Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.
Waldvogel S; Pedrazzini B; Vaucher P; Bize R; Cornuz J; Tissot JD; Favrat B · BMC medicine · 2012
Randomized trial154 participantsflagEnergy forscienceIron
- Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
Meta-analysis6,276 participants16 studies pooledflagEnergy forscienceVitamin B12
- High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
Bager P; Bossen L; Gantzel R; Grønbæk H · PloS one · 2024
Randomized trial36 participantsflagEnergy forscienceThiamin
- Intravenous iron versus blood transfusion for postpartum anemia: a systematic review and meta-analysis.
Caljé E; Groom KM; Dixon L; Marriott J; Foon R; Oyston C; Bloomfield FH; Jordan V · Systematic reviews · 2024
Meta-analysis4,196 participantsflagEnergy forscienceIron
- Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
Observational study2,142 participantsflagEnergy forscienceVitamin B12
- Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
Randomized trialflagEnergy forscienceThiamin
- Iron deficiency, general health and fatigue: results from the Australian Longitudinal Study on Women's Health.
Patterson AJ; Brown WJ; Powers JR; Roberts DC · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2001
Cohort studyflagEnergy forscienceIron
- Association between serum vitamin B12 level and frailty in older adults.
Dokuzlar O; Soysal P; Isik AT · Northern clinics of Istanbul · 2022
Cross-sectional study335 participantsflagEnergy forscienceVitamin B12
- Metabolic failure due to thiamine deficiency during critical illness.
Cobilinschi C; Andrei CA; Grinţescu IM; Mirea L · Current opinion in clinical nutrition and metabolic care · 2024
Narrative reviewflagEnergy forscienceThiamin
- Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
Randomized trial477 participantsflagEnergy forscienceIron
- Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
Randomized trial80 participantsflagEnergy forscienceThiamin
- A cross-sectional study of nutritional status in healthy, young, physically-active German omnivores, vegetarians and vegans reveals adequate vitamin B12 status in supplemented vegans.
Storz MA; Müller A; Niederreiter L; Zimmermann-Klemd AM; Suarez-Alvarez M; Kowarschik S; Strittmatter M; Schlachter E; Pasluosta C; Huber R; Hannibal L · Annals of medicine · 2023
Cross-sectional study115 participantsflagEnergy forscienceVitamin B12
- The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
Randomized trial176 participantsflagEnergy forscienceIron
- Dietary reference values for thiamin.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagEnergy forscienceThiamin
- Megaloblastic anaemia: prevalence and causative factors.
Khanduri U; Sharma A · The National medical journal of India · 2008
Observational study175 participantsflagEnergy forscienceVitamin B12
- Maternal Fatigue after Postpartum Anemia Treatment with Intravenous Ferric Carboxymaltose vs. Intravenous Ferric Derisomaltose vs. Oral Ferrous Sulphate: A Randomized Controlled Trial.
Bombač Tavčar L; Hrobat H; Gornik L; Preložnik Zupan I; Vidmar Šimic M; Pečlin P; Kavšek G; Lučovnik M · Journal of clinical medicine · 2024
Randomized trial300 participantsflagEnergy forscienceIron
- Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
Randomized trial40 participantsflagEnergy forscienceThiamin
- Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
Qualitative study5 participantsflagEnergy forscienceVitamin B12
- Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
Randomized trial252 participantsflagEnergy forscienceIron
- PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
Morais T; Couto G; Rocha R; Santana G · Arquivos de gastroenterologia · 2026
Systematic reviewflagEnergy forscienceThiamin
- A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
Case series3 participantsflagEnergy forscienceVitamin B12
- Hypophosphatemia attenuates improvements in vitality after intravenous iron treatment in patients with inflammatory bowel disease.
Bjorner JB; Kennedy N; Lindgren S; Pollock RF · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
Randomized trial97 participantsflagEnergy forscienceIron
- Thiamine deficiency-related brain dysfunction in chronic liver failure.
Butterworth RF · Metabolic brain disease · 2009
Narrative reviewflagEnergy forscienceThiamin
- Vitamin B12 Supplementation: Is More Always Better?
Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
Narrative reviewflagEnergy forscienceVitamin B12
- Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration.
Krayenbuehl PA; Battegay E; Breymann C; Furrer J; Schulthess G · Blood · 2011
Randomized trial90 participantsflagEnergy forscienceIron
- Cobalamin deficiency: clinical picture and radiological findings.
Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
Narrative reviewflagEnergy forscienceVitamin B12
- Vitamin B status in patients with chronic fatigue syndrome.
Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
Case-control study30 participantsflagEnergy forscienceThiamin
- Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
Randomized trial164 participantsflagEnergy forscienceIron
- Trends in energy and nutrient intake and risk of inadequate intakes in Catalonia, Spain (1992-2003).
Serra-Majem L; Ribas-Barba L; Salvador G; Jover L; Raidó B; Ngo J; Plasencia A · Public health nutrition · 2008
Cross-sectional study4,701 participantsflagEnergy forscienceVitamin B12
- Effects of thiamine supplementation on exercise-induced fatigue.
Suzuki M; Itokawa Y · Metabolic brain disease · 1996
Randomized trial16 participantsflagEnergy forscienceThiamin
- B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
Meta-analysis46,175 participants95 studies pooledflagBrain Health flagCognitive Support forscienceFolate
- Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
Randomized trial136 participantsflagBrain Health forscienceFolate
- Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
Randomized trial220 participantsflagBrain Health forscienceFolate
- Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
Cohort study3,974 participantsflagBrain Health forscienceFolate
- Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
Cohort study3,910 participantsflagBrain Health forscienceFolate
- Can thiamine substitution restore cognitive function in alcohol use disorder?
Listabarth S; Vyssoki B; Marculescu R; Gleiss A; Groemer M; Trojer A; Harrer C; Weber S; König D · Alcohol and alcoholism (Oxford, Oxfordshire) · 2023
Clinical trial50 participantsflagBrain Health forscienceThiamin
- EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
Galvin R; Bråthen G; Ivashynka A; Hillbom M; Tanasescu R; Leone MA; EFNS · European journal of neurology · 2011
Guideline / consensusflagBrain Health forscienceThiamin
- Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
Cantu-Weinstein A; Branning R; Alamir M; Weleff J; Do M; Nero N; Anand A · General hospital psychiatry · 2024
Systematic review688 participants27 studies pooledflagBrain Health forscienceThiamin
- Vitamin Supplementation and Dementia: A Systematic Review.
Gil Martínez V; Avedillo Salas A; Santander Ballestín S · Nutrients · 2022
Systematic reviewflagBrain Health forscienceThiamin
- Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
Cross-sectional study2,422 participantsflagBrain Health flagCognitive Support forscienceThiamin
- Relationship between vitamin B12 levels and motor development: A systematic review.
Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
Systematic review1,559 participants8 studies pooledflagBrain Health forscienceVitamin B12
- Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
Randomized trial115 participantsflagBrain Health flagCognitive Support forscienceVitamin B12
- Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
Alghamdi A · Current medical imaging · 2023
Meta-analysis12 studies pooledflagBrain Health forscienceVitamin B12
- Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
Systematic review22 studies pooledflagBrain Health forscienceVitamin B12
- Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Cohort study1,994 participantsflagBrain Health forscienceVitamin B12
- Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
Cohort study115,664 participantsflagCardiovascular Support forscienceFolate
- Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
Cohort study3,530 participantsflagCardiovascular Support forscienceFolate
- Effect of folic acid on endothelial function following acute myocardial infarction.
Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
Randomized trial40 participantsflagCardiovascular Support forscienceFolate
- Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
Randomized trial24 participantsflagCardiovascular Support forscienceFolate
- 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
Non-randomized trial20 participantsflagCardiovascular Support forscienceFolate
- Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
Cross-sectional study20,665 participantsflagCardiovascular Support flagHeart Health forscienceVitamin B12
- Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
Cohort study493 participantsflagCardiovascular Support forscienceVitamin B12
- Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
Cross-sectional study1,197 participantsflagCardiovascular Support forscienceVitamin B12
- Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
Cohort study202 participantsflagCardiovascular Support forscienceVitamin B12
- Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
Systematic reviewflagCardiovascular Support forscienceVitamin B12
- Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
Randomized trial180 participantsflagCognitive Support forscienceFolate
- Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
Meta-analysis8,122 participants9 studies pooledflagCognitive Support forscienceFolate
- Homocysteine and folate as risk factors for dementia and Alzheimer disease.
Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
Cohort study816 participantsflagCognitive Support forscienceFolate
- Folate mediates cognitive impairment of aged people with periodontitis.
Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
Cross-sectional study1,966 participantsflagCognitive Support forscienceFolate
- Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
Randomized trial335 participantsflagCognitive Support forscienceThiamin
- What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
Systematic reviewflagCognitive Support forscienceThiamin
- Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
Cross-sectional study2,896 participantsflagCognitive Support forscienceThiamin
- A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
Systematic review26 studies pooledflagCognitive Support forscienceThiamin
- Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
Systematic review46 studies pooledflagCognitive Support forscienceVitamin B12
- Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
Randomized trial218 participantsflagCognitive Support forscienceVitamin B12
- Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
Randomized trial240 participantsflagCognitive Support flagProductivity Boost forscienceVitamin B12
- Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
Cohort study249 participantsflagCognitive Support flagProductivity Boost forscienceVitamin B12
- Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
Randomized trial85 participantsflagEnergy forscienceIron
- Vitamin B12 Deficiency: Common Questions and Answers.
Patel H; McGuirk R · American family physician · 2025
Narrative reviewflagEnergy forscienceVitamin B12
- Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
Cohort study55,569 participantsflagGeneral Health forscienceFolate
- The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
Randomized trial119 participantsflagGeneral Health forscienceFolate
- Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
Song S; Song BM; Park HY · The Journal of nutrition · 2023
Cohort study21,260 participantsflagGeneral Health forscienceFolate
- The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
Seyoum Tola F · Medicine · 2024
Systematic reviewflagGeneral Health forscienceFolate
- Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
Systematic review71,847 participants46 studies pooledflagGeneral Health forscienceFolate
- Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
Randomized trial40 participantsflagGeneral Health forscienceVitamin B12
- Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
Randomized trial90 participantsflagGeneral Health forscienceVitamin B12
- A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
Randomized trial98 participantsflagGeneral Health forscienceVitamin B12
- Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
Randomized trial204 participantsflagGeneral Health forscienceVitamin B12
- The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
Clinical trial50 participantsflagGeneral Health forscienceVitamin B12
- Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
Meta-analysis2,538 participants18 studies pooledflagHair Health forscienceFolate
- Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
Case-control study200 participantsflagHair Health forscienceFolate flagHair Health forscienceVitamin B12
- Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
Randomized trialflagHair Health forscienceFolate
- Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
Randomized trialflagHair Health forscienceFolate
- Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
Randomized trialflagHair Health forscienceFolate
- The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
Case-control study100,203 participantsflagHair Health forscienceIron
- Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
Meta-analysis10,029 participants36 studies pooledflagHair Health forscienceIron
- Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
Cohort study261 participantsflagHair Health forscienceIron
- Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
Cross-sectional study100 participantsflagHair Health forscienceIron
- Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
Cohort study155 participantsflagHair Health forscienceIron
- Factors Associated with Premature Hair Graying in a Young Indian Population.
Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
Case-control study74 participantsflagHair Health forscienceVitamin B12
- Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
İritaş SY · Dermatology practical & conceptual · 2026
Case-control study600 participantsflagHair Health forscienceVitamin B12
- Hair Loss After Laparoscopic Sleeve Gastrectomy.
Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
Cohort study50 participantsflagHair Health forscienceVitamin B12
- Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
Cross-sectional study71 participantsflagHair Health forscienceVitamin B12
- Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
Randomized trial20,702 participantsflagHeart Health forscienceFolate
- Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
Case-control study985 participantsflagHeart Health forscienceFolate
- Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
Meta-analysis369,746 participants11 studies pooledflagHeart Health forscienceFolate
- Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
Meta-analysis423,304 participants25 studies pooledflagHeart Health forscienceFolate
- The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
Wondemagegn AT; Afework M · SAGE open medicine · 2022
Meta-analysis37 studies pooledflagHeart Health forscienceFolate
- Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
Cross-sectional study469 participantsflagHeart Health forscienceVitamin B12
- Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
Cohort study1,950 participantsflagHeart Health forscienceVitamin B12
- Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
Non-randomized trial16 participantsflagHeart Health forscienceVitamin B12
- The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
Observational study596 participantsflagHeart Health forscienceVitamin B12
- Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials.
Low M; Farrell A; Biggs BA; Pasricha SR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
Meta-analysis7,089 participants32 studies pooledflagProductivity Boost forscienceIron
- Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.
Murray-Kolb LE; Wenger MJ; Scott SP; Rhoten SE; Lung'aho MG; Haas JD · The Journal of nutrition · 2017
Randomized trial150 participantsflagProductivity Boost forscienceIron
- Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China.
Li R; Chen X; Yan H; Deurenberg P; Garby L; Hautvast JG · The American journal of clinical nutrition · 1994
Randomized trial80 participantsflagProductivity Boost forscienceIron
- The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh.
Barnett AL; Wenger MJ; Yunus FM; Jalal C; DellaValle DM · Nutrients · 2023
Randomized trial359 participantsflagProductivity Boost forscienceIron
- Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
Low MS; Speedy J; Styles CE; De-Regil LM; Pasricha SR · The Cochrane database of systematic reviews · 2016
Meta-analysis8,506 participants67 studies pooledflagProductivity Boost forscienceIron
- Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
Meta-analysisflagProductivity Boost forscienceVitamin B12
- Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
Cross-sectional study1,935 participantsflagProductivity Boost forscienceVitamin B12
- Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
Balatacı U; Ay B · Frontiers in pediatrics · 2026
Case-control study108 participantsflagProductivity Boost forscienceVitamin B12
- Association between vitamin B12 levels and cognitive impairment in older adults.
Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
Cross-sectional study241 participantsflagProductivity Boost forscienceVitamin B12
- Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
Randomized trial20 participantsflagProductivity Boost forscienceVitamin B12
- Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
Cohort study2,533 participantsflagProductivity Boost forscienceVitamin B12
- Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
Cross-sectional study812 participantsflagProductivity Boost forscienceVitamin B12