Bone Defense

Bone Defense

KAL4.8 (314 ratings)
Format:Tablet Quantity: 90 Tablet(s) · 30 servings
Goals
$16.29 $0.54 per serving

Product analysis

49 out of 100

Bone Defense combines calcium, vitamin D and magnesium to support bone maintenance when dietary intake falls short. Unclear blend details make it harder to judge some of the added ingredients.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality42

The mineral forms vary: copper glycinate and zinc citrate are favorable choices, while magnesium oxide has limited absorption potential. Unknown calcium proportions and unclear boron identity add uncertainty about the wider mineral mixture.

Ingredient Transparency71

Amounts and most forms are listed, so much of the formula can be checked. Missing proportions and unidentified blend components leave important details about the mixtures unclear.

Value For Money38

Value is mixed, with a favorable serving cost for vitamin K and more moderate value for calcium, copper and manganese. Magnesium, zinc, selenium and boron offer weaker value, while several other contributions remain uncertain.

Customer Satisfaction77

Customers generally rate the product positively, with a review pool of hundreds. These ratings describe satisfaction rather than proving effectiveness or safety.

Product Focus23

Bone nutrition is the clearest purpose, led by calcium, vitamin D and magnesium. The many wider health aims and unidentified blend make the role of every addition less clear.

Format
Tablet
Container
90 Tablet(s)
Per serving
$0.54
Customer rating
4.8 · 314 ratings
Report analysis

Goals

Bone Health
Impact
Highest effect
B- Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Vitamin K · 150 mcgMagnesium · 300 mgCalcium · 500 mgVitamin D · 25 mcgCopper · 1 mgManganese · 10 mgBoron · 3 mgZinc · 15 mgVitamin C · 100 mg
Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Copper Disputed 20 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Vitamin C Supportive 46 studies
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Zinc Supportive 33 studies
Impact
Highest effect
B Ingredient FitA+ PathwaysA- EvidenceA+ Formulation Logic
Vitamin D · 25 mcgMagnesium · 300 mgVitamin K · 150 mcgBoron · 3 mgSelenium · 100 mcgZinc · 15 mgVitamin C · 100 mg
Study evidence
Boron Supportive 6 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Zinc Supportive 60 studies
Immunity
Impact
High effect
C Ingredient FitB PathwaysA+ EvidenceA+ Formulation Logic
Magnesium · 300 mgVitamin C · 100 mgZinc · 15 mgVitamin D · 25 mcgSelenium · 100 mcg
Study evidence
Magnesium Supportive 8 studies
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
Cardiovascular Support
Impact
High effect
C- Ingredient FitD PathwaysB EvidenceA+ Formulation Logic
Vitamin K · 150 mcgMagnesium · 300 mgVitamin D · 25 mcgSelenium · 100 mcgVitamin C · 100 mg
Study evidence
Magnesium Supportive 123 studies
Selenium Supportive 107 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies
Impact
High effect
C- Ingredient FitB- PathwaysA EvidenceA+ Formulation Logic
Magnesium · 300 mgZinc · 15 mgVitamin D · 25 mcgBoron · 3 mg
Study evidence
Boron Disputed 3 studies
Magnesium Disputed 5 studies
Selenium No effect 16 studies
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies
Stress Relief
Impact
High effect
D+ Ingredient FitC PathwaysB EvidenceA+ Formulation Logic
Vitamin D · 25 mcgMagnesium · 300 mgVitamin C · 100 mg
Study evidence
Magnesium Supportive 13 studies
Vitamin C Supportive 11 studies
Vitamin D Supportive 41 studies
Zinc Supportive 9 studies

Ingredients

IngredientAmount per servingScore
Protein
1 Gram(s)
Vitamin C
100 mg
Vitamin D (Cholecalciferol, Vitamin D3)
25 mcg
Vitamin K (Menaquinone, Phytonadione)
150 mcg 35
Biotin
150 mcg
Calcium (Advanced Calcium Blend)
500 mg 82
Magnesium (Magnesium Oxide)
300 mg 59
Zinc (Zinc Citrate)
15 mg 84
Selenium (Selenomethionine)
100 mcg 72
Copper (Copper Glycinate)
1 mg 87
Manganese (Manganese Glycinate)
10 mg 87
Ipriflavone (7-Isopropoxyisoflavone)
100 mg
Boron (Tetra-Boron)
3 mg 46
ActiSorb Base
10 NP
Adults 18–50
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA Value
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB Value
+3
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  2. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  3. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  4. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  5. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  6. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  7. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  8. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  9. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  10. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  11. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  12. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  13. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  14. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  15. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium