AdvaClear

AdvaClear

Metagenics4.9 (80 ratings)
Format:Capsule Quantity: 42 Capsule(s) · 21 servings
Goals
$43.95 $2.09 per serving

Product analysis

52 out of 100

AdvaClear may help cover nutrient gaps that affect normal energy metabolism. Several nutrients are relatively expensive within the full product cost.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality49

Clearly identified B6 and niacin forms, along with the B5 form, are strengths. Missing forms and mixture proportions limit comparison of the much broader combination.

Ingredient Transparency73

Amounts and most forms are declared, helping compare the main contents. Several form details and all applicable mixture proportions are missing.

Value For Money34

The full product cost offers weak value for several B vitamins, copper, molybdenum and the green tea content. Value for many other ingredients remains uncertain.

Customer Satisfaction74

Customer feedback is strongly positive. The small review base limits how confidently that satisfaction can be generalized.

Product Focus31

The clearest role is nutritional support for normal energy metabolism when intake is low. The very long ingredient list does not establish faster calorie burning, extra energy or routine toxin removal.

Format
Capsule
Container
42 Capsule(s)
Per serving
$2.09
Customer rating
4.9 · 80 ratings
Report analysis

Goals

Impact
Moderate effect
C- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Folate · 445 mcg DFEVitamin B12 · 33.4 mcgVitamin B6 · 16.66 mgMolybdenum · 66 mcgSelenium · 50 mcgVitamin E · 44.6 mgZinc · 6.5 mgVitamin C · 133 mgTaurine · 117 mgRiboflavin · 5 mg

Folate and selenium support nutrient adequacy, with selected findings involving metal exposure and low nutrient status. NAC, silymarin and artichoke have clinical or disease-specific findings, while taurine relates to bile composition; the supplied evidence does not translate those roles into broad routine detoxification.

How this product is rated for Liver & Detox

Ingredient fit55

The ingredients span several purposes, with only part of the selection focused on liver support. The assessed amounts provide partial alignment with the saved ingredient comparisons.
Goal fit
The ingredients span several purposes, with only part of the selection focused on liver support.
Dose adequacy
The assessed amounts provide partial alignment with the saved ingredient comparisons.

Pathways12

The strongest saved coverage relates to liver cell integrity and fat export. No reviewed mechanism reaches the saved coverage threshold.
Depth
The strongest saved coverage relates to liver cell integrity and fat export.
Breadth
No reviewed mechanism reaches the saved coverage threshold.

Evidence95

Vitamin B9 (Folate) provides the strongest saved ingredient finding; the evidence remains specific to its reviewed context. Only part of the assessed ingredient selection matches the preparations in the saved comparisons.
Evidence strength
Vitamin B9 (Folate) provides the strongest saved ingredient finding; the evidence remains specific to its reviewed context.
Studied preparation
Only part of the assessed ingredient selection matches the preparations in the saved comparisons.

Formulation logic100

No missing required ingredient partner was identified. No configured conflict was identified in the saved findings. All ingredients assessed for amounts reach the saved minimum comparison level.
Partner coverage
No missing required ingredient partner was identified.
Conflicts
No configured conflict was identified in the saved findings.
Effective doses
All ingredients assessed for amounts reach the saved minimum comparison level.
Study evidence
Folate Supportive 16 studies
Green Tea Disputed 16 studies
Selenium Supportive 10 studies
Taurine Supportive 2 studies
Vitamin C Supportive 9 studies
Vitamin E Supportive 23 studies
Zinc Supportive 30 studies
Impact
Moderate effect
C Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin D · 0.8 mcgVitamin B5 · 33.3 mgRiboflavin · 5 mgThiamin · 10 mgVitamin B12 · 33.4 mcg

B vitamins, folate and vitamin C support normal energy metabolism and nutritional functions related to tiredness. Their clearest value is filling dietary gaps; the large vitamin amounts do not imply extra energy when intake is already adequate. The botanical amount cannot be translated into a caffeine dose.

How this product is rated for Energy

Ingredient fit63

The relevant ingredients sit within a broader formula with other nutritional or performance purposes. The amounts provide a reasonable but incomplete match to the comparison amounts.
Goal fit
The relevant ingredients sit within a broader formula with other nutritional or performance purposes.
Dose adequacy
The amounts provide a reasonable but incomplete match to the comparison amounts.

Pathways0

The saved assessment assigns nutritional support without a separate contribution to the assessed energy mechanisms. The saved findings show limited reach across the assessed energy mechanisms.
Depth
The saved assessment assigns nutritional support without a separate contribution to the assessed energy mechanisms.
Breadth
The saved findings show limited reach across the assessed energy mechanisms.

Evidence78

Vitamin B2 (Riboflavin) supplies the leading relevant support, within the nutrient or preparation-specific limits described. The saved assessment finds matching studied preparations at relevant amounts.
Evidence strength
Vitamin B2 (Riboflavin) supplies the leading relevant support, within the nutrient or preparation-specific limits described.
Studied preparation
The saved assessment finds matching studied preparations at relevant amounts.

Formulation logic100

The assessed ingredients can contribute on their own or have their required partner. No configured ingredient conflict was identified in the supplied assessment. 7 of 7 assessed ingredients meet the saved minimum amount threshold
Partner coverage
The assessed ingredients can contribute on their own or have their required partner.
Conflicts
No configured ingredient conflict was identified in the supplied assessment.
Effective doses
7 of 7 assessed ingredients meet the saved minimum amount threshold
Study evidence
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Mixed Carotenoids, Retinyl Palmitate)
750 mcg
Vitamin C (Ascorbic Acid)
133 mg
Vitamin D (Cholecalciferol)
0.8 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
44.6 mg
Thiamine (Thiamine Mononitrate)
10 mg 65
Riboflavin
5 mg
Niacin (Niacinamide)
23.3 mg 65
Vitamin B6 (Pyridoxine Hydrochloride)
16.66 mg 70
Folate (Calcium L-5-Methyltetrahydrofolate)
445 mcg DFE
Vitamin B12 (Methylcobalamin)
33.4 mcg
Biotin
66 mcg
Pantothenic Acid (Calcium D-Pantothenate)
33.3 mg 61
Zinc (Zinc Citrate)
6.5 mg
Selenium (Selenomethionine)
50 mcg
Copper (Copper Citrate)
0.66 mg 53
Manganese (Manganese Citrate)
1.66 mg
Molybdenum (Molybdenum Aspartate Complex)
66 mcg 44
Sodium (Sodium Sulfate)
40 mg
Artichoke (Cynara scolymus) leaf extract (Chlorogenic Acid, Cynarin)
167 mg
Watercress (Nasturtium officinale) aerial parts 4:1 extract
133 mg
Taurine
117 mg
Sodium Sulfate
100 mg
Pomegranate (Punica granatum L.) whole fruit extract (Gallic Acid equivalent)
87.5 mg
N-Acetyl-L-Cysteine
67 mg
decaffeinated Green Tea leaf extract (Caffeine, Catechins, Epigallocatechin Gallate)
56 mg 49
Silymarin (Milk Thistle (Silybum marianum) seed extract)
50 mg
Gluten Free Adults 18–50
Report overview
A+ Ingredient Form & Label QualityC+ Dose, Safety & Label TransparencyF Value
A serving contains 16.66 mg of vitamin B6. The cost per amount of vitamin B6 is high. The B6 form is Pyridoxine Hydrochloride.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 form is Pyridoxine Hydrochloride. The listed ingredients do not include artificial colors, titanium dioxide or talc.
Vitamin B6 Form Identification
The B6 form is Pyridoxine Hydrochloride.
Clean Label and Excipient Purity
The listed ingredients do not include artificial colors, titanium dioxide or talc.

Dose, Safety & Label Transparency68

A serving contains 16.66 mg of vitamin B6. The source is named.
Vitamin B6 Dose & Safety Policy
A serving contains 16.66 mg of vitamin B6.
Label Transparency
The amount and chemical source are stated.

Value14

The cost per amount of vitamin B6 is high.
Vitamin B6 Price Efficiency
The cost per amount of vitamin B6 is high.
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 23.3 mg of niacin. The serving price is high when attributed to niacin alone; that may overstate its cost. The stated form is niacinamide.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

The stated form is niacinamide.
Niacin Form & Goal Alignment
Niacinamide is a stated form of niacin for general use.
Precursor Source Quality
Niacinamide is the stated niacin source.

Dose, Safety & Label Transparency67

Each serving provides 23.3 mg of niacin. Niacinamide is named, but no no-flush claim is recorded.
Clarity of Chemical Form
The form is disclosed as Niacinamide.
Form-Specific Dosage Efficacy
Each serving provides 23.3 mg of niacin.
Flush Risk & Safety Labeling
Niacinamide is named, but no no-flush claim is recorded.

Value20

The serving price is high when attributed to niacin alone; that may overstate its cost.
Price Per Effective Serving
The serving price is high when attributed to niacin alone; that may overstate its cost.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
The serving provides 10 mg of thiamin, with a high cost relative to the amount provided. Thiamine Mononitrate is a standard water-soluble form of vitamin B1. No configured artificial sweeteners or colors were identified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Mononitrate is a standard water-soluble form of vitamin B1. No configured artificial sweeteners or colors were identified.
Thiamin Chemical Form
Thiamine Mononitrate is a standard water-soluble form of vitamin B1.
Excipient Purity
No configured artificial sweeteners or colors were identified.

Dose, Safety & Label Transparency72

The serving amount is stated as 10 mg of thiamin.
Thiamin Dosage Potency
Each serving provides 10 mg of thiamin.
Label Transparency & Proprietary Blends
The thiamin amount per serving is stated.

Value40

The cost is high relative to the amount of thiamin provided.
Price per Declared Dose
The cost is high relative to the amount of thiamin provided.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  17. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  18. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  19. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  20. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D