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AdvaClear

Metagenics
4.9
★ ★ ★ ★ ★
(80 ratings)
Vitamin B6 16.66 mg
Niacin 23.3 mg
Thiamin 10 mg
Vitamin B5 33.3 mg
Copper 0.66 mg
Molybdenum 66 mcg
Green Tea 56 mg
Product Image
Score67
Active folate and B12, artichoke, pomegranate, green tea, milk thistle, and well-chosen minerals create a broad liver-support formula. Several antioxidant amounts are modest, the label repeats some extract entries, and the serving offers weak value.
How scoring works
Quantity:42 Capsule(s) • (21 servings)
Goals:
Detoxification
Energy
Metabolism Boost

Score 67

Active folate and B12, artichoke, pomegranate, green tea, milk thistle, and well-chosen minerals create a broad liver-support formula. Several antioxidant amounts are modest, the label repeats some extract entries, and the serving offers weak value.
How scoring works
$43.95($2.09 per serving)
iHerb
$ 43.95
Pure Formulas
$ 43.95
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Analysis

Active folate and B12, artichoke, pomegranate, green tea, milk thistle, and well-chosen minerals create a broad liver-support formula. Several antioxidant amounts are modest, the label repeats some extract entries, and the serving offers weak value.

Synthetic pyridoxine is less direct than active P-5-P. The B6 dose is well aligned with targeted metabolic and neurological support.

A broad group of nutrients and botanicals supports antioxidant defense, methylation, sulfite metabolism, and liver protection. N-acetyl-L-cysteine, silymarin, selenium, molybdenum, active folate, and methylcobalamin give the formula strong goal relevance.

Who is it for
  • Adults focused on detoxification
  • Adults focused on energy
  • Adults focused on metabolism boost
Best for
  • Vitamin B6 supplementation
  • Niacin supplementation
  • Thiamin supplementation

Pros

  • Provides a disclosed 167.00mg of artichoke (cynara scolymus) leaf extract
  • Provides a disclosed 87.50mg of pomegranate (punica granatum l.) whole fruit extract
  • Provides a disclosed 50.00mg of silymarin

Cons

  • Several antioxidant amounts are modest
  • Some extract entries make totals less direct
  • Only twenty-one servings are supplied

Warnings

  • Preformed vitamin A from retinyl palmitate warrants care when stacking other retinol products, especially during pregnancy.
  • The vitamin B6 amount should not be casually stacked with other high-B6 supplements during long-term use.
  • Artichoke may be unsuitable with bile-duct obstruction or symptomatic gallstones.

Nutrient quality

75 High impact

Methylated B vitamins, selenomethionine, citrate minerals, and standardized artichoke support good form quality. The nutrient base is meaningful, but N-acetyl cysteine, milk thistle, and green tea are modest for targeted detoxification support.

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Ingredient transparency

80 High impact

Active amounts are supplied, though repeated extract markers and nutrient forms complicate totals. Complete non-active ingredient details are not included in the supplied label data.

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Customer satisfaction

66 High impact

The supplied average rating provides limited high-level context. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

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Value for money

38 Lower impact

Useful forms and a coherent design do not fully support the very high serving cost. Several key detoxification actives are too modest to deliver strong dose-adjusted value.

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Report analysis

Goals

Impact
High effect
A- Goal FitC Strength of SupportB CoverageB+ Formula Quality
Folate · 445 mcg DFEVitamin B12 · 33.4 mcgVitamin B6 · 16.66 mgMolybdenum · 66 mcgSelenium · 50 mcgVitamin E · 44.6 mgZinc · 6.5 mgVitamin C · 133 mgTaurine · 117 mgRiboflavin · 5 mg

A broad group of nutrients and botanicals supports antioxidant defense, methylation, sulfite metabolism, and liver protection. N-acetyl-L-cysteine, silymarin, selenium, molybdenum, active folate, and methylcobalamin give the formula strong goal relevance.

Several central actives are present at modest amounts, including N-acetyl-L-cysteine, taurine, silymarin, and green tea markers. The thoughtful combination is more convincing as broad daily support than as a high-dose targeted protocol.

Study evidence
Folate Supportive 16 studies
Green Tea Disputed 16 studies
Molybdenum Adverse 1 study
Selenium Supportive 10 studies
Taurine Supportive 2 studies
Impact
High effect
B- Goal FitB- Strength of SupportC- CoverageD+ Formula Quality
Vitamin D · 0.8 mcgVitamin B5 · 33.3 mgRiboflavin · 5 mgThiamin · 10 mgVitamin B12 · 33.4 mcg

B vitamins provide a real metabolic-energy foundation, but the overall formula is directed toward antioxidant and detoxification support rather than stamina or alertness. Artichoke, watercress, taurine, N-acetylcysteine, pomegranate, green tea, and silymarin do not create a strong second energy pathway at the listed amounts.

Active folate and methylcobalamin improve form quality, while several B-vitamin amounts are moderate. The long ingredient list includes many modest botanical and antioxidant additions, which dilutes the energy focus and makes the formula less coherent for this goal.

Study evidence
Thiamin Disputed 12 studies
Impact
Moderate effect
C- Goal FitC- Strength of SupportC- CoverageC+ Formula Quality
Biotin · 66 mcgNiacin · 23.3 mgVitamin B12 · 33.4 mcgRiboflavin · 5 mgThiamin · 10 mgVitamin B5 · 33.3 mgVitamin B6 · 16.66 mgVitamin D · 0.8 mcgZinc · 6.5 mgGreen Tea · 56 mg

B vitamins, a standardized decaffeinated green-tea extract, and several antioxidant compounds create moderate metabolic relevance. The green-tea active amount is below a strong target and the absence of caffeine limits thermogenic depth.

Artichoke, watercress, taurine, NAC, and milk thistle make the formula more oriented toward antioxidant and liver pathways. The combination is coherent for that purpose but only partly aligned with a direct metabolism boost.

Study evidence
Green Tea Supportive 31 studies
Taurine Supportive 11 studies

Ingredients

IngredientAmount per serving
Vitamin A (Mixed Carotenoids, Retinyl Palmitate)
750 mcg
Vitamin C (Ascorbic Acid)
133 mg
Vitamin D (Cholecalciferol)
0.8 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
44.6 mg
Thiamine (Thiamine Mononitrate)
10 mg
Riboflavin
5 mg
Niacin (Niacinamide)
23.3 mg
Vitamin B6 (Pyridoxine Hydrochloride)
16.66 mg
Folate (Calcium L-5-Methyltetrahydrofolate)
445 mcg DFE
Vitamin B12 (Methylcobalamin)
33.4 mcg
Biotin
66 mcg
Pantothenic Acid (Calcium D-Pantothenate)
33.3 mg
Zinc (Zinc Citrate)
6.5 mg
Selenium (Selenomethionine)
50 mcg
Copper (Copper Citrate)
0.66 mg
Manganese (Manganese Citrate)
1.66 mg
Molybdenum (Molybdenum Aspartate Complex)
66 mcg
Sodium (Sodium Sulfate)
40 mg
Artichoke (Cynara scolymus) leaf extract (Chlorogenic Acid, Cynarin)
167 mg
Watercress (Nasturtium officinale) aerial parts 4:1 extract
133 mg
Taurine
117 mg
Sodium Sulfate
100 mg
Pomegranate (Punica granatum L.) whole fruit extract (Gallic Acid equivalent)
87.5 mg
N-Acetyl-L-Cysteine
67 mg
decaffeinated Green Tea leaf extract (Caffeine, Catechins, Epigallocatechin Gallate)
56 mg
Silymarin (Milk Thistle (Silybum marianum) seed extract)
50 mg
Gluten Free Adults 18–50
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Synthetic pyridoxine is less direct than active P-5-P. The B6 dose is well aligned with targeted metabolic and neurological support. No listed additives create a clear purity concern.

B Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The complex antioxidant and botanical formula discloses both niacin and niacinamide. The amount is modest and the standard capsules offer no specialized release, so vitamin B3 serves as supporting nutrition rather than a targeted active. A very high serving cost makes it weak value for anyone mainly seeking niacin.

B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value

Thiamine Mononitrate provides a standard water-soluble thiamin form at a moderate or low dose. The capsule offers conventional oral delivery, while the exact amount is clearly disclosed. Cost efficiency is weak relative to the active dose.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States.
    Yu Z; Samavat H; Dostal AM; Wang R; Torkelson CJ; Yang CS; Butler LM; Kensler TW; Wu AH; Kurzer MS; Yuan JM · Cancer prevention research (Philadelphia, Pa.) · 2018
    Randomized trial1,021 participantsDetoxification forGreen Tea
  2. Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials.
    Isomura T; Suzuki S; Origasa H; Hosono A; Suzuki M; Sawada T; Terao S; Muto Y; Koga T · European journal of clinical nutrition · 2018
    Meta-analysis34 studies pooledDetoxification forGreen Tea
  3. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease.
    Pezeshki A; Safi S; Feizi A; Askari G; Karami F · International journal of preventive medicine · 2016
    Randomized trial80 participantsDetoxification forGreen Tea
  4. Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.
    Mielgo-Ayuso J; Barrenechea L; Alcorta P; Larrarte E; Margareto J; Labayen I · The British journal of nutrition · 2014
    Randomized trial83 participantsDetoxification forGreen Tea
  5. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  6. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  7. Vitamin B6 repletion in cirrhosis with oral pyridoxine: failure to improve amino acid metabolism.
    Henderson JM; Scott SS; Merrill AH; Hollins B; Kutner MH · Hepatology (Baltimore, Md.) · 1989
    Single-arm trial8 participantsMetabolism Boost forVitamin B6
  8. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  9. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  10. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
    Randomized trial55 participantsDetoxification forFolate
  11. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
    Yuan S; Chen J; Dan L; Xie Y; Sun Y; Li X; Larsson SC · The American journal of clinical nutrition · 2022
    Meta-analysis30,368 participants22 studies pooledDetoxification forFolate
  12. Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
    Zhang X; Xu X; Zhong Y; Power MC; Taylor BD; Carrillo G · Journal of exposure science & environmental epidemiology · 2020
    Cross-sectional study11,016 participantsDetoxification forFolate
  13. Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
    Wu Z; Hu H; Wang C; Wu J; Xiong Y; Fu Y; Cheng X; Su H; Li P · Environmental science and pollution research international · 2022
    Cross-sectional study15,501 participantsDetoxification forFolate
  14. Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Molaqanbari MR; Zarringol S; Talari HR; Taghizadeh M; Bahmani F; Mohtashamian A; Ebrahimzadeh A; Sharifi N · Advanced biomedical research · 2023
    Randomized trial66 participantsDetoxification forFolate
  15. Therapeutic benefits of green tea extract on various parameters in non-alcoholic fatty liver disease patients.
    Hussain M; Habib-Ur-Rehman; Akhtar L · Pakistan journal of medical sciences · 2024
    Randomized trial80 participantsDetoxification forGreen Tea
  16. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study.
    Sakata R; Nakamura T; Torimura T; Ueno T; Sata M · International journal of molecular medicine · 2014
    Randomized trial17 participantsDetoxification forGreen Tea
  17. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype.
    Hakim IA; Chow HH; Harris RB · The Journal of nutrition · 2008
    Randomized trialDetoxification forGreen Tea
  18. Modulation of human glutathione s-transferases by polyphenon e intervention.
    Chow HH; Hakim IA; Vining DR; Crowell JA; Tome ME; Ranger-Moore J; Cordova CA; Mikhael DM; Briehl MM; Alberts DS · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007
    Single-arm trial42 participantsDetoxification forGreen Tea
  19. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  20. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  21. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  22. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  23. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  24. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  25. Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
    Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
    Non-randomized trial24 participantsDetoxification forTaurine
  26. Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
    Single-arm trial32 participantsDetoxification forTaurine
  27. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  28. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  29. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  30. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  31. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  32. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials.
    Liu K; Zhou R; Wang B; Chen K; Shi LY; Zhu JD; Mi MT · The American journal of clinical nutrition · 2013
    Meta-analysis1,133 participants17 studies pooledMetabolism Boost forGreen Tea
  33. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans.
    Venables MC; Hulston CJ; Cox HR; Jeukendrup AE · The American journal of clinical nutrition · 2008
    Randomized trial23 participantsMetabolism Boost forGreen Tea
  34. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.
    Dulloo AG; Duret C; Rohrer D; Girardier L; Mensi N; Fathi M; Chantre P; Vandermander J · The American journal of clinical nutrition · 1999
    Randomized trial10 participantsMetabolism Boost forGreen Tea
  35. A 60-Day Green Tea Extract Supplementation Counteracts the Dysfunction of Adipose Tissue in Overweight Post-Menopausal and Class I Obese Women.
    Rondanelli M; Gasparri C; Perna S; Petrangolini G; Allegrini P; Fazia T; Bernardinelli L; Cavioni A; Mansueto F; Oberto L; Patelli Z; Tartara A; Riva A · Nutrients · 2022
    Randomized trial28 participantsMetabolism Boost forGreen Tea
  36. Epigallocatechin gallate alleviates non-alcoholic fatty liver disease through the inhibition of the expression and activity of Dipeptide kinase 4.
    Yang M; Yan R; Sha R; Wang X; Zhou S; Li B; Zheng Q; Cao Y · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trialMetabolism Boost forGreen Tea
  37. Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis.
    Wang K; Ma CH; Khoramjoo M; Kung JY; Oudit GY · BMC infectious diseases · 2026
    Meta-analysis1,030 participants27 studies pooledMetabolism Boost forTaurine
  38. Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.
    Sun Q; Wang J; Wang H; Yu H; Wan K; Ma F; Wang R · Nutrients · 2025
    Meta-analysis9 studies pooledMetabolism Boost forTaurine
  39. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
    Guan L; Miao P · European journal of pharmacology · 2021
    Meta-analysis12 studies pooledMetabolism Boost forTaurine
  40. Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects.
    Zhang M; Bi LF; Fang JH; Su XL; Da GL; Kuwamori T; Kagamimori S · Amino acids · 2005
    Randomized trial30 participantsMetabolism Boost forTaurine
  41. Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity.
    Magnusson TE; Blackwood SJ; Tischer D; Strmeň T; Pontén M; Edman S; Horwath O; Apró W; Moberg M; Chorell E; Katz A · European journal of endocrinology · 2025
    Cross-sectional study36 participantsMetabolism Boost forTaurine