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Vitamin C

notesDescription

Vitamin C (L-ascorbic acid) is a crucial water-soluble vitamin that humans cannot synthesize endogenously, making dietary intake essential. It plays a fundamental role in numerous physiological processes, acting as a potent antioxidant that helps protect cells from damage caused by free radicals. This protective action is vital for overall cellular health and can contribute to reducing oxidative stress throughout the body. Beyond its antioxidant capacity, Vitamin C is indispensable for the biosynthesis of collagen, a primary structural protein found in connective tissues, skin, bones, and blood vessels. This makes it critical for wound healing, maintaining skin integrity, and supporting healthy joints. Additionally, it is involved in the metabolism of proteins, the synthesis of neurotransmitters, and the absorption of iron, highlighting its diverse and widespread importance in bodily functions. A well-known benefit of Vitamin C is its significant role in supporting the immune system. It enhances various immune cell functions, including phagocytes and T-cells, and aids in the production of antibodies. Deficiency can lead to scurvy, characterized by fatigue, gum inflammation, and poor wound healing, underscoring the necessity of adequate intake for maintaining robust health.

ecoSources
Citrus fruits (oranges, grapefruits, lemons)Berries (strawberries, blueberries, raspberries)KiwiBell peppers (especially red and yellow)BroccoliKaleSpinachTomatoesAcerola cherries
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scheduleTiming & Intake
scheduleAnytimerestaurantWith foodlocal_drinkTake with Iron (to enhance absorption), Bioflavonoids
infoCan be taken with or without food, but taking with food may reduce gastrointestinal upset in some individuals. Splitting doses throughout the day can also optimize absorption due to its water-soluble nature.
assignmentDaily Intake
RDA (Men)90 mg
RDA (Women)75 mg
RDI90 mg
check_circleOptimal Dosage
Minimum250 mg
Maximum1000 mg
report_problemSafety & Toxicity
Upper Limit (UL)2000 mg
Toxicity Threshold3000 mg
Toxicity Effectdiarrhea, kidney stones
track_changesGoals
Immunity
health_and_safetyImmunity
Impact
Highest effect
Typical dose:500–2000 mg
Vitamin C contributes to immune defense by supporting epithelial barrier function against pathogens and enhancing the activity of immune cells like phagocytes and T-cells. Its antioxidant properties also protect these cells from damage during the high oxidative stress of an infection.
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Skin Health
face_retouching_naturalSkin Health
Impact
Highest effect
Typical dose:250–1000 mg
The body cannot produce collagen without adequate Vitamin C, making it foundational for skin strength and repair. As a potent antioxidant, it neutralizes free radicals generated by sun exposure and pollution, working synergistically with Vitamin E to protect skin integrity.
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Vision Support
visibilityVision Support
Impact
Highest effect
Typical dose:250–1000 mg
The eye's lens and aqueous humor have very high concentrations of Vitamin C to combat oxidative stress from UV light. Studies, including the AREDS trials, show that Vitamin C, as part of an antioxidant cocktail, can slow the progression of AMD and may reduce the risk of cataract formation.
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Anti-Inflammatory Support
local_hospitalAnti-Inflammatory Support
Impact
High effect
Vitamin C is essential for mitigating oxidative stress caused by the inflammatory process itself. It directly neutralizes damaging free radicals and is required to regenerate other critical antioxidants like Vitamin E, providing broad-spectrum support against the drivers of chronic inflammation.
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Bone Health
accessibility_newBone Health
Impact
High effect
Typical dose:250–1000 mg
Vitamin C's role in collagen synthesis is fundamental, not situational. It is required for enzymes that stabilize the collagen structure, directly impacting the tensile strength and integrity of the bone matrix. Without adequate Vitamin C, the collagen foundation of bone is compromised, making it more brittle.
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sync_altInteractions

add_circle_outlinePositive Interactions

add_circle
Iron
Enhances the absorption of non-heme iron from plant-based sources.
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Vitamin E
Helps regenerate oxidized Vitamin E, allowing it to continue its antioxidant function.
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Glutathione
Helps maintain glutathione in its reduced, active form, supporting its antioxidant capacity.
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Rutin
Bioflavonoids like Rutin are thought to enhance the absorption and antioxidant activity of Vitamin C.
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Green Tea
Can enhance the stability and bioavailability of Green Tea catechins, boosting their antioxidant effects.
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Collagen
Is essential for the synthesis and stability of collagen in the body.
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Curcumin
Both are strong antioxidants, and their combined effect may offer enhanced anti-inflammatory and antioxidant benefits.

remove_circle_outlineNegative Interactions

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Copper
Very high doses of Vitamin C might theoretically interfere with copper absorption, though this is generally not a significant concern at typical supplemental levels.
inventory_2Recommended products
88 Value C 500 mg

C 500 mg

21st Century
4.8
★★★★★
(34027 ratings)
Vitamin C: 500 mg
An exceptionally economical and popular 500mg Vitamin C tablet, lightly buffered with calcium for gentle daily support.
Buy for $8.99(from iHerb)
Other sellers
88 Value 100% Pure Vitamin C Powder

100% Pure Vitamin C Powder

Swanson Premium Brand
4.7
★★★★★
(430 ratings)
Vitamin C: 1000 mg
Pure Ascorbic Acid powder offering exceptional value and flexible dosing for customizable Vitamin C intake.
Buy for $20.79(from iHerb)
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78 Best Vitamin C Powder 5000 mg

Vitamin C Powder 5000 mg

Solaray
4.3
★★★★★
(66 ratings)
Vitamin C: 5000 mg
A very high-dose 5000 mg buffered Vitamin C powder (calcium ascorbate) from Solaray, offering flexible dosing and substantial nutrient support.
Buy for $22.87(from Walmart)
Other sellers (2)
85 Value Pure Buffered Calcium Ascorbate

Pure Buffered Calcium Ascorbate

NOW
4.7
★★★★★
(1363 ratings)
Vitamin C: 890 mg
A buffered, high-dose liquid Vitamin C (calcium ascorbate) with added calcium, ideal for sensitive stomachs and higher intake needs.
Buy for $7.5(from Daily Vita)
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80 Best Ultimate Ascorbate C 1000 mg

Ultimate Ascorbate C 1000 mg

Source Naturals
4.8
★★★★★
(286 ratings)
Vitamin C: 2000 mg
This product provides a high dose of buffered Vitamin C, blended with key minerals and bioflavonoids for a multi-pronged approach to daily health support.
Buy for $14.39(from Vitacost)
Other sellers (1)
92 Value Sodium Ascorbate

Sodium Ascorbate

NutriBiotic Immunity
4.9
★★★★★
(85533 ratings)
Vitamin C: 1100 mg
An ultra-economical bulk powder offering 1100mg of fully buffered Sodium Ascorbate Vitamin C per serving, perfect for high-dose, stomach-friendly daily support.
Buy for $39.74(from iHerb)
Other sellers (1)
75 Best Vitality C

Vitality C

AN American Nutriceuticals
4.8
★★★★★
(103 ratings)
Vitamin C: 4000 mg
A high-dose, buffered Vitamin C powder featuring GMS-Ribose for added energy support, ideal for those seeking comprehensive daily wellness.
Buy for $47.7(from Pure Formulas)
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68 Value Vitamin C 500 mg

Vitamin C 500 mg

Nature Made
4.6
★★★★★
(213 ratings)
Vitamin C: 500 mg
A basic 500 mg ascorbic acid tablet, offering a simple and dependable way to get daily Vitamin C support.
Buy for $12.42(from Walmart)
Other sellers (1)
90 Best Mega-Liposomal Vitamin C 3000 mg Organic Fruit Flavor

Mega-Liposomal Vitamin C 3000 mg Organic Fruit Flavor

Aurora NutraScience
4.7
★★★★★
(4753 ratings)
Vitamin C: 3000 mg
An exceptionally high-dose (3000mg) organic fruit flavored mega-liposomal liquid Vitamin C, designed for maximum absorption and potent daily support.
Buy for $39.99(from iHerb)
Other sellers (1)
88 Best Effervescent Vitamin C Magnesium Crystals

Effervescent Vitamin C Magnesium Crystals

Life Extension
4.6
★★★★★
(162 ratings)
Vitamin C: 4500 mg
This effervescent crystal product combines a high dose of buffered Vitamin C with magnesium and Vitamin B6, offering a convenient way to support general health, immunity, and energy.
Buy for $15(from Vitacost)
Other sellers (2)
75 Value Chewable C 500 mg Tangy Orange Taste

Chewable C 500 mg Tangy Orange Taste

Kirkland Signature
4.7
★★★★★
(37 ratings)
Vitamin C: 500 mg
Kirkland Signature's Chewable C provides an ultra-affordable 500 mg dose of Vitamin C in a tangy orange flavor, ideal for budget-conscious users seeking easy daily support.
Buy for $21.69(from Walmart)
Other sellers
72 Budget Healthy Eyes Lutein and Antioxidants

Healthy Eyes Lutein and Antioxidants

21st Century
4.7
★★★★★
(15376 ratings)
Vitamin C: 200 mg
An affordable supplement offering a blend of antioxidant vitamins and minerals, plus a modest amount of lutein, designed for general health and basic eye support.
Buy for $4.2(from Amazon)
Other sellers (2)
82 Best Buffered Vitamin C Powder

Buffered Vitamin C Powder

Life Extension
4.7
★★★★★
(1058 ratings)
Vitamin C: 4000 mg
A high-dose buffered Vitamin C powder designed to offer robust support while being gentler on the stomach, providing flexible intake with beneficial minerals.
Buy for $21(from Pure Formulas)
Other sellers (3)
82 Value C 500 mg

C 500 mg

Mason Natural
4.7
★★★★★
(6503 ratings)
Vitamin C: 500 mg
An exceptionally affordable and simple 500mg Vitamin C (ascorbic acid) supplement, perfect for budget-conscious individuals seeking basic daily wellness support.
Buy for $4.69(from iHerb)
Other sellers
90 Budget C-500 Calcium Ascorbate-C

C-500 Calcium Ascorbate-C

NOW
4.9
★★★★★
(7319 ratings)
Vitamin C: 500 mg
A gentle, buffered Vitamin C (500mg Calcium Ascorbate) supplement that includes a small amount of calcium and citrus bioflavonoids, making it suitable for sensitive stomachs and broad wellness support.
Buy for $5(from Daily Vita)
Other sellers (4)
70 Value C 250 mg

C 250 mg

21st Century
4.7
★★★★★
(9811 ratings)
Vitamin C: 250 mg
A very affordable tablet providing 250 mg of ascorbic acid Vitamin C and 140 mg of calcium, ideal for basic daily support.
Buy for $2.61(from iHerb)
Other sellers
68 Budget Zoo Friends with Extra C

Zoo Friends with Extra C

21st Century Zoo Friends
4.7
★★★★★
(24637 ratings)
Vitamin C: 250 mg
This chewable multivitamin offers a core set of essential vitamins with extra Vitamin C, providing general nutritional support for daily health, particularly for kids.
Buy for $4.99(from iHerb)
Other sellers (2)
88 Best Ortho C+ Lemon Flavor

Ortho C+ Lemon Flavor

AOR Advanced Orthomolecular Research Premium
4.1
★★★★★
(18 ratings)
Vitamin C: 3000 mg
This is a high-potency Vitamin C blend featuring key minerals and amino acids like Lysine and Proline, aiming to support immunity, collagen formation, and bone health.
Buy for $26.37(from Pure Formulas)
Other sellers (1)
70 Budget C-500 With Rose Hips

C-500 With Rose Hips

NOW
4.9
★★★★★
(11061 ratings)
Vitamin C: 500 mg
A 500 mg ascorbic acid tablet enhanced with rose hips, offering a classic approach to daily Vitamin C support.
Buy for $5.09(from Vitacost)
Other sellers (3)
80 Budget C 1000 mg

C 1000 mg

21st Century
4.7
★★★★★
(29273 ratings)
Vitamin C: 1000 mg
A simple, high-dose Vitamin C (1000mg) supplement in ascorbic acid form, providing foundational support at a very economical price.
Buy for $4.49(from iHerb)
Other sellers
70 Best Liquid Vitamin C 1000 mg Natural Citrus Flavors

Liquid Vitamin C 1000 mg Natural Citrus Flavors

Dynamic Health
4.6
★★★★★
(1926 ratings)
Vitamin C: 6660 mg
A 1000mg liquid Vitamin C with natural citrus flavors, offering flexible dosing, though the ingredient list presents some confusing numerical discrepancies.
Buy for $13.39(from Amazon)
Other sellers (3)
70 Value C 500 mg

C 500 mg

Swanson
4.8
★★★★★
(5414 ratings)
Vitamin C: 500 mg
A very popular and economical 500mg Ascorbic Acid capsule with concentrated rose hips extract, ideal for daily maintenance.
Buy for $14.49(from iHerb)
Other sellers (1)
68 Budget Miracle Reds

Miracle Reds

MacroLife Naturals
4.4
★★★★★
(1585 ratings)
Vitamin C: 400 mg
A comprehensive 'reds' powder with many beneficial blends, but severely lacks ingredient transparency, has critically low doses of some vitamins/minerals, and an ineffective probiotic component.
Buy for $2.86(from iHerb)
Other sellers
68 Value C 500 mg

C 500 mg

21st Century
4.8
★★★★★
(34035 ratings)
Vitamin C: 500 mg
An ultra-economical Vitamin C supplement delivering 500mg of Ascorbic Acid with a minor calcium addition for basic daily support.
Buy for $3.97(from Pure Formulas)
Other sellers (1)
78 Best Vitamin C Powder 5000 mg

Vitamin C Powder 5000 mg

Solaray
4.7
★★★★★
(348 ratings)
Vitamin C: 5000 mg
A high-potency 5000 mg pure Vitamin C (Ascorbic Acid) powder, offering flexible dosing for intensive daily support.
Buy for $18.89(from Vitacost)
Other sellers (1)
75 Best Liquid Vitamin C 1000 mg Natural Citrus Flavors

Liquid Vitamin C 1000 mg Natural Citrus Flavors

Dynamic Health
4.7
★★★★★
(1623 ratings)
Vitamin C: 6660 mg
A liquid Vitamin C supplement delivering 1000mg per serving with a natural citrus flavor, ideal for easy ingestion and high-dose support.
Buy for $7.99(from iHerb)
Other sellers (1)
57 Budget Macro Greens

Macro Greens

MacroLife Naturals
4.4
★★★★★
(1903 ratings)
Vitamin C: 475 mg
Macro Greens is a comprehensive greens powder formulated to support a wide array of health goals, including general wellness, immunity, and energy. It provides essential vitamins and minerals, along with various proprietary blends of superfoods, antioxidants, adaptogens, fibers, and enzymes. However, the extensive use of proprietary blends makes it challenging to ascertain the precise dosages and efficacy of many beneficial ingredients.
Buy for $2.86(from iHerb)
Other sellers
analyticsProduct stats
sellPrice per product
Average$28.72
Median$23.73
restaurantPrice per serving
Average$0.70
Median$0.56
sciencePrice per 100 mg
Average$0.17
Median$0.08
bar_chartPrice distribution
bar_chartPrice per serving distribution
bar_chartPrice per 100 mg
Reference amount: 100 mg
categoryForms
bar_chartPaired ingredients
water_dropIngredient forms
category Ascorbic Acid (623) 85
Ascorbic acid is the chemical name for Vitamin C and represents its purest, most fundamental form. It is a water-soluble vitamin crucial for collagen synthesis, immune function, iron absorption, and acts as a powerful antioxidant protecting cells from free radical damage.
thumb_upPros
  • Highly effective and bioavailable
  • Most researched form of Vitamin C
  • Potent antioxidant
  • Widely available and cost-effective
thumb_downCons
  • Can be acidic, potentially causing digestive upset or tooth enamel erosion in sensitive individuals
  • Short half-life in the body
sellPer product
Avg$28.97
Med$23.24
restaurantPer serving
Avg$0.75
Med$0.62
science Per 100 mg
Avg$0.21
Med$0.12
Price distribution
category Calcium Ascorbate (149) 90
Calcium ascorbate is a mineral ascorbate, formed by binding ascorbic acid to calcium. This process neutralizes the acidity of Vitamin C, making it significantly less likely to cause gastrointestinal discomfort. It provides both the benefits of Vitamin C and a small amount of elemental calcium, making it a good choice for those with sensitive stomachs or seeking mild calcium supplementation.
thumb_upPros
  • Non-acidic and gentle on the stomach
  • Good bioavailability and absorption
  • Provides a supplemental source of calcium
  • Suitable for individuals sensitive to regular ascorbic acid
thumb_downCons
  • Contains calcium, which may be a consideration for those monitoring calcium intake or with specific medical conditions
  • Slightly lower Vitamin C content by weight compared to pure ascorbic acid
sellPer product
Avg$30.53
Med$26.37
restaurantPer serving
Avg$0.67
Med$0.54
science Per 100 mg
Avg$0.15
Med$0.11
Price distribution
category Sodium Ascorbate (84) 88
Sodium ascorbate is a mineral salt of ascorbic acid, which buffers the Vitamin C to a neutral pH. This makes it a preferred option for individuals who experience gastrointestinal upset or discomfort from the acidity of regular ascorbic acid. It is highly soluble and easily absorbed, providing all the benefits of Vitamin C while also contributing a small amount of sodium.
thumb_upPros
  • Non-acidic and gentle on the stomach
  • Highly soluble and bioavailable
  • Suitable for sensitive individuals
thumb_downCons
  • Contains sodium, which should be considered by individuals on sodium-restricted diets
  • Slightly lower Vitamin C content by weight compared to pure ascorbic acid
sellPer product
Avg$20.06
Med$15.58
restaurantPer serving
Avg$0.53
Med$0.35
science Per 1000 mg
Avg$0.41
Med$0.25
Price distribution
category L-Ascorbic Acid (61) 85
L-Ascorbic Acid is simply the specific stereoisomer of ascorbic acid that is naturally found in foods and is biologically active in the human body. It is chemically identical to ascorbic acid and offers all the same powerful benefits, including its role as a potent antioxidant, and its essential functions in collagen formation and immune system support.
thumb_upPros
  • The natural and biologically active form of Vitamin C
  • Highly effective and well-researched
  • Potent antioxidant
thumb_downCons
  • Same potential acidity and digestive issues as Ascorbic Acid for sensitive individuals
  • Relatively short half-life in the body
sellPer product
Avg$24.75
Med$21.09
restaurantPer serving
Avg$0.44
Med$0.21
science Per 100 mg
Avg$0.11
Med$0.08
Price distribution
category Ascorbyl Palmitate (56) 75
Ascorbyl palmitate is a fat-soluble (lipophilic) derivative of Vitamin C, created by combining ascorbic acid with palmitic acid. Unlike water-soluble forms, its fat-soluble nature allows it to be incorporated into cell membranes, potentially providing antioxidant protection in areas water-soluble Vitamin C cannot easily reach. It is often used in topical skincare products for its stability and ability to penetrate the skin, and sometimes in oral supplements for sustained antioxidant activity.
thumb_upPros
  • Fat-soluble, allowing it to penetrate cell membranes for localized antioxidant protection
  • More stable form of Vitamin C, especially in topical applications
  • May offer sustained antioxidant activity within lipid environments
thumb_downCons
  • Lower bioavailability as a dietary supplement for systemic Vitamin C levels compared to water-soluble forms
  • Less research on its systemic efficacy for general Vitamin C replenishment
  • Not primarily used for directly boosting general Vitamin C status
sellPer product
Avg$32.36
Med$29.35
restaurantPer serving
Avg$0.85
Med$0.72
science Per 1000 mg
Avg$0.71
Med$0.66
Price distribution
category Zinc Ascorbate (34) 88
Zinc ascorbate is a mineral ascorbate that provides both essential Vitamin C and the trace mineral zinc in a single, well-absorbed compound. Both Vitamin C and zinc are critical for a robust immune system, wound healing, and powerful antioxidant protection. The ascorbate form ensures it is buffered and gentle on the stomach, making it an ideal choice for targeted immune support.
thumb_upPros
  • Synergistic benefits of Vitamin C and zinc, especially for immunity
  • Non-acidic and gentle on the stomach
  • Highly bioavailable form of both nutrients
  • Supports wound healing
thumb_downCons
  • Contains zinc, which can be toxic in excessively high doses or may interact with certain medications
  • Slightly lower Vitamin C content by weight compared to pure ascorbic acid
sellPer product
Avg$21.25
Med$19.17
restaurantPer serving
Avg$0.75
Med$0.64
science Per 1000 mg
Avg$0.56
Med$0.33
Price distribution
category Ester-C Calcium Ascorbate (27) 92
Ester-C is a brand-name, patented form of Vitamin C that combines calcium ascorbate with naturally occurring Vitamin C metabolites, primarily calcium threonate. These metabolites are thought to enhance the uptake and retention of Vitamin C within the white blood cells, leading to more sustained levels in the body. It is non-acidic, gentle on the stomach, and highly bioavailable.
thumb_upPros
  • Non-acidic and gentle on the stomach, ideal for sensitive individuals
  • Enhanced absorption and longer retention of Vitamin C in the body
  • Provides a small amount of calcium
  • Less frequent dosing may be needed due to sustained action
thumb_downCons
  • Typically more expensive than standard ascorbic acid or generic buffered forms
  • Proprietary blend, making independent comparisons sometimes challenging
sellPer product
Avg$18.28
Med$15.44
restaurantPer serving
Avg$0.22
Med$0.18
science Per 1000 mg
Avg$0.21
Med$0.20
Price distribution
category Magnesium Ascorbate (27) 88
Magnesium ascorbate is a mineral ascorbate that unites ascorbic acid with magnesium. This buffered compound is gentle on the digestive system, delivering all the advantages of Vitamin C alongside magnesium, a crucial mineral involved in over 300 enzymatic reactions in the body, including muscle and nerve function, blood glucose control, and blood pressure regulation, as well as bone health.
thumb_upPros
  • Non-acidic and gentle on the stomach
  • Provides beneficial magnesium, an essential mineral
  • Good bioavailability for both Vitamin C and magnesium
  • Supports muscle relaxation and nerve function
thumb_downCons
  • Contains magnesium, which may have a laxative effect in high doses
  • Slightly lower Vitamin C content by weight compared to pure ascorbic acid
sellPer product
Avg$37.09
Med$42.00
restaurantPer serving
Avg$0.98
Med$0.80
science Per 1000 mg
Avg$0.57
Med$0.32
Price distribution
category Niacinamide Ascorbate (27) 70
Niacinamide ascorbate is a compound formed by chemically bonding ascorbic acid to niacinamide, a form of Vitamin B3. This innovative form delivers the antioxidant and collagen-supporting properties of Vitamin C alongside the skin-benefiting and metabolic support of niacinamide. A key advantage is that it provides niacinamide's benefits without causing the uncomfortable 'niacin flush' often associated with nicotinic acid.
thumb_upPros
  • Delivers benefits of both Vitamin C and Niacinamide
  • Non-acidic and gentle on the stomach
  • Avoids the 'niacin flush' common with other forms of Vitamin B3
thumb_downCons
  • Less common and less extensively researched as a primary Vitamin C source compared to other forms
  • Contains Vitamin B3, which might not be desired by all users
  • Potentially more expensive due to its specialized nature
sellPer product
Avg$34.48
Med$30.89
restaurantPer serving
Avg$0.93
Med$0.68
science Per 100 mg
Avg$0.05
Med$0.04
Price distribution
category Rose Hip (18) 78
Rose hips are the small, reddish-orange fruits that develop after the rose flower fades. They are widely recognized as one of the richest natural plant sources of Vitamin C, often containing significantly more than oranges. Beyond Vitamin C, rose hips also provide a complex array of other beneficial compounds, including bioflavonoids, carotenoids, and other antioxidants, which are believed to enhance the absorption and efficacy of Vitamin C.
thumb_upPros
  • Natural, whole-food source of Vitamin C
  • Rich in synergistic bioflavonoids and other antioxidants
  • Generally gentle on the stomach
  • Offers additional plant-based nutrients
thumb_downCons
  • Vitamin C content can be variable depending on the source and processing
  • Generally provides lower concentration of pure Vitamin C by weight compared to isolated forms
  • May contain other plant compounds not desired by all users
sellPer product
Avg$25.32
Med$23.40
restaurantPer serving
Avg$0.35
Med$0.24
science Per 1000 mg
Avg$0.10
Med$0.08
Price distribution

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