CoEnzyme B-Complex

CoEnzyme B-Complex

KAL4.8 (585 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 30 servings
Goals
$18.09 $0.60 per serving

Product analysis

63 out of 100

CoEnzyme B-Complex may help fill gaps in B vitamins used for normal energy use and nerve function. Undisclosed proportions in its mixed forms make it harder to compare with a simpler B-complex.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality67

Folate and B5 use favourable forms, and several other B-vitamin forms are clearly identified. Undisclosed mixture proportions and some unclear individual forms limit a complete quality comparison.

Ingredient Transparency68

The listed amounts are stated, and many forms are named. Proportions in several mixed B-vitamin sources and a few individual form details remain undisclosed.

Value For Money44

Folate offers a favourable price comparison, while several other ingredients look less economical. The mixed value picture does not establish that the coenzyme label makes the combination a better buy.

Customer Satisfaction79

Customers are strongly positive about the supplement. Several hundred ratings provide a useful satisfaction picture, without establishing extra energy or focus benefits.

Product Focus57

The formula supports the normal nutrient functions of B vitamins across several body systems. Benefits mainly relate to filling dietary gaps, and the coenzyme and methylated forms do not establish better energy or thinking once needs are met.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.60
Customer rating
4.8 · 585 ratings
Report analysis

Goals

Impact
Moderate effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 20 mgRiboflavin · 20 mgThiamin · 20 mgVitamin B12 · 500 mcg

B vitamins support the normal processes that turn food into usable energy. Their practical benefit is helping meet nutrient needs, with no assumption that larger amounts improve energy when intake is already adequate.

How this product is rated for Energy

Ingredient fit75

Several nutrients relate to normal energy metabolism, alongside ingredients serving other purposes. The declared nutrient amounts make a mix of partial and fuller contributions in the saved findings.
Goal fit
Several nutrients relate to normal energy metabolism, alongside ingredients serving other purposes.
Dose adequacy
The declared nutrient amounts make a mix of partial and fuller contributions in the saved findings.

Pathways0

The saved findings assign no direct contribution to alertness, muscle energy buffering, or the other assessed energy functions. The saved findings show no coverage across the assessed direct energy functions.
Depth
The saved findings assign no direct contribution to alertness, muscle energy buffering, or the other assessed energy functions.
Breadth
The saved findings show no coverage across the assessed direct energy functions.

Evidence81

Vitamin B12 provides the strongest saved evidence contribution; its usefulness still depends on the nutritional or fatigue context. The saved preparation findings support the counted ingredients.
Evidence strength
Vitamin B12 provides the strongest saved evidence contribution; its usefulness still depends on the nutritional or fatigue context.
Studied preparation
The saved preparation findings support the counted ingredients.

Formulation logic100

The counted ingredients can contribute without an additional required partner. No configured ingredient conflict was identified in the saved findings; undisclosed amounts remain uncertain. All counted ingredients reach the saved minimum contribution level.
Partner coverage
The counted ingredients can contribute without an additional required partner.
Conflicts
No configured ingredient conflict was identified in the saved findings; undisclosed amounts remain uncertain.
Effective doses
All counted ingredients reach the saved minimum contribution level.
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 200 mcgNiacin · 40 mgVitamin B12 · 500 mcgRiboflavin · 20 mgThiamin · 20 mgVitamin B5 · 20 mgVitamin B6 · 20 mg

B vitamins help the body process carbohydrates, fats and proteins into usable energy. Their normal coenzyme roles support everyday metabolism, particularly when intake is inadequate. The generous declared amounts do not establish higher resting energy expenditure once nutritional needs are met.

How this product is rated for Metabolism Support

Ingredient fit76

The B vitamins provides the main connection to the goal. The supplied roles do not establish a routine rise in energy expenditure.
Goal fit
The B vitamins relate mainly to normal metabolic function; the formula also serves broader nutritional purposes.
Dose adequacy
Declared amounts provide partial coverage of the saved comparisons; meeting them does not demonstrate faster energy expenditure.

Pathways0

No thermogenic pathway received a contribution from this formula.
Depth
No thermogenic pathway received a contribution from this formula.
Breadth
No pathway reached the saved breadth threshold.

Evidence100

The B vitamins received evidence and preparation recognition in the saved findings. Physiological roles and metabolic markers should not be read as proof of increased energy expenditure.
Evidence strength
Vitamin B1 (Thiamin) leads the saved evidence comparison, but its supported role and population limits still govern expected benefits.
Studied preparation
Included preparations matched the saved comparison; this does not establish that the finished formula increases metabolic rate.

Formulation logic100

The included ingredients met the saved amount threshold and had no missing required partner or identified configured conflict.
Partner coverage
No required partner was missing for the included ingredients; this does not establish an added benefit from combining them.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
All included ingredients reached the saved minimum amount threshold; that threshold is a comparison rule, not proof of clinical effectiveness.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Calories
15 Calorie(s)
Total Carbohydrates
4 Gram(s)
Thiamine (Thiamine Mononitrate)
20 mg 65
Riboflavin (Riboflavin 5-Phosphate)
20 mg 64
Niacin (Inositol Hexanicotinate, Niacinamide)
40 mg 59
Vitamin B-6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
20 mg 77
Folate ((6S) 5-Methyltetrahydrofolate Glucosamine Salt)
400 mcg 96
Vitamin B12 (Cyanocobalamin, Methylcobalamin)
500 mcg 45
Biotin
200 mcg
Pantothenic Acid (Calcium Pantothenate)
20 mg 61
Choline Bitartrate
20 mg 50
Inositol (Inositol Hexanicotinate)
20 mg
PABA
20 mg 68
Adults 18–50 Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
Each serving provides 400 mcg of folate as active L-methylfolate, an amount that aligns well with the evaluation. A whole-product serving costs about $0.60.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The folate is active L-methylfolate, and a branded source is recorded. The brand claim has not been independently verified.
Folate Form Hierarchy
The folate is L-methylfolate, an active form that bypasses the MTHFR conversion step.
Patented Sources & Isomeric Purity
A branded folate source is recorded; the claim has not been independently verified.

Dose, Safety & Label Transparency100

The declared amount is 400 mcg per serving, an amount that aligns well with the evaluation on the evaluation’s declared-microgram basis for this form.
Folate Dosage by Declared Basis
The declared amount is 400 mcg per serving, an amount that aligns well with the evaluation on the evaluation’s declared-microgram basis for this form.

Value80

A whole-product serving costs about $0.60; its folate source is L-methylfolate.
Price per Bioavailable Serving
A whole-product serving costs about $0.60; its folate source is L-methylfolate.
A+ Ingredient Form & Label QualityC Dose, Safety & Label TransparencyC- Value
Each serving provides 20 mg of vitamin B6 from two identified forms. That exceeds the European adult daily upper limit before B6 from food or other supplements is counted.
How this ingredient is rated

Ingredient Form & Label Quality100

The identified B6 sources are pyridoxal 5-phosphate and pyridoxine hydrochloride; their proportions are unknown. None of the checked additives were flagged in the evaluation; other ingredients may still be present.
Vitamin B6 Form Identification
The identified B6 sources are pyridoxal 5-phosphate and pyridoxine hydrochloride; their proportions are unknown.
Clean Label and Excipient Purity
None of the checked additives were flagged in the evaluation; other ingredients may still be present.

Dose, Safety & Label Transparency65

A serving contains 20 mg of B6, exceeding the European adult daily upper limit before other sources are counted. The total amount and sources are identified, but their proportions are unknown.
Vitamin B6 Dose & Safety Policy
A serving contains 20 mg of B6, exceeding the European adult daily upper limit before other sources are counted.
Label Transparency
The total amount and sources are identified, but their proportions are unknown.

Value56

The whole-product price is about $0.030 per mg of vitamin B6.
Vitamin B6 Price Efficiency
The whole-product price is about $0.030 per mg of vitamin B6.
PABA · 20 mg OverallScore68
B+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
A serving lists 20 mg of PABA. Based on the whole-product serving price, that works out to about $3.02 per 100 mg of PABA.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

PABA is identified by name; the saved facts do not record a specific grade or purity claim.
PABA Source & Grade
PABA is named, but a pharmaceutical-grade or high-purity designation is not recorded in the saved facts.

Dose, Safety & Label Transparency70

The PABA amount is stated, and none of the three checked additive categories is recorded.
PABA Dosage Alignment
The serving contains a labeled 20 mg of PABA.
Label Disclosure Clarity
PABA is listed with its own amount of 20 mg per serving.
Additive and Excipient Quality
The saved facts record none of the checked categories: FD&C dyes, titanium dioxide or hydrogenated oils.

Value40

The whole-product cost per 100 mg of PABA is high in the comparison.
Price per 100mg PABA
The whole-product serving price corresponds to about $3.02 per 100 mg of PABA.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin