Relieve-R

Relieve-R

LifeSeasons4.2 (88 ratings)
Format:Capsule Quantity: 46 Capsule(s) · 23 servings
Goals
$29.99 $1.30 per serving

Product analysis

57 out of 100

Relieve-R may help short-term alertness and reduce sleepiness, mainly through caffeine. Caffeine can temporarily raise blood pressure and heart rate, which may matter if you are sensitive to stimulants.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality44

Vitamin B6 has a clearly identified form, but much of the remaining ingredient quality is uncertain. Several unspecified forms limit comparison of the full mix.

Ingredient Transparency85

All declared amounts and most forms are listed, making much of the serving easy to check. The forms of several ingredients, including theanine and thiamin, are not clearly disclosed.

Value For Money38

Vitamin B6 offers reasonable value, but the serving cost is high for the carnitine and theanine provided. Value from several other additions remains uncertain.

Customer Satisfaction62

Customer ratings are generally positive, though the review count is modest. They give a limited picture of satisfaction without proving the intended benefits.

Product Focus67

Caffeine provides the clearest short-term alertness benefit, while B vitamins mainly matter when intake is low. The many additional ingredients do not establish broader cognitive or productivity benefits.

Format
Capsule
Container
46 Capsule(s)
Per serving
$1.30
Customer rating
4.2 · 88 ratings
Report analysis

Goals

Impact
High effect
C Ingredient FitD- PathwaysA+ EvidenceA+ Formulation Logic
Vitamin D · 25 mcgThiamin · 50 mgVitamin B12 · 1000 mcgAcetyl L-Carnitine · 100 mgCaffeine · 75 mg

Caffeine offers short-term alertness and reduced sleepiness at the declared 75 mg per serving. Vitamins B6 and B12 support deficiency-related fatigue correction, while vitamin D fatigue findings apply to deficient adults. These nutrient roles do not establish added energy when needs are already met. Theanine does not establish standalone fatigue relief, and the thiamin amount is unresolved.

How this product is rated for Energy

Ingredient fit65

Relevant ingredients sit within a broader formula, so the product is less focused on energy alone. Amount support is mixed, and thiamin has no usable declared amount.
Goal fit
Relevant ingredients sit within a broader formula, so the product is less focused on energy alone.
Dose adequacy
Amount support is mixed, and thiamin has no usable declared amount.

Pathways44

The strongest covered route is alertness, led by caffeine.
Depth
The strongest covered route is alertness, led by caffeine.
Breadth
Coverage is concentrated in one route, rather than extending across several aspects of energy.

Evidence99

Caffeine provides the strongest evidence contribution here, with benefits limited to the relevant preparation or population.
Evidence strength
Caffeine provides the strongest evidence contribution here, with benefits limited to the relevant preparation or population.
Studied preparation
The credited preparations generally align with the saved study findings; theanine lacks that preparation support.

Formulation logic96

The credited ingredients can stand alone in the saved findings, with no identified opposing combination.
Partner coverage
The relevant ingredients do not require an additional partner in the saved findings; no extra combination benefit is established.
Conflicts
No opposing ingredient combination was identified in the evaluated conflict checks.
Effective doses
Most counted ingredients have meaningful amount support; thiamin remains unresolved because its usable amount is unknown.
Study evidence
Caffeine Supportive 68 studies
Theanine Not classified

No linked studies yet.

Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies
Impact
High effect
C- Ingredient FitD+ PathwaysB+ EvidenceA Formulation Logic
Vitamin B12 · 1000 mcgVitamin D · 25 mcg

The declared B vitamins contribute to nutrient availability for normal metabolism and blood formation. Vitamin D adds a contribution toward ordinary nutritional needs. Higher amounts do not establish extra benefit once intake is adequate.

How this product is rated for Everyday Health

Ingredient fit58

The known ingredients have a broader relationship to the retained nutritional functions. Some amounts fall below the comparison references or remain unresolved.
Goal fit
Relevant nutrients sit within a broader formulation, reducing its focus on the retained general-health functions.
Dose adequacy
The retained amounts provide partial or unresolved coverage of the saved comparison references, rather than demonstrating complete nutritional intake.

Pathways55

The strongest retained connection is one-carbon metabolism and blood formation. Coverage of other functions is narrower.
Depth
The strongest retained connection is one-carbon metabolism and blood formation, based on the known ingredient amounts.
Breadth
The contribution is concentrated in one-carbon metabolism and blood formation, with limited coverage of other retained functions.

Evidence82

Vitamin D provides the strongest retained evidence. The supplied context supports nutritional availability or limited population-specific findings, without establishing broad health improvements beyond adequate intake.
Evidence strength
Vitamin D supplies the strongest retained evidence. Its supplied context limits expectations to nutritional or population-specific outcomes.
Studied preparation
The retained preparations match the saved criteria; no superiority of chemical form or delivery is established.

Formulation logic94

The supplied checks identify no configured conflict or missing required partner. The retained amount thresholds remain comparison references rather than treatment doses.
Partner coverage
The retained ingredients have no missing required partner under the saved criteria; this does not establish an added combination benefit.
Conflicts
No configured ingredient conflict was identified from the supplied amounts.
Effective doses
Vitamin B1 (Thiamin) has no usable amount meeting the saved threshold; the other retained nutrients meet it.
Study evidence
Vitamin D Supportive 115 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
25 mcg
Vitamin B6 (Pyridoxal 5-Phosphate)
50 mg 67
Vitamin B12 (Methylcobalamin)
1000 mcg 84
White Willow bark extract (Salicin)
300 mg
Fragrant Angelica root extract
100 mg
Acetyl-L-Carnitine HCl
100 mg 55
Caffeine (Coffea arabica)
75 mg
L-Theanine
75 mg 70
Benfotiamine
50 mg 84
L-Tetrahydropalmatine (Corydalis yanhusuo)
50 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Thiamin · 50 mg OverallScore84
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Each serving provides 50 mg of thiamin as benfotiamine, a form favored by the evaluation. That amount fits the evaluation’s favored category for thiamin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability91

The thiamin comes from benfotiamine, a fat-soluble form favored by the evaluation.
Thiamin Chemical Form
Benfotiamine is a fat-soluble thiamin form favored by the evaluation.
Excipient Purity
The evaluation records no flagged sweetener or coloring concern; that does not establish the absence of other additives.

Dose, Safety & Label Transparency100

The serving declares 50 mg of thiamin, an amount favored by the evaluation.
Thiamin Dosage Potency
The declared 50 mg of thiamin per serving fits the amount favored by the evaluation.
Label Transparency & Proprietary Blends
The thiamin amount is explicitly declared as 50 mg per serving.

Value40

At the whole-product price, the cost works out to about $2.61 per 100 mg of thiamin, toward the higher-cost end of the evaluation’s comparison.
Price per Declared Dose
At the whole-product price, the cost works out to about $2.61 per 100 mg of thiamin, toward the higher-cost end of the evaluation’s comparison.
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyC Value
The 50 mg of vitamin B6 per serving is a high amount, making ongoing intake a safety consideration. The identified form is pyridoxal 5-phosphate.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 source is identified as pyridoxal 5-phosphate.
Vitamin B6 Form Identification
The B6 source is identified as pyridoxal 5-phosphate.
Clean Label and Excipient Purity
The evaluation flags no configured artificial colors, titanium dioxide or hydrogenated oils, or talc or flow agents.

Dose, Safety & Label Transparency37

The 50 mg of B6 per serving is a high amount; the evaluation treats it as a safety concern for ongoing intake. The source is identified.
Vitamin B6 Dose & Safety Policy
The 50 mg of B6 per serving is a high amount; the evaluation treats it as a safety concern for ongoing intake.
Label Transparency
The B6 source is identified as pyridoxal 5-phosphate.

Value63

The whole product costs about $1.30 per serving with 50 mg of B6; the price covers its other ingredients too.
Vitamin B6 Price Efficiency
The whole product costs about $1.30 per serving with 50 mg of B6; the price covers its other ingredients too.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving supplies 1,000 mcg of vitamin B12 as methylcobalamin. The whole-product price works out to about $1.30 per 1,000 mcg of B12.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

Methylcobalamin is the identified form of B12 and is a bioactive form.
Bioactive B12 Form Selection
Methylcobalamin is the identified form of B12 and is a bioactive form.

Dose, Safety & Label Transparency100

Both the B12 amount and its form are listed for each serving.
Therapeutic Dosage Level
The serving lists 1,000 mcg of vitamin B12.
Label and Form Transparency
The label identifies 1,000 mcg of B12 as methylcobalamin per serving.

Value20

The whole-product price works out to about $1.30 per 1,000 mcg of vitamin B12.
Price per 1,000 mcg B12
The whole-product price works out to about $1.30 per 1,000 mcg of vitamin B12.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
    Randomized trial121 participantsEnergy forAcetyl L-Carnitine
  2. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
    Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  3. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
    Randomized trial67 participantsEnergy forAcetyl L-Carnitine
  4. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
    Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
    Randomized trial239 participantsEnergy forAcetyl L-Carnitine
  5. Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
    Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
    Systematic reviewEnergy forAcetyl L-Carnitine
  6. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  7. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  8. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  9. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  10. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  11. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  12. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  13. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  14. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  15. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  16. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  17. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  18. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  19. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  20. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12