Sustained Release B-100

Sustained Release B-100

NOW4.7 (5,846 ratings)
Format:Tablet Quantity: 100 Tablet(s) · 100 servings
Goals

Product analysis

69 out of 100

Sustained Release B-100 supplies B vitamins to support normal nutrient use and help fill dietary gaps. Several ingredient forms are omitted, making the exact preparations less clear.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality58

The mix clearly identifies several B-vitamin forms, with calcium pantothenate a favorable feature. Ordinary riboflavin is less favored, and the quality of several other ingredients remains uncertain.

Ingredient Transparency86

Ingredient amounts are stated throughout, which helps with checking quantities. Several omitted forms limit a full comparison of the preparations.

Value For Money55

Riboflavin and B6 have favorable serving costs, while B5 and choline are relatively costly for their contributions. Other ingredients provide limited, moderate or uncertain value.

Customer Satisfaction89

Customer feedback is highly positive across thousands of ratings. The large response count provides a broad picture of satisfaction.

Product Focus69

The clearest role is helping meet B-vitamin needs for normal nutrient use and blood formation. Larger amounts do not establish more energy or additional heart protection when intake is adequate.

Format
Tablet
Container
100 Tablet(s)
Per serving
$0.18
Customer rating
4.7 · 5,846 ratings
Report analysis

Goals

Impact
High effect
B+ Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

B vitamins help the body use food for energy, while folate and B12 support normal blood formation. Their contribution to tiredness is most relevant when intake is low or a deficiency is corrected; larger amounts do not establish extra energy when intake is adequate. The B12 amount is below the saved inclusion requirement despite its presence.

How this product is rated for Energy

Ingredient fit85

The relevant connection comes from Vitamin B2 (Riboflavin), Vitamin B1 (Thiamin), Vitamin B5, Folate, Vitamin B6, Niacin. The amounts offer different levels of support in the saved findings.
Goal fit
Relevant energy ingredients appear alongside ingredients aimed at other purposes, so the formulation has a broader focus.
Dose adequacy
The included ingredient amounts reach the saved amount reference; this does not establish extra benefit from higher intake.

Pathways0

The saved findings concern nutrient sufficiency rather than coverage of the configured alertness, muscle-energy, cellular-energy, stress-fatigue or blood-flow pathways.
Depth
No configured energy pathway receives coverage; nutrient-related contributions are considered separately.
Breadth
No configured pathway reaches the saved coverage requirement.

Evidence78

The strongest included evidence contribution comes from Vitamin B2 (Riboflavin). Studied-preparation matching does not remove the ingredient-specific limits on fatigue benefits.
Evidence strength
Vitamin B2 (Riboflavin) provides the strongest included evidence contribution; its population and deficiency limitations still determine the benefit that can be expected.
Studied preparation
The included amounts meet the saved studied-preparation check, without establishing that the finished product itself was tested.

Formulation logic100

The included ingredients meet the saved minimum amount requirement without a missing required partner or matched conflict.
Partner coverage
The included ingredients do not lack a required partner in the saved findings; this does not imply an added combination benefit.
Conflicts
No configured ingredient conflict was matched in the supplied facts.
Effective doses
All counted ingredients meet the saved minimum amount requirement; this is distinct from a proven effective fatigue-treatment dose.
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

B vitamins support the normal processes that turn food into usable energy. Their physiological roles and serving amounts do not establish a faster resting metabolic rate when intake is adequate. The supplied evidence therefore supports normal nutrient function rather than a demonstrated increase in whole-body energy expenditure.

How this product is rated for Metabolism Support

Ingredient fit79

The contributing amounts meet part of the saved comparison range, without establishing a proven thermogenic dose.
Goal fit
The formula combines ingredients connected to metabolism with other actives, reducing its specific focus on energy expenditure.
Dose adequacy
The contributing amounts meet part of the saved comparison range, without establishing a proven thermogenic dose.

Pathways0

No contribution is established across the assessed energy-expenditure pathways.
Depth
No contribution is established across the assessed energy-expenditure pathways.
Breadth
No assessed pathway reaches the saved coverage threshold, leaving broad energy-expenditure support unestablished.

Evidence100

Vitamin B1 (Thiamin) leads the saved evidence finding; its normal metabolic or biomarker roles do not establish a routine rise in energy expenditure.
Evidence strength
Vitamin B1 (Thiamin) leads the saved evidence finding; its normal metabolic or biomarker roles do not establish a routine rise in energy expenditure.
Studied preparation
The contributing forms meet the saved preparation criteria; this does not transfer findings from other outcomes into a thermogenic benefit.

Formulation logic100

The contributing ingredients have no missing required partners or configured conflicts. Their amounts meet the saved minimum comparison threshold.
Partner coverage
No required partner is missing among contributing ingredients; this does not establish added thermogenesis from combining them.
Conflicts
No configured ingredient conflict was identified in the supplied calculation.
Effective doses
All contributing ingredients meet the saved minimum amount threshold; this comparison threshold is not proof of a clinical thermogenic effect.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies
Impact
Highest effect
A- Ingredient FitB+ PathwaysB+ EvidenceA Formulation Logic
Folate · 667 mcg DFEVitamin B12 · 100 mcg

B vitamins contribute to normal nutrient metabolism, while folate supports the nutritional needs associated with blood formation. These nutrients can help fill dietary gaps, without establishing additional health benefits when intake is already adequate. The 100 mg vitamin B6 serving also triggers the saved high-amount concern.

How this product is rated for Everyday Health

Ingredient fit85

The B-vitamin formula provides the recognized nutritional fit. Most recognized amounts meet the comparison; B12 receives partial recognition.
Goal fit
The B-vitamin formula provides the recognized nutritional fit.
Dose adequacy
Most recognized amounts meet the comparison; B12 receives partial recognition.

Pathways80

Energy metabolism and blood formation are covered.
Depth
Energy metabolism and blood formation are covered.
Breadth
Two nutrient-related pathways reach the breadth threshold.

Evidence82

Folate drives the strongest recognized contribution. Nutrient availability supports the finding, without establishing extra benefit from high B-vitamin amounts.
Evidence strength
Folate drives the strongest recognized contribution. Nutrient availability supports the finding
Studied preparation
The counted nutrient declarations match the saved preparation criteria; no chemical form or delivery superiority is established.

Formulation logic93

The 100 mg B6 serving triggers the configured high-amount concern. All ingredients included in this amount check meet the saved minimum threshold; that does not establish a clinically effective dose.
Partner coverage
Recognized ingredients can stand alone or have their required partners; this does not establish an added combination benefit.
Conflicts
The 100 mg B6 serving triggers the configured high-amount concern.
Effective doses
All ingredients included in this amount check meet the saved minimum threshold; that does not establish a clinically effective dose.
Study evidence
Folate Supportive 80 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
100 mg 76
Riboflavin
100 mg 72
Niacin (Niacinamide)
100 mg 83
Vitamin B6 (Pyridoxine Hydrochloride)
100 mg 72
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
100 mcg 21
Biotin
100 mcg
Pantothenic Acid (Calcium Pantothenate)
100 mg 70
Choline (Choline Bitartrate)
35 mg 50
Inositol
100 mg
PABA
10 mg 68
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value
Each serving provides 100 mg of niacin. The cost per serving is moderate. The form is Niacinamide.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

The form is Niacinamide.
Niacin Form & Goal Alignment
The form is Niacinamide.
Precursor Source Quality
The named form is Niacinamide.

Dose, Safety & Label Transparency92

Each serving provides 100 mg of niacin. A flush-free claim is not recorded.
Clarity of Chemical Form
The form is Niacinamide.
Form-Specific Dosage Efficacy
Each serving provides 100 mg of niacin.
Flush Risk & Safety Labeling
A flush-free claim is not recorded.

Value60

The cost per serving is moderate.
Price Per Effective Serving
The cost per serving is moderate.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Each serving provides 100 mg of thiamin, a high-potency amount, at a high cost for the amount. It uses Thiamine Hydrochloride.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Hydrochloride is a standard water-soluble form of thiamin. The listed additives do not include the flagged artificial sweeteners, colors or corn syrup.
Thiamin Chemical Form
Thiamine Hydrochloride is a standard water-soluble form of thiamin.
Excipient Purity
The listed additives do not include the flagged artificial sweeteners, colors or corn syrup.

Dose, Safety & Label Transparency100

The label specifies 100 mg of thiamin per serving, a high-potency amount.
Thiamin Dosage Potency
The serving provides 100 mg of thiamin, a high-potency amount.
Label Transparency & Proprietary Blends
The label specifies the thiamin amount and source.

Value40

The cost is high for the declared thiamin amount.
Price per Declared Dose
The cost is high for the declared thiamin amount.
Riboflavin · 100 mg OverallScore72
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
The serving provides 100 mg of riboflavin, a high amount, at a low cost per serving. It uses standard riboflavin, which needs conversion in the liver. The listed ingredients include no artificial colors, flavors or synthetic sweeteners.
How this ingredient is rated

Active Ingredient Quality & Bioavailability30

Standard riboflavin requires conversion before use in energy metabolism.
Riboflavin Form Quality
It uses standard riboflavin, which needs conversion in the liver.

Dose, Safety & Label Transparency100

Each serving provides 100 mg of riboflavin. The ingredient list contains no listed artificial colors, flavors or synthetic sweeteners.
Dosage for Energy & Metabolism
A serving supplies 100 mg of riboflavin, a high amount.
R5P Elemental Yield Transparency
The compound-yield concern for riboflavin 5-phosphate does not apply to standard riboflavin.
Additive Purity
The Other Ingredients panel lists no artificial colors, flavors or synthetic sweeteners.

Value100

The cost per serving is low.
Price per Serving Value
The serving price is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  17. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  18. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  19. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  20. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate