 3 mg of melatonin. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
The serving provides 50 mg of 5-HTP. The serving also contains 100 mg of L-theanine and 3 mg of melatonin.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value0

The cost per 100 mg of 5-HTP is very high.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is very high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsBrain Health Cognitive Support Energy forAshwagandha
  2. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsBrain Health Cognitive Support Mental Focus forAshwagandha
  3. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsBrain Health Cognitive Support Productivity Boost forAshwagandha
  4. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsBrain Health Mental Focus forAshwagandha
  5. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
    Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
    Randomized trial130 participantsBrain Health Sleep Support Stress Relief forAshwagandha
  6. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  7. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  8. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  9. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  10. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  11. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  12. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  13. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  14. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  15. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  16. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsBrain Health Mental Focus forRhodiola
  17. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
    Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
    Randomized trial100 participantsBrain Health forRhodiola
  18. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
    Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
    Narrative reviewBrain Health forRhodiola
  19. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsBrain Health Productivity Boost forRhodiola
  20. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsBrain Health Cognitive Support forRhodiola