Hair Skin & Nails

Hair Skin & Nails

21st Century4.6 (30,432 ratings)
Format:Tablet Quantity: 50 Tablet(s) · 50 servings
Goals
$7.49 $0.14 per serving

Product analysis

50 out of 100

Hair Skin & Nails provides vitamins that help the body use food for energy, especially when intake is low. Undisclosed blend components make the broad mix harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality39

The iodine form has favorable absorption potential, while the other identified forms provide a more mixed picture. Unspecified forms and uncertain absorption information limit a conclusion about the full blend.

Ingredient Transparency68

Ingredient amounts and many forms are stated, helping with basic comparisons. Undisclosed blend components or proportions prevent a complete picture.

Value For Money47

Value varies across the ingredients, with favorable serving costs for iron, phosphorus and iodine but high costs relative to choline and PABA amounts. Many other components cannot be compared reliably on value.

Customer Satisfaction89

Customer feedback is positive. A large number of ratings gives that view a broader base, though reviews do not establish effectiveness.

Product Focus10

The clearest contribution is nutritional support for energy use when intake is low. The broad blend and undisclosed components make targeted supplementation less straightforward.

Format
Tablet
Container
50 Tablet(s)
Per serving
$0.14
Customer rating
4.6 · 30,432 ratings
Report analysis

Goals

Impact
Moderate effect
C- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Iodine · 150 mcgVitamin D · 1.2 mcgVitamin B5 · 15 mgMagnesium · 20 mgRiboflavin · 5 mgThiamin · 5 mgVitamin B12 · 25 mcgIron · 3.3 mgPotassium · 5 mg
Study evidence
Iodine Adverse 3 studies
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Potassium Supportive 2 studies
Thiamin Disputed 12 studies
Vitamin D Supportive 32 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Vitamin A Palmitate)
750 mcg RAE
Vitamin C (Ascorbic Acid)
50 mg
Vitamin D3 (Cholecalciferol)
1.2 mcg
Vitamin E (DL-Alpha-Tocopheryl Acetate)
25 mg
Thiamine (Thiamine Mononitrate)
5 mg
Riboflavin
5 mg
Niacin
7.5 mg
Vitamin B6 (Pyridoxine Hydrochloride)
6.5 mg
Folate
42 mcg DFE
Vitamin B12 (Cyanocobalamin)
25 mcg
Biotin
25 mcg
Pantothenic Acid (D-Calcium Pantothenate)
15 mg
Choline (Choline Bitartrate)
25 mg 44
Calcium (Calcium Carbonate, Dicalcium Phosphate)
125 mg
Iron (Ferrous Fumarate)
3.3 mg 61
Phosphorus (Dicalcium Phosphate)
58 mg 73
Iodine (Potassium Iodide)
150 mcg 100
Magnesium (Magnesium Oxide)
20 mg
Zinc (Zinc Gluconate)
0.6 mg
Manganese (Manganese Sulfate)
0.6 mg
Potassium (Potassium Iodide, Potassium Sulfate)
5 mg
Betaine HCl
10 mg
Inositol
10 mg
PABA
10 mg 60
DNA
10 mg
RNA
10 mg
Tyrosine
7.2 mg
Cysteine Hydrochloride
3.5 mg
Soy Protein
50 mg
Proprietary Herbal Support Blend
310 mg
Gluten Free Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
A serving provides 150 mcg of iodine at a low cost per serving. The iodine comes from potassium iodide. The amount is clearly listed.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The iodine comes from potassium iodide. A marine source is not indicated, so seaweed contamination concerns do not apply to the stated source.
Iodine Form & Bioavailability
The iodine comes from potassium iodide.
Marine Source Purity & Sourcing
A marine source is not indicated, so seaweed contamination concerns do not apply to the stated source.

Dose, Safety & Label Transparency100

A serving lists 150 mcg of iodine. The amount is below the stated adult upper intake level.
Dosage Efficacy for Daily Support
A serving lists 150 mcg of iodine.
Dosage Safety & Upper Limits
The listed 150 mcg is below the stated adult upper intake level.
Elemental Iodine Transparency
The iodine amount per serving is listed.

Value100

The cost per serving is low.
Price Per Effective Serving
The cost per serving is low.
PABA · 10 mg OverallScore60
B+ Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD- Value
Each serving provides 10 mg of PABA, a relatively small amount, at a high cost for the amount. The label names PABA but doesn't specify a quality grade. Artificial colors and titanium dioxide are present.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

PABA is named, but its quality grade is not specified.
PABA Source & Grade
PABA is named without a specified quality grade.

Dose, Safety & Label Transparency50

10 mg of PABA is disclosed per serving. Artificial colors and titanium dioxide are present.
PABA Dosage Alignment
Each serving provides 10 mg of PABA, a relatively small amount.
Label Disclosure Clarity
The PABA amount is listed separately as 10 mg per serving.
Additive and Excipient Quality
Artificial colors and titanium dioxide are present.

Value40

The cost for the amount of PABA is high.
Price per 100mg PABA
The cost for the amount of PABA is high.
B Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 58 mg of phosphorus at a low cost per serving. The phosphorus source is Dicalcium Phosphate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability79

The phosphorus source is Dicalcium Phosphate.
Phosphorus Form Quality
The phosphorus source is Dicalcium Phosphate.
Form Disclosure Clarity
The phosphorus form is named.

Dose, Safety & Label Transparency53

Each serving provides 58 mg of phosphorus. The phosphorus amount is clearly stated.
Dose Adequacy and Safety
Each serving provides 58 mg of phosphorus.
Elemental Dose Transparency
The phosphorus amount is clearly stated.

Value100

The cost per serving is low.
Price Per Serving Efficiency
The cost per serving is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  2. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  3. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  4. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
    Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
    Randomized trial477 participantsEnergy forIron
  5. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
    Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
    Randomized trial176 participantsEnergy forIron
  6. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
    Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
    Randomized trial252 participantsEnergy forIron
  7. Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
    Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
    Randomized trial164 participantsEnergy forIron
  8. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
    Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Randomized trial85 participantsEnergy forIron
  9. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  10. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  11. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  12. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  13. [Efficacy of potassium N-acetylaminosuccinate (Cogitum) in the treatment of asthenic syndrome: results of double-blind placebo-controlled trial].
    Esin RG; Khayrullin IK; Esin OR; Fatykhova AF; Gismatullina EI; Isaeva YN · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2023
    Randomized trial37 participantsEnergy forPotassium
  14. Human resting energy expenditure in relation to dietary potassium.
    Dériaz O; Thériault G; Lavallée N; Fournier G; Nadeau A; Bouchard C · The American journal of clinical nutrition · 1991
    Randomized trial8 participantsEnergy forPotassium
  15. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  16. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  17. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  18. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  19. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  20. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin