AdvaClear

AdvaClear

Metagenics4.9 (127 ratings)
Format:Capsule Quantity: 126 Capsule(s) · 63 servings
Goals
$109.95 $1.74 per serving

Product analysis

52 out of 100

AdvaClear supplies nutrients that support normal energy metabolism and related body functions when intake is low. The added herbs and NAC do not establish a routine cleansing benefit.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality50

Several B-vitamin forms are clearly identified, with B5 and copper showing favorable quality characteristics. Missing forms and uncertain comparisons across other ingredients limit a judgment of the full formula.

Ingredient Transparency73

All main amounts and many forms are stated, helping you identify the contents. The proportions of combined vitamin and artichoke sources are not disclosed.

Value For Money34

The cost looks high when considered for several individual nutrients and the green-tea preparation. Value across much of the remaining mix is uncertain, with the sodium comparison giving a more moderate serving-cost picture.

Customer Satisfaction76

Customer ratings are very favorable. The modest feedback volume provides a limited picture of satisfaction without proving energy or cleansing benefits.

Product Focus32

Normal nutritional support for energy use is clearer than a broad detoxification effect. The large ingredient mix does not establish extra calorie burning, energy or general toxin removal with adequate nutrition.

Format
Capsule
Container
126 Capsule(s)
Per serving
$1.74
Customer rating
4.9 · 127 ratings
Report analysis

Goals

Impact
Moderate effect
C- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Folate · 445 mcg DFEVitamin B12 · 33.4 mcgVitamin B6 · 16.66 mgMolybdenum · 66 mcgSelenium · 50 mcgVitamin E · 44.6 mgZinc · 6.5 mgVitamin C · 133 mgTaurine · 117 mgRiboflavin · 5 mg
Study evidence
Folate Supportive 16 studies
Green Tea Disputed 16 studies
Selenium Supportive 10 studies
Taurine Supportive 2 studies
Vitamin C Supportive 9 studies
Vitamin E Supportive 23 studies
Zinc Supportive 30 studies
Impact
Moderate effect
C+ Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin D · 0.8 mcgVitamin B5 · 33.3 mgRiboflavin · 5 mgThiamin · 10 mgVitamin B12 · 33.4 mcg
Study evidence
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Betatene, Retinyl Palmitate)
750 mcg
Vitamin C (Ascorbic Acid)
133 mg
Vitamin D (Cholecalciferol)
0.8 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
44.6 mg
Thiamine (Thiamine Mononitrate)
10 mg 65
Riboflavin
5 mg
Niacin (Niacinamide)
23.3 mg 65
Vitamin B6 (Pyridoxine Hydrochloride)
16.66 mg 70
Metafolin (Folate)
445 mcg DFE
Vitamin B12 (Methylcobalamin)
33.4 mcg
Biotin
66 mcg
Pantothenic Acid (Calcium D-Pantothenate)
33.3 mg 61
Zinc (Zinc Citrate)
6.5 mg
Selenium (Selenomethionine)
50 mcg
Copper (Copper Citrate)
0.66 mg 53
Manganese (Manganese Citrate)
1.66 mg
Molybdenum (Molybdenum Aspartate Complex)
66 mcg 44
Sodium (Sodium Sulfate)
40 mg 55
Artichoke Leaf Extract (Chlorogenic Acid, Cynarin)
167 mg
Watercress aerial parts 4:1 extract
133 mg
Taurine
117 mg 42
Sodium Sulfate
100 mg 55
Pomegranate whole fruit extract
87.5 mg
N-Acetyl-L-Cysteine
67 mg
Green Tea Leaf Extract, Decaffeinated (Camellia sinensis Leaf Extract, Decaffeinated)
56 mg 49
Silymarin (Milk Thistle Seed Extract)
50 mg
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 23.3 mg of niacin. The serving price is high when attributed to this ingredient alone; that may overstate its cost. It uses niacinamide.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

It uses niacinamide.
Niacin Form & Goal Alignment
Niacinamide is the stated form.
Precursor Source Quality
The stated source is niacinamide.

Dose, Safety & Label Transparency67

Each serving provides 23.3 mg of niacin. No no-flush claim is recorded.
Clarity of Chemical Form
The form is disclosed as Niacinamide.
Form-Specific Dosage Efficacy
Each serving provides 23.3 mg of niacin.
Flush Risk & Safety Labeling
No no-flush claim is recorded.

Value20

The serving price is high when attributed to this ingredient alone; that may overstate its cost.
Price Per Effective Serving
The serving price is high when attributed to this ingredient alone; that may overstate its cost.
A+ Ingredient Form & Label QualityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 16.66 mg of vitamin B6, at a high cost per mg of B6. The serving exceeds the European adult upper limit for daily B6 intake. It uses pyridoxine hydrochloride.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 source is pyridoxine hydrochloride. The Other Ingredients findings show no artificial dyes, titanium dioxide or talc.
Vitamin B6 Form Identification
The B6 source is pyridoxine hydrochloride.
Clean Label and Excipient Purity
The Other Ingredients findings show no artificial dyes, titanium dioxide or talc.

Dose, Safety & Label Transparency68

16.66 mg per serving exceeds the European adult upper limit for daily B6 intake. The chemical source is disclosed as pyridoxine hydrochloride.
Vitamin B6 Dose & Safety Policy
16.66 mg per serving exceeds the European adult upper limit for daily B6 intake.
Label Transparency
The chemical source is disclosed as pyridoxine hydrochloride.

Value16

The cost per mg of vitamin B6 is high.
Vitamin B6 Price Efficiency
The cost per mg of vitamin B6 is high.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
Each serving provides 10 mg of thiamin, a moderate amount, at a high cost for that amount. It uses Thiamine Mononitrate, a thiamin form. The amount is clearly stated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It uses Thiamine Mononitrate, a thiamin form. The listed ingredients do not indicate the specified artificial sweeteners, corn syrup, artificial colors or titanium dioxide.
Thiamin Chemical Form
It uses Thiamine Mononitrate, a thiamin form.
Excipient Purity
The listed ingredients do not indicate the specified artificial sweeteners, corn syrup, artificial colors or titanium dioxide.

Dose, Safety & Label Transparency72

The label states 10 mg of thiamin per serving, a moderate amount.
Thiamin Dosage Potency
A serving provides 10 mg of thiamin, a moderate amount.
Label Transparency & Proprietary Blends
The label states the thiamin amount and source.

Value40

The cost is high for the declared amount of thiamin.
Price per Declared Dose
The cost is high for the declared amount of thiamin.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  17. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  18. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  19. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  20. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D