Methyl B-Complex 50

Methyl B-Complex 50

Solaray4.8 (1,012 ratings)
Format:Capsule Quantity: 60 VegCap(s) · 60 servings
Goals
$33.29 $0.55 per serving

Product analysis

66 out of 100

Methyl B-Complex 50 may help fill B-vitamin gaps that contribute to tiredness and support normal energy use. Its main benefit is meeting nutritional needs, rather than providing extra energy when those needs are already met.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality69

Several B-vitamin forms are clearly identified, including readily usable riboflavin and a well-absorbed B5 form. The folate mixture has undisclosed proportions, and some other forms remain unclear.

Ingredient Transparency69

All listed amounts and most forms are disclosed, helping you compare the formula. The proportions within the thiamin, B6 and folate combinations remain undisclosed.

Value For Money45

Value varies across the nutrients, with B6 comparing favorably and several smaller components offering less for the full serving cost. Those differences make the formula less consistently economical than any one ingredient comparison suggests.

Customer Satisfaction83

Ratings are very positive across more than a thousand customers. The feedback does not describe particular experiences that explain those ratings.

Product Focus69

The B-vitamin combination supports normal energy use and can help fill dietary gaps. Its broad mix is less targeted than choosing a nutrient for a known shortfall.

Format
Capsule
Container
60 VegCap(s)
Per serving
$0.55
Customer rating
4.8 · 1,012 ratings
Report analysis

Goals

Impact
High effect
A- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 50 mcg
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 300 mcgNiacin · 50 mgVitamin B12 · 50 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 50 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Vitamin B-1 (Thiamine Cocarboxylase, Thiamine Mononitrate)
50 mg 78
Vitamin B2 (Riboflavin 5-Phosphate)
50 mg 90
Vitamin B3 (Niacinamide)
50 mg 71
Vitamin B-6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
50 mg 73
Folic Acid (Quatrefolic (6S)-5-Methyltetrahydrofolate, Glucosamine Salt)
400 mcg 33
Vitamin B12 (Methylcobalamin)
50 mcg
Biotin
300 mcg 59
Pantothenic Acid (Calcium Pantothenate)
50 mg 70
Benfotiamine
50 mg 78
Choline Bitartrate
50 mg 55
PABA
50 mg 78
Inositol
50 mg
Adults 18–50
Report overview
C- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC- Value
A serving provides 400 mcg of folate at a moderate cost, but its DFE basis is unclear. It combines folic acid with L-5-methyltetrahydrofolate glucosamine salt in unknown proportions.
How this ingredient is rated

Active Ingredient Quality & Bioavailability55

The blend includes folic acid and active L-5-methyltetrahydrofolate glucosamine salt, but their proportions are unknown. A branded source is recorded.
Folate Form Hierarchy
Folic acid and active L-5-methyltetrahydrofolate glucosamine salt are present in unknown proportions.
Patented Sources & Isomeric Purity
A branded folate source is recorded.

Dose, Safety & Label Transparency0

The 400 mcg amount is stated, but the mixed-source DFE basis is unknown.
Folate Dosage by Declared Basis
The 400 mcg amount is stated, but the mixed-source DFE basis is unknown.

Value55

The cost per serving is moderate, but the proportions of the two folate forms are unknown.
Price per Bioavailable Serving
The cost per serving is moderate, but the proportions of the two folate forms are unknown.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
Each serving provides 50 mg of riboflavin, a high-potency amount, at a somewhat high cost per serving. It uses the active coenzyme form, riboflavin 5-phosphate. The Other Ingredients panel lists no artificial dyes or synthetic sweeteners.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses riboflavin 5-phosphate, the active coenzyme form.
Riboflavin Form Quality
It uses riboflavin 5-phosphate, the active coenzyme form.

Dose, Safety & Label Transparency100

A serving provides 50 mg of riboflavin, a high-potency amount. The Other Ingredients panel lists no artificial dyes or synthetic sweeteners.
Dosage for Energy & Metabolism
Each serving provides 50 mg of riboflavin, a high-potency amount.
R5P Elemental Yield Transparency
The riboflavin yield from the phosphate source is stated.
Additive Purity
The Other Ingredients panel lists no artificial dyes or synthetic sweeteners.

Value50

The cost per serving is somewhat high.
Price per Serving Value
The cost per serving is somewhat high.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
The serving provides 50 mg of thiamin at a high cost relative to the declared amount. The amount is in the higher-potency range. The blend names three forms but does not disclose their proportions.
How this ingredient is rated

Active Ingredient Quality & Bioavailability74

The named forms are thiamine pyrophosphate, thiamine mononitrate and benfotiamine; their proportions are unknown.
Thiamin Chemical Form
The named forms are thiamine pyrophosphate, thiamine mononitrate and benfotiamine; their proportions are unknown.
Excipient Purity
No configured unwanted color or sweetener is recorded; that does not establish a filler-free formula.

Dose, Safety & Label Transparency100

The thiamin amount is clearly stated. 50 mg per serving falls in the supplied higher-potency range.
Thiamin Dosage Potency
50 mg per serving falls in the supplied higher-potency range.
Label Transparency & Proprietary Blends
The label states 50 mg of thiamin per serving.

Value40

The cost is high relative to the declared thiamin amount.
Price per Declared Dose
The cost relative to the declared thiamin amount is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin