Fully Active B Complex with Quatrefolic

Fully Active B Complex with Quatrefolic

Doctor's Best4.7 (27,183 ratings)
Format:Capsule Quantity: 60 Veggie Cap(s) · 60 servings
Goals
$17.99 $0.29 per serving

Product analysis

72 out of 100

Fully Active B Complex with Quatrefolic can help fill B-vitamin gaps that affect normal energy use, nerve function and blood formation. Several mixtures lack proportion details, making the full formula less straightforward to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality74

Several vitamins use clearly identified forms, including active folate and a phosphate form of B2. Biotin’s exact form is unspecified, and selected vitamin forms do not by themselves establish extra benefits.

Ingredient Transparency77

Amounts are listed and most forms are identified. Three mixture breakdowns and biotin’s exact form are missing, limiting the detail behind the formula.

Value For Money58

Folate and B6 offer good value, with a favorable B2 serving cost. Niacin and B5 look less economical, so the combination’s value depends on which nutrients you need.

Customer Satisfaction91

Ratings are favorable across a very large review pool. That gives a broad picture of buyer satisfaction without proving improved energy or cognition.

Product Focus62

The clearest role is filling nutrient gaps that can affect energy, nerves and blood formation. High amounts and active forms do not establish better focus, mood or energy when intake is already adequate.

Format
Capsule
Container
60 Veggie Cap(s)
Per serving
$0.29
Customer rating
4.7 · 27,183 ratings
Report analysis

Goals

Impact
High effect
A- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 100 mgRiboflavin · 75 mgThiamin · 60 mgVitamin B12 · 1000 mcg

The B vitamins support normal metabolism and can address fatigue associated with nutritional deficiency; B12 and B6 are also relevant to deficiency-related anemia. Vitamin C contributes to filling a low-intake gap. Folate is declared in plain mcg, so its required DFE amount remains unresolved. The high amounts and selected forms do not establish extra energy when nutritional needs are already met.

How this product is rated for Energy

Ingredient fit86

Most amounts receive full recognition, vitamin C receives partial recognition, and folate lacks the required DFE amount.
Goal fit
Vitamin B12 contributes to the product's nutritional connection to fatigue; broader product uses also influence its focus.
Dose adequacy
Most amounts receive full recognition, vitamin C receives partial recognition, and folate lacks the required DFE amount.

Pathways0

The saved findings recognize no coverage of the specified alertness, exercise or fatigue pathways.
Depth
No specific route receives coverage in the saved findings, despite the nutrients' normal physiological roles.
Breadth
None of the specified routes reaches the coverage threshold.

Evidence81

Vitamin B12 leads the saved evidence finding. The relevant evidence concerns nutritional deficiency, rather than additional energy when needs are met.
Evidence strength
Vitamin B12 provides the strongest recognized evidence, with fatigue benefits limited by the relevant nutritional or population context.
Studied preparation
The recognized ingredients pass the preparation check; this does not independently prove fatigue relief from this finished product.

Formulation logic97

No unmet partner requirement or configured conflict was found. Folate remains below the amount requirement because DFE is unresolved.
Partner coverage
The recognized ingredients have no unmet partner requirement in the supplied findings.
Conflicts
No configured ingredient conflict was identified; this check does not cover every possible interaction.
Effective doses
Seven recognized ingredients meet the amount threshold; folate does not because its required DFE amount is unresolved.
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 600 mcgNiacin · 50 mgVitamin B12 · 1000 mcgRiboflavin · 75 mgThiamin · 60 mgVitamin B5 · 100 mgVitamin B6 · 50 mg

B vitamins help the body use carbohydrates, fats and protein through their coenzyme roles. Supplying more than adequate intake does not establish a rise in resting or daily energy expenditure. The formula's recognized amounts reflect a comparison framework rather than proof that high B-vitamin amounts accelerate metabolism. The mixed phosphorylated and ordinary vitamin forms do not establish additional heat production.

How this product is rated for Metabolism Support

Ingredient fit83

B vitamins supply the credited contributions, though linked to several goals.
Goal fit
B vitamins supply the credited contributions, though linked to several goals.
Dose adequacy
Amounts receive substantial recognition overall; reaching a benchmark does not establish faster metabolism.

Pathways0

The saved findings show no coverage of the configured metabolic-rate pathways, despite recognizing the nutrients' amounts.
Depth
None of the configured metabolic-rate pathways receives coverage from the credited nutrients.
Breadth
No area reaches the saved threshold for substantial coverage.

Evidence100

Thiamin leads the saved evidence finding, and the credited preparations are recognized. Normal nutrient or cellular roles still differ from measured whole-body energy expenditure.
Evidence strength
Thiamin leads the saved evidence finding; the clinical scope and outcome limitations described above still apply.
Studied preparation
The saved findings recognize the credited preparations; this does not establish a sustained metabolism or fat-loss effect.

Formulation logic100

No unmet partner requirement or configured conflict was found. All credited ingredients clear the amount threshold used for inclusion.
Partner coverage
Each credited ingredient works independently or has its required partner.
Conflicts
No configured conflict was matched among the evaluated combinations.
Effective doses
All credited ingredients clear the inclusion threshold; this is not proof of an effective energy-expenditure dose.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
40 mg
Vitamin B1 (Thiamine Hydrochloride)
60 mg 76
Vitamin B2 (Riboflavin, Riboflavin 5-Phosphate)
75 mg 96
Vitamin B3 (Niacin, Niacinamide)
50 mg 54
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
50 mg 75
Quatrefolic (Folate)
400 mcg 100
Vitamin B12 (Methylcobalamin)
1000 mcg 90
Biotin
600 mcg 59
Pantothenic Acid (D-Calcium Pantothenate)
100 mg 70
Gluten Free Adults 18–50 Vegan Vegetarian
Report overview
Folate · 400 mcg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
The serving provides 400 mcg folate as L-methylfolate, an active form. The whole-product serving costs about $0.30.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The source is L-methylfolate, an active form of folate. The saved facts identify a branded active folate source.
Folate Form Hierarchy
The source is L-methylfolate, an active form of folate.
Patented Sources & Isomeric Purity
The saved facts identify a branded active folate source.

Dose, Safety & Label Transparency100

The serving declares 400 mcg folate from L-methylfolate, on a stated-microgram basis.
Folate Dosage by Declared Basis
The serving declares 400 mcg folate from L-methylfolate, on a stated-microgram basis.

Value100

The whole-product serving costs about $0.30.
Price per Bioavailable Serving
The whole-product serving costs about $0.30.
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyA+ Value
Each serving contains 50 mg of vitamin B6, a high amount that raises safety concerns. The recorded sources are pyridoxal 5-phosphate and pyridoxine hydrochloride.
How this ingredient is rated

Ingredient Form & Label Quality100

The recorded B6 sources are pyridoxal 5-phosphate and pyridoxine hydrochloride; their individual proportions are unknown.
Vitamin B6 Form Identification
The recorded B6 forms are pyridoxal 5-phosphate and pyridoxine hydrochloride; their individual proportions are unknown.
Clean Label and Excipient Purity
The recorded other-ingredients information does not flag the colors, titanium dioxide, hydrogenated oils or talc checked here.

Dose, Safety & Label Transparency37

The 50 mg of vitamin B6 per serving is a high amount that raises safety concerns. The chemical source is identified.
Vitamin B6 Dose & Safety Policy
The 50 mg of vitamin B6 per serving is a high amount that raises safety concerns.
Label Transparency
Both chemical sources are identified; their individual shares are unknown.

Value99

A whole-product serving costs about $0.30 for 50 mg of B6, relatively low per mg. The price covers the whole product.
Vitamin B6 Price Efficiency
A whole-product serving costs about $0.30 for 50 mg of B6, relatively low per mg. The price covers the whole product.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
The serving lists 60 mg of thiamin as thiamine hydrochloride, a larger amount in this comparison. The whole-product price works out to about $0.50 per 100 mg of thiamin, which is relatively high for this comparison.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine hydrochloride is a standard water-soluble form of thiamin. The additive check did not flag a sweetener or color on its list; no minimal-additive claim was recorded.
Thiamin Chemical Form
Thiamine hydrochloride is a standard water-soluble form of thiamin.
Excipient Purity
The additive check did not flag a sweetener or color on its list; no minimal-additive claim was recorded.

Dose, Safety & Label Transparency100

The serving lists 60 mg of thiamin, a larger amount in this comparison. The amount is clearly disclosed.
Thiamin Dosage Potency
The serving lists 60 mg of thiamin, a larger amount in this comparison.
Label Transparency & Proprietary Blends
The label provides the thiamin amount: 60 mg per serving.

Value40

The whole-product price works out to about $0.50 per 100 mg of thiamin, which is relatively high for this comparison.
Price per Declared Dose
The whole-product price works out to about $0.50 per 100 mg of thiamin, which is relatively high for this comparison.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin