Glycogenics

Glycogenics

Metagenics4.8 (92 ratings)
Format:Tablet Quantity: 180 Tablet(s) · 180 servings
Goals
$79.95 $0.44 per serving

Product analysis

60 out of 100

Glycogenics supplies B vitamins that may help address nutritional shortfalls affecting energy, mood and normal metabolism. Benefits beyond adequate intake are uncertain, and the proportions of its two niacin forms are unspecified.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality58

Several B-vitamin forms are clearly identified, but other preparations remain unspecified. Naming both niacin forms does not reveal their individual contributions.

Ingredient Transparency70

All listed amounts and most forms are stated. The proportions of the niacin sources are omitted, which limits interpretation of that part of the formula.

Value For Money43

Value varies, with favorable riboflavin and B6 costs but weaker value for niacin, B5 and choline. Uncertain comparisons for other ingredients limit a firm conclusion about the full combination.

Customer Satisfaction73

Customer ratings are very positive, but the review base is small. The limited review count makes satisfaction harder to generalize.

Product Focus63

The B-vitamin emphasis connects the formula to nutrition, energy and mood when intake is low. Its broader heart and cognitive uses do not establish extra benefits in adequately nourished adults.

Format
Tablet
Container
180 Tablet(s)
Per serving
$0.44
Customer rating
4.8 · 92 ratings
Report analysis

Goals

Impact
High effect
B Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 75 mgRiboflavin · 16 mgThiamin · 14 mgVitamin B12 · 250 mcg

Riboflavin, niacin, pantothenic acid, folate, vitamins B6 and B12 and vitamin C help address nutritional gaps associated with tiredness. These nutrients support normal function when intake is low. Large amounts and methylated forms do not establish extra energy in people with adequate intake; the saved amount comparisons are not proven fatigue-treatment doses.

How this product is rated for Energy

Ingredient fit75

B vitamins and vitamin C provides a counted contribution, with amounts meeting the saved comparison to differing degrees.
Goal fit
The relevant ingredients sit within a formula that also contains ingredients aimed at other goals.
Dose adequacy
The declared amounts meet the saved comparisons to differing degrees; larger amounts do not establish benefits beyond adequacy.

Pathways0

The contribution concerns nutrient sufficiency. None of the five separately tracked energy functions received coverage.
Depth
No strongest tracked energy pathway was identified.
Breadth
None of the five tracked energy areas reaches the breadth comparison; the nutritional contribution is separate.

Evidence81

Vitamin B12 leads the saved evidence finding, with benefit tied to low B12 status.
Evidence strength
Vitamin B12 leads the saved evidence finding, with benefit tied to low B12 status.
Studied preparation
The saved findings accept the counted preparation, without establishing superiority of a particular form.

Formulation logic100

B vitamins and vitamin C needs no additional partner for the counted contribution. No configured ingredient conflict was matched.
Partner coverage
The counted ingredients can contribute without an additional partner.
Conflicts
No configured ingredient conflict was matched.
Effective doses
All counted ingredients reach the saved minimum amount comparison.
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 250 mcgNiacin · 200 mgVitamin B12 · 250 mcgRiboflavin · 16 mgThiamin · 14 mgVitamin B5 · 75 mgVitamin B6 · 22 mg

B vitamins support normal energy-yielding metabolism, but that function does not establish a faster metabolic rate from extra supplementation. Correcting a nutritional deficiency is distinct from increasing calorie use when intake is adequate. The several B vitamins and their larger declarations do not demonstrate additional thermogenesis or durable weight loss.

How this product is rated for Metabolism Support

Ingredient fit75

Seven B vitamins are retained within a broader formula.
Goal fit
Seven B vitamins are retained within a broader formula.
Dose adequacy
Retained amounts receive mixed recognition; larger vitamin amounts do not establish greater energy expenditure.

Pathways0

Normal nutrient functions remain separate from the evaluated thermogenic categories, which receive no coverage.
Depth
No evaluated thermogenic category receives coverage.
Breadth
No evaluated category reaches the breadth threshold.

Evidence100

Thiamin leads the retained evidence finding, while its normal nutrient role does not establish increased energy expenditure above adequate intake.
Evidence strength
Thiamin leads the retained evidence finding, while its normal nutrient role does not establish increased energy expenditure above adequate intake.
Studied preparation
Retained preparations with usable amounts are accepted in the saved finding; this does not establish superior effects from particular nutrient forms.

Formulation logic100

No required partner is missing and no configured conflict is triggered. Amount recognition does not establish sustained thermogenesis.
Partner coverage
Retained ingredients require no missing partner; combining them does not establish additional thermogenic benefit.
Conflicts
No configured conflict is triggered, without establishing overall safety or personal suitability.
Effective doses
All 7 retained ingredients meet the comparison amount threshold; this is not proof of a clinically effective thermogenic dose.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
125 mg
Thiamine (Thiamine Mononitrate)
14 mg 65
Riboflavin
16 mg 54
Niacin (Niacinamide)
200 mg 75
Vitamin B6 (Pyridoxine Hydrochloride)
22 mg 80
Folate (Calcium L-5-Methyltetrahydrofolate)
665 mcg DFE
Vitamin B12 (Methylcobalamin)
250 mcg 67
Biotin
250 mcg
Pantothenic Acid (Calcium D-Pantothenate)
75 mg 70
Choline (Choline Bitartrate)
100 mg 62
Myo-Inositol
94 mg
Para-Aminobenzoic Acid
15 mg 68
Gluten Free Adults 18–50 Vegetarian
Report overview
A+ Ingredient Form & Label QualityC Dose, Safety & Label TransparencyB- Value
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
Choline supplies a moderate 100 mg per serving from choline bitartrate, with the actual choline amount clearly stated. At about $0.44 per 100 mg of declared choline, its cost is high for the amount supplied.
How this ingredient is rated

Active Ingredient Quality & Bioavailability68

The choline bitartrate source is identified, and the accompanying ingredients include standard manufacturing aids without flagged problematic additives.
Choline Form Efficacy & Bioavailability
Choline bitartrate is a clearly identified standard source for general choline supply.
Formula Purity & Excipient Quality
Standard manufacturing aids are present, while the available facts flag no problematic additives.

Dose, Safety & Label Transparency77

The actual choline amount is clear, so its moderate contribution can be compared without estimating a yield from source-compound weight.
Choline Dose by Declared Basis
Each serving declares 100 mg of actual choline, a moderate contribution.
Elemental Yield Transparency
The actual choline amount and its source are identified; the declared amount is not merely an unspecified compound weight.

Value20

About $0.44 per 100 mg of declared choline makes this a costly source of choline; the calculation uses the whole product price.
Price per 100 mg of Declared Choline Basis
The whole-product cost works out to about $0.44 per 100 mg of declared choline, a high normalized cost.
PABA · 15 mg OverallScore68
B+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
Each serving supplies 15 mg of PABA, a low amount in the evaluation. The whole-product price is about $2.96 per 100 mg of PABA, a high cost for the quantity.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

PABA is identified in the saved facts, with no specific source or grade recorded.
PABA Source & Grade
The ingredient is named as PABA; the saved facts do not specify a quality grade or establish purity.

Dose, Safety & Label Transparency70

The PABA amount is individually disclosed.
PABA Dosage Alignment
The 15 mg per serving is a low amount in the evaluation.
Label Disclosure Clarity
PABA is individually listed at 15 mg per serving.
Additive and Excipient Quality
No artificial dyes, titanium dioxide, or hydrogenated oils were identified in the recorded other ingredients.

Value40

The whole-product cost is high when compared by PABA quantity.
Price per 100mg PABA
The whole-product price works out to about $2.96 per 100 mg of PABA.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin