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Liquid D-3 & MK-7

NOW
4.8
★ ★ ★ ★ ★
(5143 ratings)
Vitamin K 100 mcg
Product Image
Score86
A high-value liquid D3 and MK-7 combination with strong pathway fit and flexible delivery, limited mainly by generic K2 sourcing.
How scoring works
Quantity:1 Liquid(s) • (163 servings)
Goals:
Bone Health
General Health
Heart Health
Cardiovascular Support
Anti-Aging

Score 86

A high-value liquid D3 and MK-7 combination with strong pathway fit and flexible delivery, limited mainly by generic K2 sourcing.
How scoring works
$17.40($0.10 per serving)
Pure Formulas
$ 18.13
Vitacost
$ 19.67
Daily Vita
$ 17.40
iHerb
$ 18.36
Daily Vita
$ 13.40
Report prices

Analysis

Vitamin D3 supports calcium absorption, while MK-7 activates proteins that guide calcium use in bone and soft tissue. Both amounts are clearly disclosed and provide strong depth in their shared pathway.

Liquid delivery is well suited to fat-soluble vitamins and allows flexible administration. The MK-7 source is generic, with no branded or all-trans claim.

The product fits adults seeking combined D3 and K2 in an economical liquid. It is a targeted regulator formula rather than complete bone support because it does not supply calcium, magnesium, or protein matrix.

Who is it for
  • Adults wanting combined liquid D3 and K2
  • People who dislike pills
  • Users seeking flexible fat-soluble vitamin dosing
Best for
  • Calcium metabolism
  • Bone-support cofactors
  • Vascular calcium handling

Pros

  • Logical D3 and MK-7 pairing
  • Liquid delivery suits both vitamins
  • Strong serving value

Cons

  • No branded or all-trans MK-7 claim
  • No structural minerals
  • Narrow calcium-regulation focus

Warnings

  • MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Measure liquid servings carefully to avoid dosing errors
  • Include vitamin D from other supplements when calculating total intake

Nutrient quality

92 Highest impact

Menaquinone-7 and lanolin-derived vitamin D3 are well-regarded forms, and vitamin K2 and vitamin D3 are both meaningfully dosed. Vitamin D3 is fairly substantial but remains below the adult upper limit, while the focused formula avoids low-value active extras.

Ingredient transparency

82 Highest impact

Specific amounts are listed for both active vitamins. No proprietary blend hides active doses, while carrier oils and other inactive liquid ingredients are not provided.

Customer satisfaction

73 High impact

The supplied aggregate satisfaction metric is very strong, and the large amount of aggregate feedback makes the metric highly stable. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

95 Highest impact

Strong forms, meaningful doses, and low serving cost support excellent value. Each serving provides useful vitamin D3 and vitamin K2 at low cost, while the formula avoids unnecessary extras.

Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportA- CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 62.5 mcg

Vitamin D3 supports calcium absorption, while MK-7 helps activate proteins that direct calcium toward bone, giving the pair a strong skeletal rationale. Both amounts are clearly disclosed and the MK-7 amount falls within the preferred range.

The liquid format is appropriate for fat-soluble vitamins, although the generic MK-7 source lacks a branded or all-trans claim. MK-7 can interfere with warfarin and related vitamin K antagonists, so users of those medicines need consistent intake and clinician-guided management.

Study evidence
Vitamin K Supportive 78 studies
General Health
General Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB+ CoverageA+ Formula Quality
Vitamin D · 62.5 mcgVitamin K · 100 mcg

Vitamin D3 and MK-7 form a complementary pair for calcium metabolism, bone support, and broader foundational health. Both amounts are meaningful and clearly disclosed.

Liquid delivery is well suited to fat-soluble vitamins and allows flexible dosing. MK-7 can interfere with warfarin and other vitamin K antagonist medicines, so users of those drugs need managed, consistent intake.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB+ CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 62.5 mcg

Vitamin D3 and MK-7 form a logical calcium-management pair that may support arterial and bone health together. Both amounts are meaningful, although evidence for preventing major cardiovascular events with supplementation remains uncertain.

The liquid drop format suits fat-soluble nutrients and clearly states each amount. MK-7 can interfere with warfarin and related vitamin K antagonists, so users of those medicines need managed, consistent vitamin K intake.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 62.5 mcg

MK-7 and vitamin D3 form a logical pair for directing calcium toward bone and away from soft tissue. Both amounts are well aligned and the liquid format suits fat-soluble vitamins, although no branded or all-trans MK-7 claim is given.

The formula provides strong depth in calcium management but little coverage of lipids, rhythm, or vasodilation. MK-7 can interfere with warfarin and related vitamin K antagonists, so users of these medicines need medically managed, consistent vitamin K intake.

Study evidence
Vitamin K Supportive 40 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcgVitamin D · 62.5 mcg

MK-7 and vitamin D3 provide a focused strategy for calcium handling, vascular resilience, and bone maintenance. The liquid format suits both fat-soluble nutrients and the amounts are clearly stated.

The formula does not address most other biological drivers of aging, so it works better as targeted support than a broad longevity product. MK-7 can interfere with warfarin and related vitamin K antagonists, making consistent clinician-managed vitamin K intake important for users of those medicines.

Study evidence
Vitamin K Supportive 27 studies

Ingredients

IngredientAmount per serving
Vitamin D-3 (Lanolin)
 62.5 mcg
Vitamin K-2 (Menaquinone-7)
 100 mcg
Gluten Free Adults 18–50 Dairy Free
Report overview
Vitamin K (Menaquinone-7) · 100 mcg OverallScore95
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The liquid combines a well-aligned MK-7 dose with vitamin D3 and a delivery format suited to fat-soluble nutrients. Its low serving cost provides strong value, although no branded MK-7 source or all-trans guarantee is stated. MK-7 can interfere with warfarin and related vitamin K antagonists, so users of those medicines need managed, consistent vitamin K intake.

View ingredientView products
Loading alternative details
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
Compared with 62.5 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, the alternative provides 90 mcg of MK-7 vitamin K2, and the clearly identified MK-7 form gives a more focused ingredient basis. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Performance

Vitamin K2 as MK-7 100 mcg

Healthy Origins
Compared with 62.5 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger overall quality. Vitamin K2 can reduce the effect of warfarin-type anticoagulants.
87 Performance

Vitamin K2 100 mcg

SR Sports Research
Compared with 62.5 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger overall quality. Vitamin K2 can reduce the effect of warfarin-type anticoagulants, so intake changes require prescriber guidance.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
87 Budget

MK-7 Vitamin K-2 100 mcg

NOW
The supplied cost data do not establish a lower serving cost, so this is a fallback rather than a true cheaper choice. It still provides 100 mcg of MK-7 vitamin K2, but its vitamin K can oppose warfarin and related vitamin-K-antagonist anticoagulants, so the product is not suitable for unsupervised use with those medicines.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied cost data do not establish a lower serving cost, so this is a fallback rather than a true cheaper choice. It still provides vitamin k2, but its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
86 Value

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
125 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Vitamin K2 can interfere with warfarin-type anticoagulants.
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied value analysis is stronger. Its long supply supports strong value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Value

Low Dose Vitamin K2 (MK-7) 45 mcg

Life Extension
45 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied value analysis is stronger. Its focused formula offers good routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  4. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  5. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  6. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  7. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  8. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  9. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  10. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  11. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  12. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  13. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  14. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  15. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  16. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  17. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  18. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  19. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  20. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  21. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  22. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  23. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  24. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  25. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  26. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  27. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  28. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  29. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  30. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  31. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K