Stress-Defy

Stress-Defy

Irwin Naturals4.5 (667 ratings)
Format:Softgel Quantity: 84 Softgel(s) · 42 servings
Goals

Product analysis

47 out of 100

Stress-Defy combines theanine, B vitamins and herbs that may help tension and stress-related fatigue. The herbal blend lacks a full breakdown, making its effects harder to judge.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality39

Some B-vitamin and mineral forms are named, but many other preparations remain unspecified. The rhodiola identity and undisclosed blend contents limit comparison with particular herbal extracts.

Ingredient Transparency62

Amounts are stated across the formula, helping you check parts of the serving. Most forms and complete rhodiola and blend breakdowns are missing.

Value For Money42

Vitamin B6 compares favorably on cost, while theanine and rhodiola look costly for their amounts. Value for many of the other components remains uncertain.

Customer Satisfaction75

Customers report high satisfaction across hundreds of ratings. Their feedback reflects approval without establishing lasting stress or focus benefits.

Product Focus20

Theanine and some herbs have tentative links to relaxation and stress-related fatigue. Sedating ingredients may reduce daytime alertness, limiting the fit for productivity.

Format
Softgel
Container
84 Softgel(s)
Per serving
$0.73
Customer rating
4.5 · 667 ratings
Report analysis

Goals

Stress Relief
Impact
High effect
C Ingredient FitB+ PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 13 mgGABA · 60 mgVitamin B6 · 50 mgTheanine · 100 mg

Theanine may ease tension and short-term stress responses, while GABA has limited short-term task-stress findings that do not establish sustained relief. Rhodiola adds a possible role in stress-related fatigue, and vitamin B6 supports neurotransmitter production with limited evidence for an individual stress effect. Holy basil may contribute, but this extract is not identified as one of the studied preparations. The small magnesium amount does not meaningfully contribute.

How this product is rated for Stress Relief

Ingredient fit61

Theanine, GABA, rhodiola, B6 and holy basil contribute, though several amounts are partial.
Goal fit
Relevant calming and stress-related ingredients share the formula with ingredients aimed at other goals.
Dose adequacy
B6 reaches its saved amount anchor; theanine, rhodiola, GABA and holy basil provide partial amounts.

Pathways80

Mood-related processes and neural calming are represented most clearly; stress regulation and sleep recovery are less developed.
Depth
Mood and neurotransmitter-related processes are the strongest represented area.
Breadth
Calming and mood-related processes are represented; stress regulation and sleep recovery contribute less.

Evidence87

GABA is the strongest ingredient in the saved findings, although its support is short term. Holy basil's extract does not match an identified studied preparation.
Evidence strength
GABA provides the strongest saved support here, limited to narrow short-term stress settings.
Studied preparation
The counted preparations are recognized apart from the unidentified holy basil extract.

Formulation logic100

The counted ingredients meet the saved minimum amount threshold and work alone or have their listed partners. No evaluated ingredient conflict was identified.
Partner coverage
The counted ingredients work alone or have their listed partners; this does not establish added benefit from combining them.
Conflicts
No evaluated ingredient conflict was identified in the supplied facts.
Effective doses
All counted ingredients meet the saved minimum amount threshold; this is not a proven effective dose.
Study evidence
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Rhodiola Supportive 16 studies
Theanine Supportive 16 studies
Mood Support
Impact
High effect
C Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 50 mgMagnesium · 13 mg

Theanine may ease tension associated with stressful tasks, though 100 mg per serving is below the 200 mg used in the supplied trials. B6 can help when deficiency contributes to mood symptoms, without proving extra benefit with adequate intake. Rhodiola’s fatigue findings and oral GABA’s preparation-specific stress findings provide limited grounds for expecting routine mood improvement. Magnesium is present in a small amount.

How this product is rated for Mood Support

Ingredient fit61

Theanine, GABA, Rhodiola , Vitamin B6 provide the main counted contributions. Several counted amounts only partly match the supplied references, limiting the expected contribution.
Goal fit
Relevant ingredients share the formula with ingredients serving other purposes, reducing its focus on mood.
Dose adequacy
Several counted amounts only partly match the supplied references, limiting the expected contribution.

Pathways60

The supplied findings are strongest for monoamine signalling. One route reaches the supplied coverage threshold, leaving support concentrated rather than broad.
Depth
Monoamine signalling is the strongest represented route in the saved findings; a mechanism alone does not prove improved mood.
Breadth
One route reaches the supplied coverage threshold, leaving support concentrated rather than broad.

Evidence96

Vitamin B6 contributes the strongest evidence finding. The counted preparations match those accepted by the supplied evidence findings; this does not establish a mood benefit for every ingredient.
Evidence strength
Vitamin B6 drives the strongest evidence contribution among the counted ingredients; the population and outcome limitations still matter.
Studied preparation
The counted preparations match those accepted by the supplied evidence findings; this does not establish a mood benefit for every ingredient.

Formulation logic100

The counted ingredients have no unmet partner requirement or listed conflict. All counted ingredients meet the minimum amount threshold used here; that threshold is not a proven effective mood dose.
Partner coverage
The counted ingredients do not have an unmet partner requirement in the supplied findings; this does not establish an added combination benefit.
Conflicts
No listed ingredient conflict was identified in the supplied checks.
Effective doses
All counted ingredients meet the minimum amount threshold used here; that threshold is not a proven effective mood dose.
Study evidence
GABA Supportive 12 studies
Magnesium Supportive 60 studies
Rhodiola Supportive 15 studies
Theanine Supportive 12 studies
Vitamin B6 Supportive 19 studies
Brain Health
Impact
High effect
C Ingredient FitC PathwaysA EvidenceA+ Formulation Logic
Vitamin B6 · 50 mgThiamin · 26 mgMagnesium · 13 mg

Theanine may help with calm attention, although evidence is limited and does not establish lasting cognitive improvement. Thiamin supports normal brain function when intake is low, while B6 contributes to normal neurotransmitter function without demonstrated extra benefit from high intake. Generic ginkgo and rhodiola do not establish broad cognitive benefits or equivalence to studied extracts. Magnesium contributes only a small amount in this serving.

How this product is rated for Brain Health

Ingredient fit62

The ingredient selection connects to brain health, with serving amounts and the formula’s wider purpose shaping how focused that connection is.
Goal fit
The formula includes brain-relevant ingredients alongside a broader mix of ingredients and intended uses.
Dose adequacy
The recognized amounts provide partial overall coverage of the saved references, rather than establishing a proven effective cognitive dose.

Pathways60

The strongest saved connection is monoamine neurotransmitter synthesis; this describes the ingredient grouping rather than a demonstrated brain-health outcome. One area reaches the saved coverage threshold, leaving the connection concentrated rather than broad.
Depth
The strongest saved connection is monoamine neurotransmitter synthesis; this describes the ingredient grouping rather than a demonstrated brain-health outcome.
Breadth
One area reaches the saved coverage threshold, leaving the connection concentrated rather than broad.

Evidence92

The saved evidence findings recognize ingredients and preparations, while the supplied scientific context limits expectations for general cognitive improvement.
Evidence strength
Vitamin B6 leads the saved evidence finding, while the supplied research context limits claims of broad cognitive improvement.
Studied preparation
The saved findings recognize the included preparations; this does not establish equivalence where the supplied scientific context distinguishes extracts or populations.

Formulation logic100

The saved findings identify no missing required partners or configured conflicts. Amount recognition does not itself establish an effective cognitive outcome.
Partner coverage
The recognized ingredients have no missing required partner in the saved findings; this does not establish an added benefit from combining them.
Conflicts
No configured conflict was identified. The caffeine-specific checks do not apply because no qualifying caffeine amount is established.
Effective doses
All ingredients included in this finding meet its minimum amount threshold, which is a comparison reference rather than a proven cognitive dose.
Study evidence
Ginkgo Supportive 90 studies
Magnesium Supportive 86 studies
Rhodiola Supportive 8 studies
Theanine Supportive 17 studies
Thiamin Supportive 48 studies
Vitamin B6 Supportive 29 studies
Impact
High effect
C Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Thiamin · 26 mgVitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

Theanine has limited evidence for selected verbal-fluency and executive tasks, mainly among adults with lower starting performance; its 100 mg per serving is below the amount used in the supplied four-week trial. Ginkgo and rhodiola have preliminary attention or stress-related findings tied to particular extracts, which these unidentified extracts cannot inherit. Thiamin can help with cognitive effects of deficiency, while B6 supports neurotransmitter metabolism without established routine enhancement.

How this product is rated for Cognitive Support

Ingredient fit65

Theanine, Ginkgo, Rhodiola and thiamin provide the main relevant connections. Their amounts provide a mixed match to the reference exposures.
Goal fit
Theanine, Ginkgo, Rhodiola and thiamin provide cognitive connections within a broader formula containing ingredients aimed at other goals.
Dose adequacy
The declared amounts give an uneven match to the reference exposures; lower or unresolved amounts limit the comparison.

Pathways18

The strongest connection is stress and arousal regulation, without establishing a clinical benefit from that mechanism alone. No pathway met the coverage threshold; the connections remain limited.
Depth
The strongest connection is stress and arousal regulation, without establishing a clinical benefit from that mechanism alone.
Breadth
No pathway met the coverage threshold; the connections remain limited.

Evidence93

Vitamin B6 leads the saved evidence comparison, but its normal metabolic roles do not establish routine cognitive improvement.
Evidence strength
Vitamin B6 provides the leading evidence connection among the included ingredients; its specific limitations still apply.
Studied preparation
Ginkgo, Rhodiola lack a confirmed match to the studied preparations; the remaining included ingredients have a closer preparation match.

Formulation logic100

The included ingredients have no missing required partner or configured conflict. Their amounts meet the minimum exposure comparison.
Partner coverage
No missing required partner was identified for the included ingredients; this does not imply an extra benefit from combining them.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
The included ingredients meet the minimum exposure comparison, which is not proof of an effective cognitive dose.
Study evidence
Ginkgo Supportive 87 studies
Magnesium Supportive 24 studies
Rhodiola Supportive 7 studies
Theanine Supportive 25 studies
Thiamin Supportive 30 studies
Vitamin B6 Supportive 17 studies
Productivity Boost
Impact
Moderate effect
C Ingredient FitD- PathwaysC+ EvidenceA Formulation Logic
Vitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

Theanine at 100 mg may help aspects of sustained attention, based on a small trial. Rhodiola relates to mental fatigue under stress, and ginkgo has preparation-dependent cognitive relevance. Sedative herbs may work against daytime alertness, which limits how well the combination fits a productivity goal.

How this product is rated for Productivity Boost

Ingredient fit63

The saved assessment finds a reasonably focused contribution to the goal, while accounting for other ingredients and uses. The assessed amounts provide partial support against the saved dose references (64.4 out of 100).
Goal fit
The saved assessment finds a reasonably focused contribution to the goal, while accounting for other ingredients and uses.
Dose adequacy
The assessed amounts provide partial support against the saved dose references (64.4 out of 100).

Pathways40

The strongest saved coverage concerns calm attention, with partial coverage. One mechanism reaches the saved coverage threshold, so support is concentrated rather than broad.
Depth
The strongest saved coverage concerns calm attention, with partial coverage.
Breadth
One mechanism reaches the saved coverage threshold, so support is concentrated rather than broad.

Evidence67

Theanine leads the saved evidence comparison at an assessed amount; this is not a prediction of improved work output. Only part of the qualifying formula matches the saved studied-preparation category; rhodiola does not.
Evidence strength
Theanine leads the saved evidence comparison at an assessed amount; this is not a prediction of improved work output.
Studied preparation
Only part of the qualifying formula matches the saved studied-preparation category; rhodiola does not.

Formulation logic93

The assessed ingredients work independently or have their listed partner. The saved assessment records a sedative-herb conflict that may work against daytime alertness.
Partner coverage
The assessed ingredients work independently or have their listed partner.
Conflicts
The saved assessment records a sedative-herb conflict that may work against daytime alertness.
Effective doses
All assessed ingredients reach the saved minimum dose threshold.
Study evidence
Ginkgo Supportive 20 studies
Magnesium Supportive 10 studies
Rhodiola Supportive 7 studies
Theanine Supportive 5 studies
Mental Focus
Impact
High effect
C+ Ingredient FitC PathwaysB- EvidenceA Formulation Logic
Vitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

Theanine may support selected attention tasks, although standalone results are mixed and caffeine is absent here. Rhodiola's fatigue-related findings concern a specific SHR-5 extract, which this declaration does not identify. Ginkgo has mixed acute findings rather than reliable sustained-focus support. Thiamin can help concentration impaired by deficiency; additional intake does not establish extra focus when intake is adequate.

How this product is rated for Mental Focus

Ingredient fit65

Relevant ingredients share the formula with other purposes; its links to several goals also reduce its focus specificity. Amounts provide only partial coverage of the saved comparison.
Goal fit
Relevant ingredients share the formula with other purposes; its links to several goals also reduce its focus specificity.
Dose adequacy
The declared amounts only partly meet the saved comparison; this measures exposure against reference amounts, not the probability of benefit.

Pathways60

The strongest saved coverage concerns calm attention; this is not proof of improved attention.
Depth
The strongest saved coverage concerns calm attention; this is not proof of improved attention.
Breadth
Calm attention and cellular energy reach the saved coverage threshold; other mechanisms remain less covered.

Evidence74

The supplied scientific qualifications limit what the saved favourable findings establish about immediate attention. Some declarations do not match studied preparations.
Evidence strength
The supplied scientific qualifications limit what the saved favourable findings establish about immediate attention.
Studied preparation
The saved preparation finding is incomplete for Rhodiola; generic declarations do not establish equivalence to studied material.

Formulation logic94

No configured ingredient conflict is identified in the supplied findings. Theanine lacks the expected caffeine partner.
Partner coverage
Caffeine is absent, leaving theanine without the partner expected by the saved comparison; standalone attention findings remain mixed.
Conflicts
No configured ingredient conflict is identified in the supplied findings.
Effective doses
All ingredients counted by this rule meet its minimum amount threshold; that threshold is not a clinically proven dose for immediate focus.
Study evidence
Ginkgo Supportive 28 studies
Magnesium Supportive 6 studies
Rhodiola Supportive 15 studies
Theanine Supportive 19 studies

Ingredients

IngredientAmount per servingScore
Calories
20 Calorie(s)
Total Fat
1 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Thiamine (Thiamine Mononitrate)
26 mg 60
Riboflavin
26 mg 57
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg 68
Calcium (Calcium Citrate)
19 mg
Magnesium (Magnesium Citrate)
13 mg
Flaxseed Oil
1400 mg
Skullcap extract (Baicalein)
200 mg
Holy Basil extract (Ursolic Acid)
150 mg
GABA
60 mg 55
Gingko extract
100 mg 50
L-Theanine
100 mg 76
Rhodiola extract (Rosavins, Salidrosides)
100 mg 51
BioPerine Complex
3 mg
Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
+1
A serving provides 100 mg of L-theanine, an amount favored by the evaluation. At about $0.74 per 100 mg of theanine based on the whole-product price, the cost is high on this basis.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

The saved facts identify the form as L-theanine; no branded source or purity claim is recorded.
Isomer Specificity (L-Theanine)
The recorded form is L-theanine.
Branded Forms & Purity Standards
No branded source or additional purity claim is recorded in the saved facts.

Dose, Safety & Label Transparency100

The serving contains 100 mg of L-theanine, an amount favored by the evaluation; the amount is individually disclosed.
Theanine Dosage Efficacy
The 100 mg per serving is an amount favored by the evaluation.
Label Transparency & Blends
The 100 mg of L-theanine is individually disclosed per serving.

Value20

Based on the whole-product price, 100 mg of theanine works out to about $0.74, a high cost on this basis.
Price per 100mg L-Theanine
The whole-product price works out to about $0.74 per 100 mg of theanine.
C- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
A serving provides 26 mg of thiamin as thiamine mononitrate. The evaluation also flags a color additive in the product.
How this ingredient is rated

Active Ingredient Quality & Bioavailability58

The thiamin source is thiamine mononitrate. A color additive is flagged.
Thiamin Chemical Form
The recorded source, thiamine mononitrate, is a standard water-soluble form of vitamin B1.
Excipient Purity
The evaluation flags a color additive in the product.

Dose, Safety & Label Transparency72

The saved facts record 26 mg of thiamin per serving.
Thiamin Dosage Potency
A serving provides 26 mg of thiamin, a moderate amount in the evaluation.
Label Transparency & Proprietary Blends
The thiamin amount is recorded as 26 mg per serving.

Value40

The whole-product price works out to about $2.83 per 100 mg of thiamin.
Price per Declared Dose
The whole-product price corresponds to about $2.83 per 100 mg of thiamin.
A Ingredient Form & Label QualityF Dose, Safety & Label TransparencyB+ Value
A serving contains 50 mg of vitamin B6, exceeding the European adult upper limit for a full day. The named form is pyridoxine hydrochloride.
How this ingredient is rated

Ingredient Form & Label Quality91

Vitamin B6 is identified as pyridoxine hydrochloride.
Vitamin B6 Form Identification
The vitamin B6 form is identified as pyridoxine hydrochloride.
Clean Label and Excipient Purity
The evaluation flags titanium dioxide or hydrogenated oils in the ingredient evidence; the flag alone does not identify which.

Dose, Safety & Label Transparency37

50 mg of B6 in one serving exceeds the European adult daily upper limit. The named source is pyridoxine hydrochloride.
Vitamin B6 Dose & Safety Policy
A serving contains 50 mg of vitamin B6, more than the European adult upper limit for a full day.
Label Transparency
The chemical source is identified as pyridoxine hydrochloride.

Value82

The equivalent cost is about $0.015 per mg of vitamin B6, based on the whole-product price.
Vitamin B6 Price Efficiency
The equivalent cost is about $0.015 per mg of vitamin B6, based on the whole-product price.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.
    Tan MS; Yu JT; Tan CC; Wang HF; Meng XF; Wang C; Jiang T; Zhu XC; Tan L · Journal of Alzheimer's disease : JAD · 2015
    Meta-analysis2,561 participants9 studies pooledBrain Health forGinkgo
  2. Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
    von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
    Meta-analysis1,628 participants4 studies pooledBrain Health Cognitive Support forGinkgo
  3. Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
    Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
    Meta-analysis782 participants4 studies pooledBrain Health Productivity Boost forGinkgo
  4. Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
    Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
    Randomized trial201 participantsBrain Health Productivity Boost forGinkgo
  5. Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg.
    Herrschaft H; Nacu A; Likhachev S; Sholomov I; Hoerr R; Schlaefke S · Journal of psychiatric research · 2012
    Randomized trial410 participantsBrain Health forGinkgo
  6. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  7. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  8. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  9. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  10. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  11. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsBrain Health Mental Focus forRhodiola
  12. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
    Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
    Randomized trial100 participantsBrain Health forRhodiola
  13. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
    Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
    Narrative reviewBrain Health forRhodiola
  14. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsBrain Health Productivity Boost forRhodiola
  15. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsBrain Health Cognitive Support forRhodiola
  16. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  19. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  20. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine