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Blood Nourish-R

LifeSeasons
4.7
★ ★ ★ ★ ★
(55 ratings)
Vitamin B12 1000 mcg
Iron 50 mg
Thiamin 25 mg
Folate 400 mcg
Stinging Nettle 100 mg
Product Image
Score70
Methylcobalamin, folinate, and bisglycinate iron form a focused blood-nutrient formula with supportive botanicals. The 50 mg iron amount is high for unsupervised routine use and the product is unsuitable when iron status has not shown a need.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Energy
General Health
Hair Health
Productivity Boost

Score 70

Methylcobalamin, folinate, and bisglycinate iron form a focused blood-nutrient formula with supportive botanicals. The 50 mg iron amount is high for unsupervised routine use and the product is unsuitable when iron status has not shown a need.
How scoring works
$27.99($0.93 per serving)
iHerb
$ 27.99
Pure Formulas
$ 27.99
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Analysis

Methylcobalamin, folinate, and bisglycinate iron form a focused blood-nutrient formula with supportive botanicals. The 50 mg iron amount is high for unsupervised routine use and the product is unsuitable when iron status has not shown a need.

The bioactive methylcobalamin form is a meaningful strength. The amount per serving is well aligned with people who have higher B12 needs.

Chelated iron, methylcobalamin, folate, and thiamin directly support oxygen delivery and metabolic energy. The forms and amounts are clearly stated.

Who is it for
  • Adults focused on energy
  • Adults focused on general health
  • Adults focused on hair health
Best for
  • Vitamin B12 supplementation
  • Iron supplementation
  • Thiamin supplementation

Pros

  • Provides a disclosed 50.00mg of iron
  • Provides a disclosed 1000.00mcg of vitamin b12
  • Provides a disclosed 400.00mcg of folate

Cons

  • The 50 mg iron amount is high for routine use
  • Iron need should be established before use
  • The botanical additions do not offset the iron-related risk

Warnings

  • The 50 mg iron amount may cause nausea or constipation and should not be used without a demonstrated need for iron.
  • Iron is unsafe in iron-overload conditions and must be kept away from children because accidental overdose can be dangerous.
  • Iron can interfere with absorption of thyroid medicine and certain antibiotics unless doses are separated.

Nutrient quality

72 High impact

Chelated iron, methylcobalamin, and calcium folinate provide strong nutrient forms. The blood-building core is substantial, but the iron amount is unnecessarily aggressive for casual use.

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Ingredient transparency

80 Highest impact

All active amounts are visible, though the trace-mineral source attached to alfalfa is not clearly characterized. Complete non-active ingredient details are not included in the supplied label data.

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Customer satisfaction

65 Moderate impact

The supplied average rating provides limited high-level context. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

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Value for money

57 Moderate impact

High-quality nutrient forms partly justify the premium serving cost. A strong iron core supports use value, but several herbs add limited depth.

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Report analysis

Goals

Impact
Highest effect
A Goal FitA Strength of SupportA- CoverageB Formula Quality
Thiamin · 25 mgVitamin B12 · 1000 mcgIron · 50 mg

Chelated iron, methylcobalamin, folate, and thiamin directly support oxygen delivery and metabolic energy. The forms and amounts are clearly stated.

The iron serving is high and is most appropriate for a documented need rather than nonspecific fatigue. Missing vitamin C and several loosely related botanicals make the formula less balanced than a focused blood-building supplement.

Study evidence
Iron Supportive 74 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageB Formula Quality
Folate · 400 mcgVitamin B12 · 1000 mcg

Folate, methylcobalamin, thiamin, and iron directly support blood formation, nerve function, and cellular energy. The core vitamins and iron have established nutritional roles, while the small botanical additions have less evidence for broad wellness.

Folate and vitamin B12 are supplied at useful amounts, but 50 mg of iron is high for routine use without a confirmed need. Methylcobalamin, calcium folinate, and ferrous bisglycinate are well-chosen forms with exact amounts disclosed.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Impact
High effect
B+ Goal FitB Strength of SupportB- CoverageB- Formula Quality
Iron · 50 mg

The blood-support formula is relevant to hair shedding when iron deficiency is present. Chelated iron, active folate, methylcobalamin, and nettle provide a coherent nutrient foundation.

The iron amount is very high and vitamin C is absent, so routine use without a confirmed need is not appropriate. High-dose iron can cause digestive effects and should be matched to laboratory-confirmed iron needs.

Study evidence
Folate Mixed 15 studies
Iron Disputed 25 studies
Vitamin B12 Disputed 17 studies
Impact
High effect
C Goal FitB+ Strength of SupportC CoverageC+ Formula Quality
Iron · 50 mgVitamin B12 · 1000 mcgVitamin B12 · 1000 mcg

Iron, folate, methylcobalamin, and thiamine may reduce fatigue when low blood nutrient status is the cause. The formula is not intended as a general focus aid for users without a defined need.

The nutrient forms and amounts are substantial, although the iron amount is unusually high for unsupervised routine use. Several botanicals add complexity without improving direct productivity coverage.

Study evidence
Iron Supportive 69 studies
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Cardiovascular Support
Impact
Moderate effect
C- Goal FitB+ Strength of SupportD CoverageD+ Formula Quality
Vitamin B12 · 1000 mcgFolate · 400 mcg

Methylcobalamin and folinate provide a useful pair for homocysteine metabolism. The formula omits B6, so that cardiovascular pathway is not fully developed.

Iron and blood-building botanicals make the product more relevant to deficiency-related blood support than general heart care. The high iron amount may be inappropriate for people who do not need supplemental iron.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Impact
Moderate effect
C- Goal FitB Strength of SupportD+ CoverageF Formula Quality
Folate · 400 mcgVitamin B12 · 1000 mcgThiamin · 25 mg

Iron, folate, thiamine, and methylcobalamin may improve cognitive symptoms when anemia or deficiency is present. The formula otherwise targets blood building rather than direct memory or focus enhancement.

Active folate and B12 forms strengthen nutrient quality, while the botanical additions have little cognitive evidence. The 50 mg iron amount may cause nausea or constipation and should not be used routinely without a demonstrated need.

Study evidence
Folate Supportive 90 studies
Thiamin Supportive 48 studies
Vitamin B12 Supportive 74 studies

Ingredients

IngredientAmount per serving
Vitamin B1 (Thiamine Hydrochloride)
25 mg
Folate (Calcium Folinate)
400 mcg
Vitamin B12 (Methylcobalamin)
1000 mcg
Iron (Ferrous Bisglycinate Chelate)
50 mg
Alfalfa (ConcenTrace Trace Minerals)
100 mg
Beet
100 mg
Burdock
100 mg
Nettle leaf extract
100 mg
Red Raspberry
100 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The bioactive methylcobalamin form is a meaningful strength. The amount per serving is well aligned with people who have higher B12 needs. Cost efficiency is weak when the price is compared with the B12 delivered.

B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value
Ferrous bisglycinate offers high bioavailability, while folate and B12 support red blood cell formation. Missing vitamin C leaves absorption support incomplete, and the high-potency amount is best suited to a defined iron need. Two vegetarian capsules are manageable, but the serving cost is high.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value

Thiamine hydrochloride is a standard water-soluble form with established but unenhanced absorption. The 25 mg serving provides moderate potency below the preferred high-potency range. The exact 25 mg thiamin amount is clearly disclosed outside any proprietary blend, but the cost per active dose is high for a standard thiamin form.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.
    Waldvogel S; Pedrazzini B; Vaucher P; Bize R; Cornuz J; Tissot JD; Favrat B · BMC medicine · 2012
    Randomized trial154 participantsEnergy forIron
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
    Bager P; Bossen L; Gantzel R; Grønbæk H · PloS one · 2024
    Randomized trial36 participantsEnergy forThiamin
  4. Intravenous iron versus blood transfusion for postpartum anemia: a systematic review and meta-analysis.
    Caljé E; Groom KM; Dixon L; Marriott J; Foon R; Oyston C; Bloomfield FH; Jordan V · Systematic reviews · 2024
    Meta-analysis4,196 participantsEnergy forIron
  5. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
    Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Observational study2,142 participantsEnergy forVitamin B12
  6. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  7. Iron deficiency, general health and fatigue: results from the Australian Longitudinal Study on Women's Health.
    Patterson AJ; Brown WJ; Powers JR; Roberts DC · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2001
    Cohort studyEnergy forIron
  8. Association between serum vitamin B12 level and frailty in older adults.
    Dokuzlar O; Soysal P; Isik AT · Northern clinics of Istanbul · 2022
    Cross-sectional study335 participantsEnergy forVitamin B12
  9. Metabolic failure due to thiamine deficiency during critical illness.
    Cobilinschi C; Andrei CA; Grinţescu IM; Mirea L · Current opinion in clinical nutrition and metabolic care · 2024
    Narrative reviewEnergy forThiamin
  10. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
    Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
    Randomized trial477 participantsEnergy forIron
  11. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  12. A cross-sectional study of nutritional status in healthy, young, physically-active German omnivores, vegetarians and vegans reveals adequate vitamin B12 status in supplemented vegans.
    Storz MA; Müller A; Niederreiter L; Zimmermann-Klemd AM; Suarez-Alvarez M; Kowarschik S; Strittmatter M; Schlachter E; Pasluosta C; Huber R; Hannibal L · Annals of medicine · 2023
    Cross-sectional study115 participantsEnergy forVitamin B12
  13. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
    Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
    Randomized trial176 participantsEnergy forIron
  14. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  15. Megaloblastic anaemia: prevalence and causative factors.
    Khanduri U; Sharma A · The National medical journal of India · 2008
    Observational study175 participantsEnergy forVitamin B12
  16. Maternal Fatigue after Postpartum Anemia Treatment with Intravenous Ferric Carboxymaltose vs. Intravenous Ferric Derisomaltose vs. Oral Ferrous Sulphate: A Randomized Controlled Trial.
    Bombač Tavčar L; Hrobat H; Gornik L; Preložnik Zupan I; Vidmar Šimic M; Pečlin P; Kavšek G; Lučovnik M · Journal of clinical medicine · 2024
    Randomized trial300 participantsEnergy forIron
  17. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  18. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  19. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
    Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
    Randomized trial252 participantsEnergy forIron
  20. PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
    Morais T; Couto G; Rocha R; Santana G · Arquivos de gastroenterologia · 2026
    Systematic reviewEnergy forThiamin
  21. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  22. Hypophosphatemia attenuates improvements in vitality after intravenous iron treatment in patients with inflammatory bowel disease.
    Bjorner JB; Kennedy N; Lindgren S; Pollock RF · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Randomized trial97 participantsEnergy forIron
  23. Thiamine deficiency-related brain dysfunction in chronic liver failure.
    Butterworth RF · Metabolic brain disease · 2009
    Narrative reviewEnergy forThiamin
  24. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  25. Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration.
    Krayenbuehl PA; Battegay E; Breymann C; Furrer J; Schulthess G · Blood · 2011
    Randomized trial90 participantsEnergy forIron
  26. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  27. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forThiamin
  28. Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
    Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
    Randomized trial164 participantsEnergy forIron
  29. Trends in energy and nutrient intake and risk of inadequate intakes in Catalonia, Spain (1992-2003).
    Serra-Majem L; Ribas-Barba L; Salvador G; Jover L; Raidó B; Ngo J; Plasencia A · Public health nutrition · 2008
    Cross-sectional study4,701 participantsEnergy forVitamin B12
  30. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  31. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health Cognitive Support forFolate
  32. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health forFolate
  33. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  34. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  35. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  36. Can thiamine substitution restore cognitive function in alcohol use disorder?
    Listabarth S; Vyssoki B; Marculescu R; Gleiss A; Groemer M; Trojer A; Harrer C; Weber S; König D · Alcohol and alcoholism (Oxford, Oxfordshire) · 2023
    Clinical trial50 participantsBrain Health forThiamin
  37. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
    Galvin R; Bråthen G; Ivashynka A; Hillbom M; Tanasescu R; Leone MA; EFNS · European journal of neurology · 2011
    Guideline / consensusBrain Health forThiamin
  38. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
    Cantu-Weinstein A; Branning R; Alamir M; Weleff J; Do M; Nero N; Anand A · General hospital psychiatry · 2024
    Systematic review688 participants27 studies pooledBrain Health forThiamin
  39. Vitamin Supplementation and Dementia: A Systematic Review.
    Gil Martínez V; Avedillo Salas A; Santander Ballestín S · Nutrients · 2022
    Systematic reviewBrain Health forThiamin
  40. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsBrain Health Cognitive Support forThiamin
  41. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  42. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health Cognitive Support forVitamin B12
  43. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  44. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  45. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  46. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  47. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  48. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  49. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  50. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  51. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  52. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  53. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  54. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  55. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  56. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  57. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  58. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  59. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  60. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
    Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
    Randomized trial335 participantsCognitive Support forThiamin
  61. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
    Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
    Systematic reviewCognitive Support forThiamin
  62. Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
    Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
    Cross-sectional study2,896 participantsCognitive Support forThiamin
  63. A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
    Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
    Systematic review26 studies pooledCognitive Support forThiamin
  64. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  65. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  66. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support Productivity Boost forVitamin B12
  67. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support Productivity Boost forVitamin B12
  68. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
    Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Randomized trial85 participantsEnergy forIron
  69. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  70. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  71. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  72. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  73. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  74. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  75. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  76. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  77. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  78. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  79. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  80. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  81. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  82. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  83. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  84. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  85. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  86. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  87. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  88. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  89. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  90. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  91. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  92. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  93. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  94. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  95. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  96. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate
  97. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  98. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  99. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  100. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  101. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  102. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  103. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials.
    Low M; Farrell A; Biggs BA; Pasricha SR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Meta-analysis7,089 participants32 studies pooledProductivity Boost forIron
  104. Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.
    Murray-Kolb LE; Wenger MJ; Scott SP; Rhoten SE; Lung'aho MG; Haas JD · The Journal of nutrition · 2017
    Randomized trial150 participantsProductivity Boost forIron
  105. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China.
    Li R; Chen X; Yan H; Deurenberg P; Garby L; Hautvast JG · The American journal of clinical nutrition · 1994
    Randomized trial80 participantsProductivity Boost forIron
  106. The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh.
    Barnett AL; Wenger MJ; Yunus FM; Jalal C; DellaValle DM · Nutrients · 2023
    Randomized trial359 participantsProductivity Boost forIron
  107. Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
    Low MS; Speedy J; Styles CE; De-Regil LM; Pasricha SR · The Cochrane database of systematic reviews · 2016
    Meta-analysis8,506 participants67 studies pooledProductivity Boost forIron
  108. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  109. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  110. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  111. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  112. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  113. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  114. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12