Product Image

Advanced B Complex

AOR Advanced Orthomolecular Research Advanced
4.8
★ ★ ★ ★ ★
(3090 ratings)
Vitamin B6 33 mg
Thiamin 33 mg
Vitamin B5 100 mg
Choline 80 mg
Vitamin B12 333 mcg
Niacin 118 mg
Product Image
Score83

A well-designed active-form B complex with useful choline, inositol, and pantethine. High niacin and vitamin B6 call for deliberate use.

How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Energy
General Health
Heart Health
Mood Support
Cardiovascular Support
Cognitive Support
Metabolism Boost

Score 83

A well-designed active-form B complex with useful choline, inositol, and pantethine. High niacin and vitamin B6 call for deliberate use.

How scoring works
$30.76($0.34 per serving)
Pure Formulas
$ 30.77
Vitacost
$ 33.83
iHerb
$ 30.76
iHerb
$ 30.76
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Analysis

The capsule uses several well-defined forms, including benfotiamine, riboflavin 5-phosphate, pyridoxal 5-phosphate, methylfolate, and methylcobalamin. Pantethine complements pantothenic acid, while 80 mg choline and 131 mg inositol add meaningful breadth.

Niacin reaches 118 mg and vitamin B6 reaches 33 mg. Those amounts provide high-potency coverage but increase the chance of intolerance and make long-term dose fit important.

The formula suits users who prioritize active forms and a compact one-capsule serving. Hair support remains secondary because the design centers on metabolic cofactors rather than a complete hair-nutrient profile.

Who is it for
  • Adults seeking activated B-vitamin forms
  • People wanting methylfolate and methylcobalamin
  • Users interested in pantethine and inositol
Best for
  • Normal energy metabolism
  • Activated B-complex coverage
  • Methylated folate and B12 intake

Pros

  • Multiple activated and methylated forms
  • Includes benfotiamine and pantethine
  • Useful choline and inositol amounts
  • One-capsule serving

Cons

  • High niacin amount
  • Substantial vitamin B6 exposure
  • Not a broad hair-support formula

Warnings

  • The 118 mg niacin amount may cause flushing or digestive discomfort
  • Long-term 33 mg vitamin B6 intake may be unsuitable for some users
  • People with glucose-control or liver concerns should discuss high-niacin use with a clinician

Nutrient quality

85 Highest impact

A wide range of active coenzyme forms gives the formula excellent biochemical quality and meaningful metabolic depth. High niacin and vitamin B6 amounts make the design more intensive than basic daily maintenance requires.

Ingredient transparency

84 Highest impact

Every active has a separate amount and no proprietary blend hides the formula. Repeated source entries and an unspecified niacin form create avoidable ambiguity, while inactive ingredients are not supplied.

Customer satisfaction

77 High impact

The exceptional average rating is supported by a large review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

85 Highest impact

Premium active forms and a focused one-capsule design provide good quality value. The serving costs more than basic formulas, but the refined ingredient choices largely justify that difference.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 2.5 mgThiamin · 33 mgVitamin B12 · 333 mcg

Methylcobalamin, methylfolate, P-5-P, riboflavin phosphate, benfotiamine, and pantethine provide an unusually active B-vitamin profile for cellular energy metabolism. Vitamin B12 reaches the rubric's higher target and the one-capsule formula is tightly focused.

The product covers only metabolic cofactor pathways and provides no acute alertness, mitochondrial specialty ingredient, or adaptogen. Several B vitamins are high enough that stacking with other fortified products should be deliberate.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageB+ Formula Quality
Folate · 555 mcg DFEVitamin B12 · 333 mcg

Active forms of multiple B vitamins provide focused support for energy metabolism, methylation, and nervous-system nutrient needs. Benfotiamine, riboflavin phosphate, P-5-P, methylfolate, methylcobalamin, and pantethine are all clearly identified.

The formula is intentionally narrow and does not address fat-soluble vitamins, minerals, or essential fatty acids. Repeated entries for thiamine, pantothenic acid, and inositol make some source contributions appear less clear than the otherwise transparent label.

Study evidence
Vitamin B12 Adverse 66 studies
Heart Health
Heart Health
Impact
High effect
B- Goal FitA- Strength of SupportC CoverageA Formula Quality
Vitamin B12 · 333 mcgVitamin B6 · 33 mgFolate · 555 mcg DFE

Active folate, P5P, and methylcobalamin form a coherent homocysteine-support trio. Their cardiovascular relevance is strongest for people with inadequate status or elevated homocysteine.

The formula does not cover lipids, vascular tone, magnesium, K2, or cardiac cellular energy. High niacin and vitamin B6 amounts deserve caution during long-term daily use.

Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitB+ Strength of SupportC CoverageA- Formula Quality
Folate · 555 mcg DFEVitamin B6 · 33 mgVitamin B12 · 333 mcg

P-5-P, L-5-MTHF, methylcobalamin, choline, and inositol support neurotransmitter cofactors and methylation. The active vitamin forms are strong, while choline and inositol remain modest.

A focused B-complex can be useful when nutrient status is low but does not directly modulate stress or serotonin on its own. No adaptogen, omega-3, or dedicated mood active broadens the formula.

Study evidence
Vitamin B12 Supportive 29 studies
Vitamin B6 Supportive 19 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B- Goal FitB Strength of SupportC CoverageA- Formula Quality
Vitamin B12 · 333 mcgVitamin B6 · 33 mgFolate · 555 mcg DFENiacin · 118 mg

Active B6, folate, and B12 provide a well-built combination for homocysteine metabolism. Benefits are most relevant when intake or status is inadequate, and the formula does not directly cover lipids, blood flow, or cardiac energy.

The active forms are a strength, but the niacin form is not identified clearly enough to judge its contribution or flush risk. The 33 mg B6 amount may be unsuitable for prolonged unsupervised use because supplemental B6 can cause nerve symptoms in susceptible users.

Study evidence
Folate Supportive 93 studies
Niacin Supportive 136 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Cognitive Support
Cognitive Support
Impact
High effect
C- Goal FitB+ Strength of SupportC+ CoverageA- Formula Quality
Choline · 80 mgThiamin · 33 mgVitamin B6 · 33 mgFolate · 555 mcg DFEVitamin B12 · 333 mcg

P-5-P, active folate, methylcobalamin, benfotiamine, and other B vitamins provide a high-quality base for cognitive energy and neurotransmitter metabolism. Choline bitartrate is modest and not brain-targeted, while no direct memory or circulation active is present.

The formula may be useful when low B-vitamin status contributes to mental fatigue. Strong forms and clear amounts make it a coherent B-complex, but its cognitive pathway coverage remains narrow.

Study evidence
Choline Supportive 76 studies
Folate Supportive 68 studies
Thiamin Supportive 30 studies
Vitamin B12 Disputed 84 studies
Vitamin B6 Supportive 17 studies

Ingredients

IngredientAmount per serving
Thiamine (Benfotiamine, Vitamin B1)
 33 mg
Riboflavin (Riboflavin 5-Phosphate Sodium)
 2.5 mg
Niacin (Vitamin B3)
 118 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 33 mg
Folate (Calcium L-5-Methyltetrahydrofolate)
 555 mcg DFE
Vitamin B12 (Methylcobalamin)
 333 mcg
Biotin
167 mcg
Pantothenic Acid (Calcium D-Pantothenate, Pantethine, Vitamin B5)
 100 mg
Choline (Choline Bitartrate)
 80 mg
Inositol (Inositol Hexanicotinate)
 131 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 33 mg OverallScore94
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

P-5-P provides B6 in a metabolically ready form. The 33 mg serving falls within the preferred range. The supplied data omit the other-ingredients list, so additive purity cannot be checked. Its economical serving cost adds practical value.

View ingredientView products
Thiamin (Benfotiamine, Vitamin B1) · 33 mg OverallScore73
A Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value

Benfotiamine offers a higher-bioavailability thiamin form with useful tissue penetration. The clearly listed 33 mg dose is moderate, while the standard capsule adds no special delivery advantage. Serving cost is modest for a B-complex, but the price per active thiamin amount remains high.

View ingredientView products
Vitamin B5 (Calcium D-Pantothenate, Pantethine) · 100 mg OverallScore68
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Pantethine adds an active Coenzyme A precursor alongside calcium D-pantothenate, while the 100 mg dose supports general maintenance. The source and amount are clear, but excipient purity cannot be verified without an Other Ingredients list. The normalized cost remains high despite the premium form.

View ingredientView products
Loading alternative details
85 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Active forms of thiamine, riboflavin, vitamin B6, folate, and vitamin B12 make this a well-designed B-complex. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although folic acid is less active than methylfolate.</p>
81 Performance

Coenzyme B-Complex Caps

Country Life
<p>Multiple coenzyme vitamin forms create a well-designed B-complex with meaningful nutritional amounts. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although the high pyridoxine amount is less suitable for long-term daily use.</p>
78 Performance

Active B-Complex

Integrative Therapeutics
<p>Methylcobalamin, P-5-P, riboflavin phosphate, and substantial choline create strong energy and nervous-system support. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although the high pyridoxine amount is less suitable for long-term daily use.</p>
74 Budget

B-Complex '50'

Solgar
<p>Broad B-vitamin coverage fits energy metabolism, but the formula relies on conventional forms and an unnecessarily high vitamin B6 amount. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
76 Budget

B-100

NOW
<p>Broad B-vitamin coverage comes at very low serving cost, making the formula economical for targeted high-potency use. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
77 Budget

B-50 Complex

Nature's Way
<p>Active riboflavin improves a broad and clearly dosed B-complex base, but the vitamin B6 amount is unnecessarily high. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Value

B-Complex '100'

Solgar
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
75 Value

Sustained Release B-100

NOW
<p>Broad high-potency B-vitamin coverage supports nutritional energy metabolism, but most forms are conventional. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Value

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve this otherwise conventional high-potency B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J · Clinical nutrition (Edinburgh, Scotland) · 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  2. Choline During Pregnancy and Child Neurodevelopment: A Systematic Review of Randomized Controlled Trials and Observational Studies.
    Gould JF; Hines S; Best KP; Grzeskowiak LE; Jansen O; Green TJ · Nutrients · 2025
    Systematic review9 studies pooledCognitive Support forCholine
  3. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  4. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  5. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
    Kanti G; Anadol-Schmitz E; Bobrov P; Strassburger K; Kahl S; Zaharia OP; Sarabhai T; Karusheva Y; Burkart V; Markgraf DF; Trenkamp S; Ziegler D; Szendroedi J; Roden M; GDS Group · The Journal of clinical endocrinology and metabolism · 2021
    Cross-sectional study249 participantsMetabolism Boost forVitamin B12
  6. Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
    Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
    Meta-analysis82,246 participants9 studies pooledCognitive Support forCholine
  7. Vitamin B6 requirements of women using oral contraceptives.
    Leklem JE; Brown RR; Rose DP; Linkswiler HM · The American journal of clinical nutrition · 1975
    Non-randomized trial24 participantsMetabolism Boost forVitamin B6
  8. Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic.
    Světnička M; Sigal A; Selinger E; Heniková M; El-Lababidi E; Gojda J · Nutrients · 2022
    Cross-sectional study200 participantsMetabolism Boost forVitamin B12
  9. Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients.
    Vine J; Lee JH; Simpson MD; Grossestreuer AV; Sorour K; Zubair MM; Moskowitz A; Berg KM; Liu X; Donnino MW · Resuscitation · 2026
    Randomized trial74 participantsMetabolism Boost forThiamin
  10. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  11. Gut microbiota-mediated choline metabolism exacerbates cognitive impairment induced by chronic cerebral hypoperfusion.
    Li X; Ren Y; Gao X; Wang H; Zhang J; Xie J; Liang J; Zhao B; Zhou H; Yin J · Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Cross-sectional studyCognitive Support forCholine
  12. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  13. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  14. Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.
    Tan KML; Tint MT; Cabral RM; Lau R; Kee MZL; Garg V; De Iorio M; Tan SSL; Eriksson JG · Scientific reports · 2026
    Cohort study662 participantsMetabolism Boost forThiamin
  15. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  16. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  17. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  18. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  19. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C · Frontiers in psychiatry · 2026
    Narrative reviewMetabolism Boost forThiamin
  20. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  21. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  22. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  23. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  24. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR · Metabolomics : Official journal of the Metabolomic Society · 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  25. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis.
    Jonczyk R; Ronconi S; Rychlik M; Genschel U · Plant molecular biology · 2008
    OtherMetabolism Boost forVitamin B5
  26. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  27. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  28. Pathophysiology, prevention, and treatment of beriberi after gastric surgery.
    Wilson RB · Nutrition reviews · 2021
    Narrative reviewMetabolism Boost forThiamin
  29. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  30. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  31. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  32. Effect of chronic levodopa treatment on pyridoxine metabolism.
    Mars H · Neurology · 1975
    Non-randomized trial16 participantsMetabolism Boost forVitamin B6
  33. Insights Into Thiamine Supplementation in Patients With Septic Shock.
    Costa NA; Pereira AG; Sugizaki CSA; Vieira NM; Garcia LR; de Paiva SAR; Zornoff LAM; Azevedo PS; Polegato BF; Minicucci MF · Frontiers in medicine · 2022
    Narrative reviewMetabolism Boost forThiamin
  34. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5
  35. Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.
    Nguyen TT; Risbud RD; Mattson SN; Chambers CD; Thomas JD · The American journal of clinical nutrition · 2017
    Randomized trial55 participantsCognitive Support forCholine
  36. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma.
    Sur S; Camara M; Buchmeier A; Morgan S; Nelson HS · Annals of allergy · 1993
    Randomized trial31 participantsMetabolism Boost forVitamin B6
  37. Thiamine-dependent processes and treatment strategies in neurodegeneration.
    Gibson GE; Blass JP · Antioxidants & redox signaling · 2007
    Narrative reviewMetabolism Boost forThiamin
  38. Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
    Delaney NF; Sharma R; Tadvalkar L; Clish CB; Haller RG; Mootha VK · Proceedings of the National Academy of Sciences of the United States of America · 2018
    OtherMetabolism Boost forVitamin B5
  39. Does supplementation of choline during or after pregnancies exposed to alcohol improve neurocognitive development of children? A meta-analysis.
    Lino GM; de Carvalho IN; de Amorim VOA; Bresani-Salvi CC; Luna VLM; Galvão PVM; Conrado GAM · Pediatrics and neonatology · 2025
    Meta-analysis5 studies pooledCognitive Support forCholine
  40. Oxalate metabolism in end-stage renal disease: the effect of ascorbic acid and pyridoxine.
    Morgan SH; Maher ER; Purkiss P; Watts RW; Curtis JR · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 1988
    Single-arm trial10 participantsMetabolism Boost forVitamin B6
  41. Thiamine-responsive inborn errors of metabolism.
    Duran M; Wadman SK · Journal of inherited metabolic disease · 1985
    Narrative reviewMetabolism Boost forThiamin
  42. Dual-omics analysis reveals B vitamin regulation and metabolism in Areca Catechu inflorescence.
    Jiang W; Liu X; Li W; Yang J; Li P; Xie M; Zhou G · BMC genomics · 2026
    OtherMetabolism Boost forVitamin B5
  43. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study.
    Yamashita S; Kawada N; Wang W; Susaki K; Takeda Y; Kimura M; Iwama Y; Miura Y; Sugano M; Matsuoka R · Lipids in health and disease · 2023
    Randomized trial41 participantsCognitive Support forCholine
  44. Vitamin B6 repletion in cirrhosis with oral pyridoxine: failure to improve amino acid metabolism.
    Henderson JM; Scott SS; Merrill AH; Hollins B; Kutner MH · Hepatology (Baltimore, Md.) · 1989
    Single-arm trial8 participantsMetabolism Boost forVitamin B6
  45. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  46. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  47. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  48. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  49. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  50. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  51. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  52. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  53. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  54. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  55. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  56. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  57. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  58. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  59. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  60. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  61. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  62. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  63. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  64. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  65. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  66. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  67. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  68. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledCognitive Support forFolate
  69. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  70. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  71. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
    Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
    Randomized trial335 participantsCognitive Support forThiamin
  72. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
    Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
    Systematic reviewCognitive Support forThiamin
  73. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsCognitive Support forThiamin
  74. Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
    Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
    Cross-sectional study2,896 participantsCognitive Support forThiamin
  75. A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
    Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
    Systematic review26 studies pooledCognitive Support forThiamin
  76. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  77. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  78. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  79. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  80. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  81. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  82. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  83. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsCognitive Support forVitamin B6
  84. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  85. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  86. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  87. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  88. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  89. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  90. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  91. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  92. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  93. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  94. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  95. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  96. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  97. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  98. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  99. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  100. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  101. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  102. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  103. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  104. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  105. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  106. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  107. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  108. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  109. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  110. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  111. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  112. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  113. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  114. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  115. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  116. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  117. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  118. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  119. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  120. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  121. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  122. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  123. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  124. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  125. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  126. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  127. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  128. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  129. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  130. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  131. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  132. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  133. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  134. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  135. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  136. Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forNiacin
  137. Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
    Fangmann D; Theismann EM; Türk K; Schulte DM; Relling I; Hartmann K; Keppler JK; Knipp JR; Rehman A; Heinsen FA; Franke A; Lenk L; Freitag-Wolf S; Appel E; Gorb S; Brenner C; Seegert D; Waetzig GH; Rosenstiel P; Schreiber S; Schwarz K; Laudes M · Diabetes care · 2018
    Clinical trialMetabolism Boost forNiacin
  138. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.
    Christen S; Redeuil K; Goulet L; Giner MP; Breton I; Rota R; Frézal A; Nazari A; Van den Abbeele P; Godin JP; Nutten S; Cuenoud B · Nature metabolism · 2026
    Randomized trial65 participantsMetabolism Boost forNiacin
  139. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
    Linke A; Sonnabend M; Fasshauer M; Höllriegel R; Schuler G; Niebauer J; Stumvoll M; Blüher M · Atherosclerosis · 2009
    Randomized trial30 participantsMetabolism Boost forNiacin
  140. Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
    Vaag A; Skött P; Damsbo P; Gall MA; Richter EA; Beck-Nielsen H · The Journal of clinical investigation · 1991
    Clinical trial12 participantsMetabolism Boost forNiacin
  141. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  142. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  143. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  144. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  145. Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Rossouw JE; Labadarios D; Krasner N; Davis M; Williams R · Scandinavian journal of gastroenterology · 1978
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  146. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  147. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  148. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forVitamin B12
  149. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
    Cohort study391 participantsMood Support forVitamin B12
  150. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Arija V · Journal of reproductive and infant psychology · 2025
    Cohort study336 participantsMood Support forVitamin B12
  151. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
    Soriano-Gonzalez R; Ramirez-Olea H; Gonzalez-Soltero R; Chavez-Santoscoy RA · Frontiers in nutrition · 2025
    Systematic review24 studies pooledMood Support forVitamin B12
  152. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  153. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  154. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  155. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  156. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6