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Vitamin K-2 100 mcg

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Vitamin K 100 mcg
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Score76
An economical long-supply MK-4 capsule, limited by a modest short-lived dose, dry delivery, and an unhelpful alfalfa addition.
How scoring works
Quantity:250 Capsule(s) • (250 servings)
Goals:
General Health
Heart Health
Cardiovascular Support
Bone Health

Score 76

An economical long-supply MK-4 capsule, limited by a modest short-lived dose, dry delivery, and an unhelpful alfalfa addition.
How scoring works
$18.00($0.07 per serving)
iHerb
$ 21.42
Vitacost
$ 22.97
Daily Vita
$ 20.30
Walmart
$ 18.00
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Analysis

MK-4 supplies a defined vitamin K2 form involved in calcium regulation. The large capsule count makes ongoing use inexpensive.

The amount is modest for the shorter-acting subtype, and no lipid carrier supports absorption. Alfalfa powder is not characterized well enough to provide a meaningful additional role.

The product fits long-term budget users who intentionally choose low-dose MK-4. It remains less practical than MK-7 for sustained daily K2 coverage.

Who is it for
  • Budget-focused MK-4 users
  • Adults wanting a large supply
  • People specifically avoiding an MK-7 formula
Best for
  • Low-dose MK-4 intake
  • Basic vitamin K2 maintenance
  • Long-supply supplementation

Pros

  • MK-4 form is explicit
  • Large package
  • Very low serving cost

Cons

  • Short-acting form at a modest amount
  • No fat-based delivery
  • Alfalfa contribution is undefined

Warnings

  • MK-4 can oppose warfarin and related vitamin K antagonist medicines
  • Keep intake stable if a prescriber approves use with anticoagulation therapy
  • Take with a meal containing fat unless the label directs otherwise

Nutrient quality

71 High impact

Menaquinone-4 is a usable vitamin K2 form, though it is shorter acting than menaquinone-7, and the menaquinone-4 amount is modest for a short-acting standalone form. The listed vitamin K2 amount is not unnecessarily aggressive, while alfalfa powder adds uncertain value to the focused vitamin K2 formula.

Ingredient transparency

84 Highest impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction

73 High impact

The supplied aggregate satisfaction metric is very strong, and the large amount of aggregate feedback makes the metric highly stable. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

73 High impact

The very low serving cost helps, though the modest menaquinone-4 amount and alfalfa reduce quality. Each serving is inexpensive but provides only modest vitamin K2 depth, while alfalfa powder adds uncertain practical value.

Report analysis

Goals

General Health
Impact
High effect
B+ Goal FitC Strength of SupportD+ CoverageC Formula Quality
Vitamin K · 100 mcg

Vitamin K2 supports calcium metabolism, but the MK-4 form is shorter acting than MK-7 at the listed amount. Alfalfa powder adds little clearly defined value to the core vitamin.

The vitamin K subtype and amount are plainly disclosed. MK-4 can interfere with warfarin and other vitamin K antagonist medicines, so users of those drugs need managed, consistent intake.

Study evidence
Vitamin K Supportive 34 studies
Heart Health
Impact
Moderate effect
B- Goal FitD+ Strength of SupportD+ CoverageB- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as MK-4 supports calcium placement and may contribute to arterial health. The 100 mcg MK-4 amount is modest because MK-4 is shorter-lived and is often studied at much larger amounts.

The capsule gives clear subtype disclosure but no lipid carrier or branded source. Vitamin K2 can interfere with warfarin and related vitamin K antagonists, so users of those medicines need managed, consistent vitamin K intake.

Study evidence
Vitamin K Mixed 62 studies
Cardiovascular Support
Impact
Moderate effect
C+ Goal FitC Strength of SupportF CoverageB- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 supports calcium handling and may help keep calcium directed toward bone rather than soft tissue. The MK-4 amount is modest relative to doses used in much of the cardiovascular research.

MK-4 is clearly identified, while alfalfa adds little defined cardiovascular activity. Vitamin K2 can oppose warfarin and other vitamin K antagonist anticoagulants, so the intake must remain clinician-guided and consistent.

Study evidence
Vitamin K Supportive 40 studies
Bone Health
Impact
Moderate effect
B Goal FitF Strength of SupportD- CoverageC- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 is relevant to bone-protein activation, but the 100 mcg MK-4 amount is modest for this short-lived subtype. The dry capsule also lacks a stated lipid base to support absorption.

Alfalfa powder does not provide a clearly standardized bone-active contribution and distracts from the targeted K2 purpose. MK-4 can interfere with warfarin and related vitamin K antagonists, requiring consistent intake and clinician-guided management for users of those medicines.

Study evidence
Vitamin K Supportive 78 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-4)
100 mcg
Alfalfa powder
250 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The formula clearly supplies K2 as MK-4, which remains in circulation for less time than MK-7. A very low serving cost is useful, but the modest MK-4 amount and dry capsule format reduce its targeted value. MK-4 can interfere with warfarin and related vitamin K antagonists, so users of those medicines need managed, consistent vitamin K intake.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  5. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  6. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  7. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  8. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  9. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  10. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  11. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  12. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  13. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledGeneral Health forVitamin K
  14. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  15. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  16. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  17. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K