Arthri-Flex Advantage + Vitamin D3

Arthri-Flex Advantage + Vitamin D3

21st Century4.8 (7,047 ratings)
Format:Tablet Quantity: 120 Tablet(s) · 30 servings
Goals
$19.20 $0.64 per serving

Product analysis

61 out of 100

Arthri-Flex Advantage + Vitamin D3 combines joint-focused ingredients with nutrients that support normal bones and immunity when intake is low. Its unnamed blend components make some of the added ingredients harder to judge.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality64

Several minerals use favorable forms, including magnesium, zinc and copper glycinate. The unnamed blend and less certain quality of other ingredients limit judgment of the full mixture.

Ingredient Transparency73

Amounts and most ingredient forms are stated. The proprietary blend is not broken down, making its contents harder to compare.

Value For Money52

Value varies, with favorable comparisons for some minerals and a more costly zinc contribution. The value of several joint-focused ingredients remains uncertain.

Customer Satisfaction91

Customer feedback is very positive across several thousand ratings. That gives a broad picture of satisfaction without establishing the many proposed health benefits.

Product Focus22

The ingredient mix extends from a joint-oriented purpose into many nutritional aims. Its clearest expected benefits come from filling nutrient gaps, while unnamed blend components leave the full active lineup uncertain.

Format
Tablet
Container
120 Tablet(s)
Per serving
$0.64
Customer rating
4.8 · 7,047 ratings
Report analysis

Goals

Impact
Moderate effect
D Ingredient FitD- PathwaysA- EvidenceA+ Formulation Logic
Vitamin D · 50 mcgMagnesium · 200 mgZinc · 15 mgVitamin C · 100 mg
Study evidence
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Impact
High effect
D+ Ingredient FitC+ PathwaysA EvidenceA+ Formulation Logic
Magnesium · 200 mgVitamin D · 50 mcgCopper · 0.5 mgManganese · 5 mgZinc · 15 mgVitamin C · 100 mg
Study evidence
Copper Disputed 20 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Potassium Supportive 39 studies
Vitamin C Supportive 46 studies
Vitamin D Supportive 202 studies
Zinc Supportive 33 studies
Impact
Moderate effect
D+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin D · 50 mcgMagnesium · 200 mgPotassium · 195 mg
Study evidence
Magnesium Supportive 4 studies
Potassium Supportive 2 studies
Vitamin D Supportive 32 studies
Immunity
Impact
Moderate effect
D- Ingredient FitD PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 200 mgVitamin C · 100 mgZinc · 15 mgVitamin D · 50 mcg
Study evidence
Magnesium Supportive 8 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
Impact
Moderate effect
F Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
Magnesium · 200 mgZinc · 15 mgVitamin D · 50 mcg
Study evidence
Magnesium Disputed 5 studies
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies
Impact
Moderate effect
D- Ingredient FitD- PathwaysA- EvidenceA+ Formulation Logic
Potassium · 195 mgMagnesium · 200 mgVitamin D · 50 mcgVitamin C · 100 mg
Study evidence
Magnesium Supportive 123 studies
Potassium Supportive 117 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies

Ingredients

IngredientAmount per servingScore
Total Carbohydrates
1 Gram(s)
Vitamin C (Calcium Ascorbate)
100 mg
Vitamin D3 (Cholecalciferol)
50 mcg
Magnesium (Magnesium Glycinate)
200 mg 76
Zinc (Zinc Glycinate)
15 mg 80
Copper (Copper Glycinate)
0.5 mg 62
Manganese (Manganese Glycinate)
5 mg 78
Molybdenum (Molybdenum Glycinate)
220 mcg 90
Potassium (Potassium Chloride)
195 mg 65
Glucosamine Sulfate (Glucosamine Sulfate 2KCl)
1500 mg
MSM
1500 mg
Hyaluronic Acid (Sodium Hyaluronate)
80 mg
Proprietary Blend
1045 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
Each serving provides 5 mg of manganese at a higher cost per serving. The source is Manganese Glycinate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The manganese comes from Manganese Glycinate.
Manganese Chemical Form
The stated source is Manganese Glycinate.

Dose, Safety & Label Transparency100

The serving provides 5 mg of manganese. Both the amount and source are stated.
Manganese Dosage Efficacy & Safety
A serving contains 5 mg of manganese.
Elemental Weight Disclosure
The label states the manganese amount and source.

Value50

The cost per serving is higher.
Price per Serving vs. Median
The cost per serving is higher.
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
The serving provides 220 mcg of molybdenum, a moderate amount, at a low cost per serving. It uses Molybdenum Glycinate, a chelated form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability85

It uses Molybdenum Glycinate, a chelated form. No branded mineral source is identified in the available information.
Molybdenum Chemical Form
It uses Molybdenum Glycinate, a chelated form.
Branded or Patented Source
No branded mineral source is identified in the available information.

Dose, Safety & Label Transparency100

The serving provides 220 mcg, a moderate amount, below the adult upper limit.
Elemental Dose Optimization
The serving provides 220 mcg of molybdenum, a moderate amount.
Upper Limit (UL) Safety Compliance
The 220 mcg serving is below the adult upper limit of 2,000 mcg.

Value80

The cost per serving is low.
Price per Effective Serving
The cost per serving is low.
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
+2
The serving provides 15 mg zinc at a high cost per serving. The amount can support nutritional maintenance. It uses Zinc Bisglycinate. It also provides 0.5 mg copper.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The zinc comes as Zinc Bisglycinate.
Zinc Form Bioavailability
The zinc comes as Zinc Bisglycinate.

Dose, Safety & Label Transparency85

15 mg zinc can support nutritional maintenance. The serving also has 0.5 mg of copper.
Elemental Dose Transparency
The zinc amount and source are stated.
Zinc Dosage Safety & Effectiveness
15 mg zinc can support nutritional maintenance.
Zinc-to-Copper Mineral Balance
The serving also has 0.5 mg of copper.

Value30

The cost per serving is high.
Price Per Serving Efficiency
The cost per serving is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  2. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  3. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  4. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  5. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  6. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  7. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  8. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  9. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  10. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  11. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  12. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  13. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  14. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  15. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  16. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.
    Jehle S; Hulter HN; Krapf R · The Journal of clinical endocrinology and metabolism · 2013
    Randomized trial201 participantsBone Health forPotassium
  17. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
    Frassetto L; Morris RC; Sebastian A · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial170 participantsBone Health forPotassium
  18. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
    Jehle S; Zanetti A; Muser J; Hulter HN; Krapf R · Journal of the American Society of Nephrology : JASN · 2007
    Randomized trial161 participantsBone Health forPotassium
  19. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.
    Moseley KF; Weaver CM; Appel L; Sebastian A; Sellmeyer DE · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Randomized trial52 participantsBone Health forPotassium
  20. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives.
    He FJ; Marciniak M; Carney C; Markandu ND; Anand V; Fraser WD; Dalton RN; Kaski JC; MacGregor GA · Hypertension (Dallas, Tex. : 1979) · 2010
    Randomized trial42 participantsBone Health forPotassium